| 1 | ERBB2, NUMB, NUMBL, RAB7A
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| Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation.
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| Hirai M, Arita Y, McGlade CJ, Lee KF, Chen J, Evans SM.
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| J Clin Invest 127(2):569-582. doi: 10.1172/JCI91081. Epub 2017 Jan 9. 2017
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| 2 | NUMB, NUMBL
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| Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis.
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| Zhang Y, Li F, Song Y, Sheng X, Ren F, Xiong K, Chen L, Zhang H, Liu D, Lengner CJ, Xue L, Yu Z.
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| FASEB J 30(10):3474-3488. Epub 2016 Jul 6.
2016
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| 3 | NUMB, NUMBL
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| Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like.
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| van Lessen M, Nakayama M, Kato K, Kim JM, Kaibuchi K, Adams RH.
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| Arterioscler Thromb Vasc Biol 35(8):1815-25. doi: 10.1161/ATVBAHA.115.305473. Epub 2015 Jun 11.
2015
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| 4 | NUMB, NUMBL
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| Numb family proteins: novel players in cardiac morphogenesis and cardiac progenitor cell differentiation.
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| Wu M, Li J.
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| Biomol Concepts 6(2):137-48. doi: 10.1515/bmc-2015-0003. Review.
2015
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| 5 | NUMB, NUMBL
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| Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation.
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| Zhao C, Guo H, Li J, Myint T, Pittman W, Yang L, Zhong W, Schwartz RJ, Schwarz JJ, Singer HA, Tallquist MD, Wu M.
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| Development 141(2):281-95. doi: 10.1242/dev.093690. Epub 2013 Dec 11.
2014
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| 6 | CASP3, CCND1, MMP9, NUMBL, TRAF6
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| Numblike regulates proliferation, apoptosis, and invasion of lung cancer cell.
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| Yingjie L, Jian T, Changhai Y, Jingbo L.
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| Tumour Biol 34(5):2773-80. doi: 10.1007/s13277-013-0835-7. Epub 2013 May 17.
2013
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| 7 | NUMBL, TRAF5
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| Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation.
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| Tao T, Cheng C, Ji Y, Xu G, Zhang J, Zhang L, Shen A.
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| Mol Biol Cell 23(14):2635-44. doi: 10.1091/mbc.E11-09-0805. Epub 2012 May 16.
2012
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| 8 | NUMB, NUMBL, OFCC1
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| Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis.
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| Bogdanović O, Delfino-Machín M, Nicolás-Pérez M, Gavilán MP, Gago-Rodrigues I, Fernández-Mińán A, Lillo C, Ríos RM, Wittbrodt J, Martínez-Morales JR.
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| Dev Cell 23(4):782-95. doi: 10.1016/j.devcel.2012.09.004. Epub 2012 Oct 4.
2012
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| 9 | BMP10, NOTCH2, NUMB, NUMBL
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| Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart.
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| Yang J, Bücker S, Jungblut B, Böttger T, Cinnamon Y, Tchorz J, Müller M, Bettler B, Harvey R, Sun QY, Schneider A, Braun T.
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| Cardiovasc Res 96(2):276-85. doi: 10.1093/cvr/cvs250. Epub 2012 Aug 3.
2012
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| 10 | NUMB, NUMBL
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| Numblike and Numb differentially affect p53 and Sonic Hedgehog signaling.
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| Liu L, Lanner F, Lendahl U, Das D.
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| Biochem Biophys Res Commun 413(3):426-31. doi: 10.1016/j.bbrc.2011.08.108. Epub 2011 Aug 27.
2011
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| 11 | NUMBL, TRAF6
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| NUMBL interacts with TRAF6 and promotes the degradation of TRAF6.
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| Zhou L, Ma Q, Shi H, Huo K.
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| Biochem Biophys Res Commun 392(3):409-14. Epub 2010 Jan 15.
2010
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| 12 | NUMBL, TAB2
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| NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation.
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| Ma Q, Zhou L, Shi H, Huo K.
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| Cell Signal 20(6):1044-51. Epub 2008 Jan 31. 2008
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| 13 | LNX1, NUMBL
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| Mutation and copy number analysis of LNX1 and Numbl in nervous system tumors.
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| Blom T, Roselli A, Tanner M, Nupponen NN.
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| Cancer Genet Cytogenet 186(2):103-9.
2008
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| 14 | NUMB, NUMBL
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| Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.
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| Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N.
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| Nat Neurosci 10(7):819-27. Epub 2007 Jun 24. 2007
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| 15 | NUMB, NUMBL
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| Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche.
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| Kuo CT, Mirzadeh Z, Soriano-Navarro M, Rasin M, Wang D, Shen J, Sestan N, Garcia-Verdugo J, Alvarez-Buylla A, Jan LY, Jan YN.
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| Cell 127(6):1253-64. 2006
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| 16 | ATXN2, BHLHE22, CASK, CELF3, CNPY3, EP400, FOXP2, JPH3, KMT2D, MAGI1, MAML3, MED12, MED15, NUMBL, PAXIP1, TNRC15, TNRC17, TNRC18, TNRC6A, TOX3, ZNF384
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| cDNAs with long CAG trinucleotide repeats from human brain.
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| Margolis RL, Abraham MR, Gatchell SB, Li SH, Kidwai AS, Breschel TS, Stine OC, Callahan C, McInnis MG, Ross CA.
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| Hum Genet 100(1):114-22. 1997
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| 17 | AGFG2, CDC40, NUMB, NUMBL, SH3BP4
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| Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.
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| Salcini AE, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, Cesareni G, Pelicci PG, Di Fiore PP.
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| Genes Dev 11(17):2239-49. 1997
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| 18 | CDC40, NUMB, NUMBL, SH3BP4
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| A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution.
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| Wong WT, et al.
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| Proc Natl Acad Sci U S A 92(21):9530-4. 1995
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