| 1 | BMP15, NR5A1, NR5A2
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| Roles of NR5A1 and NR5A2 in the regulation of steroidogenesis by Clock gene and bone morphogenetic proteins by human granulosa cells.2021 PMID: .
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| Suyama A, Iwata N, Soejima Y, Nakano Y, Yamamoto K, Nada T, Otsuka F.
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| Endocr J. Nov 29;68(11):1283-1291. doi: 10.1507/endocrj.EJ21-0223. Epub 2021 Jun 26. 2021
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| 2 | NR5A2
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| Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas.
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| Cobo I, Martinelli P, Flández M, Bakiri L, Zhang M, Carrillo-de-Santa-Pau E, Jia J, Sánchez-Arévalo Lobo VJ, Megías D, Felipe I, Del Pozo N, Millán I, Thommesen L, Bruland T, Olson SH, Smith J, Schoonjans K, Bamlet WR, Petersen GM, Malats N, Amundadottir LT, Wagner EF, Real FX.
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| Nature 554(7693):533-537. doi: 10.1038/nature25751. Epub 2018 Feb 14.
2018
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| 3 | NR5A2
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| The Orphan Nuclear Receptor Liver Homolog Receptor-1 (Nr5a2) Regulates Ovarian Granulosa Cell Proliferation.
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| Meinsohn MC, Morin F, Bertolin K, Duggavathi R, Schoonjans K, Murphy BD.
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| J Endocr Soc 2(1):24-41. doi: 10.1210/js.2017-00329. eCollection 2018 Jan 1.
2017
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| 4 | NR5A2
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| NR5A2 discovering compounds that block tumor growth in PDAC.
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| Fletterick R.
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| J Surg Oncol 116(1):89-93. doi: 10.1002/jso.24639. Epub 2017 Apr 26. Review.
2017
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| 5 | FASLG, NR5A2
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| Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcription and associated T-cell effector functions.
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| Schwaderer J, Gaiser AK, Phan TS, Delgado ME, Brunner T.
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| Cell Death Dis 8(4):e2745. doi: 10.1038/cddis.2017.173.
2017
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| 6 | NR5A2
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| Effect of NR5A2 inhibition on pancreatic cancer stem cell (CSC) properties and epithelial-mesenchymal transition (EMT) markers.
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| Luo Z, Li Y, Zuo M, Liu C, Yan D, Wang H, Li D.
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| Mol Carcinog 56(5):1438-1448. doi: 10.1002/mc.22604. Epub 2017 Jan 12. Erratum in: Mol Carcinog. 2018 Jan;57(1):142.
2017
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| 7 | NR5A2
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| Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development.
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| Nissim S, Weeks O, Talbot JC, Hedgepeth JW, Wucherpfennig J, Schatzman-Bone S, Swinburne I, Cortes M, Alexa K, Megason S, North TE, Amacher SL, Goessling W.
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| Dev Biol 418(1):108-123. doi: 10.1016/j.ydbio.2016.07.019. Epub 2016 Jul 26.
2016
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| 8 | NR5A2
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| Polymorphisms in NR5A2, gene encoding liver receptor homolog-1 are associated with preterm birth.
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| Kaluarachchi DC, Momany AM, Busch TD, Gimenez LG, Saleme C, Cosentino V, Christensen K, Dagle JM, Ryckman KK, Murray JC.
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| Pediatr Res 79(5):776-80. doi: 10.1038/pr.2016.7. Epub 2016 Jan 13.
2016
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| 9 | ILF3, NR5A2, SERBP1
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| SERBP1 Is a Component of the Liver Receptor Homologue-1 Transcriptional Complex.
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| Mari Y, West GM, Scharager-Tapia C, Pascal BD, Garcia-Ordonez RD, Griffin PR.
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| J Proteome Res 14(11):4571-80. doi: 10.1021/acs.jproteome.5b00379. Epub 2015 Oct 7.
2015
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| 10 | NR5A2
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| A calreticulin-dependent nuclear export signal is involved in the regulation of liver receptor homologue-1 protein folding.
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| Yang FM, Feng SJ, Lai TC, Hu MC.
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| Biochem J 471(2):199-209. doi: 10.1042/BJ20150252. Epub 2015 Aug 12.
