| 1 | GRM1, NRG1
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| Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.
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| Ledonne A, Nobili A, Latagliata EC, Cavallucci V, Guatteo E, Puglisi-Allegra S, D'Amelio M, Mercuri NB.
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| Mol Psychiatry 20(8):959-73. doi: 10.1038/mp.2014.109. Epub 2014 Sep 30.
2015
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| 2 | NRG1, NRG3
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| Transient overexposure of neuregulin 3 during early postnatal development impacts selective behaviors in adulthood.
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| Paterson C, Law AJ.
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| PLoS One 9(8):e104172. doi: 10.1371/journal.pone.0104172. eCollection 2014.
2014
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| 3 | EGR3, NRG1
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| Neuregulin1 signaling targets SRF and CREB and activates the muscle spindle-specific gene Egr3 through a composite SRF-CREB-binding site.
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| Herndon CA, Ankenbruck N, Lester B, Bailey J, Fromm L.
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| Exp Cell Res 319(5):718-30. doi: 10.1016/j.yexcr.2013.01.001. Epub 2013 Jan 11.
2013
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| 4 | BDNF, ERBB2, NRG1
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| RET and NRG1 interplay in Hirschsprung disease.
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| Gui H, Tang WK, So MT, Proitsi P, Sham PC, Tam PK, Sau-Wai Ngan E, Cherny SS, Garcia-Barceló MM.
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| Hum Genet 132(5):591-600. doi: 10.1007/s00439-013-1272-9. Epub 2013 Feb 12.
2013
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| 5 | NRG1
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| Nrg1 functions as a global transcriptional repressor of glucose-repressed genes through its direct binding to the specific promoter regions.
|
| Lee SB, Kang HS, Kim T.
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| Biochem Biophys Res Commun 439(4):501-5. doi: 10.1016/j.bbrc.2013.09.015. Epub 2013 Sep 8.
2013
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| 6 | KALRN, NRG1
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| Neuregulin1 signaling promotes dendritic spine growth through kalirin.
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| Cahill ME, Remmers C, Jones KA, Xie Z, Sweet RA, Penzes P.
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| J Neurochem 126(5):625-35. doi: 10.1111/jnc.12330. Epub 2013 Jun 27.
2013
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| 7 | ERBB2, ERBIN, NRG1
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| Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy.
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| Pan P, Dobrowsky RT.
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| Acta Neuropathol Commun 1:39. doi: 10.1186/2051-5960-1-39.
2013
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| 8 | BACE1, NRG1
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| Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles.
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| Cheret C, Willem M, Fricker FR, Wende H, Wulf-Goldenberg A, Tahirovic S, Nave KA, Saftig P, Haass C, Garratt AN, Bennett DL, Birchmeier C.
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| EMBO J 32(14):2015-28. doi: 10.1038/emboj.2013.146. Epub 2013 Jun 21.
2013
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| 9 | ERBB4, NRG1
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| Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development.
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| Ortega MC, Bribián A, Peregrín S, Gil MT, Marín O, de Castro F.
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| Exp Neurol 235(2):610-20. Epub 2012 Apr 2.
2012
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| 10 | NRG1
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| Mutations in the NRG1 gene are associated with Hirschsprung disease.
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| Tang CS, Ngan ES, Tang WK, So MT, Cheng G, Miao XP, Leon TY, Leung BM, Hui KJ, Lui VH, Chen Y, Chan IH, Chung PH, Liu XL, Wong KK, Sham PC, Cherny SS, Tam PK, Garcia-Barcelo MM.
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| Hum Genet 131(1):67-76. doi: 10.1007/s00439-011-1035-4. Epub 2011 Jun 25.
2012
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| 11 | ERBB2, ERBIN, NRG1
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| Erbin is required for myelination in regenerated axons after injury.
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| Liang C, Tao Y, Shen C, Tan Z, Xiong WC, Mei L.
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| J Neurosci 32(43):15169-80. doi: 10.1523/JNEUROSCI.2466-12.2012.
2012
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| 12 | NOTCH1, NRG1
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| A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth.
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| Zhang K, Wong P, Zhang L, Jacobs B, Borden EC, Aster JC, Bedogni B.
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| Oncogene 31(43):4609-18. doi: 10.1038/onc.2011.606. Epub 2012 Jan 16.
2012
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| 13 | NRG1
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| Neuregulin1 as Novel Therapy for Heart Failure.
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| Yan X, Morgan JP.
