Citations for
1BPIFA1, ORAI1
Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor.
Wu T, Huang J, Moore PJ, Little MS, Walton WG, Fellner RC, Alexis NE, Peter Di Y, Redinbo MR, Tilley SL, Tarran R.
Nat Commun 8:14118. doi: 10.1038/ncomms14118. 2017
2ORAI1, STIM2
Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels.
Rana A, Yen M, Sadaghiani AM, Malmersjö S, Park CY, Dolmetsch RE, Lewis RS.
J Cell Biol 209(5):653-69. doi: 10.1083/jcb.201412060. 2015
3ORAI1, STIM2
A STIM2 splice variant negatively regulates store-operated calcium entry.
Miederer AM, Alansary D, Schwär G, Lee PH, Jung M, Helms V, Niemeyer BA.
Nat Commun 6:6899. doi: 10.1038/ncomms7899. 2015
4ORAI1, STIM1, STIM2
STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia.
Michaelis M, Nieswandt B, Stegner D, Eilers J, Kraft R.
Glia 63(4):652-63. doi: 10.1002/glia.22775. 2015
5ORAI1, STIM1, STIM2
Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site.
Wang X, Wang Y, Zhou Y, Hendron E, Mancarella S, Andrake MD, Rothberg BS, Soboloff J, Gill DL.
Nat Commun 5:3183. doi: 10.1038/ncomms4183. 2014
6ORAI1, STIM1
Regulation of CRAC channels by protein interactions and post-translational modification.
Srikanth S, Ribalet B, Gwack Y.
Channels (Austin) 7(3). [Epub ahead of print] 2013
7ORAI1, STIM1
Differential roles of the C- and N-termini of Orai1 in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.
Zheng H, Zhou MH, Hu C, Kuo E, Peng X, Hu J, Kuo L, Zhang SL.
J Biol Chem Biol Chem. 2013 Feb 27. [Epub ahead of print] 2013
8ORAI1, STIM1
The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function.
Jha A, Ahuja M, Maléth J, Moreno CM, Yuan JP, Kim MS, Muallem S.
J Cell Biol 202(1):71-9. doi: 10.1083/jcb.201301148. Epub 2013 Jul 1. 2013
9ORAI1
Thrombin-sensitive expression of the store operated Ca(2+) channel Orai1 in platelets.
Münzer P, Tolios A, Pelzl L, Schmid E, Schmidt EM, Walker B, Fröhlich H, Borst O, Gawaz M, Lang F.
Biochem Biophys Res Commun 436(1):25-30. doi: 10.1016/j.bbrc.2013.05.031. Epub 2013 May 16. 2013
10ORAI1
Orai1 function is essential for T cell homing to lymph nodes.
Greenberg ML, Yu Y, Leverrier S, Zhang SL, Parker I, Cahalan MD.
J Immunol 190(7):3197-206. doi: 10.4049/jimmunol.1202212. Epub 2013 Mar 1. 2013
11ORAI1
The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress.
Henke N, Albrecht P, Bouchachia I, Ryazantseva M, Knoll K, Lewerenz J, Kaznacheyeva E, Maher P, Methner A.
Cell Death Dis 4:e470. doi: 10.1038/cddis.2012.216. 2013
12ORAI1, UBQLN1
Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization.
Lee JE, Jeon IS, Han NE, Song HJ, Kim EG, Choi JW, Song KD, Lee HK, Choi JK.
Mol Cells 35(1):41-6. doi: 10.1007/s10059-013-2268-7. Epub 2013 Jan 9. 2013
13ORAI1, STIM1
STIM1 regulates platelet-derived growth factor-induced migration and Ca2+ influx in human airway smooth muscle cells.
Suganuma N, Ito S, Aso H, Kondo M, Sato M, Sokabe M, Hasegawa Y.
PLoS One 7(9):e45056. doi: 10.1371/journal.pone.0045056. Epub 2012 Sep 11. 2012
14ASPH, ORAI1, STIM1
Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1).
Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y.
Proc Natl Acad Sci U S A 109(22):8682-7. doi: 10.1073/pnas.1200667109. Epub 2012 May 14. 2012
15ORAI1
Orai1 mediates exacerbated Ca(2+) entry in dystrophic skeletal muscle.
Zhao X, Moloughney JG, Zhang S, Komazaki S, Weisleder N.
PLoS One 7(11):e49862. doi: 10.1371/journal.pone.0049862. Epub 2012 Nov 19. 2012
16ORAI1
Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation.
