1 | CCM2, NPPA, NPR1, PAK4
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| CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading.
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| Miura K, Nojiri T, Akitake Y, Ando K, Fukuhara S, Zenitani M, Kimura T, Hino J, Miyazato M, Hosoda H, Kangawa K.
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| Biochem J 474(11):1897-1918. doi: 10.1042/BCJ20160841.
2017
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2 | G6PD, PAK4
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| PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth.
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| Zhang X, Zhang X, Li Y, Shao Y, Xiao J, Zhu G, Li F.
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| Cell Death Dis 8(5):e2820. doi: 10.1038/cddis.2017.85.
2017
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3 | PAK4, SH3RF2
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| SH3RF2 Functions as an Oncogene by Mediating PAK4 Protein Stability.
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| Kim TW, Kang YK, Park ZY, Kim YH, Hong SW, Su JO, Sohn HA, Yang SJ, Jang YJ, Lee DC, Kim SY, Yoo HS, Kim E, Yeom YI, Park KC.
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| Carcinogenesis arcinogenesis. 2013 Oct 15. [Epub ahead of print]
2013
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4 | PAK4, STMN2
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| PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis.
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| Guo Q, Su N, Zhang J, Li X, Miao Z, Wang G, Cheng M, Xu H, Cao L, Li F.
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| Oncogene ncogene. 2013 Jul 29. doi: 10.1038/onc.2013.296. [Epub ahead of print]
2013
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5 | PAK4
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| The Pak4 protein kinase is required for oncogenic transformation of MDA-MB-231 breast cancer cells.
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| Wong LE, Chen N, Karantza V, Minden A.
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| Oncogenesis 2:e50. doi: 10.1038/oncsis.2013.13.
2013
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6 | PAK4
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| p21-activated kinase 4 regulation of endometrial cancer cell migration and invasion involves the ERK1/2 pathway mediated MMP-2 secretion.
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| Lu W, Xia YH, Qu JJ, He YY, Li BL, Lu C, Luo X, Wan XP.
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| Neoplasma 60(5):493-503. doi: 10.4149/neo_2013_064.
2013
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7 | LIMK1, PAK4
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| PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity.
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| Whale AD, Dart A, Holt M, Jones GE, Wells CM.
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| Oncogene 32(16):2114-20. doi: 10.1038/onc.2012.233. Epub 2012 Jun 11.
2013
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8 | PAK4
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| P21-activated kinase 4 (PAK4) is required for metaphase spindle positioning and anchoring.
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| Bompard G, Rabeharivelo G, Cau J, Abrieu A, Delsert C, Morin N.
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| Oncogene 32(7):910-9. doi: 10.1038/onc.2012.98. Epub 2012 Mar 26.
2013
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9 | MMP2, PAK4
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| Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma.
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| Kesanakurti D, Chetty C, Rajasekhar Maddirela D, Gujrati M, Rao JS.
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| Cell Death Dis 3:e445. doi: 10.1038/cddis.2012.182.
2012
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10 | PAK4
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| Role for p21-activated kinase PAK4 in development of the mammalian heart.
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| Nekrasova T, Minden A.
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| Transgenic Res 21(4):797-811. doi: 10.1007/s11248-011-9578-7. Epub 2011 Dec 16.
2012
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11 | PAK4
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| A key role for Pak4 in proliferation and differentiation of neural progenitor cells.
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| Tian Y, Lei L, Minden A.
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| Dev Biol 353(2):206-16. Epub 2011 Mar 4.
2011
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12 | PAK1, PAK2, PAK3, PAK4, PAK6, PAK7
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| Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.
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| Delorme-Walker VD, Peterson JR, Chernoff J, Waterman CM, Danuser G, DerMardirossian C, Bokoch GM.
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| J Cell Biol 193(7):1289-303.
2011
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13 | PAK4
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| PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression.
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| Nekrasova T, Minden A.
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| J Cell Biochem 112(7):1795-806. doi: 10.1002/jcb.23092.
2011
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14 | PAK4
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| PAK4 phosphorylates myosin regulatory light chain and contributes to Fcγ receptor-mediated phagocytosis.
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| Bright MD, Frankel G.
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| Int J Biochem Cell Biol 43(12):1776-81. doi: 10.1016/j.biocel.2011.08.015. Epub 2011 Sep 3.
2011
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15 | PAK4
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| The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis.
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| Liu Y, Chen N, Cui X, Zheng X, Deng L, Price S, Karantza V, Minden A.
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| Oncogene 29(44):5883-94. Epub 2010 Aug 9.
2010
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16 | PAK4
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| Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor.
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| Paliouras GN, Naujokas MA, Park M.
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| Mol Cell Biol 29(11):3018-32. Epub 2009 Mar 16.
2009
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17 | AKT1, PAK4, RIOK3
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| Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.
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| Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP, Protopopova M, Ivanova E, Zhang J, Feng B, Tsao MS, Redston M, Protopopov A, Xiao Y, Futreal PA, Hahn WC, Klimstra DS, Chin L, DePinho RA.
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| Proc Natl Acad Sci U S A 105(49):19372-7. Epub 2008 Dec 2.
2008
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18 | PAK4
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| A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGF.
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| Ahmed T, Shea K, Masters JR, Jones GE, Wells CM.
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| Cell Signal 20(7):1320-8. Epub 2008 Mar 12.
2008
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19 | PAK4
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| PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation.
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| Gringel A, Walz D, Rosenberger G, Minden A, Kutsche K, Kopp P, Linder S.
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| J Cell Physiol 209(2):568-79.
2006
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20 | PAK4
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| PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor.
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| Li X, Minden A.
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| J Biol Chem 280(50):41192-200. Epub 2005 Oct 14.
2005
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21 | PAK4
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| PAK4 mediates morphological changes through the regulation of GEF-H1.
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| Callow MG, Zozulya S, Gishizky ML, Jallal B, Smeal T.
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| J Cell Sci 118(Pt 9):1861-72. Epub 2005 Apr 12.
2005
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22 | PAK4
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| Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor.
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| Barac A, Basile J, Vázquez-Prado J, Gao Y, Zheng Y, Gutkind JS.
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| J Biol Chem 279(7):6182-9. Epub 2003 Nov 18.
2004
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23 | PAK4
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| PAK4 kinase is essential for embryonic viability and for proper neuronal development.
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| Qu J, Li X, Novitch BG, Zheng Y, Kohn M, Xie JM, Kozinn S, Bronson R, Beg AA, Minden A.
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| Mol Cell Biol 23(20):7122-33. 2003
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24 | FGF7, FGFR2, PAK4
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| p21-activated protein kinase 4 (PAK4) interacts with the keratinocyte growth factor receptor and participates in keratinocyte growth factor-mediated inhibition of oxidant-induced cell death.
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| Lu Y, Pan ZZ, Devaux Y, Ray P.
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| J Biol Chem 278(12):10374-80. Epub 2003 Jan 15.
2003
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25 | PAK1, PAK2, PAK3, PAK4
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| Pak to the future.
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| Bagrodia S, Cerione RA.
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| Trends Cell Biol 9(9):350-5. Review. 1999
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26 | CDC42, PAK4
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| PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.
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| Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A.
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| EMBO J 17(22):6527-40. 1998
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