| 1 | BPIFA1, ORAI1
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| Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor.
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| Wu T, Huang J, Moore PJ, Little MS, Walton WG, Fellner RC, Alexis NE, Peter Di Y, Redinbo MR, Tilley SL, Tarran R.
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| Nat Commun 8:14118. doi: 10.1038/ncomms14118.
2017
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| 2 | ORAI1, STIM2
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| Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels.
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| Rana A, Yen M, Sadaghiani AM, Malmersjö S, Park CY, Dolmetsch RE, Lewis RS.
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| J Cell Biol 209(5):653-69. doi: 10.1083/jcb.201412060.
2015
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| 3 | ORAI1, STIM2
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| A STIM2 splice variant negatively regulates store-operated calcium entry.
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| Miederer AM, Alansary D, Schwär G, Lee PH, Jung M, Helms V, Niemeyer BA.
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| Nat Commun 6:6899. doi: 10.1038/ncomms7899.
2015
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| 4 | ORAI1, STIM1, STIM2
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| STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia.
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| Michaelis M, Nieswandt B, Stegner D, Eilers J, Kraft R.
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| Glia 63(4):652-63. doi: 10.1002/glia.22775.
2015
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| 5 | ORAI1, STIM1, STIM2
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| Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site.
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| Wang X, Wang Y, Zhou Y, Hendron E, Mancarella S, Andrake MD, Rothberg BS, Soboloff J, Gill DL.
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| Nat Commun 5:3183. doi: 10.1038/ncomms4183.
2014
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| 6 | ORAI1, STIM1
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| Regulation of CRAC channels by protein interactions and post-translational modification.
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| Srikanth S, Ribalet B, Gwack Y.
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| Channels (Austin) 7(3). [Epub ahead of print]
2013
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| 7 | ORAI1, STIM1
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| Differential roles of the C- and N-termini of Orai1 in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.
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| Zheng H, Zhou MH, Hu C, Kuo E, Peng X, Hu J, Kuo L, Zhang SL.
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| J Biol Chem Biol Chem. 2013 Feb 27. [Epub ahead of print]
2013
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| 8 | ORAI1, STIM1
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| The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function.
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| Jha A, Ahuja M, Maléth J, Moreno CM, Yuan JP, Kim MS, Muallem S.
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| J Cell Biol 202(1):71-9. doi: 10.1083/jcb.201301148. Epub 2013 Jul 1.
2013
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| 9 | ORAI1
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| Thrombin-sensitive expression of the store operated Ca(2+) channel Orai1 in platelets.
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| Münzer P, Tolios A, Pelzl L, Schmid E, Schmidt EM, Walker B, Fröhlich H, Borst O, Gawaz M, Lang F.
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| Biochem Biophys Res Commun 436(1):25-30. doi: 10.1016/j.bbrc.2013.05.031. Epub 2013 May 16.
2013
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| 10 | ORAI1
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| Orai1 function is essential for T cell homing to lymph nodes.
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| Greenberg ML, Yu Y, Leverrier S, Zhang SL, Parker I, Cahalan MD.
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| J Immunol 190(7):3197-206. doi: 10.4049/jimmunol.1202212. Epub 2013 Mar 1.
2013
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| 11 | ORAI1
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| The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress.
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| Henke N, Albrecht P, Bouchachia I, Ryazantseva M, Knoll K, Lewerenz J, Kaznacheyeva E, Maher P, Methner A.
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| Cell Death Dis 4:e470. doi: 10.1038/cddis.2012.216.
2013
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| 12 | ORAI1, UBQLN1
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| Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization.
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| Lee JE, Jeon IS, Han NE, Song HJ, Kim EG, Choi JW, Song KD, Lee HK, Choi JK.
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| Mol Cells 35(1):41-6. doi: 10.1007/s10059-013-2268-7. Epub 2013 Jan 9.
2013
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| 13 | ORAI1, STIM1
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| STIM1 regulates platelet-derived growth factor-induced migration and Ca2+ influx in human airway smooth muscle cells.
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| Suganuma N, Ito S, Aso H, Kondo M, Sato M, Sokabe M, Hasegawa Y.
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| PLoS One 7(9):e45056. doi: 10.1371/journal.pone.0045056. Epub 2012 Sep 11.
2012
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| 14 | ASPH, ORAI1, STIM1
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| Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1).
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| Srikanth S, Jew M, Kim KD, Yee MK, Abramson J, Gwack Y.
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| Proc Natl Acad Sci U S A 109(22):8682-7. doi: 10.1073/pnas.1200667109. Epub 2012 May 14. 2012
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| 15 | ORAI1
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| Orai1 mediates exacerbated Ca(2+) entry in dystrophic skeletal muscle.
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| Zhao X, Moloughney JG, Zhang S, Komazaki S, Weisleder N.
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| PLoS One 7(11):e49862. doi: 10.1371/journal.pone.0049862. Epub 2012 Nov 19.
2012
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| 16 | ORAI1
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| Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation.
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| Hwang SY, Foley J, Numaga-Tomita T, Petranka JG, Bird GS, Putney JW Jr.