Hwang SY, Foley J, Numaga-Tomita T, Petranka JG, Bird GS, Putney JW Jr.
Cell Calcium 52(6):488-500. doi: 10.1016/j.ceca.2012.10.001. Epub 2012 Oct 31. 2012
17ORAI1
Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities.
Fukushima M, Tomita T, Janoshazi A, Putney JW.
J Cell Sci 125(Pt 18):4354-61. doi: 10.1242/jcs.104919. Epub 2012 May 28. 2012
18ORAI1, STIM1
Gated regulation of CRAC channel ion selectivity by STIM1.
McNally BA, Somasundaram A, Yamashita M, Prakriya M.
Nature 482(7384):241-5. doi: 10.1038/nature10752. 2012
19ORAI1, SGK1
Translational regulation of the serum- and glucocorticoid-inducible kinase-1 (SGK1) in platelets.
Pelzl L, Tolios A, Schmidt EM, Alesutan I, Walker B, Münzer P, Borst O, Gawaz M, Lang F.
Biochem Biophys Res Commun 425(1):1-5. doi: 10.1016/j.bbrc.2012.07.026. Epub 2012 Jul 16. 2012
20ATP2A3, ORAI1, STIM1, STIM2
STIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human platelets.
Zbidi H, Jardin I, Woodard GE, Lopez JJ, Berna-Erro A, Salido GM, Rosado JA.
J Biol Chem 286(14):12257-70. Epub 2011 Feb 14. 2011
21CASP8, FADD, FAS, ORAI1
CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.
Khadra N, Bresson-Bepoldin L, Penna A, Chaigne-Delalande B, Ségui B, Levade T, Vacher AM, Reiffers J, Ducret T, Moreau JF, Cahalan MD, Vacher P, Legembre P.
Proc Natl Acad Sci U S A 108(47):19072-7. doi: 10.1073/pnas.1116946108. Epub 2011 Nov 7. 2011
22ORAI1, STIM1
STIM1 gates the store-operated calcium channel ORAI1 in vitro.
Zhou Y, Meraner P, Kwon HT, Machnes D, Masatsugu OH, Zimmer J, Huang Y, Stura A, Rao A, Hogan PG.
Nat Struct Mol Biol 17(1):112-6. Epub 2009 Dec 27. 2010
23ORAI1, RACK1, TRPC3
TRPC3 regulates agonist-stimulated Ca2+ mobilization by mediating the interaction between type I inositol 1,4,5-trisphosphate receptor, RACK1, and Orai1.
Woodard GE, López JJ, Jardín I, Salido GM, Rosado JA.
J Biol Chem 285(11):8045-53. Epub 2009 Dec 18.PMID: 20022948 2010
24ATP2C2, ORAI1
Store-independent activation of Orai1 by SPCA2 in mammary tumors.
Feng M, Grice DM, Faddy HM, Nguyen N, Leitch S, Wang Y, Muend S, Kenny PA, Sukumar S, Roberts-Thomson SJ, Monteith GR, Rao R.
Cell 143(1):84-98. 2010
25ORAI1, STIM1
SOAR and the polybasic STIM1 domains gate and regulate Orai channels.
Yuan JP, Zeng W, Dorwart MR, Choi YJ, Worley PF, Muallem S.
Nat Cell Biol 11(3):337-43. Epub 2009 Feb 1. 2009
26ORAI1, STIM1
STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.
Park CY, Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS.
Cell 136(5):876-90. Epub 2009 Feb 26. 2009
27IDTCI, ORAI1
The Orai1 severe combined immune deficiency mutation and calcium release-activated Ca2+ channel function in the heterozygous condition.
Thompson JL, Mignen O, Shuttleworth TJ.
J Biol Chem 284(11):6620-6. Epub 2008 Dec 15. 2009
28ORAI1, STIM1
A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.
Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C.
J Biol Chem 284(13):8421-6. Epub 2009 Feb 3. 2009
29ORAI1, ORAI2, ORAI3, STIM1, STIM2
STIM protein coupling in the activation of Orai channels.
Wang Y, Deng X, Zhou Y, Hendron E, Mancarella S, Ritchie MF, Tang XD, Baba Y, Kurosaki T, Mori Y, Soboloff J, Gill DL.
Proc Natl Acad Sci U S A 106(18):7391-6. Epub 2009 Apr 17. 2009
30ORAI1, ORAI2, ORAI3, STIM1, STIM2
STIM and Orai: Dynamic Intermembrane Coupling to Control Cellular Calcium Signals.