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| Curr Pharm Des urr Pharm Des. 2011 Jun 1. [Epub ahead of print]
2011
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| 14 | NRG1
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| Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons.
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| Ting AK, Chen Y, Wen L, Yin DM, Shen C, Tao Y, Liu X, Xiong WC, Mei L.
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| J Neurosci. 31(1):15-25. 2011
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| 15 | ADAM10, BACE1, NRG1
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| Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination.
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| Luo X, Prior M, He W, Hu X, Tang X, Shen W, Yadav S, Kiryu-Seo S, Miller R, Trapp BD, Yan R.
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| J Biol Chem 286(27):23967-74. Epub 2011 May 16.
2011
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| 16 | DTNBP1, NRG1
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| Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia.
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| Yamamori H, Hashimoto R, Verrall L, Yasuda Y, Ohi K, Fukumoto M, Umeda-Yano S, Ito A, Takeda M.
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| J Hum Genet 56(7):478-83. doi: 10.1038/jhg.2011.40. Epub 2011 Apr 21.
2011
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| 17 | ERBB4, NRG1
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| The ERBB4 intracellular domain (4ICD) regulates NRG1-induced gene expression in hippocampal neurons.
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| Allison JG, Das PM, Ma J, Inglis FM, Jones FE.
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| Neurosci Res 70(2):155-63. Epub 2011 Feb 23.
2011
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| 18 | DTNA, ERBB2, ERBB4, NRG1
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| Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin.
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| Schmidt N, Akaaboune M, Gajendran N, Martinez-Pena y Valenzuela I, Wakefield S, Thurnheer R, Brenner HR.
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| J Cell Biol 195(7):1171-84. doi: 10.1083/jcb.201107083. Epub 2011 Dec 19.
2011
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| 19 | NRG1
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| Neuronal Neuregulin 1 type III directs Schwann cell migration.
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| Perlin JR, Lush ME, Stephens WZ, Piotrowski T, Talbot WS.
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| Development. 138(21):4639-48. 2011
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| 20 | NRG1, NRG3
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| Neuregulins are essential for spermatogonial proliferation and meiotic initiation in neonatal mouse testis.
|
| Zhang J, Eto K, Honmyou A, Nakao K, Kiyonari H, Abé S.
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| Development 138(15):3159-68. doi: 10.1242/dev.062380. Epub 2011 Jun 29.
2011
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| 21 | ERBB4, NRG1
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| Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling.
|
| Fazzari P, Paternain AV, Valiente M, Pla R, Luján R, Lloyd K, Lerma J, Marín O, Rico B.
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| Nature 464(7293):1376-80. Epub 2010 Apr 14.PMID: 20393464 2010
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| 22 | ERBB2, NRG1
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| Nrg1/ErbB signaling networks in Schwann cell development and myelination.
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| Newbern J, Birchmeier C.
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| Semin Cell Dev Biol emin Cell Dev Biol. 2010 Sep 9. [Epub ahead of print]PMID: 20832498 2010
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| 23 | NRG1, NRG3
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| Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain.
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| Kao WT, Wang Y, Kleinman JE, Lipska BK, Hyde TM, Weinberger DR, Law AJ.
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| Proc Natl Acad Sci U S A 107(35):15619-24. Epub 2010 Aug 16.PMID: 20713722 2010
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| 24 | MUC5AC, MUC5B, NRG1
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| Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium.
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| Kettle R, Simmons J, Schindler F, Jones P, Dicker T, Dubois G, Giddings J, Van Heeke G, Jones CE.
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| Am J Respir Cell Mol Biol 42(4):472-81. Epub 2009 Jun 25.
2010
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| 25 | NRG1
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| Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease.
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| Garcia-Barcelo MM, Tang CS, Ngan ES, Lui VC, Chen Y, So MT, Leon TY, Miao XP, Shum CK, Liu FQ, Yeung MY, Yuan ZW, Guo WH, Liu L, Sun XB, Huang LM, Tou JF, Song YQ, Chan D, Cheung KM, Wong KK, Cherny SS, Sham PC, Tam PK.
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| Proc Natl Acad Sci U S A 106(8):2694-9. Epub 2009 Feb 5.
2009
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| 26 | NRG1
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| Differential distribution of neuregulin in human brain and spinal fluid.
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| Pankonin MS, Sohi J, Kamholz J, Loeb JA.
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| Brain Res 1258:1-11. Epub 2008 Dec 29.
2009
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| 27 | NRG1
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| Neuregulin-1 signaling in brain endothelial cells.
