| 1 | PAK1, PAK2
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| PAK1 and PAK2 in cell metabolism regulation
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| Kořánová T, Dvořáček L, Grebeňová D, Röselová P, Obr A, Kuželová K.
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| J Cell Biochem. Feb;123(2):375-389. doi: 10.1002/jcb.30175. Epub 2021 Nov 8. 2022
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| 2 | PAK1, PAK2
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| The p21-activated kinase 2 (PAK2), but not PAK1, regulates contraction-stimulated skeletal muscle glucose transport
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| Mřller LLV, Nielsen IL, Knudsen JR, Andersen NR, Jensen TE, Sylow L, Richter EA.
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| Physiol Rep. Jun;8(12):e14460. doi: 10.14814/phy2.14460. 2020
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| 3 | NUDT21, pAK1
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| Nudt21 regulates the alternative polyadenylation of Pak1 and is predictive in the prognosis of glioblastoma patients.
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| Chu Y, Elrod N, Wang C, Li L, Chen T, Routh A, Xia Z, Li W, Wagner EJ, Ji P.
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| Oncogene 38(21):4154-4168. doi: 10.1038/s41388-019-0714-9. Epub 2019 Jan 31.
2019
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| 4 | MCSZ2, PAK1
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| Activating Mutations in PAK1, Encoding p21-Activated Kinase 1, Cause a Neurodevelopmental Disorder.
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| Harms FL, Kloth K, Bley A, Denecke J, Santer R, Lessel D, Hempel M, Kutsche K.
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| Am J Hum Genet 103(4):579-591. doi: 10.1016/j.ajhg.2018.09.005.
2018
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| 5 | ARHGEF7, GIT1, PAK1
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| GIT1/βPIX signaling proteins and PAK1 kinase regulate microtubule nucleation.
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| Černohorská M, Sulimenko V, Hájková Z, Sulimenko T, Sládková V, Vinopal S, Dráberová E, Dráber P.
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| Biochim Biophys Acta 1863(6 Pt A):1282-97. doi: 10.1016/j.bbamcr.2016.03.016.
2016
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| 6 | HSPA5, INPP5K, PAK1
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| Glucose-regulated protein 78 (GRP78) binds directly to PIP3 phosphatase SKIP and determines its localization.
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| Ijuin T, Hatano N, Takenawa T.
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| Genes Cells 21(5):457-65. doi: 10.1111/gtc.12353. Epub 2016 Mar 4.
2016
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| 7 | PAK1, PAK3
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| Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain.
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| Kim DJ, Choi CK, Lee CS, Park MH, Tian X, Kim ND, Lee KI, Choi JK, Ahn JH, Shin EY, Shin I, Kim EG.
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| Exp Mol Med 48:e229. doi: 10.1038/emm.2016.13.
2016
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| 8 | INPP5K, PAK1
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| Improvement of insulin signaling in myoblast cells by an addition of SKIP-binding peptide within Pak1 kinase domain.
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| Ijuin T, Takenawa T.
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| Biochem Biophys Res Commun 456(1):41-6. doi: 10.1016/j.bbrc.2014.11.031. Epub 2014 Nov 18.
2015
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| 9 | ARHGEF7, GIT1, PAK1, RAC1
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| GIT1 and βPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission.
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| Smith KR, Davenport EC, Wei J, Li X, Pathania M, Vaccaro V, Yan Z, Kittler JT.
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| Cell Rep 9(1):298-310. doi: 10.1016/j.celrep.2014.08.061.
2014
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| 10 | MAP2K1, MAP2K2, PAK1
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| p21-activated kinase 1 (PAK1) can promote ERK activation in a kinase-independent manner.
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| Wang Z, Fu M, Wang L, Liu J, Li Y, Brakebusch C, Mei Q.
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| J Biol Chem 288(27):20093-9. doi: 10.1074/jbc.M112.426023. Epub 2013 May 7.
2013
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| 11 | NCAM1, PAK1
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| The neural cell adhesion molecule (NCAM) associates with and signals through p21-activated kinase 1 (Pak1).
