Citations for
1NRXN1, SORCS1
SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function.
Ribeiro LF, Verpoort B, Nys J, Vennekens KM, Wierda KD, de Wit J.
PLoS Biol. Oct 28;17(10):e3000466. doi: 10.1371/journal.pbio.3000466. eCollection 2019 Oct. 2019
2LRRTM1, LRRTM2, NRXN1
Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction
Terada T, Yoshida T, Uemura T, Fukai S.
Nat Commun. Sep 27;9(1):3964. doi: 10.1038/s41467-018-06333-8. 2018
3NRXN1, SORCS1
The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors.
Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Rice HC, Chamma I, Wang YZ, Zemla R, Lavallée-Adam M, Vennekens KM, O'Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR 3rd, Ghosh A, de Wit J.
Neuron Aug 19;87(4):764-80. doi: 10.1016/j.neuron.2015.08.007. 2015
4NRXN1
Molecular Analysis of a Deletion Hotspot in the NRXN1 Region Reveals the Involvement of Short Inverted Repeats in Deletion CNVs.
Chen X, Shen Y, Zhang F, Chiang C, Pillalamarri V, Blumenthal I, Talkowski M, Wu BL, Gusella JF.
Am J Hum Genet 92(3):375-86. doi: 10.1016/j.ajhg.2013.02.006. 2013
5NLGN1, NLGN2, NRXN1
Promoter-like sequences regulating transcriptional activity in neurexin and neuroligin genes
Runkel F, Rohlmann A, Reissner C, Brand SM, Missler M.
J Neurochem. Oct;127(1):36-47. doi: 10.1111/jnc.12372. Epub 2013 Aug 21 2013
6NRXN1, NRXN3
Rare deletions at the neurexin 3 locus in autism spectrum disorder.
Vaags AK, Lionel AC, Sato D, Goodenberger M, Stein QP, Curran S, Ogilvie C, Ahn JW, Drmic I, Senman L, Chrysler C, Thompson A, Russell C, Prasad A, Walker S, Pinto D, Marshall CR, Stavropoulos DJ, Zwaigenbaum L, Fernandez BA, Fombonne E, Bolton PF, Collier DA, Hodge JC, Roberts W, Szatmari P, Scherer SW.
Am J Hum Genet 90(1):133-41. Epub 2011 Dec 29. 2012
7NRXN1, NRXN2, NRXN3
Exonal Elements and Factors Involved in the Depolarization-Induced Alternative Splicing of Neurexin 2.
Rozic G, Lupowitz Z, Zisapel N.
J Mol Neurosci Mol Neurosci. 2012 Nov 21. [Epub ahead of print] 2012
8KHDRBS1, NRXN1
SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1.
Iijima T, Wu K, Witte H, Hanno-Iijima Y, Glatter T, Richard S, Scheiffele P.
Cell 147(7):1601-14. 2011
9NRXN1, NRXN2
Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia.
Gauthier J, Siddiqui TJ, Huashan P, Yokomaku D, Hamdan FF, Champagne N, Lapointe M, Spiegelman D, Noreau A, Lafrenière RG, Fathalli F, Joober R, Krebs MO, DeLisi LE, Mottron L, Fombonne E, Michaud JL, Drapeau P, Carbonetto S, Craig AM, Rouleau GA.
Hum Genet 130(4):563-73. doi: 10.1007/s00439-011-0975-z. Epub 2011 Mar 22. 2011
10NRXN1
Intragenic rearrangements in NRXN1 in three families with autism spectrum disorder, developmental delay, and speech delay.
Wiśniowiecka-Kowalnik B, Nesteruk M, Peters SU, Xia Z, Cooper ML, Savage S, Amato RS, Bader P, Browning MF, Haun CL, Duda AW 3rd, Cheung SW, Stankiewicz P.
Am J Med Genet B Neuropsychiatr Genet 153B(5):983-93.PMID: 20162629 2010
11NRXN1
Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders.
Ching MS, Shen Y, Tan WH, Jeste SS, Morrow EM, Chen X, Mukaddes NM, Yoo SY, Hanson E, Hundley R, Austin C, Becker RE, Berry GT, Driscoll K, Engle EC, Friedman S, Gusella JF, Hisama FM, Irons MB, Lafiosca T, LeClair E, Miller DT, Neessen M, Picker JD, Rappaport L, Rooney CM, Sarco DP, Stoler JM, Walsh CA, Wolff RR, Zhang T, Nasir RH, Wu BL; Children's Hospital Boston Genotype Phenotype Study Group.
Am J Med Genet B Neuropsychiatr Genet 153B(4):937-47.PMID: 20468056 2010
12CNTNAP2, NRXN1, PTHS2, PTHS3
CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila.
Zweier C, de Jong EK, Zweier M, Orrico A, Ousager LB, Collins AL, Bijlsma EK, Oortveld MA, Ekici AB, Reis A, Schenck A, Rauch A.
Am J Hum Genet 85(5):655-66. Epub 2009 Nov 5.PMID: 19896112 2009
13NRXN1
Disruption of the neurexin 1 gene is associated with schizophrenia.
