| 1 | PARD3, PARD3B
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| Par3A is dispensable for the function of the glomerular filtration barrier of the kidney.
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| Koehler S, Tellkamp F, Niessen CM, Bloch W, Kerjaschki D, Schermer B, Benzing T, Brinkkoetter PT.
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| Am J Physiol Renal Physiol 311(1):F112-9. doi: 10.1152/ajprenal.00171.2016. Epub 2016 Apr 27.
2016
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| 2 | CDH5, PALS1, PARD3
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| VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation.
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| Brinkmann BF, Steinbacher T, Hartmann C, Kummer D, Pajonczyk D, Mirzapourshafiyi F, Nakayama M, Weide T, Gerke V, Ebnet K.
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| Mol Biol Cell. Sep 15;27(18):2811-21. doi: 10.1091/mbc.E16-02-0127. Epub 2016 Jul 27. 2016
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| 3 | CLASP2, PARD3, PRKCI
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| PAR3 and aPKC regulate Golgi organization through CLASP2 phosphorylation to generate cell polarity.
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| Matsui T, Watanabe T, Matsuzawa K, Kakeno M, Okumura N, Sugiyama I, Itoh N, Kaibuchi K.
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| Mol Biol Cell 26(4):751-61. doi: 10.1091/mbc.E14-09-1382. Epub 2014 Dec 17.
2015
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| 4 | CCDC88A, GNAI3, PARD3
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| Regulation of epithelial cell polarity by PAR-3 depends on Girdin transcription and Girdin-Gαi3 signaling.
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| Sasaki K, Kakuwa T, Akimoto K, Koga H, Ohno S.
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| J Cell Sci 128(13):2244-58. doi: 10.1242/jcs.160879. Epub 2015 May 14.
2015
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| 5 | LATS1, PARD3, PPP1CA, TAZ
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| PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction.
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| Lv XB, Liu CY, Wang Z, Sun YP, Xiong Y, Lei QY, Guan KL.
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| EMBO Rep 16(8):975-85. doi: 10.15252/embr.201439951. Epub 2015 Jun 26.
2015
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| 6 | MYL1, PARD3
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| Par-3 modulates intestinal epithelial barrier function through regulating intracellular trafficking of occludin and myosin light chain phosphorylation.
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| Yu M, Yang S, Qiu Y, Chen G, Wang W, Xu C, Cai W, Sun L, Xiao W, Yang H.
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| J Gastroenterol 50(11):1103-13. doi: 10.1007/s00535-015-1066-z. Epub 2015 Mar 28.
2015
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| 7 | LRRC4, PARD3, pARD6A
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| NGL-2 Is a New Partner of PAR Complex in Axon Differentiation.
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| Xu G, Wang R, Wang Z, Lei Q, Yu Z, Liu C, Li P, Yang Z, Cheng X, Li G, Wu M.
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| J Neurosci 35(18):7153-64. doi: 10.1523/JNEUROSCI.4726-14.2015.
2015
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| 8 | PARD3
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| Pard3 regulates contact between neural crest cells and the timing of Schwann cell differentiation but is not essential for neural crest migration or myelination.
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| Blasky AJ, Pan L, Moens CB, Appel B.
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| Dev Dyn 243(12):1511-23. doi: 10.1002/dvdy.24172. Epub 2014 Oct 1.
2014
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| 9 | PARD3, PARD6A, PRKCI
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| The PAR polarity complex and cerebellar granule neuron migration.
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| Ramahi JS, Solecki DJ.
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| Adv Exp Med Biol 800:113-31. doi: 10.1007/978-94-007-7687-6_7. Review.
2014
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| 10 | ADGRB1, PARD3, TIAM1
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| The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites.
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| Duman JG, Tzeng CP, Tu YK, Munjal T, Schwechter B, Ho TS, Tolias KF.
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| J Neurosci 33(16):6964-78. doi: 10.1523/JNEUROSCI.3978-12.2013. 2013
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| 11 | PARD3
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| Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion.
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| Moore R, Theveneau E, Pozzi S, Alexandre P, Richardson J, Merks A, Parsons M, Kashef J, Linker C, Mayor R.
