Citations for
1NUP98, XPO1
Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes.
Oka M, Mura S, Yamada K, Sangel P, Hirata S, Maehara K, Kawakami K, Tachibana T, Ohkawa Y, Kimura H, Yoneda Y.
Elife 5:e09540. doi: 10.7554/eLife.09540. 2016
A conserved role for human Nup98 in altering chromatin structure and promoting epigenetic transcriptional memory.
Light WH, Freaney J, Sood V, Thompson A, D'Urso A, Horvath CM, Brickner JH.
PLoS Biol 11(3):e1001524. doi: 10.1371/journal.pbio.1001524. Epub 2013 Mar 26. 2013
Nucleoporin Nup98 mediates galectin-3 nuclear-cytoplasmic trafficking.
Funasaka T, Balan V, Raz A, Wong RW.
Biochem Biophys Res Commun 434(1):155-61. doi: 10.1016/j.bbrc.2013.03.052. Epub 2013 Mar 26. 2013
Dynamic association of NUP98 with the human genome.
Liang Y, Franks TM, Marchetto MC, Gage FH, Hetzer MW.
PLoS Genet 9(2):e1003308. doi: 10.1371/journal.pgen.1003308. Epub 2013 Feb 28. 2013
In vivo analysis of human nucleoporin repeat domain interactions.
Xu S, Powers MA.
Mol Biol Cell 24(8):1222-31. doi: 10.1091/mbc.E12-08-0585. Epub 2013 Feb 20. 2013
6NUP98, POU1F1
POU1F1 is a novel fusion partner of NUP98 in acute myeloid leukemia with t(3;11)(p11;p15).
Lisboa S, Cerveira N, Bizarro S, Correia C, Vieira J, Torres L, Mariz JM, Teixeira MR.
Mol Cancer 12:5. doi: 10.1186/1476-4598-12-5. 2013
The role of Nup98 in transcription regulation in healthy and diseased cells.
Franks TM, Hetzer MW.
Trends Cell Biol 23(3):112-7. doi: 10.1016/j.tcb.2012.10.013. Epub 2012 Dec 13. 2013
NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern.
de Rooij JD, Hollink IH, Arentsen-Peters ST, van Galen JF, Berna Beverloo H, Baruchel A, Trka J, Reinhardt D, Sonneveld E, Zimmermann M, Alonzo TA, Pieters R, Meshinchi S, van den Heuvel-Eibrink MM, Zwaan CM.
Leukemia 27(12):2280-8. doi: 10.1038/leu.2013.87. Epub 2013 Mar 27. 2013
Functional analysis of the NUP98-CCDC28A fusion protein.
Petit A, Ragu C, Soler G, Ottolenghi C, Schluth C, Radford-Weiss I, Schneider-Maunoury S, Callebaut I, Dastugue N, Drabkin HA, Bernard OA, Romana S, Penard-Lacronique V.
Haematologica 97(3):379-87. Epub 2011 Nov 4. 2012
Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes.
Singer S, Zhao R, Barsotti AM, Ouwehand A, Fazollahi M, Coutavas E, Breuhahn K, Neumann O, Longerich T, Pusterla T, Powers MA, Giles KM, Leedman PJ, Hess J, Grunwald D, Bussemaker HJ, Singer RH, Schirmacher P, Prives C.
Mol Cell 48(5):799-810. doi: 10.1016/j.molcel.2012.09.020. Epub 2012 Oct 24. 2012
Structural organization of the nuclear pore permeability barrier.
Liashkovich I, Meyring A, Oberleithner H, Shahin V.
J Control Release 160(3):601-8. doi: 10.1016/j.jconrel.2012.02.016. Epub 2012 Feb 22. 2012
Domain topology of nucleoporin Nup98 within the nuclear pore complex.
Chatel G, Desai SH, Mattheyses AL, Powers MA, Fahrenkrog B.
J Struct Biol 177(1):81-9. doi: 10.1016/j.jsb.2011.11.004. Epub 2011 Nov 12. 2012
13CDK1, NEK6, NEK7, NUP98
Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry.