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| Cell Calcium 52(6):488-500. doi: 10.1016/j.ceca.2012.10.001. Epub 2012 Oct 31.
2012
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| 17 | ORAI1
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| Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities.
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| Fukushima M, Tomita T, Janoshazi A, Putney JW.
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| J Cell Sci 125(Pt 18):4354-61. doi: 10.1242/jcs.104919. Epub 2012 May 28.
2012
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| 18 | ORAI1, STIM1
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| Gated regulation of CRAC channel ion selectivity by STIM1.
|
| McNally BA, Somasundaram A, Yamashita M, Prakriya M.
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| Nature 482(7384):241-5. doi: 10.1038/nature10752.
2012
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| 19 | ORAI1, SGK1
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| Translational regulation of the serum- and glucocorticoid-inducible kinase-1 (SGK1) in platelets.
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| Pelzl L, Tolios A, Schmidt EM, Alesutan I, Walker B, Münzer P, Borst O, Gawaz M, Lang F.
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| Biochem Biophys Res Commun 425(1):1-5. doi: 10.1016/j.bbrc.2012.07.026. Epub 2012 Jul 16.
2012
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| 20 | ATP2A3, ORAI1, STIM1, STIM2
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| STIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human platelets.
|
| Zbidi H, Jardin I, Woodard GE, Lopez JJ, Berna-Erro A, Salido GM, Rosado JA.
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| J Biol Chem 286(14):12257-70. Epub 2011 Feb 14.
2011
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| 21 | CASP8, FADD, FAS, ORAI1
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| CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation.
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| Khadra N, Bresson-Bepoldin L, Penna A, Chaigne-Delalande B, Ségui B, Levade T, Vacher AM, Reiffers J, Ducret T, Moreau JF, Cahalan MD, Vacher P, Legembre P.
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| Proc Natl Acad Sci U S A 108(47):19072-7. doi: 10.1073/pnas.1116946108. Epub 2011 Nov 7.
2011
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| 22 | ORAI1, STIM1
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| STIM1 gates the store-operated calcium channel ORAI1 in vitro.
|
| Zhou Y, Meraner P, Kwon HT, Machnes D, Masatsugu OH, Zimmer J, Huang Y, Stura A, Rao A, Hogan PG.
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| Nat Struct Mol Biol 17(1):112-6. Epub 2009 Dec 27.
2010
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| 23 | ORAI1, RACK1, TRPC3
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| TRPC3 regulates agonist-stimulated Ca2+ mobilization by mediating the interaction between type I inositol 1,4,5-trisphosphate receptor, RACK1, and Orai1.
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| Woodard GE, López JJ, Jardín I, Salido GM, Rosado JA.
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| J Biol Chem 285(11):8045-53. Epub 2009 Dec 18.PMID: 20022948 2010
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| 24 | ATP2C2, ORAI1
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| Store-independent activation of Orai1 by SPCA2 in mammary tumors.
|
| Feng M, Grice DM, Faddy HM, Nguyen N, Leitch S, Wang Y, Muend S, Kenny PA, Sukumar S, Roberts-Thomson SJ, Monteith GR, Rao R.
|
| Cell 143(1):84-98.
2010
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| 25 | ORAI1, STIM1
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| SOAR and the polybasic STIM1 domains gate and regulate Orai channels.
|
| Yuan JP, Zeng W, Dorwart MR, Choi YJ, Worley PF, Muallem S.
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| Nat Cell Biol 11(3):337-43. Epub 2009 Feb 1.
2009
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| 26 | ORAI1, STIM1
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| STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.
|
| Park CY, Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS.
|
| Cell 136(5):876-90. Epub 2009 Feb 26.
2009
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| 27 | IDTCI, ORAI1
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| The Orai1 severe combined immune deficiency mutation and calcium release-activated Ca2+ channel function in the heterozygous condition.
|
| Thompson JL, Mignen O, Shuttleworth TJ.
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| J Biol Chem 284(11):6620-6. Epub 2008 Dec 15.
2009
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| 28 | ORAI1, STIM1
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| A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.
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| Muik M, Fahrner M, Derler I, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C.
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| J Biol Chem 284(13):8421-6. Epub 2009 Feb 3.
2009
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| 29 | ORAI1, ORAI2, ORAI3, STIM1, STIM2
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| STIM protein coupling in the activation of Orai channels.
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| Wang Y, Deng X, Zhou Y, Hendron E, Mancarella S, Ritchie MF, Tang XD, Baba Y, Kurosaki T, Mori Y, Soboloff J, Gill DL.
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| Proc Natl Acad Sci U S A 106(18):7391-6. Epub 2009 Apr 17.
2009
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| 30 | ORAI1, ORAI2, ORAI3, STIM1, STIM2
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| STIM and Orai: Dynamic Intermembrane Coupling to Control Cellular Calcium Signals.
|
| Deng X, Wang Y, Zhou Y, Soboloff J, Gill DL.
|
| J Biol Chem 284(34):22501-5. Epub 2009 May 27.