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| Development 140(23):4763-75. doi: 10.1242/dev.098509. Epub 2013 Oct 30.
2013
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| 12 | KIF3A, MAPK1, PARD3
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| ERK2-mediated phosphorylation of Par3 regulates neuronal polarization.
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| Funahashi Y, Namba T, Fujisue S, Itoh N, Nakamuta S, Kato K, Shimada A, Xu C, Shan W, Nishioka T, Kaibuchi K.
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| J Neurosci 33(33):13270-85. doi: 10.1523/JNEUROSCI.4210-12.2013.
2013
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| 13 | GAB1, MARK2, PARD3, PARD6A
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| The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold.
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| Yang Z, Xue B, Umitsu M, Ikura M, Muthuswamy SK, Neel BG.
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| Mol Cell 47(3):469-83. doi: 10.1016/j.molcel.2012.06.037. 2012
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| 14 | BDNF, PARD3, RAC1
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| Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein.
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| Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO.
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| J Biol Chem 287(2):1600-8. doi: 10.1074/jbc.M111.312736. Epub 2011 Nov 29.
2012
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| 15 | TIAM1, pARD3
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| Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.
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| Wang S, Watanabe T, Matsuzawa K, Katsumi A, Kakeno M, Matsui T, Ye F, Sato K, Murase K, Sugiyama I, Kimura K, Mizoguchi A, Ginsberg MH, Collard JG, Kaibuchi K.
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| J Cell Biol 199(2):331-45. doi: 10.1083/jcb.201202041.
2012
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| 16 | PARD3, PARD6A, PRKCI, TIAM1
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| Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.
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| Wang S, Watanabe T, Matsuzawa K, Katsumi A, Kakeno M, Matsui T, Ye F, Sato K, Murase K, Sugiyama I, Kimura K, Mizoguchi A, Ginsberg MH, Collard JG, Kaibuchi K.
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| J Cell Biol 199(2):331-45. doi: 10.1083/jcb.201202041.
2012
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| 17 | CDC42, PARD3, PARD6A
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| Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3.
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| Cadot B, Gache V, Vasyutina E, Falcone S, Birchmeier C, Gomes ER.
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| EMBO Rep 13(8):741-9. doi: 10.1038/embor.2012.89. Epub 2012 Jun 26.
2012
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| 18 | PARD3
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| Interactions between the PDZ domains of Bazooka (Par-3) and phosphatidic acid: in vitro characterization and role in epithelial development.
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| Yu CG, Harris TJ.
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| Mol Biol Cell 23(18):3743-53. doi: 10.1091/mbc.E12-03-0196.
2012
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| 19 | FRMD6, PARD3, PRKCI, ROCK1
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| Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.
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| Ishiuchi T, Takeichi M.
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| Nat Cell Biol 13(7):860-6. doi: 10.1038/ncb2274.
2011
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| 20 | PARD3, SIAH1
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| Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit.
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| Famulski JK, Trivedi N, Howell D, Yang Y, Tong Y, Gilbertson R, Solecki DJ.
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| Science 330(6012):1834-8. Epub 2010 Nov 25.
2010
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| 21 | PARD3, TP53BP2
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| ASPP2 regulates epithelial cell polarity through the PAR complex.
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| Cong W, Hirose T, Harita Y, Yamashita A, Mizuno K, Hirano H, Ohno S.
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| Curr Biol 20(15):1408-14. doi: 10.1016/j.cub.2010.06.024. Epub 2010 Jul 8. 2010
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| 22 | PARD3, PARD3B, PARD6A, PARD6B
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| Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.
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| Horikoshi Y, Suzuki A, Yamanaka T, Sasaki K, Mizuno K, Sawada H, Yonemura S, Ohno S.
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| J Cell Sci 122(Pt 10):1595-606. Epub 2009 Apr 28.PMID: 19401335 2009
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| 23 | PARD3, SPTLC1
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| Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis.
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| Tamehiro N, Mujawar Z, Zhou S, Zhuang DZ, Hornemann T, von Eckardstein A, Fitzgerald ML.
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| J Biol Chem 284(37):24881-90. Epub 2009 Jul 10.PMID: 19592499 2009
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| 24 | AURKA, PARD3
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| Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora a and regulates its function in neuronal polarity.
