| 1 | NR4A2, SLC18A1, SLC6A3, TH
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| Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells.
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| Paliga D, Raudzus F, Leppla SH, Heumann R, Neumann S.
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| Mol Neurobiol 56(5):3393-3403. doi: 10.1007/s12035-018-1311-6. Epub 2018 Aug 18.
2019
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| 2 | NR4A2, WWOX
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| Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families.
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| Leppa VM, Kravitz SN, Martin CL, Andrieux J, Le Caignec C, Martin-Coignard D, DyBuncio C, Sanders SJ, Lowe JK, Cantor RM, Geschwind DH.
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| Am J Hum Genet 99(3):540-54. doi: 10.1016/j.ajhg.2016.06.036. Epub 2016 Aug 25.
2016
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| 3 | LMX1A, NR4A2, PITX3
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| Functional roles of Nurr1, Pitx3, and Lmx1a in neurogenesis and phenotype specification of dopamine neurons during in vitro differentiation of embryonic stem cells.
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| Hong S, Chung S, Leung K, Hwang I, Moon J, Kim KS.
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| Stem Cells Dev 23(5):477-87. doi: 10.1089/scd.2013.0406. Epub 2013 Dec 4.
2014
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| 4 | FGF23, NR4A2, PTH
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| Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription.
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| Meir T, Durlacher K, Pan Z, Amir G, Richards WG, Silver J, Naveh-Many T.
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| Kidney Int 86(6):1106-15. doi: 10.1038/ki.2014.215.
2014
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| 5 | NR4A1, NR4A2, NR4A3
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| Regulation of NR4A by nutritional status, gender, postnatal development and hormonal deficiency.
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| Pérez-Sieira S, López M, Nogueiras R, Tovar S.
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| Sci Rep 4:4264. doi: 10.1038/srep04264.
2014
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| 6 | FOXA2, NR4A2
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| Foxa2 acts as a co-activator potentiating expression of the Nurr1-induced DA phenotype via epigenetic regulation.
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| Yi SH, He XB, Rhee YH, Park CH, Takizawa T, Nakashima K, Lee SH.
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| Development 141(4):761-72. doi: 10.1242/dev.095802.
2014
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| 7 | NR4A2
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| Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons.
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| Kadkhodaei B, Alvarsson A, Schintu N, Ramsköld D, Volakakis N, Joodmardi E, Yoshitake T, Kehr J, Decressac M, Björklund A, Sandberg R, Svenningsson P, Perlmann T.
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| Proc Natl Acad Sci U S A 110(6):2360-5. doi: 10.1073/pnas.1221077110. Epub 2013 Jan 22.
2013
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| 8 | CRH, NR4A1, NR4A2, TYRP1, UCN
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| Involvement of Nurr-1/Nur77 in corticotropin-releasing factor/urocortin1-induced tyrosinase-related protein 1 gene transcription in human melanoma HMV-II cells.
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| Watanuki Y, Takayasu S, Kageyama K, Iwasaki Y, Sakihara S, Terui K, Nigawara T, Suda T.
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| Mol Cell Endocrinol 370(1-2):42-51. doi: 10.1016/j.mce.2013.01.022. Epub 2013 Feb 14.
2013
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| 9 | NR4A1, NR4A2, NR4A3
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| Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.
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| Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, Morita R, Kimura A, Ichinose H, Metzger D, Chambon P, Yoshimura A.
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| Nat Immunol 14(3):230-7. doi: 10.1038/ni.2520. Epub 2013 Jan 20.
2013
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| 10 | NR4A2, TH
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| Nurr1 represses tyrosine hydroxylase expression via SIRT1 in human neural stem cells.
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| Kim TE, Seo JS, Yang JW, Kim MW, Kausar R, Joe E, Kim BY, Lee MA.
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| PLoS One 8(8):e71469. doi: 10.1371/journal.pone.0071469. eCollection 2013. Erratum in: PLoS One. 2014;9(11):e113335. Seo, Ji Sun [correct 2013
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| 11 | NR4A1, NR4A2, NR4A3, PIN1
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| Dual function of Pin1 in NR4A nuclear receptor activation: enhanced activity of NR4As and increased Nur77 protein stability.
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| van Tiel CM, Kurakula K, Koenis DS, van der Wal E, de Vries CJ.
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| Biochim Biophys Acta 1823(10):1894-904. doi: 10.1016/j.bbamcr.2012.06.030. Epub 2012 Jul 10.
2012
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| 12 | NR4A1, NR4A2
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| Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory.
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| McNulty SE, Barrett RM, Vogel-Ciernia A, Malvaez M, Hernandez N, Davatolhagh MF, Matheos DP, Schiffman A, Wood MA.