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| Lok J, Sardi SP, Guo S, Besancon E, Ha DM, Rosell A, Kim WJ, Corfas G, Lo EH.
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| J Cereb Blood Flow Metab 29(1):39-43. Epub 2008 Aug 27.
2009
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| 28 | GJB1, NRG1
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| Connexin 32 increases the proliferative response of Schwann cells to neuregulin-1 (Nrg1).
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| Freidin M, Asche S, Bargiello TA, Bennett MV, Abrams CK.
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| Proc Natl Acad Sci U S A 106(9):3567-72. Epub 2009 Feb 13.
2009
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| 29 | ERBIN, NRG1
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| Erbin regulates NRG1 signaling and myelination.
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| Tao Y, Dai P, Liu Y, Marchetto S, Xiong WC, Borg JP, Mei L.
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| Proc Natl Acad Sci U S A 106(23):9477-82. Epub 2009 May 20. 2009
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| 30 | NRG1
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| The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.
|
| Chua YL, Ito Y, Pole JC, Newman S, Chin SF, Stein RC, Ellis IO, Caldas C, O'Hare MJ, Murrell A, Edwards PA.
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| Oncogene 28(46):4041-52. Epub 2009 Oct 5.PMID: 19802002 2009
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| 31 | NRG1
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| Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain.
|
| Wood JD, Bonath F, Kumar S, Ross CA, Cunliffe VT.
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| Hum Mol Genet. 18(3):391-404 2009
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| 32 | ERBB4, NRG1
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| Association and interaction analyses of NRG1 and ERBB4 genes with schizophrenia in a Japanese population.
|
| Shiota S, Tochigi M, Shimada H, Ohashi J, Kasai K, Kato N, Tokunaga K, Sasaki T.
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| J Hum Genet 53(10):929-35. Epub 2008 Aug 14.
2008
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| 33 | GDNF, NRG1
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| Identification of neuregulin as a factor required for formation of aligned spermatogonia.
|
| Hamra FK, Chapman KM, Nguyen D, Garbers DL.
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| J Biol Chem 282(1):721-30. Epub 2006 Nov 10. 2007
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| 34 | NRG1
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| Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.
|
| Tan W, Wang Y, Gold B, Chen J, Dean M, Harrison PJ, Weinberger DR, Law AJ.
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| J Biol Chem 282(33):24343-51. Epub 2007 Jun 12. 2007
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| 35 | NRG1
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| Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease.
|
| Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE, Weinberger DR.
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| Proc Natl Acad Sci U S A 103(17):6747-52. Epub 2006 Apr 17. 2006
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| 36 | DAOA, PRODH, DTNBP1, NRG1, DISC1, NOS1Ap, ZDHHC8, CLINT1, TAAR6, COMT, GABRA1, GABRP, HPI
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| Schizophrenia genetics: uncovering positional candidate genes.
|
| Karayiorgou M, Gogos JA.
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| Eur J Hum Genet 14(5):512-9. 2006
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| 37 | DTNBP1, NRG1, TAAR6, DTNBP1, COMT, RGS4, PPP3CC, ZDHHC8, AKT1, DAOA, G30
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| Molecular genetic studies of schizophrenia.
|
| Riley B, Kendler KS.
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| Eur J Hum Genet 14(6):669-80. 2006
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| 38 | NRG1
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| Neuregulin 1 growth factors regulate proliferation but not apoptosis of a CNS neuronal progenitor cell line.
|
| Edwards JM, Bottenstein JE.
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| Brain Res 1108(1):63-75. Epub 2006 Jul 21. 2006
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| 39 | COMT, DAO, DAOA, DISC1, DTNBP1, HPI, MAFD13, MAFD17, NRG1, P2RX7, PPP3CC, PRODH, RGS4, SCZD23, TAAR6, ZDHHC8
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| The genetics of schizophrenia and bipolar disorder: dissecting psychosis.
|
| Craddock N, O'donovan MC, Owen MJ.
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| J Med Genet 42(3):193-204. 2005
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| 40 | NRG1
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| Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses.
|
| Go RC, Perry RT, Wiener H, Bassett SS, Blacker D, Devlin B, Sweet RA.
|
| Am J Med Genet B Neuropsychiatr Genet 139(1):28-32. 2005
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| 41 | NRG1
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| Heregulin induces glial cell line-derived neurotrophic growth factor-independent, non-branching growth and differentiation of ureteric bud epithelia.
|
| Sakurai H, Bush KT, Nigam SK.