Rujescu D, Ingason A, Cichon S, Pietiläinen OP, Barnes MR, Toulopoulou T, Picchioni M, Vassos E, Ettinger U, Bramon E, Murray R, Ruggeri M, Tosato S, Bonetto C, Steinberg S, Sigurdsson E, Sigmundsson T, Petursson H, Gylfason A, Olason PI, Hardarsson G, Jonsdottir GA, Gustafsson O, Fossdal R, Giegling I, Möller HJ, Hartmann AM, Hoffmann P, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Djurovic S, Melle I, Andreassen OA, Hansen T, Werge T, Kiemeney LA, Franke B, Veltman J, Buizer-Voskamp JE; GROUP Investigators, Sabatti C, Ophoff RA, Rietschel M, Nöthen MM, Stefansson K, Peltonen L, St Clair D, Stefansson H, Collier DA.
Hum Mol Genet 18(5):988-96. doi: 10.1093/hmg/ddn351. Epub 2008 Oct 22. 2009
14LRRTM2, NRXN1
LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation. . 2009 PMID:
de Wit J, Sylwestrak E, O'Sullivan ML, Otto S, Tiglio K, Savas JN, Yates JR 3rd, Comoletti D, Taylor P, Ghosh A.
Neuron Dec 24;64(6):799-806. doi: 10.1016/j.neuron.2009.12.019. 2009
15AUTS19, NRXN1
Disruption of neurexin 1 associated with autism spectrum disorder.
Kim HG, Kishikawa S, Higgins AW, Seong IS, Donovan DJ, Shen Y, Lally E, Weiss LA, Najm J, Kutsche K, Descartes M, Holt L, Braddock S, Troxell R, Kaplan L, Volkmar F, Klin A, Tsatsanis K, Harris DJ, Noens I, Pauls DL, Daly MJ, MacDonald ME, Morton CC, Quade BJ, Gusella JF.
Am J Hum Genet 82(1):199-207. 2008
16NRXN1, APBA1,AUTS12
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia.
Kirov G, Gumus D, Chen W, Norton N, Georgieva L, Sari M, O'Donovan MC, Erdogan F, Owen MJ, Ropers HH, Ullmann R.
Hum Mol Genet 17(3):458-65. Epub 2007 Nov 6. 2008
17ANKRD11, DEL15Q24, DEL16P112P, DELXP22, DPP10, DPP6, DPYD, NLGN4, NLGN4X, NRXN1, PCDH9, PTCHD1, SHANK3
Structural variation of chromosomes in autism spectrum disorder.
Marshall CR, Noor A, Vincent JB, Lionel AC, Feuk L, Skaug J, Shago M, Moessner R, Pinto D, Ren Y, Thiruvahindrapduram B, Fiebig A, Schreiber S, Friedman J, Ketelaars CE, Vos YJ, Ficicioglu C, Kirkpatrick S, Nicolson R, Sloman L, Summers A, Gibbons CA, Teebi A, Chitayat D, Weksberg R, Thompson A, Vardy C, Crosbie V, Luscombe S, Baatjes R, Zwaigenbaum L, Roberts W, Fernandez B, Szatmari P, Scherer SW.
Am J Hum Genet 82(2):477-88. Epub 2008 Jan 17. 2008
18NRXN1
A patient with vertebral, cognitive and behavioural abnormalities and a de novo deletion of NRXN1alpha.
Zahir FR, Baross A, Delaney AD, Eydoux P, Fernandes ND, Pugh T, Marra MA, Friedman JM.
J Med Genet 45(4):239-43. Epub 2007 Dec 5. 2008
19NRXN1
Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers.
Nussbaum J, Xu Q, Payne TJ, Ma JZ, Huang W, Gelernter J, Li MD.
Hum Mol Genet 17(11):1569-77. Epub 2008 Feb 11. 2008
20ASTN1, ASTN2, CTNND2, MYT1L, NRXN1
Recurrent CNVs disrupt three candidate genes in schizophrenia patients.
Vrijenhoek T, Buizer-Voskamp JE, van der Stelt I, Strengman E; Genetic Risk and Outcome in Psychosis (GROUP) Consortium, Sabatti C, Geurts van Kessel A, Brunner HG, Ophoff RA, Veltman JA.
Am J Hum Genet 83(4):504-10. 2008
21NRXN1, NRXN2, NRXN3
Regulation of neurexin 1beta tertiary structure and ligand binding through alternative splicing.
Shen KC, Kuczynska DA, Wu IJ, Murray BH, Sheckler LR, Rudenko G.
Structure 16(3):422-31.PMID: 18334217 2008
22AUTS11P, AUTS19, AUTS5, AUTS7, AUTS9, NRXN1
Mapping autism risk loci using genetic linkage and chromosomal rearrangements.