2015
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| 11 | NR5A2
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| Human sperm liver receptor homolog-1 (LRH-1) acts as a downstream target of the estrogen signaling pathway.
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| Montanaro D, Santoro M, Carpino A, Perrotta I, De Amicis F, Sirianni R, Rago V, Gervasi S, Aquila S.
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| J Anat 227(4):541-9. doi: 10.1111/joa.12352. Epub 2015 Aug 4.
2015
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| 12 | NR5A2
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| Liver receptor homolog-1 (LRH-1): a potential therapeutic target for cancer.
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| Nadolny C, Dong X.
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| Cancer Biol Ther 16(7):997-1004. doi: 10.1080/15384047.2015.1045693. Epub 2015 May 7. Review.
2015
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| 13 | CDKN1A, FOXA1, NR5A2
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| LRH-1 controls proliferation in breast tumor cells by regulating CDKN1A gene expression.
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| Bianco S, Jangal M, Garneau D, Gévry N.
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| Oncogene 34(34):4509-18. doi: 10.1038/onc.2014.382. Epub 2014 Dec 1.
2015
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| 14 | NR5A2
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| The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.
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| Hale MA, Swift GH, Hoang CQ, Deering TG, Masui T, Lee YK, Xue J, MacDonald RJ.
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| Development 141(16):3123-33. doi: 10.1242/dev.109405. Epub 2014 Jul 25.
2014
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| 15 | NR5A2
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| Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution.
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| Mamrosh JL, Lee JM, Wagner M, Stambrook PJ, Whitby RJ, Sifers RN, Wu SP, Tsai MJ, Demayo FJ, Moore DD.
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| Elife 3:e01694. doi: 10.7554/eLife.01694. Erratum in: Elife. 2015;4:e10084.
2014
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| 16 | NR5A2
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| Activation of nuclear receptor NR5A2 increases Glut4 expression and glucose metabolism in muscle cells.
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| Bolado-Carrancio A, Riancho JA, Sainz J, Rodríguez-Rey JC.
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| Biochem Biophys Res Commun 446(2):614-9. doi: 10.1016/j.bbrc.2014.03.010. Epub 2014 Mar 12.
2014
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| 17 | NR5A2, RARG
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| Retinoic acid receptor γ (Rarg) and nuclear receptor subfamily 5, group A, member 2 (Nr5a2) promote conversion of fibroblasts to functional neurons.
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| Shi Z, Shen T, Liu Y, Huang Y, Jiao J.
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| J Biol Chem 289(10):6415-28. doi: 10.1074/jbc.M113.515601. Epub 2014 Jan 23.
2014
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| 18 | NR5A2
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| Liver receptor homolog-1 is essential for pregnancy.
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| Zhang C, Large MJ, Duggavathi R, DeMayo FJ, Lydon JP, Schoonjans K, Kovanci E, Murphy BD.
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| Nat Med 19(8):1061-6. doi: 10.1038/nm.3192. Epub 2013 Jun 30.
2013
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| 19 | NR5A2
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| Structure-based discovery of antagonists of nuclear receptor LRH-1.
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| Benod C, Carlsson J, Uthayaruban R, Hwang P, Irwin JJ, Doak AK, Shoichet BK, Sablin EP, Fletterick RJ.
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| J Biol Chem 288(27):19830-44. doi: 10.1074/jbc.M112.411686. Epub 2013 May 10.
2013
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| 20 | KISS1, NR5A2
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| Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.
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| Atkin SD, Owen BM, Bookout AL, Cravo RM, Lee C, Elias CF, Elmquist JK, Kliewer SA, Mangelsdorf DJ.
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| Mol Endocrinol 27(4):598-605. doi: 10.1210/me.2012-1371. Epub 2013 Mar 15.
2013
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| 21 | NR5A2
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| A novel isoform of liver receptor homolog-1 is regulated by steroidogenic factor-1 and the specificity protein family in ovarian granulosa cells.
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| Kawabe S, Yazawa T, Kanno M, Usami Y, Mizutani T, Imamichi Y, Ju Y, Matsumura T, Orisaka M, Miyamoto K.
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| Endocrinology 154(4):1648-60. doi: 10.1210/en.2012-2008. Epub 2013 Mar 7.
