| 1 | NRP1, NRP2, PLXNA1
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| Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism. 2021 PMID:
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| Men M, Chen DN, Li JD, Wang X, Zeng W, Jiang F, Zheng R, Dai W.
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| Mol Genet Genomic Med. Nov;9(11):e1816. doi: 10.1002/mgg3.1816. Epub 2021 Oct 11. 2021
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| 2 | NRCAM, NRP2, PLXNA3, SEMA3F
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| Semaphorin3F Drives Dendritic Spine Pruning Through Rho-GTPase Signaling.
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| Duncan BW, Mohan V, Wade SD, Truong Y, Kampov-Polevoi A, Temple BR, Maness PF.
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| Mol Neurobiol. Aug;58(8):3817-3834. doi: 10.1007/s12035-021-02373-2. Epub 2021 Apr 15. 2021
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| 3 | NRP1, NRP2, PLXNA1, SEMA3A
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| PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons
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| Oleari R, Caramello A, Campinoti S, Lettieri A, Ioannou E, Paganoni A, Fantin A, Cariboni A, Ruhrberg C.
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| Development. Nov 5;146(21):dev176461. doi: 10.1242/dev.176461. 2019
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| 4 | NRP2
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| Deletion of neuropilin 2 enhances detrusor contractility following bladder outlet obstruction.
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| Vasquez E, Cristofaro V, Lukianov S, Burkhard FC, Gheinani AH, Monastyrskaya K, Bielenberg DR, Sullivan MP, Adam RM.
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| JCI Insight 2(3):e90617. doi: 10.1172/jci.insight.90617.
2017
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| 5 | NRP2
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| The neuropilin 2 isoform NRP2b uniquely supports TGFβ-mediated progression in lung cancer.
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| Gemmill RM, Nasarre P, Nair-Menon J, Cappuzzo F, Landi L, D'Incecco A, Uramoto H, Yoshida T, Haura EB, Armeson K, Drabkin HA.
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| Sci Signal 10(462). pii: eaag0528. doi: 10.1126/scisignal.aag0528.
2017
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| 6 | BPTF, NRP2, WDFY1
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| NRP2 transcriptionally regulates its downstream effector WDFY1.
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| Dutta S, Roy S, Polavaram NS, Baretton GB, Muders MH, Batra S, Datta K.
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| Sci Rep 6:23588. doi: 10.1038/srep23588.
2016
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| 7 | NRP2, WDFY1
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| Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology.
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| Dutta S, Roy S, Polavaram NS, Stanton MJ, Zhang H, Bhola T, Hönscheid P, Donohue TM Jr, Band H, Batra SK, Muders MH, Datta K.
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| Cancer Res 76(2):418-28. doi: 10.1158/0008-5472.CAN-15-1488. Epub 2015 Nov 11.
2016
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| 8 | NRP2, PLXND1, SEMA3G
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| Semaphorin 3G Provides a Repulsive Guidance Cue to Lymphatic Endothelial Cells via Neuropilin-2/PlexinD1.
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| Liu X, Uemura A, Fukushima Y, Yoshida Y, Hirashima M.
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| Cell Rep 17(9):2299-2311. doi: 10.1016/j.celrep.2016.11.008.
2016
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| 9 | NRP2
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| Neuropilin 2 Signaling Is Involved in Cell Positioning of Adult-born Neurons through Glycogen Synthase Kinase-3β (GSK3β).
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| Ng T, Hor CH, Chew B, Zhao J, Zhong Z, Ryu JR, Goh EL.
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| J Biol Chem 291(48):25088-25095. Epub 2016 Sep 29.
2016
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| 10 | NRP1, NRP2, SEMA3A, SEMA3C, SEMA3F
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| Class 3 semaphorins induce F-actin reorganization in human dendritic cells: Role in cell migration.
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| Curreli S, Wong BS, Latinovic O, Konstantopoulos K, Stamatos NM.
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| J Leukoc Biol 100(6):1323-1334. Epub 2016 Jul 12.
2016
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| 11 | NRP2
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| The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain.
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| Kanatani S, Honda T, Aramaki M, Hayashi K, Kubo K, Ishida M, Tanaka DH, Kawauchi T, Sekine K, Kusuzawa S, Kawasaki T, Hirata T, Tabata H, Uhlén P, Nakajima K.
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| Proc Natl Acad Sci U S A 112(36):E4985-94. doi: 10.1073/pnas.1420701112. Epub 2015 Aug 24.
