Citations for
1MCSZ2, PAK1
Activating Mutations in PAK1, Encoding p21-Activated Kinase 1, Cause a Neurodevelopmental Disorder.
Harms FL, Kloth K, Bley A, Denecke J, Santer R, Lessel D, Hempel M, Kutsche K.
Am J Hum Genet 103(4):579-591. doi: 10.1016/j.ajhg.2018.09.005. 2018
2ARHGEF7, GIT1, PAK1
GIT1/βPIX signaling proteins and PAK1 kinase regulate microtubule nucleation.
Černohorská M, Sulimenko V, Hájková Z, Sulimenko T, Sládková V, Vinopal S, Dráberová E, Dráber P.
Biochim Biophys Acta 1863(6 Pt A):1282-97. doi: 10.1016/j.bbamcr.2016.03.016. 2016
3HSPA5, INPP5K, PAK1
Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization.
Ijuin T, Hatano N, Takenawa T.
Genes Cells 21(5):457-65. doi: 10.1111/gtc.12353. Epub 2016 Mar 4. 2016
4PAK1, PAK3
Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain.
Kim DJ, Choi CK, Lee CS, Park MH, Tian X, Kim ND, Lee KI, Choi JK, Ahn JH, Shin EY, Shin I, Kim EG.
Exp Mol Med 48:e229. doi: 10.1038/emm.2016.13. 2016
5INPP5K, PAK1
Improvement of insulin signaling in myoblast cells by an addition of SKIP-binding peptide within Pak1 kinase domain.
Ijuin T, Takenawa T.
Biochem Biophys Res Commun 456(1):41-6. doi: 10.1016/j.bbrc.2014.11.031. Epub 2014 Nov 18. 2015
6ARHGEF7, GIT1, PAK1, RAC1
GIT1 and βPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission.
Smith KR, Davenport EC, Wei J, Li X, Pathania M, Vaccaro V, Yan Z, Kittler JT.
Cell Rep 9(1):298-310. doi: 10.1016/j.celrep.2014.08.061. 2014
7MAP2K1, MAP2K2, PAK1
p21-activated kinase 1 (PAK1) can promote ERK activation in a kinase-independent manner.
Wang Z, Fu M, Wang L, Liu J, Li Y, Brakebusch C, Mei Q.
J Biol Chem 288(27):20093-9. doi: 10.1074/jbc.M112.426023. Epub 2013 May 7. 2013
8NCAM1, PAK1
The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated kinase 1 (Pak1).
Li S, Leshchyns'ka I, Chernyshova Y, Schachner M, Sytnyk V.
J Neurosci 33(2):790-803. doi: 10.1523/JNEUROSCI.1238-12.2013. 2013
9CSNK2A1, PAK1
Protein kinase CK2 phosphorylates and activates p21-activated kinase 1.
Shin YJ, Kim YB, Kim JH.
Mol Biol Cell 24(18):2990-9. doi: 10.1091/mbc.E13-04-0204. Epub 2013 Jul 24. 2013
10DLG1, DLG2, DLG3, DLG4, EPHB1, PAK1
Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.
Murata Y, Constantine-Paton M.
J Neurosci 33(11):5040-52. doi: 10.1523/JNEUROSCI.2896-12.2013. 2013
11PAK1, SYT2
The endocytic adapter E-Syt2 recruits the p21 GTPase activated kinase PAK1 to mediate actin dynamics and FGF signalling.
Jean S, Tremblay MG, Herdman C, Guillou F, Moss T.
Biol Open 1(8):731-8. doi: 10.1242/bio.2012968. Epub 2012 Jun 12. 2012
12PAK1
PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling.
Shrestha Y, Schafer EJ, Boehm JS, Thomas SR, He F, Du J, Wang S, Barretina J, Weir BA, Zhao JJ, Polyak K, Golub TR, Beroukhim R, Hahn WC.
Oncogene 31(29):3397-408. doi: 10.1038/onc.2011.515. Epub 2011 Nov 21. 2012
13PAK1, PAK3
The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.
