| 1 | NRP1, NRP2, PLXNA1
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| Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism. 2021 PMID:
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| Men M, Chen DN, Li JD, Wang X, Zeng W, Jiang F, Zheng R, Dai W.
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| Mol Genet Genomic Med. Nov;9(11):e1816. doi: 10.1002/mgg3.1816. Epub 2021 Oct 11. 2021
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| 2 | NRP1, NRP2, PLXNA1, SEMA3A
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| PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons
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| Oleari R, Caramello A, Campinoti S, Lettieri A, Ioannou E, Paganoni A, Fantin A, Cariboni A, Ruhrberg C.
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| Development. Nov 5;146(21):dev176461. doi: 10.1242/dev.176461. 2019
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| 3 | EFNB1, NRP1
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| Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons.
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| Mire E, Hocine M, Bazellières E, Jungas T, Davy A, Chauvet S, Mann F.
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| Curr Biol 28(11):1768-1782.e4. doi: 10.1016/j.cub.2018.04.026. Epub 2018 May 17.
2018
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| 4 | NRP1, NRP2, SEMA3A, SEMA3C, SEMA3F
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| Class 3 semaphorins induce F-actin reorganization in human dendritic cells: Role in cell migration.
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| Curreli S, Wong BS, Latinovic O, Konstantopoulos K, Stamatos NM.
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| J Leukoc Biol 100(6):1323-1334. Epub 2016 Jul 12.
2016
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| 5 | NRP1, PTN
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| Pleiotrophin exerts its migration and invasion effect through the neuropilin-1 pathway.
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| Elahouel R, Blanc C, Carpentier G, Frechault S, Cascone I, Destouches D, Delbé J, Courty J, Hamma-Kourbali Y.
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| Neoplasia 17(8):613-24. doi: 10.1016/j.neo.2015.07.007.
2015
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| 6 | GIPC1, NRP1, PLEKHG5, VEGFA
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| VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells.
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| Yoshida A, Shimizu A, Asano H, Kadonosono T, Kondoh SK, Geretti E, Mammoto A, Klagsbrun M, Seo MK.
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| Biol Open. Jul 24;4(9):1063-76. doi: 10.1242/bio.010918 2015
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| 7 | FLT1, LGALS1, NRP1
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| Galectin-1 induces vascular permeability through the neuropilin-1/vascular endothelial growth factor receptor-1 complex.
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| Wu MH, Ying NW, Hong TM, Chiang WF, Lin YT, Chen YL.
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| Angiogenesis 17(4):839-49. doi: 10.1007/s10456-014-9431-8. Epub 2014 Apr 10.
2014
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| 8 | NRP1, NRP2
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| Neuropilins define distinct populations of neural crest cells.
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| Lumb R, Wiszniak S, Kabbara S, Scherer M, Harvey N, Schwarz Q.
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| Neural Dev 9:24. doi: 10.1186/1749-8104-9-24.
2014
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| 9 | NRP1, SEMA4A
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| Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis.
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| Delgoffe GM, Woo SR, Turnis ME, Gravano DM, Guy C, Overacre AE, Bettini ML, Vogel P, Finkelstein D, Bonnevier J, Workman CJ, Vignali DA.
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| Nature 501(7466):252-6. doi: 10.1038/nature12428. Epub 2013 Aug 4.
2013
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| 10 | NRP1, PLXNA1
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| Neuropilin-1 biases dendrite polarization in the retina
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| Kita EM, Bertolesi GE, Hehr CL, Johnston J, McFarlane S.
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| Development. Jul;140(14):2933-41. doi: 10.1242/dev.088286. Epub 2013 Jun 5. 2013
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| 11 | NRP1, PLXNA1, SEMA3A, VAMP2
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| The vesicular SNARE Synaptobrevin is required for Semaphorin 3A axonal repulsion.
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| Zylbersztejn K, Petkovic M, Burgo A, Deck M, Garel S, Marcos S, Bloch-Gallego E, Nothias F, Serini G, Bagnard D, Binz T, Galli T.
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| J Cell Biol 196(1):37-46. doi: 10.1083/jcb.201106113. Epub 2012 Jan 2.
