1 | OXSR1, SLC12A2, STK39, WNK1
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| WNK1 kinase balances T cell adhesion versus migration in vivo.
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| Köchl R, Thelen F, Vanes L, Brazão TF, Fountain K, Xie J, Huang CL, Lyck R, Stein JV, Tybulewicz VL.
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| Nat Immunol 17(9):1075-83. doi: 10.1038/ni.3495. Epub 2016 Jul 11. Erratum in: Nat Immunol. 2017 Jan 19;18(2):246.
2016
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2 | OXSR1, SLC12A2, STK39
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| The Ste20 kinases SPAK and OSR1 travel between cells through exosomes.
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| Koumangoye R, Delpire E.
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| Am J Physiol Cell Physiol 311(1):C43-53. doi: 10.1152/ajpcell.00080.2016. Epub 2016 Apr 27.
2016
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3 | OXSR1, SLC12A3, STK39, WNK1, WNK4
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| Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
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| Bazúa-Valenti S, Gamba G.
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| Am J Physiol Cell Physiol 308(10):C779-91. doi: 10.1152/ajpcell.00065.2015. Epub 2015 Mar 18. Review. 2015
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4 | KCNJ2, OXSR1, STK39
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| SPAK and OSR1 Sensitive Kir2.1 K+ Channels.
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| Fezai M, Ahmed M, Hosseinzadeh Z, Elvira B, Lang F.
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| Neurosignals 23(1):20-33. doi: 10.1159/000442601. Epub 2015 Dec 17.
2015
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5 | KCNE1, KCNQ1, OXSR1, STK39
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| SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.
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| Elvira B, Warsi J, Fezai M, Munoz C, Lang F.
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| Cell Physiol Biochem 37(5):2032-42. doi: 10.1159/000438563. Epub 2015 Nov 20.
2015
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6 | OXSR1, SLC1A1, STK39
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| SPAK and OSR1 Sensitivity of Excitatory Amino Acid Transporter EAAT3.
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| Borrás J, Salker MS, Elvira B, Warsi J, Fezai M, Hoseinzadeh Z, Lang F.
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| Nephron 130(3):221-8. doi: 10.1159/000433567. Epub 2015 Jun 25.
2015
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7 | OXSR1, SLC6A8, STK39
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| Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1.
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| Fezai M, Elvira B, Borras J, Ben-Attia M, Hoseinzadeh Z, Lang F.
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| Kidney Blood Press Res 39(6):546-54. doi: 10.1159/000368465. Epub 2014 Dec 8. 2014
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8 | OXSR1, STK39, WNK1, WNK4
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| Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
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| Vorontsova I, Lam L, Delpire E, Lim J, Donaldson P.
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| Invest Ophthalmol Vis Sci 56(1):310-21. doi: 10.1167/iovs.14-15911. 2014
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9 | OXSR1, STK39, WNK1
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| Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.
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| Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH.
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| Proc Natl Acad Sci U S A 111(45):15999-6004. doi: 10.1073/pnas.1419057111. Epub 2014 Oct 31. 2014
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10 | OXSR1
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| Structural and biochemical insights into the activation mechanisms of germinal center kinase OSR1.
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| Li C, Feng M, Shi Z, Hao Q, Song X, Wang W, Zhao Y, Jiao S, Zhou Z.
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| J Biol Chem 289(52):35969-78. doi: 10.1074/jbc.M114.592097. Epub 2014 Nov 11.
2014
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11 | OXSR1, WNK1
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| WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
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| Xie J, Yoon J, Yang SS, Lin SH, Huang CL.
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| J Biol Chem 288(12):8566-74. doi: 10.1074/jbc.M113.451575. Epub 2013 Feb 5. 2013
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12 | OXSR1, SLC12A3
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| Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination.
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| Hossain Khan MZ, Sohara E, Ohta A, Chiga M, Inoue Y, Isobe K, Wakabayashi M, Oi K, Rai T, Sasaki S, Uchida S.
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| Biochem Biophys Res Commun 425(2):456-61. doi: 10.1016/j.bbrc.2012.07.124. Epub 2012 Jul 27. 2012
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13 | OXSR1, SLC12A1, SLC12A3, STK39
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| SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.