Laurell E, Beck K, Krupina K, Theerthagiri G, Bodenmiller B, Horvath P, Aebersold R, Antonin W, Kutay U.
Cell 144(4):539-50. 2011
14NSD1, NUP98
NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern.
Hollink IH, van den Heuvel-Eibrink MM, Arentsen-Peters ST, Pratcorona M, Abbas S, Kuipers JE, van Galen JF, Beverloo HB, Sonneveld E, Kaspers GJ, Trka J, Baruchel A, Zimmermann M, Creutzig U, Reinhardt D, Pieters R, Valk PJ, Zwaan CM.
Blood 118(13):3645-56. Epub 2011 Aug 2. 2011
15AES, NUP62, NUP98
Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.
Sarma NJ, Yaseen NR.
J Biol Chem 286(45):38989-9001. doi: 10.1074/jbc.M111.297952. Epub 2011 Sep 21. 2011
Nup98 regulates bipolar spindle assembly through association with microtubules and opposition of MCAK.
Cross MK, Powers MA.
Mol Biol Cell 22(5):661-72. doi: 10.1091/mbc.E10-06-0478. Epub 2011 Jan 5. 2011
Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms.
Iwamoto M, Asakawa H, Hiraoka Y, Haraguchi T.
Genes Cells 15(7):661-9. Epub 2010 Jun 7.PMID: 20545767 2010
The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules.
Voronina E, Seydoux G.
Development 137(9):1441-50. Epub 2010 Mar 24.PMID: 20335358 2010
Nup98-homeodomain fusions interact with endogenous Nup98 during interphase and localize to kinetochores and chromosome arms during mitosis.
Xu S, Powers MA.
Mol Biol Cell 21(9):1585-96. Epub 2010 Mar 17.PMID: 20237156 2010
20NUP98, PSIP1
t(9;11)(p22;p15) [NUP98/PSIP1] is a poor prognostic marker associated with de novo acute myeloid leukaemia expressing both mature and immature surface antigens.
Lundin C, Horvat A, Karlsson K, Olofsson T, Paulsson K, Johansson B.
Leuk Res euk Res. 2010 Dec 16. [Epub ahead of print] No abstract available. 2010
21NUP50, NUP62, NUP98
Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm.
Kalverda B, Pickersgill H, Shloma VV, Fornerod M.
Cell 140(3):360-71. 2010
22NUP98, XPO1
The mobile FG nucleoporin Nup98 is a cofactor for Crm1-dependent protein export.
Oka M, Asally M, Yasuda Y, Ogawa Y, Tachibana T, Yoneda Y.
Mol Biol Cell 21(11):1885-96. Epub 2010 Apr 7. 2010
23KDM5A, NUP98
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.
Wang GG, Song J, Wang Z, Dormann HL, Casadio F, Li H, Luo JL, Patel DJ, Allis CD.
Nature ature. 2009 May 10. [Epub ahead of print] 2009
Nuclear pore proteins and cancer.
Xu S, Powers MA.
Semin Cell Dev Biol 20(5):620-30. Epub 2009 Mar 18. Review.PMID: 19577736 2009
25HOXC13, NUP98
Acute myeloid leukemia with NUP98-HOXC13 fusion and FLT3 internal tandem duplication mutation: case report and literature review.
Tosić N, Stojiljković M, Colović N, Colović M, Pavlović S.
Cancer Genet Cytogenet 193(2):98-103. Review. 2009
26HOXA9, NUP98
Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia with NUP98-HOXA9.
Aoki T, Miyamoto T, Yoshida S, Yamamoto A, Yamauchi T, Yoshimoto G, Mori Y, Kamezaki K, Iwasaki H, Takenaka K, Harada N, Nagafuji K, Teshima T, Akashi K.
Int J Hematol 88(5):571-4. Epub 2008 Nov 13.PMID: 19005624 2008
A new fusion gene NUP98-IQCG identified in an acute T-lymphoid/myeloid leukemia with a t(3;11)(q29q13;p15)del(3)(q29) translocation.