2013
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| 22 | ESR1, GREB1, NR5A2
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| The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferation.
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| Chand AL, Wijayakumara DD, Knower KC, Herridge KA, Howard TL, Lazarus KA, Clyne CD.
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| PLoS One 7(2):e31593. doi: 10.1371/journal.pone.0031593. Epub 2012 Feb 16.
2012
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| 23 | NR5A2, POU5F1
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| Regulation of OCT4 gene expression by liver receptor homolog-1 in human embryonic carcinoma cells.
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| Sung B, Do HJ, Park SW, Huh SH, Oh JH, Chung HJ, Kang MJ, Kim JH, Kim NH, Kim JH.
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| Biochem Biophys Res Commun 427(2):315-20. doi: 10.1016/j.bbrc.2012.09.049. Epub 2012 Sep 18.
2012
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| 24 | NR5A2
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| Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation.
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| Benod C, Vinogradova MV, Jouravel N, Kim GE, Fletterick RJ, Sablin EP.
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| Proc Natl Acad Sci U S A 108(41):16927-31. Epub 2011 Sep 26.
2011
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| 25 | CYP7A1, NR5A2
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| Liver receptor homolog-1 is critical for adequate up-regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration.
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| Out C, Hageman J, Bloks VW, Gerrits H, Sollewijn Gelpke MD, Bos T, Havinga R, Smit MJ, Kuipers F, Groen AK.
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| Hepatology 53(6):2075-85. doi: 10.1002/hep.24286.
2011
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| 26 | NR0B2, NR5A2, SIRT1
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| Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation.
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| Chanda D, Xie YB, Choi HS.
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| Nucleic Acids Res 38(14):4607-19. Epub 2010 Apr 7.
2010
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| 27 | NR5A2
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| Localization and regulation of aromatase liver receptor homologue-1 in the developing rat testis.
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| Sierens J, Jakody I, Poobalan Y, Meachem SJ, Knower K, Young MJ, Sirianni R, Pezzi V, Clyne CD.
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| Mol Cell Endocrinol 323(2):307-13. Epub 2010 Mar 7.PMID: 20214950 2010
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| 28 | NR5A2
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| The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.
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| Heng JC, Feng B, Han J, Jiang J, Kraus P, Ng JH, Orlov YL, Huss M, Yang L, Lufkin T, Lim B, Ng HH.
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| Cell Stem Cell 6(2):167-74. Epub 2010 Jan 21.PMID: 20096661 2010
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| 29 | NR5A1, NR5A2, STAR
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| Identification of a novel distal control region upstream of the human steroidogenic acute regulatory protein (StAR) gene that participates in SF-1-dependent chromatin architecture.
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| Mizutani T, Yazawa T, Ju Y, Imamichi Y, Uesaka M, Inaoka Y, Matsuura K, Kamiki Y, Oki M, Umezawa A, Miyamoto K.
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| J Biol Chem 285(36):28240-51. Epub 2010 Jul 3. 2010
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| 30 | FOS, NR54A1, NR5A2
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| The nuclear receptors SF1 and LRH1 are expressed in endometrial cancer cells and regulate steroidogenic gene transcription by cooperating with AP-1 factors.
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| Dubé C, Bergeron F, Vaillant MJ, Robert NM, Brousseau C, Tremblay JJ.
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| Cancer Lett 275(1):127-38. Epub 2008 Nov 20.
2009
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| 31 | NR5A1, NR5A2
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| Liver receptor homolog-1 regulates the transcription of steroidogenic enzymes and induces the differentiation of mesenchymal stem cells into steroidogenic cells.
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| Yazawa T, Inanoka Y, Mizutani T, Kuribayashi M, Umezawa A, Miyamoto K.
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| Endocrinology 150(8):3885-93. Epub 2009 Apr 9.PMID: 19359379 2009
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| 32 | NR0B1, NR5A2
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| The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.
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| Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ.
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| Proc Natl Acad Sci U S A 105(47):18390-5. Epub 2008 Nov 17.
2008
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| 33 | NR5A2
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| Liver receptor homolog-1, an emerging metabolic modulator.
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| Lee YK, Moore DD.
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| Front Biosci 13:5950-8. Review.PMID: 18508634 2008
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| 34 | NR5A2
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| Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.
