| 1 | LINGO1, NTRK1, NTRK2, NTRK3
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| Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling.
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| Meabon JS, de Laat R, Ieguchi K, Serbzhinsky D, Hudson MP, Huber BR, Wiley JC, Bothwell M.
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| Mol Cell Neurosci 70:1-10. doi: 10.1016/j.mcn.2015.11.002. Epub 2015 Nov 3.
2016
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| 2 | NTRK1, STX8
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| Syntaxin 8 modulates the post-synthetic trafficking of the TrkA receptor and inflammatory pain transmission.
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| Chen B, Zhao L, Li X, Ji YS, Li N, Xu XF, Chen ZY.
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| J Biol Chem 289(28):19556-69. doi: 10.1074/jbc.M114.567925. Epub 2014 May 28.
2014
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| 3 | LHX8, NGF, NTRK1
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| LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop
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| Tomioka T, Shimazaki T, Yamauchi T, Oki T, Ohgoh M, Okano H.
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| J Biol Chem. Jan 10;289(2):1000-10. doi: 10.1074/jbc.M113.494385. Epub 2013 Nov 21. 2014
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| 4 | NTRK1, RASGRF1
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| Ras guanine nucleotide releasing factor 1 (RasGrf1) enhancement of Trk receptor-mediated neurite outgrowth requires activation of both H-Ras and Rac.
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| Talebian A, Robinson-Brookes K, MacDonald JI, Meakin SO.
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| J Mol Neurosci 49(1):38-51. doi: 10.1007/s12031-012-9847-9. Epub 2012 Jun 29.
2013
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| 5 | NGFR, NTRK1
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| An intracellular domain fragment of the p75 neurotrophin receptor (p75(NTR)) enhances tropomyosin receptor kinase A (TrkA) receptor function.
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| Matusica D, Skeldal S, Sykes AM, Palstra N, Sharma A, Coulson EJ.
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| J Biol Chem 288(16):11144-54. doi: 10.1074/jbc.M112.436469. Epub 2013 Mar 7.
2013
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| 6 | NGFR, NTRK1, RBFOX3
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| Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression.
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| Hagel C, Treszl A, Fehlert J, Harder J, von Haxthausen F, Kern M, von Bueren AO, Kordes U.
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| J Neurooncol Neurooncol. 2013 2013
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| 7 | NGFR, NTRK1
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| Localization of nerve growth factor (NGF) receptors in the mitochondrial compartment: characterization and putative role.
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| Carito V, Pingitore A, Cione E, Perrotta I, Mancuso D, Russo A, Genchi G, Caroleo MC.
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| Biochim Biophys Acta 1820(2):96-103. doi: 10.1016/j.bbagen.2011.10.015. Epub 2011 Nov 21.
2012
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| 8 | NGFR, NTRK1
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| NGF causes TrkA to specifically attract microtubules to lipid rafts.
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| Pryor S, McCaffrey G, Young LR, Grimes ML.
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| PLoS One 7(4):e35163. doi: 10.1371/journal.pone.0035163. Epub 2012 Apr 4.
2012
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| 9 | NTRK1, RUSC1
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| Crystal structure and functional implication of the RUN domain of human NESCA.
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| Sun Q, Han C, Liu L, Wang Y, Deng H, Bai L, Jiang T.
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| Protein Cell 3(8):609-17. doi: 10.1007/s13238-012-2052-3. Epub 2012 Jul 22.
2012
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| 10 | MYCN, NGFR, NTRK1
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| A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.
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| Iraci N, Diolaiti D, Papa A, Porro A, Valli E, Gherardi S, Herold S, Eilers M, Bernardoni R, Della Valle G, Perini G.
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| Cancer Res 71(2):404-12. Epub 2010 Dec 1.
2011
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| 11 | APP, NTRK1
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| APP is phosphorylated by TrkA and regulates NGF/TrkA signaling.
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| Matrone C, Barbagallo AP, La Rosa LR, Florenzano F, Ciotti MT, Mercanti D, Chao MV, Calissano P, D'Adamio L.
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| J Neurosci 31(33):11756-61. doi: 10.1523/JNEUROSCI.1960-11.2011.
2011
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| 12 | NTRK1, NTRK2, NTRK3
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| Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not.
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| Nikoletopoulou V, Lickert H, Frade JM, Rencurel C, Giallonardo P, Zhang L, Bibel M, Barde YA.