2015
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| 12 | NRP2, SEMA3F
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| Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo.
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| Nakayama H, Bruneau S, Kochupurakkal N, Coma S, Briscoe DM, Klagsbrun M.
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| Sci Rep 5:11789. doi: 10.1038/srep11789.
2015
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| 13 | NRP2, PAX8
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| Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells.
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| Lucci V, Di Palma T, Zannini M.
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| PLoS One 10(6):e0128315. doi: 10.1371/journal.pone.0128315. eCollection 2015.
2015
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| 14 | NRP1, NRP2
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| Neuropilins define distinct populations of neural crest cells.
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| Lumb R, Wiszniak S, Kabbara S, Scherer M, Harvey N, Schwarz Q.
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| Neural Dev 9:24. doi: 10.1186/1749-8104-9-24.
2014
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| 15 | NRP2, SEMA3F
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| Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors.
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| Mendes-da-Cruz DA, Brignier AC, Asnafi V, Baleydier F, Messias CV, Lepelletier Y, Bedjaoui N, Renand A, Smaniotto S, Canioni D, Milpied P, Balabanian K, Bousso P, Leprêtre S, Bertrand Y, Dombret H, Ifrah N, Dardenne M, Macintyre E, Savino W, Hermine O.
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| PLoS One 9(7):e103405. doi: 10.1371/journal.pone.0103405. eCollection 2014.
2014
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| 16 | NRP2, PXN
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| Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression.
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| German AE, Mammoto T, Jiang E, Ingber DE, Mammoto A.
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| J Cell Sci 127(Pt 8):1672-83. doi: 10.1242/jcs.132316. Epub 2014 Feb 12.
2014
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| 17 | FLT4, NRP2
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| Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations.
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| Partanen TA, Vuola P, Jauhiainen S, Lohi J, Salminen P, Pitkäranta A, Häkkinen SK, Honkonen K, Alitalo K, Ylä-Herttuala S.
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| Angiogenesis 16(1):137-46. doi: 10.1007/s10456-012-9305-x. Epub 2012 Sep 9.
2013
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| 18 | GATA2, LMO2, NRP2
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| GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2.
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| Coma S, Allard-Ratick M, Akino T, van Meeteren LA, Mammoto A, Klagsbrun M.
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| Angiogenesis 16(4):939-52. doi: 10.1007/s10456-013-9370-9.
2013
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| 19 | NRP2
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| Nrp2 deficiency leads to trabecular bone loss and is accompanied by enhanced osteoclast and reduced osteoblast numbers.
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| Verlinden L, Kriebitzsch C, Beullens I, Tan BK, Carmeliet G, Verstuyf A.
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| Bone 55(2):465-75. doi: 10.1016/j.bone.2013.03.023. Epub 2013 Apr 15.
2013
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| 20 | NRP2
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| Role of neuropilin-2 in the ipsilateral growth of midbrain dopaminergic axons.
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| Torigoe M, Yamauchi K, Tamada A, Matsuda I, Aiba A, Castellani V, Murakami F.
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| Eur J Neurosci 37(10):1573-83. doi: 10.1111/ejn.12190. Epub 2013 Mar 27.
2013
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| 21 | NRP1, NRP2
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| NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system.
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| Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A, Ruhrberg C.
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| Dev Biol 369(2):277-85. doi: 10.1016/j.ydbio.2012.06.026. Epub 2012 Jul 10.
2012
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| 22 | NRP2
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| Increased smooth muscle contractility in mice deficient for neuropilin 2.
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| Bielenberg DR, Seth A, Shimizu A, Pelton K, Cristofaro V, Ramachandran A, Zwaans BM, Chen C, Krishnan R, Seth M, Huang L, Takashima S, Klagsbrun M, Sullivan MP, Adam RM.
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| Am J Pathol 181(2):548-59. doi: 10.1016/j.ajpath.2012.04.013. Epub 2012 Jun 9.
2012
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| 23 | NRP2
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| Neuropilin-2: a novel biomarker for malignant melanoma?
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| Rushing EC, Stine MJ, Hahn SJ, Shea S, Eller MS, Naif A, Khanna S, Westra WH, Jungbluth AA, Busam KJ, Mahalingam M, Alani RM.
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| Hum Pathol 43(3):381-9. doi: 10.1016/j.humpath.2011.05.008. Epub 2011 Aug 15.
2012
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| 24 | NRP1, NRP2, SEMA3C
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| Motoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb-derived chemotropic semaphorins.
