Citations for
1OPTN, TBK1
The TBK1-binding domain of optineurin promotes type I interferon responses.
Meena NP, Zhu G, Mittelstadt PR, Giardino Torchia ML, Pourcelot M, Arnoult D, Ashwell JD, Munitic I.
FEBS Lett 590(10):1498-508. doi: 10.1002/1873-3468.12176. Epub 2016 May 4. 2016
2OPTN, TBK1
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.
Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I.
Proc Natl Acad Sci U S A 113(15):4039-44. doi: 10.1073/pnas.1523926113. Epub 2016 Mar 30. 2016
3OPTN
Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease.
Nakamura M, Murray ME, Lin WL, Kusaka H, Dickson DW.
Am J Neurodegener Dis 3(2):93-102. eCollection 2014. 2014
4HACE1, OPTN, SQSTM1
Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression.
Liu Z, Chen P, Gao H, Gu Y, Yang J, Peng H, Xu X, Wang H, Yang M, Liu X, Fan L, Chen S, Zhou J, Sun Y, Ruan K, Cheng S, Komatsu M, White E, Li L, Ji H, Finley D, Hu R.
Cancer Cell 26(1):106-20. doi: 10.1016/j.ccr.2014.05.015. 2014
5NRL, OPTN
Interaction between optineurin and the bZIP transcription factor NRL.
Wang C, Hosono K, Ohtsubo M, Ohishi K, Gao J, Nakanishi N, Hikoya A, Sato M, Hotta Y, Minoshima S.
Cell Biol Int 38(1):16-25. doi: 10.1002/cbin.10174. Epub 2013 Sep 12. 2014
6OPTN, TBC1D17
E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.
Chalasani ML, Kumari A, Radha V, Swarup G.
PLoS One 9(4):e95758. doi: 10.1371/journal.pone.0095758. eCollection 2014. 2014
7APP, MAP1LC3B, OPTN
Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome.
Cho MH, Cho K, Kang HJ, Jeon EY, Kim HS, Kwon HJ, Kim HM, Kim DH, Yoon SY.
Autophagy 10(10):1761-75. doi: 10.4161/auto.29647. Epub 2014 Jul 22. 2014
8IFNG, IRF1, OPTN
IRF-1-binding site in the first intron mediates interferon-γ-induced optineurin promoter activation.
Sudhakar C, Vaibhava V, Swarup G.
Biochem Biophys Res Commun 437(1):179-84. doi: 10.1016/j.bbrc.2013.06.065. Epub 2013 Jun 27. 2013
9IRF3, OPTN
Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.
Munitic I, Giardino Torchia ML, Meena NP, Zhu G, Li CC, Ashwell JD.
J Immunol 191(12):6231-40. doi: 10.4049/jimmunol.1301696. Epub 2013 Nov 15. 2013
10ALS12, OPTN
Optineurin suppression causes neuronal cell death via NF-κB pathway.
Akizuki M, Yamashita H, Uemura K, Maruyama H, Kawakami H, Ito H, Takahashi R.
J Neurochem 126(6):699-704. doi: 10.1111/jnc.12326. Epub 2013 Jun 17. 2013
11OPTN
Optineurin and amyotrophic lateral sclerosis.
Maruyama H, Kawakami H.
Geriatr Gerontol Int 13(3):528-32. doi: 10.1111/ggi.12022. Epub 2012 Dec 26. Review. 2013
12OPTN, RAB25
Structural and functional analysis of FIP2 binding to the endosome-localised Rab25 GTPase.
Lall P, Horgan CP, Oda S, Franklin E, Sultana A, Hanscom SR, McCaffrey MW, Khan AR.
Biochim Biophys Acta 1834(12):2679-90. doi: 10.1016/j.bbapap.2013.09.005. Epub 2013 Sep 19. 2013
13ASL12, OPTN
Screening for OPTN mutations in a cohort of British amyotrophic lateral sclerosis patients.
Johnson L, Miller JW, Gkazi AS, Vance C, Topp SD, Newhouse SJ, Al-Chalabi A, Smith BN, Shaw CE.
Neurobiol Aging 33(12):2948.e15-7. doi: 10.1016/j.neurobiolaging.2012.06.023. Epub 2012 Aug 11. 2012
14OPTN, RAB8A, TBC1D17
Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17.
Vaibhava V, Nagabhushana A, Chalasani ML, Sudhakar C, Kumari A, Swarup G.
J Cell Sci 125(Pt 21):5026-39. doi: 10.1242/jcs.102327. Epub 2012 Aug 1. 2012
15OPTN
Absence of altered expression of optineurin in primary open angle glaucoma patients.
Abu-Amero KK, Azad TA, Spaeth GL, Myers J, Katz LJ, Moster M, Bosley TM.
Mol Vis 18:1421-7. Epub 2012 Jun 1. 2012
16OPTN
Optineurin: a new vision of cell division control.
Kachaner D, Laplantine E, Gťnin P, Weil R.
Cell Cycle 11(8):1481-2. doi: 10.4161/cc.20116. Epub 2012 Apr 15. No abstract available. 2012
17OPTN, PLK1
Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression.
Kachaner D, Filipe J, Laplantine E, Bauch A, Bennett KL, Superti-Furga G, IsraŽl A, Weil R.
Mol Cell 45(4):553-66. doi: 10.1016/j.molcel.2011.12.030. 2012
18OPTN
Cellular and molecular biology of optineurin.
Ying H, Yue BY.
Int Rev Cell Mol Biol 294:223-58. doi: 10.1016/B978-0-12-394305-7.00005-7. Review. 2012
19OPTN
Optineurin in Huntington's disease intranuclear inclusions.