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| Lee YK, Schmidt DR, Cummins CL, Choi M, Peng L, Zhang Y, Goodwin B, Hammer RE, Mangelsdorf DJ, Kliewer SA.
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| Mol Endocrinol 22(6):1345-56. Epub 2008 Mar 6.PMID: 18323469 2008
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| 35 | CYP7A1, NR5A2
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| Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression.
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| Song X, Kaimal R, Yan B, Deng R.
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| J Lipid Res 49(5):973-84. doi: 10.1194/jlr.M700417-JLR200. Epub 2008 Feb 12.
2008
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| 36 | NR5A2
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| LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.
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| Coste A, Dubuquoy L, Barnouin R, Annicotte JS, Magnier B, Notti M, Corazza N, Antal MC, Metzger D, Desreumaux P, Brunner T, Auwerx J, Schoonjans K.
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| Proc Natl Acad Sci U S A 104(32):13098-103. Epub 2007 Aug 1. 2007
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| 37 | NR5A2
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| Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation.
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| Schoonjans K, Dubuquoy L, Mebis J, Fayard E, Wendling O, Haby C, Geboes K, Auwerx J.
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| Proc Natl Acad Sci U S A 102(6):2058-62. Epub 2005 Jan 31. 2005
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| 38 | NR0B1, NR5A2
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| Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP.
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| Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR.
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| Nat Struct Mol Biol 12(4):357-63. Epub 2005 Feb 22. 2005
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| 39 | CYP11A1, NR5A2
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| The orphan nuclear receptor, liver receptor homolog-1, regulates cholesterol side-chain cleavage cytochrome p450 enzyme in human granulosa cells.
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| Kim JW, Havelock JC, Carr BR, Attia GR.
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| J Clin Endocrinol Metab 90(3):1678-85. Epub 2004 Dec 21. 2005
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| 40 | NR5A2
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| The nuclear receptor liver receptor homolog-1 is an estrogen receptor target gene.
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| Annicotte JS, Chavey C, Servant N, Teyssier J, Bardin A, Licznar A, Badia E, Pujol P, Vignon F, Maudelonde T, Lazennec G, Cavailles V, Fajas L.
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| Oncogene 24(55):8167-75. 2005
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| 41 | NR5A2
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| The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element.
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| Pare JF, Malenfant D, Courtemanche C, Jacob-Wagner M, Roy S, Allard D, Belanger L.
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| J Biol Chem 279(20):21206-16. Epub 2004 Mar 10. 2004
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| 42 | NR5A2
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| Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene.
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| Zhang CK, Lin W, Cai YN, Xu PL, Dong H, Li M, Kong YY, Fu G, Xie YH, Huang GM, Wang Y.
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| Gene 273(2):239-49. 2001
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| 43 | NR1H4, NR5A2
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| Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydroxylase transcription.
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| del Castillo-Olivares A, Gil G.
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| Nucleic Acids Res 28(18):3587-93. 2000
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| 44 | CYP7A1, NR0B2, NR5A2
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| A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.
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| Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, Galardi C, Wilson JG, Lewis MC, Roth ME, Maloney PR, Willson TM, Kliewer SA.
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| Mol Cell 6(3):517-26. 2000
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| 45 | NR0B2, NR1H3, NR5A2
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| Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.
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| Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, Mangelsdorf DJ.
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| Mol Cell 6(3):507-15. 2000
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| 46 | ABCA1, ABCB11, NR0B2, NR1H3, NR1H4, NR5A2, SCARB1, SLC10A1, SCARB1
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| Don't know much bile-ology.
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| Chawla A, Saez E, Evans RM.
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| Cell 103(1):1-4. No abstract available. 2000
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| 47 | NR5A2
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| CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene.
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| Nitta M, Ku S, Brown C, Okamoto AY, Shan B.
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| Proc Natl Acad Sci U S A 96(12):6660-5. 1999
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| 48 | NR5A2
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| Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization.
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| Galarneau L, et al.
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| Cytogenet Cell Genet 82 : 269-270. 1998
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| 49 | NR5A2
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| Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus.
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| Li M, Xie YH, Kong YY, Wu X, Zhu L, Wang Y.
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| J Biol Chem 273(44):29022-31. 1998
|