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| Nature 467(7311):59-63. 2010
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| 13 | NGF, NTRK1
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| Absence of nerve growth factor and comparison of tyrosine kinase receptor A levels in mature spermatozoa from oligoasthenozoospermic, asthenozoospermic and fertile men.
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| Li C, Zheng L, Wang C, Zhou X.
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| Clin Chim Acta 411(19-20):1482-6. Epub 2010 Jun 11.
2010
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| 14 | HSAN4, NTRK1
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| Skoura - a genetic island for congenital insensitivity to pain and anhidrosis among Moroccan Jews, as determined by a novel mutation in the NTRK1 gene.
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| Suriu C, Khayat M, Weiler M, Kfir N, Cohen C, Zinger A, Aslanidis C, Schmitz G, Falik-Zaccai TC.
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| Clin Genet 75(3):230-6.
2009
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| 15 | NTRK1
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| TrkA overexpression enhances growth and metastasis of breast cancer cells.
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| Lagadec C, Meignan S, Adriaenssens E, Foveau B, Vanhecke E, Romon R, Toillon RA, Oxombre B, Hondermarck H, Le Bourhis X.
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| Oncogene 28(18):1960-70. Epub 2009 Mar 30.
2009
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| 16 | CCT5, ELP1, HSAN1, HSAN2A, HSAN3, HSAN4, HSAN5, NGF, NTRK1, SNSP, SPTLC1, WNK1
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| Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation.
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| Rotthier A, Baets J, De Vriendt E, Jacobs A, Auer-Grumbach M, Lévy N, Bonello-Palot N, Kilic SS, Weis J, Nascimento A, Swinkels M, Kruyt MC, Jordanova A, De Jonghe P, Timmerman V.
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| Brain 132(Pt 10):2699-711. Epub 2009 Aug 3.PMID: 19651702 2009
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| 17 | ACIN1, NGF, NTRK1
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| NGF inhibits human leukemia proliferation by downregulating cyclin A1 expression through promoting acinus/CtBP2 association.
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| Chan CB, Liu X, Jang SW, Hsu SI, Williams I, Kang S, Chen J, Ye K.
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| Oncogene 28(43):3825-36. Epub 2009 Aug 10.
2009
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| 18 | HSAN4, NTRK1
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| Novel NTRK1 mutations cause hereditary sensory and autonomic neuropathy type IV: demonstration of a founder mutation in the Turkish population.
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| Tüysüz B, Bayrakli F, DiLuna ML, Bilguvar K, Bayri Y, Yalcinkaya C, Bursali A, Ozdamar E, Korkmaz B, Mason CE, Ozturk AK, Lifton RP, State MW, Gunel M.
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| Neurogenetics 9(2):119-25. Epub 2008 Mar 6.
2008
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| 19 | NTRK1
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| Nuclear localization of TRK-A in liver cells.
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| Bonacchi A, Taddei ML, Petrai I, Efsen E, Defranco R, Nosi D, Torcia M, Rosini P, Formigli L, Rombouts K, Zecchi S, Milani S, Pinzani M, Laffi G, Marra F.
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| Histol Histopathol 23(3):327-40.
2008
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| 20 | HSAN4, NTRK1
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| Novel missense, insertion and deletion mutations in the neurotrophic tyrosine kinase receptor type 1 gene (NTRK1) associated with congenital insensitivity to pain with anhidrosis.
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| Huehne K, Zweier C, Raab K, Odent S, Bonnaure-Mallet M, Sixou JL, Landrieu P, Goizet C, Sarlangue J, Baumann M, Eggermann T, Rauch A, Ruppert S, Stettner GM, Rautenstrauss B.
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| Neuromuscul Disord 18(2):159-66. Epub 2008 Feb 20.PMID: 18077166 2008
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| 21 | NTRK1
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| Detection of new anti-neutral glycosphingolipids antibodies and their effects on Trk neurotrophin receptors.
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| Mihara T, Ueda A, Hirayama M, Takeuchi T, Yoshida S, Naito K, Yamamoto H, Mutoh T.
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| FEBS Lett 580(21):4991-5. Epub 2006 Aug 17. 2006
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| 22 | APPL1, GIPC1, NTRK1
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| APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction.
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| Lin DC, Quevedo C, Brewer NE, Bell A, Testa JR, Grimes ML, Miller FD, Kaplan DR.
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| Mol Cell Biol 26(23):8928-41. Epub 2006 Sep 25.
