Citations for
1NRL
Nrl-Cre transgenic mouse mediates loxP recombination in developing rod photoreceptors.
Brightman DS, Razafsky D, Potter C, Hodzic D, Chen S.
Genesis 54(3):129-35. doi: 10.1002/dvg.22918. Epub 2016 Feb 5. 2016
2NRL, OPTN
Interaction between optineurin and the bZIP transcription factor NRL.
Wang C, Hosono K, Ohtsubo M, Ohishi K, Gao J, Nakanishi N, Hikoya A, Sato M, Hotta Y, Minoshima S.
Cell Biol Int 38(1):16-25. doi: 10.1002/cbin.10174. Epub 2013 Sep 12. 2014
3NRL, REEP6
Regulation of a novel isoform of Receptor Expression Enhancing Protein REEP6 in rod photoreceptors by bZIP transcription factor NRL.
Hao H, Veleri S, Sun B, Kim DS, Keeley PW, Kim JW, Yang HJ, Yadav SP, Manjunath SH, Sood R, Liu P, Reese BE, Swaroop A.
Hum Mol Genet 23(16):4260-71. doi: 10.1093/hmg/ddu143. Epub 2014 Apr 1. 2014
4CRX, KCNV2, NRL, RCD5
RETINA-specific expression of Kcnv2 is controlled by cone-rod homeobox (Crx) and neural retina leucine zipper (Nrl).
Aslanidis A, Karlstetter M, Walczak Y, Jägle H, Langmann T.
Adv Exp Med Biol 801:31-41. doi: 10.1007/978-1-4614-3209-8_5. 2014
5NRL, OTX2
OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness.
Roger JE, Hiriyanna A, Gotoh N, Hao H, Cheng DF, Ratnapriya R, Kautzmann MA, Chang B, Swaroop A.
J Clin Invest 124(2):631-43. doi: 10.1172/JCI72722. Epub 2014 Jan 2. 2014
6NRL, RP27
Detection of novel genetic variation in autosomal dominant retinitis pigmentosa.
Borrąs E, de Sousa Dias M, Hernan I, Pascual B, Mańé B, Gamundi MJ, Delįs B, Carballo M.
Clin Genet 84(5):441-52. doi: 10.1111/cge.12151. Epub 2013 Apr 15. 2013
7NRL, RP27
Novel p.M96T variant of NRL and shRNA-based suppression and replacement of NRL mutants associated with autosomal dominant retinitis pigmentosa.
Hernan I, Gamundi MJ, Borrąs E, Maseras M, Garcķa-Sandoval B, Blanco-Kelly F, Ayuso C, Carballo M.
Clin Genet 82(5):446-52. doi: 10.1111/j.1399-0004.2011.01796.x. Epub 2011 Nov 2. 2012
8KAT5, NRL, RHO
Transcriptional activity of neural retina leucine zipper (Nrl) is regulated by c-Jun N-terminal kinase and Tip60 during retina development.
Kim JW, Jang SM, Kim CH, An JH, Choi KH.
Mol Cell Biol 32(9):1720-32. doi: 10.1128/MCB.06440-11. Epub 2012 Feb 21. 2012
9NRL, RORB
Combinatorial regulation of photoreceptor differentiation factor, neural retina leucine zipper gene NRL, revealed by in vivo promoter analysis.
Kautzmann MA, Kim DS, Felder-Schmittbuhl MP, Swaroop A.
J Biol Chem 286(32):28247-55. Epub 2011 Jun 14. 2011
10CRX, NRL, OTX2, RORB
Transcriptional regulation of neural retina leucine zipper (Nrl), a photoreceptor cell fate determinant.
Montana CL, Lawrence KA, Williams NL, Tran NM, Peng GH, Chen S, Corbo JC.
J Biol Chem 286(42):36921-31. doi: 10.1074/jbc.M111.279026. Epub 2011 Aug 24. 2011
11MEF2C, NRL
The transcription factor neural retina leucine zipper (NRL) controls photoreceptor-specific expression of myocyte enhancer factor Mef2c from an alternative promoter.
Hao H, Tummala P, Guzman E, Mali RS, Gregorski J, Swaroop A, Mitton KP.
J Biol Chem 286(40):34893-902. doi: 10.1074/jbc.M111.271072. Epub 2011 Aug 17. 2011
12NR2E3, NRL
Association of NR2E3 but not NRL mutations with retinitis pigmentosa in the Chinese population.
Yang Y, Zhang X, Chen LJ, Chiang SW, Tam PO, Lai TY, Chan CK, Wang N, Lam DS, Pang CP.
Invest Ophthalmol Vis Sci. 51(4):2229-35. 2010
13NRL, PPP2R5C
Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development.
Kim JW, Jang SM, Kim CH, An JH, Kang EJ, Choi KH.
FEBS J 277(24):5051-60. doi: 10.1111/j.1742-4658.2010.07910.x. Epub 2010 Nov 16. 2010
14NRL, RORB
Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development.
Jia L, Oh EC, Ng L, Srinivas M, Brooks M, Swaroop A, Forrest D.
Proc Natl Acad Sci U S A 106(41):17534-9. Epub 2009 Sep 24. 2009
15NR2E3, NRL
Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors.
Oh EC, Cheng H, Hao H, Jia L, Khan NW, Swaroop A.
Brain Res 1236:16-29. doi: 10.1016/j.brainres.2008.01.028. Epub 2008 Jan 18. 2008
16NRL
Retinopathy mutations in the bZIP protein NRL alter phosphorylation and transcriptional activity.
Kanda A, Friedman JS, Nishiguchi KM, Swaroop A.
Hum Mutat 28(6):589-98. 2007
17CRX, FIZ1, NRL, PDE6B
FIZ1 is expressed during photoreceptor maturation, and synergizes with NRL and CRX at rod-specific promoters in vitro.
