Citations for
1IIAE9, NUP214
NUP214 deficiency causes severe encephalopathy and microcephaly in humans.
Shamseldin HE, Makhseed N, Ibrahim N, Al-Sheddi T, Alobeid E, Abdulwahab F, Alkuraya FS.
Hum Genet 138(3):221-229. doi: 10.1007/s00439-019-01979-w. Epub 2019 Feb 13. 2019
2IIAE9, NUP214
Pathogenic Variants in NUP214 Cause "Plugged" Nuclear Pore Channels and Acute Febrile Encephalopathy.
Fichtman B, Harel T, Biran N, Zagairy F, Applegate CD, Salzberg Y, Gilboa T, Salah S, Shaag A, Simanovsky N, Ayoubieh H, Sobreira N, Punzi G, Pierri CL, Hamosh A, Elpeleg O, Harel A, Edvardson S.
Am J Hum Genet 105(1):48-64. doi: 10.1016/j.ajhg.2019.05.003. Epub 2019 Jun 6. 2019
3DEK, NUP214
The DEK oncoprotein and its emerging roles in gene regulation.
Sandén C, Gullberg U.
Leukemia eukemia. 2015 Mar 13. doi: 10.1038/leu.2015.72. [Epub ahead of print] 2015
Several phenylalanine-glycine motives in the nucleoporin Nup214 are essential for binding of the nuclear export receptor CRM1.
Roloff S, Spillner C, Kehlenbach RH.
J Biol Chem 288(6):3952-63. doi: 10.1074/jbc.M112.433243. Epub 2012 Dec 21. 2013
5NUP214, NUP62
Nuclear distributions of NUP62 and NUP214 suggest architectural diversity and spatial patterning among nuclear pore complexes.
Kinoshita Y, Kalir T, Dottino P, Kohtz DS.
PLoS One 7(4):e36137. doi: 10.1371/journal.pone.0036137. Epub 2012 Apr 27. 2012
6DEK, NUP214
A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor.
Sawatsubashi S, Murata T, Lim J, Fujiki R, Ito S, Suzuki E, Tanabe M, Zhao Y, Kimura S, Fujiyama S, Ueda T, Umetsu D, Ito T, Takeyama K, Kato S.
Genes Dev 24(2):159-70. Epub 2009 Dec 29.PMID: 20040570 2010
7DDX19B, NUP214
The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner.
von Moeller H, Basquin C, Conti E.
Nat Struct Mol Biol 16(3):247-54. Epub 2009 Feb 15. 2009
8DDX19B, NUP214
Structural and functional analysis of the interaction between the nucleoporin Nup214 and the DEAD-box helicase Ddx19.
Napetschnig J, Kassube SA, Debler EW, Wong RW, Blobel G, Hoelz A.
Proc Natl Acad Sci U S A 106(9):3089-94. Epub 2009 Feb 10. 2009
9NUP214, NUP62
Oxidative stress inhibits nuclear protein export by multiple mechanisms that target FG nucleoporins and Crm1.
Crampton N, Kodiha M, Shrivastava S, Umar R, Stochaj U.
Mol Biol Cell 20(24):5106-16. doi: 10.1091/mbc.E09-05-0397. Epub . 2009
10NUP214, VDR
Oncogenic nucleoporin CAN/Nup214 interacts with vitamin D receptor and modulates its function.
Miyauchi Y, Sakaguchi N, Okada T, Makishima M, Ozono K, Michigami T.
J Cell Biochem 106(6):1090-101. doi: 10.1002/jcb.22101. 2009
11NUP214, DEK
Identification of a novel and myeloid specific role of the leukemia-associated fusion protein DEK-NUP214 leading to increased protein synthesis.
Ageberg M, Drott K, Olofsson T, Gullberg U, Lindmark A.
Genes Chromosomes Cancer 47(4):276-87. 2008
12NUP214, SET
The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia.
Van Vlierberghe P, van Grotel M, Tchinda J, Lee C, Beverloo HB, van der Spek PJ, Stubbs A, Cools J, Nagata K, Fornerod M, Buijs-Gladdines J, Horstmann M, van Wering ER, Soulier J, Pieters R, Meijerink JP.
Blood 111(9):4668-80. Epub 2008 Feb 25. 2008
Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN.
Napetschnig J, Blobel G, Hoelz A.
Proc Natl Acad Sci U S A 104(6):1783-8. Epub 2007 Jan 30. 2007
Nup214 is required for CRM1-dependent nuclear protein export in vivo.
Hutten S, Kehlenbach RH.
Mol Cell Biol 26(18):6772-85. 2006
15NUP214, ABL1, EML1
Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32).
De Keersmaecker K, Graux C, Odero MD, Mentens N, Somers R, Maertens J, Wlodarska I, Vandenberghe P, Hagemeijer A, Marynen P, Cools J.
Blood 105(12):4849-52. Epub 2005 Feb 15. 2005
16ABL1, NUP214, FUBP3
Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia.
Graux C, Cools J, Melotte C, Quentmeier H, Ferrando A, Levine R, Vermeesch JR, Stul M, Dutta B, Boeckx N, Bosly A, Heimann P, Uyttebroeck A, Mentens N, Somers R, MacLeod RA, Drexler HG, Look AT, Gilliland DG, Michaux L, Vandenberghe P, Wlodarska I, Marynen P, Hagemeijer A.
Nat Genet 36(10):1084-9. Epub 2004 Sep 12. 2004
Mapping ESTs to the TSC1 candidate interval by use of the 'Science 96' transcript map.
Wolfe J, Jeremiah S, Young J, Burley MW, Stewart H, McCulley M, Grant C, Naz K, Povey S.
Ann Hum Genet 61(Pt 5):401-9. 1997
Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements.
Fornerod M, et al.
Oncogene 10 : 1739-1748. 1995
The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm.
Kraemer D, et al.
Proc Natl Acad Sci U S A 91 : 1519-1523. 1994
20DEK, NUP214, CAN
The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.
von Lindern M, et al.
Mol Cell Biol 12 : 1687-1697. 1992
21NUP214, SET
can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes : characterization of the set gene.
von Lindern M, et al.
Mol Cell Biol 12 : 3346-3355. 1992
22NUP214, DEK, CAN
The translocation (6;9)(p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features.
Soekarman D, et al.
Blood 79 : 2990-2997. 1992
23NUP214, DEK, CAN
Characterization of the translocation breakpoint sequences of two DEK-CAN fusion genes present in t(6;9) acute myeloid leukemia and a SET-CAN fusion gene found in a case of acute undifferentiated leukemia.
Von Lindern M, et al.
Genes Chromosomes Cancer 5 : 227-234. 1992
24NUP214, D9S46, DEK,CAN
The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34.
von Lindern M, et al.
Mol Cell Biol 10 : 4016-4026. 1990