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| J Biol Chem 280(51):42181-7. Epub 2005 Sep 23. 2005
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| 42 | NRG1
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| A case control and family based association study of the neuregulin1 gene and schizophrenia.
|
| Zhao X, Shi Y, Tang J, Tang R, Yu L, Gu N, Feng G, Zhu S, Liu H, Xing Y, Zhao S, Sang H, Guan Y, St Clair D, He L.
|
| J Med Genet 41(1):31-4. No abstract available. 2004
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| 43 | NRG1
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| Axonal neuregulin-1 regulates myelin sheath thickness.
|
| Michailov GV, Sereda MW, Brinkmann BG, Fischer TM, Haug B, Birchmeier C, Role L, Lai C, Schwab MH, Nave KA.
|
| Science 304(5671):700-3. Epub 2004 Mar 25. 2004
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| 44 | NRG1, NRG2, NRG3, ERBB2, ERBB3, ERBB4, EGFR
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| Neuregulin promotes autophagic cell death of prostate cancer cells.
|
| Tal-Or P, Di-Segni A, Lupowitz Z, Pinkas-Kramarski R.
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| Prostate 55(2):147-57. 2003
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| 45 | NRG1
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| Differentiation-dependent regulation of skeletal myogenesis by neuregulin-1.
|
| Ford BD, Han B, Fischbach GD.
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| Biochem Biophys Res Commun 306(1):276-81. 2003
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| 46 | NRG1
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| Neuregulin 1 and susceptibility to schizophrenia.
|
| Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, Gunnarsdottir S, Ivarsson O, Chou TT, Hjaltason O, Birgisdottir B, Jonsson H, Gudnadottir VG, Gudmundsdottir E, Bjornsson A, Ingvarsson B, Ingason A, Sigfusson S, Hardardottir H, Harvey RP, Lai D, Zhou M, Brunner D, Mutel V, Gonzalo A, Lemke G, Sainz J, Johannesson G, Andresson T, Gudbjartsson D, Manolescu A, Frigge ML, Gurney ME, Kong A, Gulcher JR, Petursson H, Stefansson K.
|
| Am J Hum Genet 71(4):877-92. 2002
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| 47 | NRG1
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| A role for neuregulin1 signaling in muscle spindle differentiation.
|
| Hippenmeyer S, Shneider NA, Birchmeier C, Burden SJ, Jessell TM, Arber S.
|
| Neuron. 36(6):1035-49. 2002
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| 48 | NRG1
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| A novel role of neuregulin in skeletal muscle. Neuregulin stimulates glucose uptake, glucose transporter translocation, and transporter expression in muscle cells.
|
| Suarez E, Bach D, Cadefau J, Palacin M, Zorzano A, Guma A.
|
| J Biol Chem 276(21):18257-64. 2001
|
| 49 | MMP9, NRG1
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| Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells
|
| Yao J, Xiong S, Klos K, Nguyen N, Grijalva R, Li P, Yu D.
|
| Oncogene 20(56):8066-74. 2001
|
| 50 | NRG1, NRG2
|
| Molecular requirements for the effect of neuregulin on cell spreading, motility and colony organization.
|
| Chausovsky A, Waterman H, Elbaum M, Yarden Y, Geiger B, Bershadsky AD.
|
| Oncogene 19(7):878-88. 2000
|
| 51 | NRG1
|
| Neuregulin-1 and human epidermal growth factor receptors 2 and 3 play a role in human lung development in vitro.
|
| Patel NV, Acarregui MJ, Snyder JM, Klein JM, Sliwkowski MX, Kern JA.
|
| Am J Respir Cell Mol Biol 22(4):432-40. 2000
|
| 52 | NRG1, STIP1
|
| Gamma-heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation.
|
| Liu X, Baker E, Eyre HJ, Sutherland GR, Zhou M.
|
| Oncogene 18(50):7110-4. 1999
|
| 53 | NRG1
|
| Expression patterns of transmembrane and released forms of neuregulin during spinal cord and neuromuscular synapse development.
|
| Loeb JA, Khurana TS, Robbins JT, Yee AG, Fischbach GD.
|
| Development 126(4):781-91. 1999
|
| 54 | NRG1, STIP1
|
| gamma-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line.
|
| Wang XZ, Jolicoeur EM, Conte N, Chaffanet M, Zhang Y, Mozziconacci MJ, Feiner H, Birnbaum D, Pebusque MJ, Ron D.