2012
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| 12 | NRP1, SEMA3A
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| Osteoprotection by semaphorin 3A.
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| Hayashi M, Nakashima T, Taniguchi M, Kodama T, Kumanogoh A, Takayanagi H.
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| Nature 485(7396):69-74. doi: 10.1038/nature11000.
2012
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| 13 | NRP1, NRP2
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| NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system.
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| Maden CH, Gomes J, Schwarz Q, Davidson K, Tinker A, Ruhrberg C.
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| Dev Biol 369(2):277-85. doi: 10.1016/j.ydbio.2012.06.026. Epub 2012 Jul 10.
2012
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| 14 | NRP1, NRP2, SEMA3C
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| Motoneuronal Sema3C is essential for setting stereotyped motor tract positioning in limb-derived chemotropic semaphorins.
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| Sanyas I, Bozon M, Moret F, Castellani V.
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| Development 139(19):3633-43. doi: 10.1242/dev.080051. Epub 2012 Aug 16.
2012
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| 15 | NRP1, PHACTR1
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| Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells.
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| Allain B, Jarray R, Borriello L, Leforban B, Dufour S, Liu WQ, Pamonsinlapatham P, Bianco S, Larghero J, Hadj-Slimane R, Garbay C, Raynaud F, Lepelletier Y.
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| Cell Signal 24(1):214-23. doi: 10.1016/j.cellsig.2011.09.003. Epub 2011 Sep 10.
2012
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| 16 | NRP1, SEMA3A, TAOK2
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| Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.
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| de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH.
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| Nat Neurosci 15(7):1022-31. doi: 10.1038/nn.3141.
2012
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| 17 | BCAR1, NRP1
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| Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells.
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| Evans IM, Yamaji M, Britton G, Pellet-Many C, Lockie C, Zachary IC, Frankel P.
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| Mol Cell Biol 31(6):1174-85. Epub 2011 Jan 18.
2011
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| 18 | BCAR1, NRP1
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| Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas.
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| Pellet-Many C, Frankel P, Evans IM, Herzog B, Jünemann-Ramírez M, Zachary IC.
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| Biochem J 435(3):609-18.
2011
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| 19 | NRP1
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| Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output.
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| Ballmer-Hofer K, Andersson AE, Ratcliffe LE, Berger P.
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| Blood 118(3):816-26. Epub 2011 May 17.
2011
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| 20 | NRP1, VEGFA
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| VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation.
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| Herzog B, Pellet-Many C, Britton G, Hartzoulakis B, Zachary IC.
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| Mol Biol Cell. 22(15):2766-76. 2011
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| 21 | NRP1
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| VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels.
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| Cariboni A, Davidson K, Dozio E, Memi F, Schwarz Q, Stossi F, Parnavelas JG, Ruhrberg C.
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| Development. 138(17):3723-33. 2011
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| 22 | NRP1
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| A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours.
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| Beck B, Driessens G, Goossens S, Youssef KK, Kuchnio A, Caauwe A, Sotiropoulou PA, Loges S, Lapouge G, Candi A, Mascre G, Drogat B, Dekoninck S, Haigh JJ, Carmeliet P, Blanpain C.
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| Nature 478(7369):399-403. doi: 10.1038/nature10525.
2011
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| 23 | FER, NRP1
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| Neuropilin 1 directly interacts with Fer kinase to mediate semaphorin 3A-induced death of cortical neurons.
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| Jiang SX, Whitehead S, Aylsworth A, Slinn J, Zurakowski B, Chan K, Li J, Hou ST.
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| J Biol Chem 285(13):9908-18. Epub 2010 Feb 4.PMID: 20133938 2010
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| 24 | NRP1, PDGFRA, PDGFRB
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| Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells.
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| Ball SG, Bayley C, Shuttleworth CA, Kielty CM.
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| Biochem J 427(1):29-40. 2010
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| 25 | NRP1
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| Extracellular protein kinase CK2 is a novel associating protein of neuropilin-1.
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| Shintani Y, Takashima S, Kato H, Komamura K, Kitakaze M.
