Citations for
1NR4A2, WWOX
Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families.
Leppa VM, Kravitz SN, Martin CL, Andrieux J, Le Caignec C, Martin-Coignard D, DyBuncio C, Sanders SJ, Lowe JK, Cantor RM, Geschwind DH.
Am J Hum Genet 99(3):540-54. doi: 10.1016/j.ajhg.2016.06.036. Epub 2016 Aug 25. 2016
2LMX1A, NR4A2, PITX3
Functional roles of Nurr1, Pitx3, and Lmx1a in neurogenesis and phenotype specification of dopamine neurons during in vitro differentiation of embryonic stem cells.
Hong S, Chung S, Leung K, Hwang I, Moon J, Kim KS.
Stem Cells Dev 23(5):477-87. doi: 10.1089/scd.2013.0406. Epub 2013 Dec 4. 2014
3FGF23, NR4A2, PTH
Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription.
Meir T, Durlacher K, Pan Z, Amir G, Richards WG, Silver J, Naveh-Many T.
Kidney Int 86(6):1106-15. doi: 10.1038/ki.2014.215. 2014
4NR4A1, NR4A2, NR4A3
Regulation of NR4A by nutritional status, gender, postnatal development and hormonal deficiency.
Pérez-Sieira S, López M, Nogueiras R, Tovar S.
Sci Rep 4:4264. doi: 10.1038/srep04264. 2014
5FOXA2, NR4A2
Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation.
Yi SH, He XB, Rhee YH, Park CH, Takizawa T, Nakashima K, Lee SH.
Development 141(4):761-72. doi: 10.1242/dev.095802. 2014
6NR4A2
Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons.
Kadkhodaei B, Alvarsson A, Schintu N, Ramsköld D, Volakakis N, Joodmardi E, Yoshitake T, Kehr J, Decressac M, Björklund A, Sandberg R, Svenningsson P, Perlmann T.
Proc Natl Acad Sci U S A 110(6):2360-5. doi: 10.1073/pnas.1221077110. Epub 2013 Jan 22. 2013
7CRH, NR4A1, NR4A2, TYRP1, UCN
Involvement of Nurr-1/Nur77 in corticotropin-releasing factor/urocortin1-induced tyrosinase-related protein 1 gene transcription in human melanoma HMV-II cells.
Watanuki Y, Takayasu S, Kageyama K, Iwasaki Y, Sakihara S, Terui K, Nigawara T, Suda T.
Mol Cell Endocrinol 370(1-2):42-51. doi: 10.1016/j.mce.2013.01.022. Epub 2013 Feb 14. 2013
8NR4A1, NR4A2, NR4A3
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.
Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, Morita R, Kimura A, Ichinose H, Metzger D, Chambon P, Yoshimura A.
Nat Immunol 14(3):230-7. doi: 10.1038/ni.2520. Epub 2013 Jan 20. 2013
9NR4A1, NR4A2, NR4A3, PIN1
Dual function of Pin1 in NR4A nuclear receptor activation: enhanced activity of NR4As and increased Nur77 protein stability.
van Tiel CM, Kurakula K, Koenis DS, van der Wal E, de Vries CJ.
Biochim Biophys Acta 1823(10):1894-904. doi: 10.1016/j.bbamcr.2012.06.030. Epub 2012 Jul 10. 2012
10NR4A1, NR4A2
Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory.
McNulty SE, Barrett RM, Vogel-Ciernia A, Malvaez M, Hernandez N, Davatolhagh MF, Matheos DP, Schiffman A, Wood MA.
Learn Mem 19(12):588-92. doi: 10.1101/lm.026385.112. 2012
11NR4A1, NR4A2, NR4A3
The Nuclear Orphan Receptors NR4A as Therapeutic Target in Cancer Therapy.
Deutsch AJ, Angerer H, Fuchs TE, Neumeister P.
Anticancer Agents Med Chem 12(9):1001-14. 2012
12NR4A2, TOP2B
Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons.
Heng X, Jin G, Zhang X, Yang D, Zhu M, Fu S, Li X, Le W.
Mol Neurodegener 7:4. doi: 10.1186/1750-1326-7-4. 2012
13BDNF, CREB1, NR4A2
Nurr1 protein is required for N-methyl-D-aspartic acid (NMDA) receptor-mediated neuronal survival.