|
| Oncogene 18(41):5718-21. 1999
|
| 55 | CHRNA7, NRG1
|
| A cysteine-rich isoform of neuregulin controls the level of expression of neuronal nicotinic receptor channels during synaptogenesis.
|
| Yang X, Kuo Y, Devay P, Yu C, Role L.
|
| Neuron 20(2):255-70. 1998
|
| 56 | NRG1
|
| Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition.
|
| Wang JY, Frenzel KE, Wen D, Falls DL.
|
| J Biol Chem. 273(32):20525-34. 1998
|
| 57 | GRIN2C, NRG1
|
| Neuregulin-beta induces expression of an NMDA-receptor subunit.
|
| Ozaki M, Sasner M, Yano R, Lu HS, Buonanno A.
|
| Nature 390(6661):691-4. 1997
|
| 58 | NRG1
|
| Gamma-heregulin: a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175.
|
| Schaefer G, Fitzpatrick VD, Sliwkowski MX.
|
| Oncogene 15(12):1385-94. 1997
|
| 59 | NRG1
|
| Isoform-specific expression and function of neuregulin.
|
| Meyer D, Yamaai T, Garratt A, Riethmacher-Sonnenberg E, Kane D, Theill LE, Birchmeier C.
|
| Development. 124(18):3575-86. 1997
|
| 60 | GTF2E2, NRG1, NEFL, FGFR1, POLB, PPP2CB, WRN
|
| Integrated map of the chromosome 8p12-p21 region, a region involved in human cancers and Werner syndrome.
|
| Imbert A, et al.
|
| Genomics 32 : 29-38. 1996
|
| 61 | ADRB3, GNRH1, NRG1
|
| Analysis of CA repeat polymorphisms places three human gene loci on the 8p linkage map.
|
| Bruskiewich R, et al.
|
| Cytogenet Cell Genet 73 : 331-333. 1996
|
| 62 | CHRNE, NRG1
|
| Identification of an element crucial for the sub-synaptic expression of the acetylcholine receptor epsilon-subunit gene.
|
| Duclert A, Savatier N, Schaeffer L, Changeux JP.
|
| J Biol Chem 271(29):17433-8. 1996
|
| 63 | NRG1
|
| Sensory and motor neuron-derived factor. A novel heregulin variant highly expressed in sensory and motor neurons.
|
| Ho WH, Armanini MP, Nuijens A, Phillips HS, Osheroff PL.
|
| J Biol Chem 270(44):26722. No abstract available. 1995
|
| 64 | ERBB3, NRG1
|
| Binding of Neu differentiation factor with the extracellular domain of Her2 and Her3.
|
| Horan T, Wen J, Arakawa T, Liu N, Brankow D, Hu S, Ratzkin B, Philo JS.
|
| J Biol Chem. 270(41):24604-8. 1995
|
| 65 | NRG1
|
| Neu differentiation factor inhibits EGF binding. A model for trans-regulation within the ErbB family of receptor tyrosine kinases.
|
| Karunagaran D, Tzahar E, Liu N, Wen D, Yarden Y.
|
| J Biol Chem. 270(17):9982-90. 1995
|
| 66 | NRG1
|
| Structural and functional aspects of the multiplicity of Neu differentiation factors.
|
| Wen D, Suggs SV, Karunagaran D, Liu N, Cupples RL, Luo Y, Janssen AM, Ben-Baruch N, Trollinger DB, Jacobsen VL, et al.
|
| Mol Cell Biol 14(3):1909-19. 1994
|
| 67 | NRG1
|
| Assignment of heregulin (HGL) to human chromosome 8p22-p11 by PCR analysis of somatic cell hybrid DNA.
|
| Lee J, et al.
|
| Genomics 16 : 790-791. 1993
|
| 68 | NRG1
|
| Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21.
|
| Orr-Urtreger A, et al.
|
| Proc Natl Acad Sci U S A 90 : 1867-1871. 1993
|
| 69 | NRG1
|
| Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system.
|
| Marchionni MA, Goodearl AD, Chen MS, Bermingham-McDonogh O, Kirk C, Hendricks M, Danehy F, Misumi D, Sudhalter J, Kobayashi K, et al.
|
| Nature 362(6418):312-8. 1993
|
| 70 | NRG1
|
| Identification of heregulin, a specific activator of p185erbB2.
|
| Holmes WE, et al.
|
| Science 256(5060):1205-10. 1992
|