Citations for
1OXSR1, SLC12A2, STK39, WNK1
WNK1 kinase balances T cell adhesion versus migration in vivo.
Köchl R, Thelen F, Vanes L, Brazão TF, Fountain K, Xie J, Huang CL, Lyck R, Stein JV, Tybulewicz VL.
Nat Immunol 17(9):1075-83. doi: 10.1038/ni.3495. Epub 2016 Jul 11. Erratum in: Nat Immunol. 2017 Jan 19;18(2):246. 2016
2OXSR1, SLC12A2, STK39
The Ste20 kinases SPAK and OSR1 travel between cells through exosomes.
Koumangoye R, Delpire E.
Am J Physiol Cell Physiol 311(1):C43-53. doi: 10.1152/ajpcell.00080.2016. Epub 2016 Apr 27. 2016
3OXSR1, SLC12A3, STK39, WNK1, WNK4
Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
Bazúa-Valenti S, Gamba G.
Am J Physiol Cell Physiol 308(10):C779-91. doi: 10.1152/ajpcell.00065.2015. Epub 2015 Mar 18. Review. 2015
4KCNJ2, OXSR1, STK39
SPAK and OSR1 Sensitive Kir2.1 K+ Channels.
Fezai M, Ahmed M, Hosseinzadeh Z, Elvira B, Lang F.
Neurosignals 23(1):20-33. doi: 10.1159/000442601. Epub 2015 Dec 17. 2015
5KCNE1, KCNQ1, OXSR1, STK39
SPAK and OSR1 Sensitive Cell Membrane Protein Abundance and Activity of KCNQ1/E1 K+ Channels.
Elvira B, Warsi J, Fezai M, Munoz C, Lang F.
Cell Physiol Biochem 37(5):2032-42. doi: 10.1159/000438563. Epub 2015 Nov 20. 2015
6OXSR1, SLC1A1, STK39
SPAK and OSR1 Sensitivity of Excitatory Amino Acid Transporter EAAT3.
Borrás J, Salker MS, Elvira B, Warsi J, Fezai M, Hoseinzadeh Z, Lang F.
Nephron 130(3):221-8. doi: 10.1159/000433567. Epub 2015 Jun 25. 2015
7OXSR1, SLC6A8, STK39
Negative regulation of the creatine transporter SLC6A8 by SPAK and OSR1.
Fezai M, Elvira B, Borras J, Ben-Attia M, Hoseinzadeh Z, Lang F.
Kidney Blood Press Res 39(6):546-54. doi: 10.1159/000368465. Epub 2014 Dec 8. 2014
8OXSR1, STK39, WNK1, WNK4
Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
Vorontsova I, Lam L, Delpire E, Lim J, Donaldson P.
Invest Ophthalmol Vis Sci 56(1):310-21. doi: 10.1167/iovs.14-15911. 2014
9OXSR1, STK39, WNK1
Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.
Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH.
Proc Natl Acad Sci U S A 111(45):15999-6004. doi: 10.1073/pnas.1419057111. Epub 2014 Oct 31. 2014
10OXSR1
Structural and biochemical insights into the activation mechanisms of germinal center kinase OSR1.
Li C, Feng M, Shi Z, Hao Q, Song X, Wang W, Zhao Y, Jiao S, Zhou Z.
J Biol Chem 289(52):35969-78. doi: 10.1074/jbc.M114.592097. Epub 2014 Nov 11. 2014
11OXSR1, WNK1
WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
Xie J, Yoon J, Yang SS, Lin SH, Huang CL.
J Biol Chem 288(12):8566-74. doi: 10.1074/jbc.M113.451575. Epub 2013 Feb 5. 2013
12OXSR1, SLC12A3
Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination.
Hossain Khan MZ, Sohara E, Ohta A, Chiga M, Inoue Y, Isobe K, Wakabayashi M, Oi K, Rai T, Sasaki S, Uchida S.