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| Learn Mem 19(12):588-92. doi: 10.1101/lm.026385.112.
2012
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| 13 | NR4A1, NR4A2, NR4A3
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| The Nuclear Orphan Receptors NR4A as Therapeutic Target in Cancer Therapy.
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| Deutsch AJ, Angerer H, Fuchs TE, Neumeister P.
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| Anticancer Agents Med Chem 12(9):1001-14.
2012
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| 14 | NR4A2, TOP2B
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| Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons.
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| Heng X, Jin G, Zhang X, Yang D, Zhu M, Fu S, Li X, Le W.
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| Mol Neurodegener 7:4. doi: 10.1186/1750-1326-7-4.
2012
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| 15 | BDNF, CREB1, NR4A2
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| Nurr1 protein is required for N-methyl-D-aspartic acid (NMDA) receptor-mediated neuronal survival.
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| Barneda-Zahonero B, Servitja JM, Badiola N, Mińano-Molina AJ, Fadó R, Saura CA, Rodríguez-Alvarez J.
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| J Biol Chem 287(14):11351-62. doi: 10.1074/jbc.M111.272427. Epub 2012 Jan 31.
2012
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| 16 | MIR132, NR4A2
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| miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression.
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| Yang D, Li T, Wang Y, Tang Y, Cui H, Tang Y, Zhang X, Chen D, Shen N, Le W.
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| J Cell Sci 125(Pt 7):1673-82. doi: 10.1242/jcs.086421. Epub 2012 Feb 10. 2012
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| 17 | NR4A1, NR4A2
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| Nuclear receptors Nur77 and Nurr1 modulate mesenchymal stromal cell migration.
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| Maijenburg MW, Gilissen C, Melief SM, Kleijer M, Weijer K, Ten Brinke A, Roelofs H, Van Tiel CM, Veltman JA, de Vries CJ, van der Schoot CE, Voermans C.
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| Stem Cells Dev 21(2):228-38. doi: 10.1089/scd.2011.0076. Epub 2011 Jun 1.
2012
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| 18 | NR4A2
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| Apoptosis inducer NGFI-B is degraded by the proteasome and stabilized by treatment with EGF.
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| Strřm BO, Paulsen RE.
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| Biochem Biophys Res Commun 417(4):1292-7. doi: 10.1016/j.bbrc.2011.12.132. Epub 2012 Jan 3.
2012
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| 19 | NR4A2, PITX3
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| Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson's disease.
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| Liu H, Wei L, Tao Q, Deng H, Ming M, Xu P, Le W.
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| Eur J Neurol 19(6):870-5. doi: 10.1111/j.1468-1331.2011.03644.x. Epub 2012 Feb 6.
2012
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| 20 | NR4A1, NR4A2, NR4A3
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| Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation.
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| Lundequist A, Calounova G, Wensman H, Rönnberg E, Pejler G.
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| Mol Immunol 48(15-16):1753-61. doi: 10.1016/j.molimm.2011.04.017. Epub 2011 May 31.
2011
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| 21 | NR4A1, NR4A2, PRKDC
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| Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair.
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| Malewicz M, Kadkhodaei B, Kee N, Volakakis N, Hellman U, Viktorsson K, Leung CY, Chen B, Lewensohn R, van Gent DC, Chen DJ, Perlmann T.
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| Genes Dev 25(19):2031-40. doi: 10.1101/gad.16872411.
2011
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| 22 | NR4A2
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| Expression of Nurr1 during rat brain and spinal cord development.
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| Li Y, Cong B, Ma C, Qi Q, Fu L, Zhang G, Min Z.
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| Neurosci Lett 488(1):49-54. doi: 10.1016/j.neulet.2010.10.078. Epub 2010 Nov 5.
2011
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| 23 | CREB1, NR4A1, NR4A2, NR4A3
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| NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.
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| Volakakis N, Kadkhodaei B, Joodmardi E, Wallis K, Panman L, Silvaggi J, Spiegelman BM, Perlmann T.
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| Proc Natl Acad Sci U S A 107(27):12317-22. Epub 2010 Jun 21. 2010
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| 24 | NR4A2, RET
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| Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain.
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| Galleguillos D, Fuentealba JA, Gómez LM, Saver M, Gómez A, Nash K, Burger C, Gysling K, Andrés ME.
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| J Neurochem 114(4):1158-67. Epub 2010 Jun 1.PMID: 20533997 2010
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| 25 | CDKN2C, NR4A2
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| The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells.
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| Sirin O, Lukov GL, Mao R, Conneely OM, Goodell MA.
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| Nat Cell Biol 12(12):1213-9. doi: 10.1038/ncb2125. Epub 2010 Nov 14.