Pan Q, Zhu YJ, Gu BW, Cai X, Bai XT, Yun HY, Zhu J, Chen B, Weng L, Chen Z, Xue YQ, Chen SJ.
Oncogene 27(24):3414-23. Epub 2007 Dec 17.PMID: 18084320 2008
28HOXD13, NUP98
Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.
Slape C, Liu LY, Beachy S, Aplan PD.
Blood 112(5):2017-9. Epub 2008 Jun 19. 2008
29LNP1, NUP98
t(3;11)(q12;p15)/NUP98-LOC348801 fusion transcript in acute myeloid leukemia.
Gorello P, Brandimarte L, La Starza R, Pierini V, Bury L, Rosati R, Martelli MF, Vandenberghe P, Wlodarska I, Mecucci C.
Haematologica 93(9):1398-401. Epub 2008 Jul 4. 2008
Fusion of NUP98 and the SET binding protein 1 (SETBP1) gene in a paediatric acute T cell lymphoblastic leukaemia with t(11;18)(p15;q12).
Panagopoulos I, Kerndrup G, Carlsen N, Stršmbeck B, Isaksson M, Johansson B.
Br J Haematol 136(2):294-6. 2007
NUP98 dysregulation in myeloid leukemogenesis.
Moore MA, Chung KY, Plasilova M, Schuringa JJ, Shieh JH, Zhou P, Morrone G.
Ann N Y Acad Sci 1106:114-42. Epub 2007 Apr 18. Review. 2007
32KDM5A, NUP98
Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene.
van Zutven LJ, Onen E, Velthuizen SC, van Drunen E, von Bergh AR, van den Heuvel-Eibrink MM, Veronese A, Mecucci C, Negrini M, de Greef GE, Beverloo HB.
Genes Chromosomes Cancer 45(5):437-46. 2006
33NUP93, NUP98
Caspases target only two architectural components within the core structure of the nuclear pore complex.
Patre M, Tabbert A, Hermann D, Walczak H, Rackwitz HR, Cordes VC, Ferrando-May E.
J Biol Chem 281(2):1296-304. Epub 2005 Nov 14. 2006
HOXA9 activates transcription of the gene encoding gp91Phox during myeloid differentiation.
Bei L, Lu Y, Eklund EA.
J Biol Chem 280(13):12359-70. Epub 2005 Jan 28. 2005
35NUP98, NUP153
Distinct functional domains within nucleoporins Nup153 and Nup98 mediate transcription-dependent mobility.
Griffis ER, Craige B, Dimaano C, Ullman KS, Powers MA.
Mol Biol Cell 15(4):1991-2002. Epub 2004 Jan 12. 2004
36HOXC13, NUP98
Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid leukemia with t(11;12)(p15;q13).
La Starza R, Trubia M, Crescenzi B, Matteucci C, Negrini M, Martelli MF, Pelicci PG, Mecucci C.
Genes Chromosomes Cancer 36(4):420-3. 2003
NUP98 is fused to adducin 3 in a patient with T-cell acute lymphoblastic leukemia and myeloid markers, with a new translocation t(10;11)(q25;p15).
Lahortiga I, Vizmanos JL, Agirre X, Vazquez I, Cigudosa JC, Larrayoz MJ, Sala F, Gorosquieta A, Perez-Equiza K, Calasanz MJ, Odero MD.
Cancer Res 63(12):3079-83. 2003
38HOXA13, NUP98
The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9.
Taketani T, Taki T, Ono R, Kobayashi Y, Ida K, Hayashi Y.
Genes Chromosomes Cancer 34(4):437-43. 2002
39NSD1, NUP98
Cryptic translocation t(5;11)(q35;p15.5) with involvement of the NSD1 and NUP98 genes without 5q deletion in childhood acute myeloid leukemia.
Panarello C, Rosanda C, Morerio C.
Genes Chromosomes Cancer 35(3):277-81. 2002
40HOXD11, NUP98
The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15).
Taketani T, Taki T, Shibuya N, Ito E, Kitazawa J, Terui K, Hayashi Y.