Mali RS, Zhang X, Hoerauf W, Doyle D, Devitt J, Loffreda-Wren J, Mitton KP.
Exp Eye Res 84(2):349-60. Epub 2006 Dec 4. 2007
18NRL
Retinopathy mutations in the bZIP protein NRL alter phosphorylation and transcriptional activity.
Kanda A, Friedman JS, Nishiguchi KM, Swaroop A.
Hum Mutat 28(6):589-98. 2007
19NR2E3, NR1D1, CRX, NRL
Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors.
Cheng H, Khanna H, Oh EC, Hicks D, Mitton KP, Swaroop A.
Hum Mol Genet 13(15):1563-75. Epub 2004 Jun 09. 2004
20NRL, RP27
Recessive NRL mutations in patients with clumped pigmentary retinal degeneration and relative preservation of blue cone function.
Nishiguchi KM, Friedman JS, Sandberg MA, Swaroop A, Berson EL, Dryja TP.
Proc Natl Acad Sci U S A 101(51):17819-24. Epub 2004 Dec 09. 2004
21NRL,NR2E3
Mutation analysis of NR2E3 and NRL genes in Enhanced S Cone Syndrome.
Wright AF, Reddick AC, Schwartz SB, Ferguson JS, Aleman TS, Kellner U, Jurklies B, Schuster A, Zrenner E, Wissinger B, Lennon A, Shu X, Cideciyan AV, Stone EM, Jacobson SG, Swaroop A.
Hum Mutat 24(5):439. 2004
22NRL,TBP
The minimal transactivation domain of the basic motif-leucine zipper transcription factor NRL interacts with TATA-binding protein.
Friedman JS, Khanna H, Swain PK, Denicola R, Cheng H, Mitton KP, Weber CH, Hicks D, Swaroop A.
J Biol Chem 279(45):47233-41. Epub 2004 Aug 24. 2004
23CRX,NRL,PDE6A
Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity.
Pittler SJ, Zhang Y, Chen S, Mears AJ, Zack DJ, Ren Z, Swain PK, Yao S, Swaroop A, White JB.
J Biol Chem 279(19):19800-7. Epub 2004 Mar 4. 2004
24NRL
Mutation screening of patients with Leber Congenital Amaurosis or the enhanced S-Cone Syndrome reveals a lack of sequence variations in the NRL gene.
Acar C, Mears AJ, Yashar BM, Maheshwary AS, Andreasson S, Baldi A, Sieving PA, Iannaccone A, Musarella MA, Jacobson SG, Swaroop A.
Mol Vis 9:14-7. 2003
25NRL
Phenotype of retinitis pigmentosa associated with the Ser50Thr mutation in the NRL gene.
Bessant DA, Holder GE, Fitzke FW, Payne AM, Bhattacharya SS, Bird AC.
Arch Ophthalmol 121(6):793-802. 2003
26NRL
Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor.
Mitton KP, Swain PK, Khanna H, Dowd M, Apel IJ, Swaroop A.
Hum Mol Genet. 12(4):365-73. 2003
27NRL
Nrl is required for rod photoreceptor development.
Mears AJ, Kondo M, Swain PK, Takada Y, Bush RA, Saunders TL, Sieving PA, Swaroop A.
Nat Genet 29(4):447-52. 2001
28NRL, RP27
NRL S50T mutation and the importance of 'founder effects' in inherited retinal dystrophies.
Bessant DA, Payne AM, Plant C, Bird AC, Swaroop A, Bhattacharya SS.
Eur J Hum Genet 8(10):783-7. 2000
29NRL
The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation.
Mitton KP, Swain PK, Chen S, Xu S, Zack DJ, Swaroop A.
J Biol Chem. 275(38):29794-9. 2000
30NRL, RP27
A mutation in NRL is associated with autosomal dominant retinitis pigmentosa.
Bessant DA, et al.
Nat Genet 21(4):355-6. No abstract available 1999
31NRL
Human bZIP transcription factor gene NRL: structure, genomic sequence, and fine linkage mapping at 14q11.2 and negative mutation analysis in patients with retinal degeneration.
Farjo Q, Jackson A, Pieke-Dahl S, Scott K, Kimberling WJ, Sieving PA, Richards JE, Swaroop A.
Genomics 45(2):395-401. 1997
32NRL
The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures.
Kumar R, Chen S, Scheurer D, Wang QL, Duh E, Sung CH, Rehemtulla A, Swaroop A, Adler R, Zack DJ.
J Biol Chem. 271(47):29612-8. 1996
33NRL
Molecular characterization of the murine neural retina leucine zipper gene, Nrl.
Farjo Q, et al.
Genomics 18 : 216-222. 1993
34NRL
Neural retina-specific leucine zipper gene NRL (D14S46E) maps to human chromosome 14q11.1-q11.2.
Yang-Feng TL, et al.
Genomics 14 : 491-492. 1992
35NRL
Genetic mapping of NRL, a human retina-specific gene located on chromosome 14.
Pieke Dahl S, et al.
Am J Hum Genet 51 : A185. 1992
36NRL
A conserved retina-specific gene encodes a basic motif/leucine zipper domain.
Swaroop A, et al.
Proc Natl Acad Sci U S A 89 : 266-270. 1992
37NRL
Molecular structure, chromosomal localization, and conservation of NRS1, a novel human neural retina specific gene of jun/fos oncogene family.
Jackson A, et al.
Am J Hum Genet 49S : 408. 1991
38MAFG, MAFK, NRL
v-maf, a viral oncogene that encodes a leucine zipper motif.
Nishizawa M, et al.
Proc Natl Acad Sci U S A 86 : 7711-7715. 1989