Combeau G, Kreis P, Domenichini F, Amar M, Fossier P, Rousseau V, Barnier JV.
J Biol Chem 287(36):30084-96. doi: 10.1074/jbc.M112.355073. Epub 2012 Jul 19. 2012
14PAK1, STK11, STRADA
STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells.
Eggers CM, Kline ER, Zhong D, Zhou W, Marcus AI.
J Biol Chem 287(22):18758-68. doi: 10.1074/jbc.M111.316422. Epub 2012 Apr 6. 2012
15PAK1
p21-activated kinase interacts with Wnt signaling to regulate tissue polarity and gene expression.
Goh KY, Ng NW, Hagen T, Inoue T.
Proc Natl Acad Sci U S A 109(39):15853-8. 2012
16MORC2, PAK1
MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response.
Li DQ, Nair SS, Ohshiro K, Kumar A, Nair VS, Pakala SB, Reddy SD, Gajula RP, Eswaran J, Aravind L, Kumar R.
Cell Rep 2(6):1657-69. doi: 10.1016/j.celrep.2012.11.018. 2012
17PAK1
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.
Ong CC, Jubb AM, Haverty PM, Zhou W, Tran V, Truong T, Turley H, O'Brien T, Vucic D, Harris AL, Belvin M, Friedman LS, Blackwood EM, Koeppen H, Hoeflich KP.
Proc Natl Acad Sci U S A 108(17):7177-82. Epub 2011 Apr 11. 2011
18PAK1, PAK3
p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties.
Huang W, Zhou Z, Asrar S, Henkelman M, Xie W, Jia Z.
Mol Cell Biol 31(3):388-403. Epub 2010 Nov 29. 2011
19PAK1, PAK2, PAK3, PAK4, PAK6, PAK7
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.
Delorme-Walker VD, Peterson JR, Chernoff J, Waterman CM, Danuser G, DerMardirossian C, Bokoch GM.
J Cell Biol 193(7):1289-303. 2011
20KIF3A, PAK1
Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms.
Sipe CW, Lu X.
Development 138(16):3441-9. Epub 2011 Jul 13. 2011
21AJUBA, AKT1, PAK1
Ajuba is required for Rac activation and maintenance of E-cadherin adhesion.
Nola S, Daigaku R, Smolarczyk K, Carstens M, Martin-Martin B, Longmore G, Bailly M, Braga VM.
J Cell Biol 195(5):855-71. doi: 10.1083/jcb.201107162. Epub 2011 Nov 21. 2011
22CHL1, PAK1, PAK2, PAK3
CHL1 cooperates with PAK1-3 to regulate morphological differentiation of embryonic cortical neurons.
Demyanenko GP, Halberstadt AI, Rao RS, Maness PF.
Neuroscience 165(1):107-15. Epub 2009 Oct 9.PMID: 19819308 2010
23CDH1, PAK1
Pak1 control of E-cadherin endocytosis regulates salivary gland lumen size and shape.
Pirraglia C, Walters J, Myat MM.
Development 137(24):4177-89. Epub 2010 Nov 10. 2010
24PAK1, PAK3
p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2.
Chow HY, Stepanova D, Koch J, Chernoff J.
PLoS One 5(11):e13791. 2010
25CDC42, PAK1, PAK2
Dual role of Cdc42 in spindle orientation control of adherent cells.
Mitsushima M, Toyoshima F, Nishida E.
Mol Cell Biol 29(10):2816-27. Epub 2009 Mar 9. 2009
26CDK11A, CDK11B, PAK1
CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression.
Kong X, Gan H, Hao Y, Cheng C, Jiang J, Hong Y, Yang J, Zhu H, Chi Y, Yun X, Gu J.
J Biochem 146(3):417-27. Epub 2009 Jun 11.PMID: 19520772 2009
27DYNLL1, PAK1
Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.
Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U, Williams JC.
PLoS One 4(6):e6025.PMID: 19557173 2009
28ARHGEF7, GIT1, PAK1, PAK2, SCRIB
Scrib regulates PAK activity during the cell migration process.