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| Khazaei MR, Püschel AW.
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| J Biol Chem 284(48):33571-9. Epub 2009 Oct 6.PMID: 19812038 2009
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| 25 | PARD3
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| Defective expression of polarity protein PAR-3 gene (PARD3) in esophageal squamous cell carcinoma.
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| Zen K, Yasui K, Gen Y, Dohi O, Wakabayashi N, Mitsufuji S, Itoh Y, Zen Y, Nakanuma Y, Taniwaki M, Okanoue T, Yoshikawa T.
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| Oncogene 28(32):2910-8. Epub 2009 Jun 8.PMID: 19503097 2009
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| 26 | DYNC1I2, PARD3
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| Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration.
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| Schmoranzer J, Fawcett JP, Segura M, Tan S, Vallee RB, Pawson T, Gundersen GG.
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| Curr Biol 19(13):1065-74. doi: 10.1016/j.cub.2009.05.065. Epub 2009 Jun 18.
2009
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| 27 | KIRREL, NPHP1, NPHS1, PAED6B, PARD3, PARD6A
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| Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.
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| Hartleben B, Schweizer H, Lübben P, Bartram MP, Möller CC, Herr R, Wei C, Neumann-Haefelin E, Schermer B, Zentgraf H, Kerjaschki D, Reiser J, Walz G, Benzing T, Huber TB.
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| J Biol Chem 283(34):23033-8. Epub 2008 Jun 18. 2008
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| 28 | PARD3, MAGI2
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| Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis.
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| Wapenaar MC, Monsuur AJ, van Bodegraven AA, Weersma RK, Bevova MR, Linskens RK, Howdle P, Holmes G, Mulder CJ, Dijkstra G, van Heel DA, Wijmenga C.
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| Gut 57(4):463-7. Epub 2007 Nov 7. 2008
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| 29 | PARD3, NGFR
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| The polarity protein Par-3 directly interacts with p75NTR to regulate myelination.
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| Chan JR, Jolicoeur C, Yamauchi J, Elliott J, Fawcett JP, Ng BK, Cayouette M.
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| Science 314(5800):832-6. 2006
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| 30 | PARD3
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| Par-3 mediates the inhibition of LIM kinase 2 to regulate cofilin phosphorylation and tight junction assembly.
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| Chen X, Macara IG.
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| J Cell Biol 172(5):671-8. 2006
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| 31 | PARD3, TIAM1
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| Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.
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| Chen X, Macara IG.
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| Nat Cell Biol 7(3):262-9. Epub 2005 Feb 20. 2005
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| 32 | PARD3
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| Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human Par3-related cell polarity protein.
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| Izaki T, Kamakura S, Kohjima M, Sumimoto H.
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| Biochem Biophys Res Commun 329(1):211-8.
2005
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| 33 | PARD3, PARD3B
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| Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human Par3-related cell polarity protein.
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| Izaki T, Kamakura S, Kohjima M, Sumimoto H.
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| Biochem Biophys Res Commun 329(1):211-8.
2005
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| 34 | PARD3
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| Gene amplification of atypical PKC-binding PARD3 in radiation-transformed neoplastic retinal pigment epithelial cell lines.
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| Zitzelsberger H, Hieber L, Richter H, Unger K, Briscoe CV, Peddie C, Riches A.
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| Genes Chromosomes Cancer 40(1):55-9. 2004
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| 35 | PARD3, PARD3B
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| Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties.
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| Gao L, Macara I, Joberty G.
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| Gene 294(1-2):99. 2002
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| 36 | EKD1, PARD3, PARD6A
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| Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures.
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| Suzuki A, Yamanaka T, Hirose T, Manabe N, Mizuno K, Shimizu M, Akimoto K, Izumi Y, Ohnishi T, Ohno S.
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| J Cell Biol 152(6):1183-96. 2001
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| 37 | CDC42, EKD1, PARD3, PARD6A, PARD6B, PARD6G
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| The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.
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| Joberty G, Petersen C, Gao L, Macara IG.
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| Nat Cell Biol 2(8):531-9. 2000
|