2006
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| 23 | DNAJA3, NTRK1
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| Human tumorous imaginal disc 1 (TID1) associates with Trk receptor tyrosine kinases and regulates neurite outgrowth in nnr5-TrkA cells.
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| Liu HY, MacDonald JI, Hryciw T, Li C, Meakin SO.
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| J Biol Chem 280(20):19461-71. Epub 2005 Mar 7. 2005
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| 24 | NTRK1, RUNX1T1, RUNX1
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| AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.
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| Mulloy JC, Jankovic V, Wunderlich M, Delwel R, Cammenga J, Krejci O, Zhao H, Valk PJ, Lowenberg B, Nimer SD.
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| Proc Natl Acad Sci U S A 102(11):4016-21. Epub 2005 Feb 24. 2005
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| 25 | NTRK1
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| Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3.
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| Lambiase A, Merlo D, Mollinari C, Bonini P, Rinaldi AM, D' Amato M, Micera A, Coassin M, Rama P, Bonini S, Garaci E.
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| Proc Natl Acad Sci U S A 102(46):16795-800. Epub 2005 Nov 7. 2005
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| 26 | KALRN, NTRK1
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| Critical role for Kalirin in nerve growth factor signaling through TrkA.
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| Chakrabarti K, Lin R, Schiller NI, Wang Y, Koubi D, Fan YX, Rudkin BB, Johnson GR, Schiller MR.
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| Mol Cell Biol 25(12):5106-18. 2005
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| 27 | SH2D1A, NTRK1, NTRK2, NTRK3
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| SLAM-associated protein as a potential negative regulator in Trk signaling.
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| Lo KY, Chin WH, Ng YP, Cheng AW, Cheung ZH, Ip NY.
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| J Biol Chem 280(50):41744-52. Epub 2005 Oct 13. 2005
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| 28 | HSAN4, NTRK1
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| A novel lymphocyte signaling defect: trk A mutation in the syndrome of congenital insensitivity to pain and anhidrosis (CIPA).
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| Melamed I, Levy J, Parvari R, Gelfand EW.
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| J Clin Immunol 24(4):441-8. 2004
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| 29 | NTRK1
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| TrkA as a life and death receptor: receptor dose as a mediator of function.
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| Yan C, Liang Y, Nylander KD, Schor NF.
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| Cancer Res 62(17):4867-75. 2002
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| 30 | NTRK1
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| Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor.
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| Mardy S, Miura Y, Endo F, Matsuda I, Indo Y.
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| Hum Mol Genet 10(3):179-88. 2001
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| 31 | HSAN4, NTRK1
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| Congenital insensitivity to pain with anhidrosis (CIPA): Novel mutations of the TRKA (NTRK1) gene, a putative uniparental disomy, and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate kinase deficiency.
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| Indo Y, Mardy S, Miura Y, Moosa A, Ismail EA, Toscano E, Andria G, Pavone V, Brown DL, Brooks A, Endo F, Matsuda I.
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| Hum Mutat 18(4):308-18. 2001
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| 32 | HSAN4, NTRK1
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| Mutation and polymorphism analysis of theTRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor in congenital insensitivity to pain with anhidrosis (CIPA) families
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| Miura Y, Mardy S, Awaya Y, Nihei K, Endo F, Matsuda I, Indo Y.
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| Hum Genet 106:116-124 2000
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| 33 | HSAN4, NTRK1
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| Congenital insensitivity to pain with anhidrosis (CIPA) in Israeli-Bedouins: genetic heterogeneity, novel mutations in the TRKA/NGF receptor gene, clinical findings, and results of nerve conduction studies.
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| Shatzky S, Moses S, Levy J, Pinsk V, Hershkovitz E, Herzog L, Shorer Z, Luder A, Parvari R.
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| Am J Med Genet 92(5):353-60. 2000
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| 34 | HSAN4, NTRK1
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| Complete paternal uniparental isodisomy for chromosome 1 revealed by mutation analyses of the TRKA (NTRK1) gene encoding a receptor tyrosine kinase for nerve growth factor in a patient with congenital insensitivity to pain with anhidrosis
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| Miura Y, Hiura M, Torigoe K, Numata O, Kuwahara A, Matsunaga M, Hasegawa S, Boku N, Ino H, Mardy S, Endo F, Matsuda I, Indo Y.
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| Hum Genet 107(3):205-9. 2000
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| 35 | HSAN4, NTRK1
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| A Novel NTRK1 Mutation Associated with Congenital Insensitivity to Pain with Anhidrosis.