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| Li S, Leshchyns'ka I, Chernyshova Y, Schachner M, Sytnyk V.
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| J Neurosci 33(2):790-803. doi: 10.1523/JNEUROSCI.1238-12.2013.
2013
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| 12 | CSNK2A1, PAK1
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| Protein kinase CK2 phosphorylates and activates p21-activated kinase 1.
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| Shin YJ, Kim YB, Kim JH.
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| Mol Biol Cell 24(18):2990-9. doi: 10.1091/mbc.E13-04-0204. Epub 2013 Jul 24.
2013
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| 13 | DLG1, DLG2, DLG3, DLG4, EPHB1, PAK1
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| Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.
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| Murata Y, Constantine-Paton M.
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| J Neurosci 33(11):5040-52. doi: 10.1523/JNEUROSCI.2896-12.2013.
2013
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| 14 | ARHGAP15, PAK1, PAK2
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| ArhGAP15, a Rac-specific GTPase-activating protein, plays a dual role in inhibiting small GTPase signaling.
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| Radu M, Rawat SJ, Beeser A, Iliuk A, Tao WA, Chernoff J.
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| J Biol Chem. Jul 19;288(29):21117-21125. doi: 10.1074/jbc.M113.459719. Epub 2013 Jun 11. 2013
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| 15 | PAK1, SYT2
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| The endocytic adapter E-Syt2 recruits the p21 GTPase activated kinase PAK1 to mediate actin dynamics and FGF signalling.
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| Jean S, Tremblay MG, Herdman C, Guillou F, Moss T.
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| Biol Open 1(8):731-8. doi: 10.1242/bio.2012968. Epub 2012 Jun 12.
2012
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| 16 | PAK1
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| PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling.
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| Shrestha Y, Schafer EJ, Boehm JS, Thomas SR, He F, Du J, Wang S, Barretina J, Weir BA, Zhao JJ, Polyak K, Golub TR, Beroukhim R, Hahn WC.
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| Oncogene 31(29):3397-408. doi: 10.1038/onc.2011.515. Epub 2011 Nov 21.
2012
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| 17 | PAK1, PAK3
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| The p21-activated kinase PAK3 forms heterodimers with PAK1 in brain implementing trans-regulation of PAK3 activity.
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| Combeau G, Kreis P, Domenichini F, Amar M, Fossier P, Rousseau V, Barnier JV.
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| J Biol Chem 287(36):30084-96. doi: 10.1074/jbc.M112.355073. Epub 2012 Jul 19.
2012
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| 18 | PAK1, STK11, STRADA
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| STE20-related kinase adaptor protein α (STRADα) regulates cell polarity and invasion through PAK1 signaling in LKB1-null cells.
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| Eggers CM, Kline ER, Zhong D, Zhou W, Marcus AI.
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| J Biol Chem 287(22):18758-68. doi: 10.1074/jbc.M111.316422. Epub 2012 Apr 6.
2012
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| 19 | PAK1
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| p21-activated kinase interacts with Wnt signaling to regulate tissue polarity and gene expression.
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| Goh KY, Ng NW, Hagen T, Inoue T.
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| Proc Natl Acad Sci U S A 109(39):15853-8.
2012
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| 20 | MORC2, PAK1
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| MORC2 signaling integrates phosphorylation-dependent, ATPase-coupled chromatin remodeling during the DNA damage response.
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| Li DQ, Nair SS, Ohshiro K, Kumar A, Nair VS, Pakala SB, Reddy SD, Gajula RP, Eswaran J, Aravind L, Kumar R.
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| Cell Rep 2(6):1657-69. doi: 10.1016/j.celrep.2012.11.018.
2012
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| 21 | PAK1
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| Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.
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| Ong CC, Jubb AM, Haverty PM, Zhou W, Tran V, Truong T, Turley H, O'Brien T, Vucic D, Harris AL, Belvin M, Friedman LS, Blackwood EM, Koeppen H, Hoeflich KP.