Schwab C, Yu S, McGeer EG, McGeer PL.
Neurosci Lett 506(1):149-54. doi: 10.1016/j.neulet.2011.10.070. Epub 2011 Nov 6. 2012
20MYO6, OPTN
Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane.
Bond LM, Peden AA, Kendrick-Jones J, Sellers JR, Buss F.
Mol Biol Cell 22(1):54-65. Epub 2010 Dec 9. 2011
21OPTN, TBK1
TBK1 mediates crosstalk between the innate immune response and autophagy.
Weidberg H, Elazar Z.
Sci Signal 4(187):pe39. doi: 10.1126/scisignal.2002355. Review. 2011
22ALS12, OPTN
Mutations of optineurin in amyotrophic lateral sclerosis.
Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji R, Kawakami H.
Nature 465(7295):223-6. Epub 2010 Apr 28. 2010
23CSF1, OPTN, TNFRSF11A
Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.
Albagha OM, Visconti MR, Alonso N, Langston AL, Cundy T, Dargie R, Dunlop MG, Fraser WD, Hooper MJ, Isaia G, Nicholson GC, del Pino Montes J, Gonzalez-Sarmiento R, di Stefano M, Tenesa A, Walsh JP, Ralston SH.
Nat Genet 42(6):520-4. Epub 2010 May 2.PMID: 20436471 2010
24GLC1A, GLC1E, MYOC, OPTN
Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG.
McDonald KK, Abramson K, Beltran MA, Ramirez MG, Alvarez M, Ventura A, Santiago-Turla C, Schmidt S, Hauser MA, Allingham RR.
J Hum Genet 55(10):697-700. Epub 2010 Jul 29. 2010
25OPTN, TAX1BP1
NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein.
Journo C, Filipe J, About F, Chevalier SA, Afonso PV, Brady JN, Flynn D, Tangy F, IsraŽl A, Vidalain PO, Mahieux R, Weil R.
PLoS Pathog 5(7):e1000521. Epub 2009 Jul 17. 2009
26OPTN
Absence of optineurin (OPTN) gene mutations in Taiwanese patients with juvenile-onset open-angle glaucoma.
Yen YC, Yang JJ, Chou MC, Li SY.
Mol Vis 14:487-94. 2008
27CYP1B1, GLC1A, GLC1E, GLC3A, MYOC, OPTN
Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients.
Kumar A, Basavaraj MG, Gupta SK, Qamar I, Ali AM, Bajaj V, Ramesh TK, Prakash DR, Shetty JS, Dorairaj SK.
Mol Vis 13:667-76. 2007
28MYOC, OPTN, WDR36, GLC1A, GLC1E, GLC1G
Gene mapping for primary open angle glaucoma.
Fan BJ, Wang DY, Lam DS, Pang CP.
Clin Biochem 39(3):249-58. Epub 2005 Dec 5. Review. 2006
29NFKBIL1, TNXB, NOTCH4, MRPL48, PAAF1, UCP2, OPTN, CCDC3, LTB4R2
Whole genome association study of rheumatoid arthritis using 27 039 microsatellites.
Tamiya G, Shinya M, Imanishi T, Ikuta T, Makino S, Okamoto K, Furugaki K, Matsumoto T, Mano S, Ando S, Nozaki Y, Yukawa W, Nakashige R, Yamaguchi D, Ishibashi H, Yonekura M, Nakami Y, Takayama S, Endo T, Saruwatari T, Yagura M, Yoshikawa Y, Fujimoto K, Oka A, Chiku S, Linsen SE, Giphart MJ, Kulski JK, Fukazawa T, Hashimoto H, Kimura M, Hoshina Y, Suzuki Y, Hotta T, Mochida J, Minezaki T, Komai K, Shiozawa S, Taniguchi A, Yamanaka H, Kamatani N, Gojobori T, Bahram S, Inoko H.
Hum Mol Genet 14(16):2305-21. Epub 2005 Jul 6. 2005
30OPTN, GLC1E
Clinical features and course of patients with glaucoma with the E50K mutation in the optineurin gene.
Aung T, Rezaie T, Okada K, Viswanathan AC, Child AH, Brice G, Bhattacharya SS, Lehmann OJ, Sarfarazi M, Hitchings RA.
Invest Ophthalmol Vis Sci 46(8):2816-22. 2005
31OPTN, GLC1E
Mutations in the optineurin gene in Japanese patients with primary open-angle glaucoma and normal tension glaucoma.
Toda Y, Tang S, Kashiwagi K, Mabuchi F, Iijima H, Tsukahara S, Yamagata Z.
Am J Med Genet 125A(1):1-4. 2004
32OPTN, GLC1E
The M98K variant of the OPTINEURIN (OPTN) gene modifies initial intraocular pressure in patients with primary open angle glaucoma.
Melki R, Belmouden A, Akhayat O, Brezin A, Garchon HJ.
J Med Genet 40(11):842-4. No abstract available. 2003
33OPTN
Optineurin gene expression level in human trabecular meshwork does not change in response to pressure elevation.
Kamphuis W, Schneemann A.
Ophthalmic Res 35(2):93-6. 2003
34GLC1E, OPTN, OPA1
Adult-onset primary open-angle glaucoma caused by mutations in optineurin.
Rezaie T, Child A, Hitchings R, Brice G, Miller L, Coca-Prados M, Heon E, Krupin T, Ritch R, Kreutzer D, Crick RP, Sarfarazi M.
Science 295(5557):1077-9. 2002