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| Grimm PR, Taneja TK, Liu J, Coleman R, Chen YY, Delpire E, Wade JB, Welling PA.
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| J Biol Chem 287(45):37673-90. doi: 10.1074/jbc.M112.402800. Epub 2012 Sep 12. 2012
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14 | OXSR1, STK39
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| Kinases SPAK and OSR1 are upregulated by estradiol and activate NKCC1 in the developing hypothalamus.
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| Nugent BM, Valenzuela CV, Simons TJ, McCarthy MM.
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| J Neurosci 32(2):593-8. doi: 10.1523/JNEUROSCI.5415-11.2012. 2012
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15 | OXSR1, PLSCR1, RELL1, RELT
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| Identification of PLSCR1 as a protein that interacts with RELT family members.
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| Cusick JK, Mustian A, Jacobs AT, Reyland ME.
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| Mol Cell Biochem 362(1-2):55-63. doi: 10.1007/s11010-011-1127-4. Epub 2011 Nov 4. 2012
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16 | OXSR1, WNK1
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| Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.
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| Sengupta S, Tu SW, Wedin K, Earnest S, Stippec S, Luby-Phelps K, Cobb MH.
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| J Biol Chem 287(45):37868-79. doi: 10.1074/jbc.M112.398750. Epub 2012 Sep 18.
2012
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17 | OXSR1, WNK1
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| WNK1 is required for mitosis and abscission.
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| Tu SW, Bugde A, Luby-Phelps K, Cobb MH.
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| Proc Natl Acad Sci U S A 108(4):1385-90. Epub 2011 Jan 10.
2011
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18 | OXSR1
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| Crystal structure of domain-swapped STE20 OSR1 kinase domain.
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| Lee SJ, Cobb MH, Goldsmith EJ.
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| Protein Sci 18(2):304-13.
2009
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19 | OXSR1, SLC12A3, STK39, WNK1
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| Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
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| Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR.
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| J Cell Sci 121(Pt 5):675-84. Epub 2008 Feb 12.PMID: 18270262 2008
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20 | OXSR1, STK39, WNK1, WNK2, WNK3, WNK4
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| The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.
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| Richardson C, Alessi DR.
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| J Cell Sci 121(Pt 20):3293-304. Review.
2008
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21 | OXSR1, STK39
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| Structural insights into the recognition of substrates and activators by the OSR1 kinase.
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| Villa F, Goebel J, Rafiqi FH, Deak M, Thastrup J, Alessi DR, van Aalten DM.
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| EMBO Rep 8(9):839-45. Epub 2007 Aug 17. 2007
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22 | OXSR1, STK39
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| Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
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| Gagnon KB, England R, Delpire E.
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| Mol Cell Biol 26(2):689-98. 2006
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23 | STK39, OXSR1
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| Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
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| Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR.
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| Biochem J 397(1):223-31. 2006
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24 | OXSR1, RELL1, RELL2, RELT
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| Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1.
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| Cusick JK, Xu LG, Bin LH, Han KJ, Shu HB.
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| Biochem Biophys Res Commun 340(2):535-43. Epub 2005 Dec 19.
2006
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25 | WNK1, STK39, OXSR1
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| WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
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| Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H.
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| J Biol Chem 280(52):42685-93. Epub 2005 Oct 31. 2005
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26 | OXSR1
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| The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.
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| Vitari AC, Deak M, Morrice NA, Alessi DR.
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| Biochem J. 391(Pt 1):17-24. 2005
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27 | OXSR1
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| Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.
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| Chen W, Yazicioglu M, Cobb MH.
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| J Biol Chem 279(12):11129-36. Epub 2004 Jan 5. 2004
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28 | OXSR1
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| Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3.
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| Tamari M, et al.
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| J Hum Genet 44(2):116-20. 1999
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29 | ENDOGL1, ENDOGL2, GOLGB1, OXSR1, SLC22A13, XYLB
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| Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.
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| Tamari M, Daigo Y, Ishikawa S, Nakamura Y.
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| DNA Res 6(1):37-44 1999
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