Deng X, Wang Y, Zhou Y, Soboloff J, Gill DL.
J Biol Chem 284(34):22501-5. Epub 2009 May 27. 2009
31ORAI1, STIM1, STIM2
The short N-terminal domains of STIM1 and STIM2 control the activation kinetics of Orai1 channels.
Zhou Y, Mancarella S, Wang Y, Yue C, Ritchie M, Gill DL, Soboloff J.
J Biol Chem 284(29):19164-8. Epub 2009 Jun 1. 2009
32ORAI1, STIM1
A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels.
Kawasaki T, Lange I, Feske S.
Biochem Biophys Res Commun 385(1):49-54. Epub 2009 May 9. Erratum in: Biochem Biophys Res Commun. 2009 Sep 25;387(3):623. 2009
33ORAI1, ORAI2, ORAI3, STIM1, STIM2
Biochemical and functional properties of the store-operated Ca2+ channels.
Salido GM, Sage SO, Rosado JA.
Cell Signal 21(4):457-61. Epub 2008 Nov 13. Review.PMID: 19049864 2009
34ORAI1, STIM1
Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.
Frischauf I, Muik M, Derler I, Bergsmann J, Fahrner M, Schindl R, Groschner K, Romanin C.
J Biol Chem 284(32):21696-706. Epub 2009 Jun 8.PMID: 19506081 2009
35ORAI1, STIM1
STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels.
Mullins FM, Park CY, Dolmetsch RE, Lewis RS.
Proc Natl Acad Sci U S A 106(36):15495-500. Epub 2009 Aug 21.PMID: 19706428 2009
36IMD9, ORAI1
ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia.
McCarl CA, Picard C, Khalil S, Kawasaki T, Röther J, Papolos A, Kutok J, Hivroz C, Ledeist F, Plogmann K, Ehl S, Notheis G, Albert MH, Belohradsky BH, Kirschner J, Rao A, Fischer A, Feske S.
J Allergy Clin Immunol 124(6):1311-1318.e7. doi: 10.1016/j.jaci.2009.10.007. 2009
37ORAI1, STIM1
Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.
Lioudyno MI, Kozak JA, Penna A, Safrina O, Zhang SL, Sen D, Roos J, Stauderman KA, Cahalan MD.
Proc Natl Acad Sci U S A 105(6):2011-6. Epub 2008 Feb 4. 2008
38ORAI1, ORAI3
Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3.
Zhang SL, Kozak JA, Jiang W, Yeromin AV, Chen J, Yu Y, Penna A, Shen W, Chi V, Cahalan MD.
J Biol Chem 283(25):17662-71. Epub 2008 Apr 17. 2008
39ORAI1, ORAI3
2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.
Schindl R, Bergsmann J, Frischauf I, Derler I, Fahrner M, Muik M, Fritsch R, Groschner K, Romanin C.
J Biol Chem 283(29):20261-7. Epub 2008 May 21. 2008
40ORAI1, STIM2
STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation.
Parvez S, Beck A, Peinelt C, Soboloff J, Lis A, Monteilh-Zoller M, Gill DL, Fleig A, Penner R.
FASEB J 22(3):752-61. Epub 2007 Sep 28.PMID: 17905723 2008
41STIM1, ORAI1
Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.
Li Z, Lu J, Xu P, Xie X, Chen L, Xu T.
J Biol Chem 282(40):29448-56. Epub 2007 Aug 16. 2007
42ORAI1, ORAI2, ORAI3
Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels.
DeHaven WI, Smyth JT, Boyles RR, Putney JW Jr.
J Biol Chem 282(24):17548-56. Epub 2007 Apr 23. 2007
43ORAI1
CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca2+ Entry.
Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP.
Science [Epub ahead of print] 2006
44ORAI1
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A.
Nature 441(7090):179-85. Epub 2006 Apr 2. 2006
45ORAI1
Orai1 is an essential pore subunit of the CRAC channel.
Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG.
Nature 443(7108):230-3. Epub 2006 Aug 20. 2006
46ORAI1
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai.
Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O, Cahalan MD.
Nature 443(7108):226-9. Epub 2006 Aug 20. 2006
47IDTCI, ORAI1
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A.
Nature 441(7090):179-85. Epub 2006 Apr 2. 2006
48IMD9, ORAI1
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A.
Nature 441(7090):179-85. Epub 2006 Apr 2. 2006