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| Sanyas I, Bozon M, Moret F, Castellani V.
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| Development 139(19):3633-43. doi: 10.1242/dev.080051. Epub 2012 Aug 16.
2012
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| 25 | NRP2
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| Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland.
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| Goel HL, Bae D, Pursell B, Gouvin LM, Lu S, Mercurio AM.
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| Development 138(14):2969-76. doi: 10.1242/dev.051318.
2011
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| 26 | FLT4, NRP2, VEGFC
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| Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.
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| Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivée B, Del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A.
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| J Cell Biol 188(1):115-30. doi: 10.1083/jcb.200903137.
2010
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| 27 | NRP1, NRP2
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| Neuropilin-1 and neuropilin-2 are differentially expressed in human proteinuric nephropathies and cytokine-stimulated proximal tubular cells.
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| Schramek H, Sarközi R, Lauterberg C, Kronbichler A, Pirklbauer M, Albrecht R, Noppert SJ, Perco P, Rudnicki M, Strutz FM, Mayer G.
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| Lab Invest 89(11):1304-16. Epub 2009 Sep 7.PMID: 19736548 2009
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| 28 | NRP1, NRP2
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| Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.
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| Bae D, Lu S, Taglienti CA, Mercurio AM.
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| J Biol Chem 283(42):28074-80. Epub 2008 Aug 14. 2008
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| 29 | FEOA,IDH1,NRP2
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| Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis.
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| Min JL, Meulenbelt I, Kloppenburg M, van Duijn CM, Slagboom PE.
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| Eur J Hum Genet 15(7):791-9. Epub 2007 Apr 4. 2007
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| 30 | FIGF, FLT1, FLT4, KDR, NRP1, NRP2, PGF, VEGFA, VEGFB, VEGFC
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| Biology of vascular endothelial growth factors.
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| Roy H, Bhardwaj S, YlŠ-Herttuala S.
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| FEBS Lett 580(12):2879-87. Epub 2006 Apr 17. 2006
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| 31 | NRP1, NRP2
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| Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis.
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| Takashima S, Kitakaze M, Asakura M, Asanuma H, Sanada S, Tashiro F, Niwa H, Miyazaki Ji J, Hirota S, Kitamura Y, Kitsukawa T, Fujisawa H, Klagsbrun M, Hori M.
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| Proc Natl Acad Sci U S A 99(6):3657-62. 2002
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| 32 | NRP1, NRP2
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| Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions.
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| Marin O, Yaron A, Bagri A, Tessier-Lavigne M, Rubenstein JL.
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| Science 293(5531):872-5. 2001
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| 33 | NRP2
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| Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins.
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| Giger RJ, Cloutier JF, Sahay A, Prinjha RK, Levengood DV, Moore SE, Pickering S, Simmons D, Rastan S, Walsh FS, Kolodkin AL, Ginty DD, Geppert M.
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| Neuron 25(1):29-41. 2000
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| 34 | NRP1, NRP2
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| Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms.
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| Rossignol M, Gagnon ML, Klagsbrun M.
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| Genomics 70(2):211-22. 2000
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| 35 | ABI2, ALS2, CFLAR, NRP2
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| A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34.
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| Hadano S, et al.
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| Genomics 55 : 106-112. 1999
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| 36 | NRP1, NRP2
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| Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively.
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| Rossignol M, et al.
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| Genomics 57(3):459-60. No abstract available 1999
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| 37 | NRP1,NRP2
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| Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.
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| Soker S, et al.
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| Cell 92(6):735-45. 1998
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| 38 | NRP1, NRP2
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| Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity.
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| Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL.
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| Neuron 21(5):1079-92.PMID: 9856463 1998
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| 39 | NRP1, NRP2
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| Neuropilin is a receptor for the axonal chemorepellent Semaphorin III.
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| He Z, Tessier-Lavigne M.
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| Cell 90(4):739-51. 1997
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| 40 | NRP2, SEMA3A
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| Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III.
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| Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M.
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| Neuron. 19(3):547-59. 1997
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| 41 | MAML1, NRP1, NRP2, PTPRU, PTPRT
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| Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain.
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| Zondag GC, Koningstein GM, Jiang YP, Sap J, Moolenaar WH, Gebbink MF.
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| J Biol Chem 270(24):14247-50. 1995
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| 42 | NRP1, NRP2
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| The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors.
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| Takagi S, Hirata T, Agata K, Mochii M, Eguchi G, Fujisawa H.
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| Neuron 7(2):295-307. 1991
|