Barneda-Zahonero B, Servitja JM, Badiola N, Mińano-Molina AJ, Fadó R, Saura CA, Rodríguez-Alvarez J.
J Biol Chem 287(14):11351-62. doi: 10.1074/jbc.M111.272427. Epub 2012 Jan 31. 2012
14MIR132, NR4A2
miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression.
Yang D, Li T, Wang Y, Tang Y, Cui H, Tang Y, Zhang X, Chen D, Shen N, Le W.
J Cell Sci 125(Pt 7):1673-82. doi: 10.1242/jcs.086421. Epub 2012 Feb 10. 2012
15NR4A1, NR4A2
Nuclear receptors Nur77 and Nurr1 modulate mesenchymal stromal cell migration.
Maijenburg MW, Gilissen C, Melief SM, Kleijer M, Weijer K, Ten Brinke A, Roelofs H, Van Tiel CM, Veltman JA, de Vries CJ, van der Schoot CE, Voermans C.
Stem Cells Dev 21(2):228-38. doi: 10.1089/scd.2011.0076. Epub 2011 Jun 1. 2012
16NR4A2
Apoptosis inducer NGFI-B is degraded by the proteasome and stabilized by treatment with EGF.
Strřm BO, Paulsen RE.
Biochem Biophys Res Commun 417(4):1292-7. doi: 10.1016/j.bbrc.2011.12.132. Epub 2012 Jan 3. 2012
17NR4A2, PITX3
Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson's disease.
Liu H, Wei L, Tao Q, Deng H, Ming M, Xu P, Le W.
Eur J Neurol 19(6):870-5. doi: 10.1111/j.1468-1331.2011.03644.x. Epub 2012 Feb 6. 2012
18NR4A1, NR4A2, NR4A3
Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation.
Lundequist A, Calounova G, Wensman H, Rönnberg E, Pejler G.
Mol Immunol 48(15-16):1753-61. doi: 10.1016/j.molimm.2011.04.017. Epub 2011 May 31. 2011
19NR4A1, NR4A2, PRKDC
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair.
Malewicz M, Kadkhodaei B, Kee N, Volakakis N, Hellman U, Viktorsson K, Leung CY, Chen B, Lewensohn R, van Gent DC, Chen DJ, Perlmann T.
Genes Dev 25(19):2031-40. doi: 10.1101/gad.16872411. 2011
20NR4A2
Expression of Nurr1 during rat brain and spinal cord development.
Li Y, Cong B, Ma C, Qi Q, Fu L, Zhang G, Min Z.
Neurosci Lett 488(1):49-54. doi: 10.1016/j.neulet.2010.10.078. Epub 2010 Nov 5. 2011
21CREB1, NR4A1, NR4A2, NR4A3
NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.
Volakakis N, Kadkhodaei B, Joodmardi E, Wallis K, Panman L, Silvaggi J, Spiegelman BM, Perlmann T.
Proc Natl Acad Sci U S A 107(27):12317-22. Epub 2010 Jun 21. 2010
22NR4A2, RET
Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain.
Galleguillos D, Fuentealba JA, Gómez LM, Saver M, Gómez A, Nash K, Burger C, Gysling K, Andrés ME.
J Neurochem 114(4):1158-67. Epub 2010 Jun 1.PMID: 20533997 2010
23CDKN2C, NR4A2
The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells.
Sirin O, Lukov GL, Mao R, Conneely OM, Goodell MA.
Nat Cell Biol 12(12):1213-9. doi: 10.1038/ncb2125. Epub 2010 Nov 14. 2010
24NR4A2
Orphan nuclear receptor Nurr1 induces neuron differentiation from embryonic cortical precursor cells via an extrinsic paracrine mechanism.
Bae EJ, Lee HS, Park CH, Lee SH.
FEBS Lett 583(9):1505-10. Epub 2009 Apr 10. 2009
25AIFM1, HDAC2, HTRA1, LGALS9, MX1, NR4A2, PRDX2, TFNA13, UNC5D
Left ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy.
Colak D, Kaya N, Al-Zahrani J, Al Bakheet A, Muiya P, Andres E, Quackenbush J, Dzimiri N.