2009
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| 31 | ORAI1, STIM1, STIM2
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| The short N-terminal domains of STIM1 and STIM2 control the activation kinetics of Orai1 channels.
|
| Zhou Y, Mancarella S, Wang Y, Yue C, Ritchie M, Gill DL, Soboloff J.
|
| J Biol Chem 284(29):19164-8. Epub 2009 Jun 1.
2009
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| 32 | ORAI1, STIM1
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| A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels.
|
| Kawasaki T, Lange I, Feske S.
|
| Biochem Biophys Res Commun 385(1):49-54. Epub 2009 May 9. Erratum in: Biochem Biophys Res Commun. 2009 Sep 25;387(3):623.
2009
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| 33 | ORAI1, ORAI2, ORAI3, STIM1, STIM2
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| Biochemical and functional properties of the store-operated Ca2+ channels.
|
| Salido GM, Sage SO, Rosado JA.
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| Cell Signal 21(4):457-61. Epub 2008 Nov 13. Review.PMID: 19049864 2009
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| 34 | ORAI1, STIM1
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| Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.
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| Frischauf I, Muik M, Derler I, Bergsmann J, Fahrner M, Schindl R, Groschner K, Romanin C.
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| J Biol Chem 284(32):21696-706. Epub 2009 Jun 8.PMID: 19506081 2009
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| 35 | ORAI1, STIM1
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| STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels.
|
| Mullins FM, Park CY, Dolmetsch RE, Lewis RS.
|
| Proc Natl Acad Sci U S A 106(36):15495-500. Epub 2009 Aug 21.PMID: 19706428 2009
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| 36 | IMD9, ORAI1
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| ORAI1 deficiency and lack of store-operated Ca2+ entry cause immunodeficiency, myopathy, and ectodermal dysplasia.
|
| McCarl CA, Picard C, Khalil S, Kawasaki T, Röther J, Papolos A, Kutok J, Hivroz C, Ledeist F, Plogmann K, Ehl S, Notheis G, Albert MH, Belohradsky BH, Kirschner J, Rao A, Fischer A, Feske S.
|
| J Allergy Clin Immunol 124(6):1311-1318.e7. doi: 10.1016/j.jaci.2009.10.007.
2009
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| 37 | ORAI1, STIM1
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| Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.
|
| Lioudyno MI, Kozak JA, Penna A, Safrina O, Zhang SL, Sen D, Roos J, Stauderman KA, Cahalan MD.
|
| Proc Natl Acad Sci U S A 105(6):2011-6. Epub 2008 Feb 4. 2008
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| 38 | ORAI1, ORAI3
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| Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3.
|
| Zhang SL, Kozak JA, Jiang W, Yeromin AV, Chen J, Yu Y, Penna A, Shen W, Chi V, Cahalan MD.
|
| J Biol Chem 283(25):17662-71. Epub 2008 Apr 17. 2008
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| 39 | ORAI1, ORAI3
|
| 2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size.
|
| Schindl R, Bergsmann J, Frischauf I, Derler I, Fahrner M, Muik M, Fritsch R, Groschner K, Romanin C.
|
| J Biol Chem 283(29):20261-7. Epub 2008 May 21.
2008
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| 40 | ORAI1, STIM2
|
| STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation.
|
| Parvez S, Beck A, Peinelt C, Soboloff J, Lis A, Monteilh-Zoller M, Gill DL, Fleig A, Penner R.
|
| FASEB J 22(3):752-61. Epub 2007 Sep 28.PMID: 17905723 2008
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| 41 | STIM1, ORAI1
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| Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation.
|
| Li Z, Lu J, Xu P, Xie X, Chen L, Xu T.
|
| J Biol Chem 282(40):29448-56. Epub 2007 Aug 16. 2007
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| 42 | ORAI1, ORAI2, ORAI3
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| Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels.
|
| DeHaven WI, Smyth JT, Boyles RR, Putney JW Jr.
|
| J Biol Chem 282(24):17548-56. Epub 2007 Apr 23. 2007
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| 43 | ORAI1
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| CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca2+ Entry.
|
| Vig M, Peinelt C, Beck A, Koomoa DL, Rabah D, Koblan-Huberson M, Kraft S, Turner H, Fleig A, Penner R, Kinet JP.
|
| Science [Epub ahead of print] 2006
|
| 44 | ORAI1
|
| A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
|
| Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A.
|
| Nature 441(7090):179-85. Epub 2006 Apr 2. 2006
|
| 45 | ORAI1
|
| Orai1 is an essential pore subunit of the CRAC channel.
|
| Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG.
|
| Nature 443(7108):230-3. Epub 2006 Aug 20. 2006
|
| 46 | ORAI1
|
| Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai.
|
| Yeromin AV, Zhang SL, Jiang W, Yu Y, Safrina O, Cahalan MD.
|
| Nature 443(7108):226-9. Epub 2006 Aug 20. 2006
|
| 47 | IDTCI, ORAI1
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| A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
|
| Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A.
|
| Nature 441(7090):179-85. Epub 2006 Apr 2.
2006
|
| 48 | IMD9, ORAI1
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| A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.
|
| Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A.
|
| Nature 441(7090):179-85. Epub 2006 Apr 2.
2006
|