Biochem Biophys Res Commun 425(2):456-61. doi: 10.1016/j.bbrc.2012.07.124. Epub 2012 Jul 27. 2012
13OXSR1, SLC12A1, SLC12A3, STK39
SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.
Grimm PR, Taneja TK, Liu J, Coleman R, Chen YY, Delpire E, Wade JB, Welling PA.
J Biol Chem 287(45):37673-90. doi: 10.1074/jbc.M112.402800. Epub 2012 Sep 12. 2012
14OXSR1, STK39
Kinases SPAK and OSR1 are upregulated by estradiol and activate NKCC1 in the developing hypothalamus.
Nugent BM, Valenzuela CV, Simons TJ, McCarthy MM.
J Neurosci 32(2):593-8. doi: 10.1523/JNEUROSCI.5415-11.2012. 2012
15OXSR1, PLSCR1, RELL1, RELT
Identification of PLSCR1 as a protein that interacts with RELT family members.
Cusick JK, Mustian A, Jacobs AT, Reyland ME.
Mol Cell Biochem 362(1-2):55-63. doi: 10.1007/s11010-011-1127-4. Epub 2011 Nov 4. 2012
16OXSR1, WNK1
Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity.
Sengupta S, Tu SW, Wedin K, Earnest S, Stippec S, Luby-Phelps K, Cobb MH.
J Biol Chem 287(45):37868-79. doi: 10.1074/jbc.M112.398750. Epub 2012 Sep 18. 2012
17OXSR1, WNK1
WNK1 is required for mitosis and abscission.
Tu SW, Bugde A, Luby-Phelps K, Cobb MH.
Proc Natl Acad Sci U S A 108(4):1385-90. Epub 2011 Jan 10. 2011
18OXSR1
Crystal structure of domain-swapped STE20 OSR1 kinase domain.
Lee SJ, Cobb MH, Goldsmith EJ.
Protein Sci 18(2):304-13. 2009
19OXSR1, SLC12A3, STK39, WNK1
Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1.
Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, Morrice NA, Alessi DR.
J Cell Sci 121(Pt 5):675-84. Epub 2008 Feb 12.PMID: 18270262 2008
20OXSR1, STK39, WNK1, WNK2, WNK3, WNK4
The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.
Richardson C, Alessi DR.
J Cell Sci 121(Pt 20):3293-304. Review. 2008
21OXSR1, STK39
Structural insights into the recognition of substrates and activators by the OSR1 kinase.
Villa F, Goebel J, Rafiqi FH, Deak M, Thastrup J, Alessi DR, van Aalten DM.
EMBO Rep 8(9):839-45. Epub 2007 Aug 17. 2007
22OXSR1, STK39
Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
Gagnon KB, England R, Delpire E.
Mol Cell Biol 26(2):689-98. 2006
23STK39, OXSR1
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR.
Biochem J 397(1):223-31. 2006
24OXSR1, RELL1, RELL2, RELT
Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1.
Cusick JK, Xu LG, Bin LH, Han KJ, Shu HB.
Biochem Biophys Res Commun 340(2):535-43. Epub 2005 Dec 19. 2006
25WNK1, STK39, OXSR1
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H.
J Biol Chem 280(52):42685-93. Epub 2005 Oct 31. 2005
26OXSR1
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.
Vitari AC, Deak M, Morrice NA, Alessi DR.
Biochem J. 391(Pt 1):17-24. 2005
27OXSR1
Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily.
Chen W, Yazicioglu M, Cobb MH.
J Biol Chem 279(12):11129-36. Epub 2004 Jan 5. 2004
28OXSR1
Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3.
Tamari M, et al.
J Hum Genet 44(2):116-20. 1999
29ENDOGL1, ENDOGL2, GOLGB1, OXSR1, SLC22A13, XYLB
Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3.
Tamari M, Daigo Y, Ishikawa S, Nakamura Y.
DNA Res 6(1):37-44 1999