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| Proc Natl Acad Sci U S A 108(17):7177-82. Epub 2011 Apr 11.
2011
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| 22 | PAK1, PAK3
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| p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties.
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| Huang W, Zhou Z, Asrar S, Henkelman M, Xie W, Jia Z.
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| Mol Cell Biol 31(3):388-403. Epub 2010 Nov 29. 2011
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| 23 | PAK1, PAK2, PAK3, PAK4, PAK6, PAK7
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| Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration.
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| Delorme-Walker VD, Peterson JR, Chernoff J, Waterman CM, Danuser G, DerMardirossian C, Bokoch GM.
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| J Cell Biol 193(7):1289-303.
2011
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| 24 | KIF3A, PAK1
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| Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms.
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| Sipe CW, Lu X.
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| Development 138(16):3441-9. Epub 2011 Jul 13.
2011
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| 25 | AJUBA, AKT1, PAK1
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| Ajuba is required for Rac activation and maintenance of E-cadherin adhesion.
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| Nola S, Daigaku R, Smolarczyk K, Carstens M, Martin-Martin B, Longmore G, Bailly M, Braga VM.
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| J Cell Biol 195(5):855-71. doi: 10.1083/jcb.201107162. Epub 2011 Nov 21.
2011
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| 26 | CHL1, PAK1, PAK2, PAK3
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| CHL1 cooperates with PAK1-3 to regulate morphological differentiation of embryonic cortical neurons.
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| Demyanenko GP, Halberstadt AI, Rao RS, Maness PF.
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| Neuroscience 165(1):107-15. Epub 2009 Oct 9.PMID: 19819308 2010
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| 27 | CDH1, PAK1
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| Pak1 control of E-cadherin endocytosis regulates salivary gland lumen size and shape.
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| Pirraglia C, Walters J, Myat MM.
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| Development 137(24):4177-89. Epub 2010 Nov 10.
2010
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| 28 | PAK1, PAK3
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| p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2.
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| Chow HY, Stepanova D, Koch J, Chernoff J.
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| PLoS One 5(11):e13791.
2010
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| 29 | CDC42, PAK1, PAK2
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| Dual role of Cdc42 in spindle orientation control of adherent cells.
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| Mitsushima M, Toyoshima F, Nishida E.
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| Mol Cell Biol 29(10):2816-27. Epub 2009 Mar 9.
2009
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| 30 | CDK11A, CDK11B, PAK1
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| CDK11p58 phosphorylation of PAK1 Ser174 promotes DLC2 binding and roles on cell cycle progression.
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| Kong X, Gan H, Hao Y, Cheng C, Jiang J, Hong Y, Yang J, Zhu H, Chi Y, Yun X, Gu J.
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| J Biochem 146(3):417-27. Epub 2009 Jun 11.PMID: 19520772 2009
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| 31 | DYNLL1, PAK1
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| Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.
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| Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U, Williams JC.
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| PLoS One 4(6):e6025.PMID: 19557173 2009
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| 32 | ARHGEF7, GIT1, PAK1, PAK2, SCRIB
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| Scrib regulates PAK activity during the cell migration process.
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| Nola S, Sebbagh M, Marchetto S, Osmani N, Nourry C, Audebert S, Navarro C, Rachel R, Montcouquiol M, Sans N, Etienne-Manneville S, Borg JP, Santoni MJ.
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| Hum Mol Genet 17(22):3552-65. Epub 2008 Aug 20. 2008
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| 33 | PAK1, PAK2
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| Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.
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| Coniglio SJ, Zavarella S, Symons MH.
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| Mol Cell Biol 28(12):4162-72. Epub 2008 Apr 14.
2008
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| 34 | PAK1, RAC1, RAC3
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| PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac.
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| Lozano E, Frasa MA, Smolarczyk K, Knaus UG, Braga VM.
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| J Cell Sci 121(Pt 7):933-8. Epub 2008 Mar 4.