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| Biochem Biophys Res Commun 385(4):618-23. Epub 2009 May 30.
2009
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| 26 | NRP1, NRP2
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| Neuropilin-1 and neuropilin-2 are differentially expressed in human proteinuric nephropathies and cytokine-stimulated proximal tubular cells.
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| Schramek H, Sarközi R, Lauterberg C, Kronbichler A, Pirklbauer M, Albrecht R, Noppert SJ, Perco P, Rudnicki M, Strutz FM, Mayer G.
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| Lab Invest 89(11):1304-16. Epub 2009 Sep 7.PMID: 19736548 2009
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| 27 | NRP1, NRP2
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| Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.
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| Bae D, Lu S, Taglienti CA, Mercurio AM.
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| J Biol Chem 283(42):28074-80. Epub 2008 Aug 14. 2008
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| 28 | LGALS1, NRP1
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| Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells.
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| Hsieh SH, Ying NW, Wu MH, Chiang WF, Hsu CL, Wong TY, Jin YT, Hong TM, Chen YL.
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| Oncogene 27(26):3746-53. Epub 2008 Jan 28.PMID: 18223683 2008
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| 29 | NRP1, SEMA3A
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| Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions.
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| Lepelletier Y, Smaniotto S, Hadj-Slimane R, Villa-Verde DM, Nogueira AC, Dardenne M, Hermine O, Savino W.
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| Proc Natl Acad Sci U S A 104(13):5545-50. Epub 2007 Mar 16. 2007
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| 30 | E2F1, NRP1
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| Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo.
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| Jiang SX, Sheldrick M, Desbois A, Slinn J, Hou ST.
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| Mol Cell Biol 27(5):1696-705. Epub 2006 Dec 18. 2007
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| 31 | CHL1, NRP1
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| Close homolog of L1 and neuropilin 1 mediate guidance of thalamocortical axons at the ventral telencephalon.
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| Wright AG, Demyanenko GP, Powell A, Schachner M, Enriquez-Barreto L, Tran TS, Polleux F, Maness PF.
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| J Neurosci 27(50):13667-79.PMID: 18077678 2007
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| 32 | NRP1
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| Vieira JM, Schwarz Q, Ruhrberg C.
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| Selective requirements for NRP1 ligands during neurovascular patterning.
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| Development. 134(10):1833-43. 2007
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| 33 | FIGF, FLT1, FLT4, KDR, NRP1, NRP2, PGF, VEGFA, VEGFB, VEGFC
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| Biology of vascular endothelial growth factors.
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| Roy H, Bhardwaj S, YlŠ-Herttuala S.
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| FEBS Lett 580(12):2879-87. Epub 2006 Apr 17. 2006
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| 34 | NRP1
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| Identification of two novel alternatively spliced Neuropilin-1 isoforms.
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| Cackowski FC, Xu L, Hu B, Cheng SY.
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| Genomics 84(1):82-94. 2004
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| 35 | NRP1
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| Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system.
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| Gerhardt H, Ruhrberg C, Abramsson A, Fujisawa H, Shima D, Betsholtz C.
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| Dev Dyn. 231(3):503-9. 2004
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| 36 | NRP1, NRP2
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| Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis.
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| Takashima S, Kitakaze M, Asakura M, Asanuma H, Sanada S, Tashiro F, Niwa H, Miyazaki Ji J, Hirota S, Kitamura Y, Kitsukawa T, Fujisawa H, Klagsbrun M, Hori M.
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| Proc Natl Acad Sci U S A 99(6):3657-62. 2002
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| 37 | NRP1
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| A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response.
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| Tordjman R, Lepelletier Y, Lemarchandel V, Cambot M, Gaulard P, Hermine O, Romeo PH.
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| Nat Immunol 3(5):477-82. 2002
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| 38 | NRP1
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| Neuropilin-1 is differentially expressed in myoepithelial cells and vascular smooth muscle cells in preneoplastic and neoplastic human breast: a possible marker for the progression of breast cancer.
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| Stephenson JM, Banerjee S, Saxena NK, Cherian R, Banerjee SK.
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| Int J Cancer 101(5):409-14. 2002
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| 39 | NRP1, VEGFA
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| Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain.