Nola S, Sebbagh M, Marchetto S, Osmani N, Nourry C, Audebert S, Navarro C, Rachel R, Montcouquiol M, Sans N, Etienne-Manneville S, Borg JP, Santoni MJ.
Hum Mol Genet 17(22):3552-65. Epub 2008 Aug 20. 2008
29PAK1, PAK2
Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.
Coniglio SJ, Zavarella S, Symons MH.
Mol Cell Biol 28(12):4162-72. Epub 2008 Apr 14. 2008
30PAK1, RAC1, RAC3
PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac.
Lozano E, Frasa MA, Smolarczyk K, Knaus UG, Braga VM.
J Cell Sci 121(Pt 7):933-8. Epub 2008 Mar 4. 2008
31PAK1
16-kDa prolactin inhibits endothelial cell migration by down-regulating the Ras-Tiam1-Rac1-Pak1 signaling pathway.
Lee SH, Kunz J, Lin SH, Yu-Lee LY.
Cancer Res 67(22):11045-53. 2007
32PAK1
PAK1 hyperactivation is sufficient for mammary gland tumor formation.
Wang RA, Zhang H, Balasenthil S, Medina D, Kumar R.
Oncogene 25(20):2931-6. 2006
33GIT1, ARHGEF6, AKT1, PAK1, PAK2, PAK3
A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC.
Zhang H, Webb DJ, Asmussen H, Niu S, Horwitz AF.
J Neurosci 25(13):3379-88. 2005
34PAK1, CIB1
Essential role of CIB1 in regulating PAK1 activation and cell migration.
Leisner TM, Liu M, Jaffer ZM, Chernoff J, Parise LV.
J Cell Biol 170(3):465-76. 2005
35PAK1, TBCB
p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B.
Vadlamudi RK, Barnes CJ, Rayala S, Li F, Balasenthil S, Marcus S, Goodson HV, Sahin AA, Kumar R.
Mol Cell Biol 25(9):3726-36. 2005
36PAK1, SPEN
An essential role of Pak1 phosphorylation of SHARP in Notch signaling.
Vadlamudi RK, Manavathi B, Singh RR, Nguyen D, Li F, Kumar R.
Oncogene 24(28):4591-6. 2005
37LAMTOR3, PAK1
The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals.
Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD.
Mol Cell Biol 25(12):5119-33. 2005
38DSCAM, PAK1
The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.
Li W, Guan KL.
J Biol Chem 279(31):32824-31. Epub 2004 May 28. 2004
39PAK1, PGM1
Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase.
Gururaj A, Barnes CJ, Vadlamudi RK, Kumar R.
Oncogene 23(49):8118-27. 2004
40PPM1E, PPM1F, PAK1
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.
Koh CG, Tan EJ, Manser E, Lim L.
Curr Biol 12(4):317-21. 2002
41PAK1
Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils.
Dharmawardhane S, Brownson D, Lennartz M, Bokoch GM.
J Leukoc Biol 66(3):521-7 1999
42PAK1
Inhibition of myosin light chain kinase by p21-activated kinase.
Sanders LC, Matsumura F, Bokoch GM, de Lanerolle P.
Science 283(5410):2083-5. 1999
43PAK1
p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts.
Sells MA, Boyd JT, Chernoff J.
J Cell Biol 145(4):837-49. 1999
44PAK1, PAK2, PAK3, PAK4
Pak to the future.
Bagrodia S, Cerione RA.
Trends Cell Biol 9(9):350-5. Review. 1999
45LRRC32, PAK1, UVRAG
Detailed map of a region commonly amplified at 11q13-q14 in human breast carcinoma.
Bekri S, Adelaide J, Merscher S, Grosgeorge J, Caroli-Bosc F, Perucca-Lostanlen D, Kelley PM, Pebusque MJ, Theillet C, Birnbaum D, Gaudray P.
Cytogenet Cell Genet 79(1-2):125-31. 1997
46PAK1
Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.
Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J.
Curr Biol 6(5):598-605. 1996
47PAK1
A brain serine/threonine protein kinase activated by Cdc-42 and Rac1.
Manser E, et al.
Nature 367 : 40-46. 1994