2008
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| 35 | PAK1
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| 16-kDa prolactin inhibits endothelial cell migration by down-regulating the Ras-Tiam1-Rac1-Pak1 signaling pathway.
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| Lee SH, Kunz J, Lin SH, Yu-Lee LY.
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| Cancer Res 67(22):11045-53. 2007
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| 36 | PAK1
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| PAK1 hyperactivation is sufficient for mammary gland tumor formation.
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| Wang RA, Zhang H, Balasenthil S, Medina D, Kumar R.
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| Oncogene 25(20):2931-6. 2006
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| 37 | GIT1, ARHGEF6, AKT1, PAK1, PAK2, PAK3
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| A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC.
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| Zhang H, Webb DJ, Asmussen H, Niu S, Horwitz AF.
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| J Neurosci 25(13):3379-88. 2005
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| 38 | PAK1, CIB1
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| Essential role of CIB1 in regulating PAK1 activation and cell migration.
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| Leisner TM, Liu M, Jaffer ZM, Chernoff J, Parise LV.
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| J Cell Biol 170(3):465-76. 2005
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| 39 | PAK1, TBCB
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| p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B.
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| Vadlamudi RK, Barnes CJ, Rayala S, Li F, Balasenthil S, Marcus S, Goodson HV, Sahin AA, Kumar R.
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| Mol Cell Biol 25(9):3726-36.
2005
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| 40 | PAK1, SPEN
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| An essential role of Pak1 phosphorylation of SHARP in Notch signaling.
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| Vadlamudi RK, Manavathi B, Singh RR, Nguyen D, Li F, Kumar R.
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| Oncogene 24(28):4591-6.
2005
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| 41 | LAMTOR3, PAK1
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| The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals.
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| Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD.
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| Mol Cell Biol 25(12):5119-33. 2005
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| 42 | DSCAM, PAK1
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| The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak.
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| Li W, Guan KL.
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| J Biol Chem 279(31):32824-31. Epub 2004 May 28. 2004
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| 43 | PAK1, PGM1
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| Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase.
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| Gururaj A, Barnes CJ, Vadlamudi RK, Kumar R.
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| Oncogene 23(49):8118-27.
2004
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| 44 | PPM1E, PPM1F, PAK1
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| The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.
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| Koh CG, Tan EJ, Manser E, Lim L.
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| Curr Biol 12(4):317-21. 2002
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| 45 | PAK1
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| Localization of p21-activated kinase 1 (PAK1) to pseudopodia, membrane ruffles, and phagocytic cups in activated human neutrophils.
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| Dharmawardhane S, Brownson D, Lennartz M, Bokoch GM.
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| J Leukoc Biol 66(3):521-7 1999
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| 46 | PAK1
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| Inhibition of myosin light chain kinase by p21-activated kinase.
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| Sanders LC, Matsumura F, Bokoch GM, de Lanerolle P.
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| Science 283(5410):2083-5. 1999
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| 47 | PAK1
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| p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts.
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| Sells MA, Boyd JT, Chernoff J.
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| J Cell Biol 145(4):837-49. 1999
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| 48 | PAK1, PAK2, PAK3, PAK4
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| Pak to the future.
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| Bagrodia S, Cerione RA.
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| Trends Cell Biol 9(9):350-5. Review. 1999
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| 49 | LRRC32, PAK1, UVRAG
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| Detailed map of a region commonly amplified at 11q13-q14 in human breast carcinoma.
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| Bekri S, Adelaide J, Merscher S, Grosgeorge J, Caroli-Bosc F, Perucca-Lostanlen D, Kelley PM, Pebusque MJ, Theillet C, Birnbaum D, Gaudray P.
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| Cytogenet Cell Genet 79(1-2):125-31. 1997
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| 50 | PAK1
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| Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway.
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| Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J.
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| Curr Biol 6(5):598-605. 1996
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| 51 | PAK1
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| A brain serine/threonine protein kinase activated by Cdc-42 and Rac1.
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| Manser E, et al.
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| Nature 367 : 40-46. 1994
|