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| Mamluk R, Gechtman Z, Kutcher ME, Gasiunas N, Gallagher J, Klagsbrun M.
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| J Biol Chem. 277(27):24818-25 2002
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| 40 | NRP1
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| Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish.
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| Lee P, Goishi K, Davidson AJ, Mannix R, Zon L, Klagsbrun M.
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| Proc Natl Acad Sci U S A. 99(16):10470-5. 2002
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| 41 | NRP1
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| Neurophilin-1 is a downstream target of transcription factor Ets-1 in human umbilical vein endothelial cells.
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| Teruyama K, Abe M, Nakano T, Takahashi S, Yamada S, Sato Y.
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| FEBS Lett 504(1-2):1-4. 2001
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| 42 | NRP1, NRP2
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| Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions.
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| Marin O, Yaron A, Bagri A, Tessier-Lavigne M, Rubenstein JL.
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| Science 293(5531):872-5. 2001
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| 43 | NRP1, VEGFA
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| VEGF overexpression in clinically localized prostate tumors and neuropilin-1 overexpression in metastatic forms.
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| Latil A, Bieche I, Pesche S, Valeri A, Fournier G, Cussenot O, Lidereau R.
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| Int J Cancer 89(2):167-71. 2000
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| 44 | NRP1
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| Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity.
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| Gagnon ML, Bielenberg DR, Gechtman Z, Miao HQ, Takashima S, Soker S, Klagsbrun M.
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| Proc Natl Acad Sci U S A 97(6):2573-8. 2000
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| 45 | NRP1, NRP2
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| Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms.
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| Rossignol M, Gagnon ML, Klagsbrun M.
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| Genomics 70(2):211-22. 2000
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| 46 | NRP1
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| Expression and regulation of neuropilin-1 in human astrocytomas.
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| Ding H, Wu X, Roncari L, Lau N, Shannon P, Nagy A, Guha A.
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| Int J Cancer 88(4):584-92. 2000
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| 47 | NRP1, NRP2
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| Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively.
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| Rossignol M, et al.
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| Genomics 57(3):459-60. No abstract available 1999
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| 48 | APOE, NRP1, SEMA3A
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| Association of the APOE epsilon4 allele with disease activity in multiple sclerosis.
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| Evangelou N, et al.
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| J Neurol Neurosurg Psychiatry 67(2):203-5 1999
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| 49 | NRP1, PLXNA1, SEMA3A
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| Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.
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| Takahashi T, et al.
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| Cell 99(1):59-69 1999
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| 50 | NRP1, SEMA3A, SEMA3C, SEMA3F
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| A dominant negative receptor for specific secreted semaphorins is generated by deleting an extracellular domain from neuropilin-1.
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| Renzi MJ, Feiner L, Koppel AM, Raper JA.
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| J Neurosci 19(18):7870-80 1999
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| 51 | NRP1,NRP2
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| Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.
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| Soker S, et al.
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| Cell 92(6):735-45. 1998
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| 52 | NRP1, NRP2
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| Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity.
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| Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL.
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| Neuron 21(5):1079-92.PMID: 9856463 1998
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| 53 | NRP1
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| Neuropilin is a semaphorin III receptor.
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| Kolodkin AL, et al.
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| Cell 90(4):753-62. 1997
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| 54 | NRP1, NRP2
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| Neuropilin is a receptor for the axonal chemorepellent Semaphorin III.
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| He Z, Tessier-Lavigne M.
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| Cell 90(4):739-51. 1997
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| 55 | MAML1, NRP1, NRP2, PTPRU, PTPRT
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| Homophilic interactions mediated by receptor tyrosine phosphatases mu and kappa. A critical role for the novel extracellular MAM domain.
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| Zondag GC, Koningstein GM, Jiang YP, Sap J, Moolenaar WH, Gebbink MF.
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| J Biol Chem 270(24):14247-50. 1995
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| 56 | NRP1, NRP2
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| The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors.
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| Takagi S, Hirata T, Agata K, Mochii M, Eguchi G, Fujisawa H.
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| Neuron 7(2):295-307. 1991
|