Cancer Res 62(1):33-7. 2002
A t(4;11)(q21;p15) in a case of T-cell lymphoma and a case of acute myelogenous leukemia.
Thangavelu M, Huang B, Lemieux M, Tom W, Richkind KE.
Cancer Genet Cytogenet 132(2):109-15. 2002
42NUP98, WHSC1L1
NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15).
Rosati R, La Starza R, Veronese A, Aventin A, Schwienbacher C, Vallespi T, Negrini M, Martelli MF, Mecucci C.
Blood 99(10):3857-60. Erratum in: Blood 2002 Aug 15;100(4):1132. 2002
43HOXC11, NUP98
Novel NUP98-HOXC11 fusion gene resulted from a chromosomal break within exon 1 of HOXC11 in acute myeloid leukemia with t(11;12)(p15;q13).
Taketani T, Taki T, Shibuya N, Kikuchi A, Hanada R, Hayashi Y.
Cancer Res 62(16):4571-4. 2002
44NSD1, NUP98
A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.
Jaju RJ, Fidler C, Haas OA, Strickson AJ, Watkins F, Clark K, Cross NC, Cheng JF, Aplan PD, Kearney L, Boultwood J, Wainscoat JS.
Blood 98(4):1264-7. 2001
45AMLT2, NUP98
Generation of the NUP98-HOXD13 fusion transcript by a rare translocation, t(2;11)(q31;p15), in a case of infant leukaemia.
Shimada H, Arai Y, Sekiguchi S, Ishii T, Tanitsu S, Sasaki M.
Br J Haematol 110(1):210-3. Review. 2000
t(4;11)(q21;p15) translocation involving NUP98 and RAP1GDS1 genes: characterization of a new subset of T acute lymphoblastic leukaemia.
Mecucci C, La Starza R, Negrini M, Sabbioni S, Crescenzi B, Leoni P, Di Raimondo F, Krampera M, Cimino G, Tafuri A, Cuneo A, Vitale A, Foa R.
Br J Haematol 109(4):788-93. 2000
Heterogenous fusion transcripts involving the NUP98 gene and HOXD13 gene activation in a case of acute myeloid leukemia with the t(2;11)(q31;p15) translocation.
Arai Y, Kyo T, Miwa H, Arai K, Kamada N, Kita K, Ohki M.
Leukemia 14(9):1621-9. 2000
48TNPO1, NUP98
The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import.
Fontoura BM, Blobel G, Yaseen NR.
J Biol Chem 275(40):31289-96. 2000
49NUP98, PSIP1
t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF).
Ahuja HG, Hong J, Aplan PD, Tcheurekdjian L, Forman SJ, Slovak ML.
Cancer Res 60(22):6227-9. 2000
50DDX10, NUP98
Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome.
Nakao K, Nishino M, Takeuchi K, Iwata M, Kawano A, Arai Y, Ohki M.
Intern Med 39(5):412-5. 2000
Low frequency of rearrangements of the homeobox gene HOXA9/t(7;11) in adult acute myeloid leukemia.
Kwong YL, et al.
Genes Chromosomes Cancer 25(1):70-4. 1999
52AMLT2, NUP98, PBX1
NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15).
Nakamura T, et al.
Blood 94(2):741-7 1999
The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia.
Hussey DJ, Nicola M, Moore S, Peters GB, Dobrovic A.
Blood 94(6):2072-9 1999
54NUP98, TOP1
The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion.
Ahuja HG, Felix CA, Aplan PD.
Blood 94(9):3258-61 1999
The vertebrate GLFG nucleoporin, Nup98, is an essential component of multiple RNA export pathways.
Powers MA, et al.
J Cell Biol 136 : 241-250. 1997
56DDX10, NUP98
The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.
Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M.
Blood 89(11):3936-44. 1997
Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia.
Nakamura T, et al.
Nat Genet 12 : 154-158. 1996
The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.
Borrow J, et al.
Nat Genet 12 : 159-167. 1996
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex.
Radu A, et al.
Cell 81 : 215-222. 1995