1 | OTUD5, STING1
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| OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING
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| Guo Y, Jiang F, Kong L, Wu H, Zhang H, Chen X, Zhao J, Cai B, Li Y, Ma C, Yi F, Zhang L, Liu B, Zheng Y, Zhang L, Gao C
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| Cell Mol Immunol. Aug;18(8):1945-1955. doi: 10.1038/s41423-020-00531-5. Epub 2020 Sep 2. 2021
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2 | MTOR, OTUD5
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| Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways
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| Cho JH, Kim K, Kim SA, Park S, Park BO, Kim JH, Kim SY, Kwon MJ, Han MH, Lee SB, Park BC, Park SG, Kim JH, Kim S.
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| Cell Death Differ. Mar;28(3):900-914. doi: 10.1038/s41418-020-00649-z. Epub 2020 Oct 27. 2021
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3 | MCAND, OTUD5
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| OTUD5 Variants Associated With X-Linked Intellectual Disability and Congenital Malformation.
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| Saida K, Fukuda T, Scott DA, Sengoku T, Ogata K, Nicosia A, Hernandez-Garcia A, Lalani SR, Azamian MS, Streff H, Liu P, Dai H, Mizuguchi T, Miyatake S, Asahina M, Ogata T, Miyake N, Matsumoto N.
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| Front Cell Dev Biol. Mar 3;9:631428. doi: 10.3389/fcell.2021.631428. 2021
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4 | MCAND, OTUD5
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| Linkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation
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| Beck DB, Basar MA, Asmar AJ, Thompson JJ, Oda H, Uehara DT, Saida K, Pajusalu S, Talvik I, D'Souza P, Bodurtha J, Mu W, Barañano KW, Miyake N, Wang R, Kempers M, Tamada T, Nishimura Y, Okada S, Kosho T, Dale R, Mitra A, Macnamara E; Undiagnosed Diseases Network, Matsumoto N, Inazawa J, Walkiewicz M, Õunap K, Tifft CJ, Aksentijevich I, Kastner DL, Rocha PP, Werner A.
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| Sci Adv. Jan 20;7(4):eabe2116. doi: 10.1126/sciadv.abe2116 2021
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5 | MCAND, OTUD5
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| An X-linked syndrome with severe neurodevelopmental delay, hydrocephalus, and early lethality caused by a missense variation in the OTUD5 gene.
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| Tripolszki K, Sasaki E, Hotakainen R, Kassim AH, Pereira C, Rolfs A, Bauer P, Reardon W, Bertoli-Avella AM.
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| Clin Genet. Feb;99(2):303-308. doi: 10.1111/cge.13873. Epub 2020 Nov 9 2021
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6 | OTUD5
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| Phosphorylation-dependent activity of the deubiquitinase DUBA.
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| Huang OW, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, Phung Q, Bosanac I, Arnott D, Dixit VM, Hymowitz SG, Starovasnik MA, Cochran AG.
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| Nat Struct Mol Biol. Jan 15;19(2):171-5. doi: 10.1038/nsmb.2206. 2021
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7 | OTUD5, TRIM25
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| OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity
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| Li F, Sun Q, Liu K, Zhang L, Lin N, You K, Liu M, Kon N, Tian F, Mao Z, Li T, Tong T, Qin J, Gu W, Li D, Zhao W.
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| Nat Commun. Aug 21;11(1):4184. doi: 10.1038/s41467-020-17926-7. 2020
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8 | OTUD5, UBR5
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| The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin.
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| de Vivo A, Sanchez A, Yegres J, Kim J, Emly S, Kee Y.
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| Nucleic Acids Res. Jan 25;47(2):729-746. doi: 10.1093/nar/gky1219. 2019
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9 | OTUD5, PDCD5
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| Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress
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| Park SY, Choi HK, Choi Y, Kwak S, Choi KC, Yoon HG.
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| Cancer Lett. Feb 1;357(1):419-427. doi: 10.1016/j.canlet.2014.12.005. Epub 2014 Dec 8. 2015
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10 | OTUD5, TP53
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| OTUD5 regulates p53 stability by deubiquitinating p53
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| Luo J, Lu Z, Lu X, Chen L, Cao J, Zhang S, Ling Y, Zhou X.
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| PLoS One. Oct 15;8(10):e77682. doi: 10.1371/journal.pone.0077682. 2013
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11 | OTUD5
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| DUBA: a deubiquitinase that regulates type I interferon production.
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| Kayagaki N, Phung Q, Chan S, Chaudhari R, Quan C, O'Rourke KM, Eby M, Pietras E, Cheng G, Bazan JF, Zhang Z, Arnott D, Dixit VM.
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| Science. Dec 7;318(5856):1628-32. doi: 10.1126/science.1145918. Epub 2007 Nov 8 2007
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