Citations for
1NDC80, NUF2, SPC24, SPC25
Ectopic expression of plasma membrane targeted subunits of the Ndc80-complex as a tool to study kinetochore biochemistry.
Holmström TH, Rehnberg J, Ahonen LJ, Kallio MJ.
Mol Oncol ol Oncol. 2009 Feb 21. [Epub ahead of print]PMID: 19393581 2009
2NDC80, NUF2, SPC24, SPC25
siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis.
Kaneko N, Miura K, Gu Z, Karasawa H, Ohnuma S, Sasaki H, Tsukamoto N, Yokoyama S, Yamamura A, Nagase H, Shibata C, Sasaki I, Horii A.
Biochem Biophys Res Commun 390(4):1235-40. Epub 2009 Oct 28.PMID: 19878654 2009
3NDC80, NUF2, SPC24, SPC25
Orientation and structure of the Ndc80 complex on the microtubule lattice.
Wilson-Kubalek EM, Cheeseman IM, Yoshioka C, Desai A, Milligan RA.
J Cell Biol 182(6):1055-61. Epub 2008 Sep 15.PMID: 18794333 2008
Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment.
Liu D, Ding X, Du J, Cai X, Huang Y, Ward T, Shaw A, Yang Y, Hu R, Jin C, Yao X.
J Biol Chem 282(29):21415-24. Epub 2007 May 29. 2007
5NDC80, NUF2
Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis.
Hayama S, Daigo Y, Kato T, Ishikawa N, Yamabuki T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y.
Cancer Res 66(21):10339-48. 2006
6NDC80, NUF2, SPC24, SPC25
Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain.
Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC.
Structure 14(6):1003-9.PMID: 16765893 2006
Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites.
DeLuca JG, Dong Y, Hergert P, Strauss J, Hickey JM, Salmon ED, McEwen BF.
Mol Biol Cell 16(2):519-31. Epub 2004 Nov 17. 2005
8NDC80, NUF2, SPC24, SPC25
Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.
Ciferri C, De Luca J, Monzani S, Ferrari KJ, Ristic D, Wyman C, Stark H, Kilmartin J, Salmon ED, Musacchio A.
J Biol Chem 280(32):29088-95. Epub 2005 Jun 16.PMID: 15961401 2005
9NDC80, NUF2, SPC24, SPC25
The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment.
McCleland ML, Kallio MJ, Barrett-Wilt GA, Kestner CA, Shabanowitz J, Hunt DF, Gorbsky GJ, Stukenberg PT.
Curr Biol 14(2):131-7.PMID: 14738735 2004
hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells.
DeLuca JG, Moree B, Hickey JM, Kilmartin JV, Salmon ED.
J Cell Biol 159(4):549-55. Epub 2002 Nov 18. 2002
A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint.
Nabetani A, Koujin T, Tsutsumi C, Haraguchi T, Hiraoka Y.
Chromosoma 110(5):322-34. 2001
The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation.
Wigge PA, Kilmartin JV.
J Cell Biol 152(2):349-60. 2001