The Autism Genome Project Consortium; Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, Liu XQ, Vincent JB, Skaug JL, Thompson AP, Senman L, Feuk L, Qian C, Bryson SE, Jones MB, Marshall CR, Scherer SW, Vieland VJ, Bartlett C, Mangin LV, Goedken R, Segre A, Pericak-Vance MA, Cuccaro ML, Gilbert JR, Wright HH, Abramson RK, Betancur C, Bourgeron T, Gillberg C, Leboyer M, Buxbaum JD, Davis KL, Hollander E, Silverman JM, Hallmayer J, Lotspeich L, Sutcliffe JS, Haines JL, Folstein SE, Piven J, Wassink TH, Sheffield V, Geschwind DH, Bucan M, Brown WT, Cantor RM, Constantino JN, Gilliam TC, Herbert M, Lajonchere C, Ledbetter DH, Lese-Martin C, Miller J, Nelson S, Samango-Sprouse CA, Spence S, State M, Tanzi RE, Coon H, Dawson G, Devlin B, Estes A, Flodman P, Klei L, McMahon WM, Minshew N, Munson J, Korvatska E, Rodier PM, Schellenberg GD, Smith M, Spence MA, Stodgell C, Tepper PG, Wijsman EM, Yu CE, Roge B, Mantoulan C, Wittemeyer K, Poustka A, Felder B, Klauck SM, Schuster C, Poustka F, Bolte S, Feineis-Matthews S, Herbrecht E, Schmotzer G, Tsiantis J, Papanikolaou K, Maestrini E, Bacchelli E, Blasi F, Carone S, Toma C, Van Engeland H, de Jonge M, Kemner C, Koop F, Langemeijer M, Hijimans C, Staal WG, Baird G, Bolton PF, Rutter ML, Weisblatt E, Green J, Aldred C, Wilkinson JA, Pickles A, Le Couteur A, Berney T, McConachie H, Bailey AJ, Francis K, Honeyman G, Hutchinson A, Parr JR, Wallace S, Monaco AP, Barnby G, Kobayashi K, Lamb JA, Sousa I, Sykes N, Cook EH, Guter SJ, Leventhal BL, Salt J, Lord C, Corsello C, Hus V, Weeks DE, Volkmar F, Tauber M, Fombonne E, Shih A.
Nat Genet 39(3):319-28. Epub 2007 Feb 18. 2007
23AUTS20, NLGN, NLGN4X, NRXN1, RPL10, SHANK3
Contribution of SHANK3 Mutations to Autism Spectrum Disorder.
Moessner R, Marshall CR, Sutcliffe JS, Skaug J, Pinto D, Vincent J, Zwaigenbaum L, Fernandez B, Roberts W, Szatmari P, Scherer SW.
Am J Hum Genet 81(6):1289-97. Epub 2007 Oct 16. 2007
24AUTS19, NRXN1
High frequency of neurexin 1beta signal peptide structural variants in patients with autism.
Feng J, Schroer R, Yan J, Song W, Yang C, Bockholt A, Cook EH Jr, Skinner C, Schwartz CE, Sommer SS.
Neurosci Lett 409(1):10-3. Epub 2006 Oct 10. 2006
25NRXN1
Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins.
Comoletti D, Flynn RE, Boucard AA, Demeler B, Schirf V, Shi J, Jennings LL, Newlin HR, SŸdhof TC, Taylor P.
Biochemistry 45(42):12816-27. 2006
26AUTS19, NRXN1
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism.
Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, SŸdhof TC.
J Biol Chem 280(23):22365-74. Epub 2005 Mar 29. 2005
27NRXN1
Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta.
Comoletti D, Flynn R, Jennings LL, Chubykin A, Matsumura T, Hasegawa H, Sudhof TC, Taylor P.
J Biol Chem 278(50):50497-505. Epub 2003 Sep 30. 2003
28NRXN1, NRXN2, NRXN3
Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.
Rowen L, Young J, Birditt B, Kaur A, Madan A, Philipps DL, Qin S, Minx P, Wilson RK, Hood L, Graveley BR.
Genomics 79(4):587-97. 2002
29CASK, NRXN1
CASK and protein 4.1 support F-actin nucleation on neurexins.
Biederer T, Sudhof TC.
J Biol Chem 276(51):47869-76. Epub 2001 Oct 16. 2001
30NRXN1
The structure of the ligand-binding domain of neurexin Ibeta: regulation of LNS domain function by alternative splicing.
Rudenko G, et al.
Cell 99(1):93-101 1999
31NRXN1, NRXN2, NRXN3, CNTNAP1
Neurexins : three genes and 1001 products.
Missler M, Sudhof TC.
Trends Genet 14(1):20-6. 1998
32ADGRV1, NRXN1
Alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis.
Sugita S, et al.
J Biol Chem 273 : 32715-32724. 1998
33ADRBK1, AR, ZFHX3, CACNA1A, CAPNS1, FOXE1, FOXF1, FMR1, AFF2, HCN1, NRXN1, CA10
CCG repeats in cDNAs from human brain.
Kleiderlein JJ, Nisson PE, Jessee J, Li WB, Becker KG, Derby ML, Ross CA, Margolis RL.
Hum Genet 103(6):666-73. 1998
34NRXN1
Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.
Ushkaryov YA, Hata Y, Ichtchenko K, Moomaw C, Afendis S, Slaughter CA, Sudhof TC.
J Biol Chem 269 : 11987-11992. 1994