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| Greco A, et al.
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| Am J Hum Genet 64(4):1207-1210. No abstract available 1999
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| 36 | HSAN4, NTRK1
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| Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding A high-affinity receptor for nerve growth factor.
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| Mardy S, et al.
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| Am J Hum Genet 64(6):1570-9. 1999
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| 37 | NTRK1, HSAN4
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| A novel point mutation affecting the tyrosine kinase domain of the TRKA gene in a family with congenital insensitivity to pain with anhidrosis.
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| Yotsumoto S, et al.
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| J Invest Dermatol 112(5):810-4. 1999
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| 38 | NTRK1
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| Molecular cloning and characterization of the 5' region of the mouse trkA proto-oncogene.
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| Sacristan MP, de Diego JG, Bonilla M, Martin-Zanca D.
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| Oncogene 18(42):5836-42 1999
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| 39 | NTRK1, NTRK2, NTRK3
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| Mapping of the tyrosine kinase receptors trkA(NTRK1),trkB (NTRK2) and trkC (NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization.
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| Valent A, Danglot G, Bernheim A.
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| Eur J Hum Genet 5(2):102-4. 1997
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| 40 | NTRK1, TPR
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| Chromosome 1 rearrangements involving the genes TPR and NTRK1 produce structurally different thyroid-specific TRK oncogenes.
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| Greco A, Miranda C, Pagliardini S, Fusetti L, Bongarzone I, Pierotti MA.
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| Genes Chromosomes Cancer 19(2):112-23. 1997
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| 41 | NTRK1
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| Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor.
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| Indo Y, Mardy S, Tsuruta M, Karim MA, Matsuda I.
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| Jpn J Hum Genet 42(2):343-51. 1997
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| 42 | HSAN4, NTRK1
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| Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis.
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| Indo Y, et al.
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| Nat Genet 13 : 485-488. 1996
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| 43 | NTRK1
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| Genomic organization of the human NTRK1 gene.
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| Greco A, et al.
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| Oncogene 13 : 2463-2466. 1996
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| 44 | NTRK1
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| Rapid physical mapping of the human trk protooncogene (NTRK1) to human chromosome 1q21-q22 by P1 clone selection, fluorescence in situ hybridization (FISH), and computer-assisted microscopy.
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| Weier HUG, et al.
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| Genomics 26 : 390-393. 1995
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| 45 | NTRK1, TPM3
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| A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas.
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| Butti MG, et al.
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| Genomics 28 : 15-24. 1995
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| 46 | NTRK1
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| Characterization of the NTRK1 genomic region involved in chromosomal rearrangements generating TRK oncogenes.
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| Greco A, et al.
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| Genomics 18 : 397-400. 1993
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| 47 | NTRK1
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| The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor.
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| Meakin SO, et al.
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| Proc Natl Acad Sci U S A 89 : 2374-2378. 1992
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| 48 | TPR, NTRK1
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| TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas.
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| Greco A, et al.
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| Oncogene 7 : 237-242. 1992
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| 49 | NTRK1
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| Intrachromosomal rearrangements lead to the activation of tyrosine kinase oncogenes in papillary thyroid carcinomas: 2)the TRK case.
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| Radice P, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 1862. 1991
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| 50 | NTRK1
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| The trk proto-oncogene encodes a receptor for nerve growth factor.
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| Klein R, et al.
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| Cell 65 : 189-197. 1991
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| 51 | NTRK1
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| Molecular investigations on the high-affinity nerve growth factor receptor.
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| Meakin SO, et al.
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| Neuron 6 : 153-163. 1991
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| 52 | NTRK1
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| High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.
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| Hempstead BL, et al.
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| Nature 350 : 678-683. 1991
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| 53 | NTRK1
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| The trk proto-oncogene product : a signal transducing receptor for nerve growth factor.
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| Kaplan DR, et al.
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| Science 252 : 554-558. 1991
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| 54 | NTRK1
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| Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24.
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| Morris CM, et al.
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| Oncogene 6(6):1093-5 1991
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| 55 | NTRK1
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| Human TRK proto-oncogene maps to chromosome 1q32-q41.
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| Miozzo M, et al.
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| Oncogene 5(9):1411-4 1990
|
| 56 | NTRK1
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| A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences.
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| Martin-Zanca D, et al.
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| Nature 319 : 743-748. 1986
|