Genomics 94(1):20-31. Epub 2009 Mar 28. 2009
26FABP5, NR4A2
NR4A orphan nuclear receptors influence retinoic acid and docosahexaenoic acid signaling via up-regulation of fatty acid binding protein 5.
Volakakis N, Joodmardi E, Perlmann T.
Biochem Biophys Res Commun 390(4):1186-91. Epub 2009 Oct 25.PMID: 19861119 2009
27NR4A2
Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines.
Doi Y, Oki S, Ozawa T, Hohjoh H, Miyake S, Yamamura T.
Proc Natl Acad Sci U S A 105(24):8381-6. Epub 2008 Jun 11. 2008
28NR4A2, UCP1
Orphan nuclear receptor NOR-1 enhances 3',5'-cyclic adenosine 5'-monophosphate-dependent uncoupling protein-1 gene transcription.
Kumar N, Liu D, Wang H, Robidoux J, Collins S.
Mol Endocrinol 22(5):1057-64. Epub 2008 Jan 31.PMID: 18238829 2008
29NR4A2, PARK26
Decreased NURR1 gene expression in patients with Parkinson's disease.
Le W, Pan T, Huang M, Xu P, Xie W, Zhu W, Zhang X, Deng H, Jankovic J.
J Neurol Sci 273(1-2):29-33. Epub 2008 Aug 5. 2008
30NR4A2
Transcriptional repression of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilage.
Mix KS, Attur MG, Al-Mussawir H, Abramson SB, Brinckerhoff CE, Murphy EP.
J Biol Chem 282(13):9492-504. Epub 2007 Feb 5. 2007
31NR4A2, PARK12
Nurr1 in Parkinson's disease and related disorders.
Chu Y, Le W, Kompoliti K, Jankovic J, Mufson EJ, Kordower JH.
J Comp Neurol 494(3):495-514. 2006
32NR4A2, PITX3
Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.
Martinat C, Bacci JJ, Leete T, Kim J, Vanti WB, Newman AH, Cha JH, Gether U, Wang H, Abeliovich A.
Proc Natl Acad Sci U S A [Epub ahead of print] 2006
33NR4A1, NR4A2, NR4A3
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism.
Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P.
Nat Med 12(9):1048-55. Epub 2006 Aug 13. 2006
34NR4A2
Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder.
Smith KM, Bauer L, Fischer M, Barkley R, Navia BA.
Am J Med Genet B Neuropsychiatr Genet 133(1):57-63. 2005
35NR4A2, PARK26
The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease.
Jankovic J, Chen S, Le WD.
Prog Neurobiol 77(1-2):128-38. Epub 2005 Oct 21. Review. 2005
36NR4A2
Defining an N-terminal activation domain of the orphan nuclear receptor Nurr1.
Nordzell M, Aarnisalo P, Benoit G, Castro DS, Perlmann T.
Biochem Biophys Res Commun 313(1):205-11. 2004
37NR4A1, NR4A2
The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production.
Bassett MH, Suzuki T, Sasano H, White PC, Rainey WE.
Mol Endocrinol 18(2):279-90. Epub 2003 Nov 26. 2004
38NR4A2
Mutations in NR4A2 associated with familial Parkinson disease.
Le WD, Xu P, Jankovic J, Jiang H, Appel SH, Smith RG, Vassilatis DK.
Nat Genet 33(1):85-9. 2003
39NR4A2
Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors.
Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP, Perlmann T.
Nature 423(6939):555-60. 2003
40NR4A2
Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons.
Smits SM, Ponnio T, Conneely OM, Burbach JP, Smidt MP.
Eur J Neurosci 18(7):1731-8. 2003
41NR4A2
Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem.
Wallen A A, Castro DS, Zetterstrom RH, Karlen M, Olson L, Ericson J, Perlmann T.
Mol Cell Neurosci 18(6):649-63. 2001
42NR2F1, NR2F6, NR4A2
Identification of nuclear orphan receptors as regulators of expression of a neurotransmitter receptor gene.
Chew LJ, Huang F, Boutin JM, Gallo V.
J Biol Chem 274(41):29366-75. 1999
43NR4A2
cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line.
Okabe T, et al.
J Immunol 154 : 3871-3879. 1995
44NR4A2
NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3.
Mages HW, et al.
Mol Endocrinol 8 : 1583-1591. 1994