2010
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| 26 | NR4A2
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| Orphan nuclear receptor Nurr1 induces neuron differentiation from embryonic cortical precursor cells via an extrinsic paracrine mechanism.
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| Bae EJ, Lee HS, Park CH, Lee SH.
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| FEBS Lett 583(9):1505-10. Epub 2009 Apr 10.
2009
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| 27 | AIFM1, HDAC2, HTRA1, LGALS9, MX1, NR4A2, PRDX2, TFNA13, UNC5D
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| Left ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy.
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| Colak D, Kaya N, Al-Zahrani J, Al Bakheet A, Muiya P, Andres E, Quackenbush J, Dzimiri N.
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| Genomics 94(1):20-31. Epub 2009 Mar 28.
2009
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| 28 | FABP5, NR4A2
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| NR4A orphan nuclear receptors influence retinoic acid and docosahexaenoic acid signaling via up-regulation of fatty acid binding protein 5.
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| Volakakis N, Joodmardi E, Perlmann T.
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| Biochem Biophys Res Commun 390(4):1186-91. Epub 2009 Oct 25.PMID: 19861119 2009
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| 29 | NR4A2
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| Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines.
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| Doi Y, Oki S, Ozawa T, Hohjoh H, Miyake S, Yamamura T.
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| Proc Natl Acad Sci U S A 105(24):8381-6. Epub 2008 Jun 11. 2008
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| 30 | NR4A2, UCP1
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| Orphan nuclear receptor NOR-1 enhances 3',5'-cyclic adenosine 5'-monophosphate-dependent uncoupling protein-1 gene transcription.
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| Kumar N, Liu D, Wang H, Robidoux J, Collins S.
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| Mol Endocrinol 22(5):1057-64. Epub 2008 Jan 31.PMID: 18238829 2008
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| 31 | NR4A2, PARK26
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| Decreased NURR1 gene expression in patients with Parkinson's disease.
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| Le W, Pan T, Huang M, Xu P, Xie W, Zhu W, Zhang X, Deng H, Jankovic J.
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| J Neurol Sci 273(1-2):29-33. Epub 2008 Aug 5. 2008
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| 32 | NR4A2
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| Transcriptional repression of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilage.
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| Mix KS, Attur MG, Al-Mussawir H, Abramson SB, Brinckerhoff CE, Murphy EP.
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| J Biol Chem 282(13):9492-504. Epub 2007 Feb 5. 2007
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| 33 | NR4A2, PARK12
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| Nurr1 in Parkinson's disease and related disorders.
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| Chu Y, Le W, Kompoliti K, Jankovic J, Mufson EJ, Kordower JH.
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| J Comp Neurol 494(3):495-514. 2006
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| 34 | NR4A2, PITX3
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| Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype.
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| Martinat C, Bacci JJ, Leete T, Kim J, Vanti WB, Newman AH, Cha JH, Gether U, Wang H, Abeliovich A.
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| Proc Natl Acad Sci U S A [Epub ahead of print] 2006
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| 35 | NR4A1, NR4A2, NR4A3
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| NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism.
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| Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P.
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| Nat Med 12(9):1048-55. Epub 2006 Aug 13. 2006
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| 36 | NR4A2
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| Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder.
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| Smith KM, Bauer L, Fischer M, Barkley R, Navia BA.
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| Am J Med Genet B Neuropsychiatr Genet 133(1):57-63. 2005
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| 37 | NR4A2, PARK26
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| The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease.
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| Jankovic J, Chen S, Le WD.
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| Prog Neurobiol 77(1-2):128-38. Epub 2005 Oct 21. Review. 2005
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| 38 | NR4A2
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| Defining an N-terminal activation domain of the orphan nuclear receptor Nurr1.
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| Nordzell M, Aarnisalo P, Benoit G, Castro DS, Perlmann T.
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| Biochem Biophys Res Commun 313(1):205-11. 2004
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| 39 | NR4A1, NR4A2
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| The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production.
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| Bassett MH, Suzuki T, Sasano H, White PC, Rainey WE.
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| Mol Endocrinol 18(2):279-90. Epub 2003 Nov 26. 2004
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| 40 | NR4A2
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| Mutations in NR4A2 associated with familial Parkinson disease.
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| Le WD, Xu P, Jankovic J, Jiang H, Appel SH, Smith RG, Vassilatis DK.
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| Nat Genet 33(1):85-9. 2003
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| 41 | NR4A2
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| Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors.
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| Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, Xu H, Walker NP, Perlmann T.
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| Nature 423(6939):555-60. 2003
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| 42 | NR4A2
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| Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons.
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| Smits SM, Ponnio T, Conneely OM, Burbach JP, Smidt MP.
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| Eur J Neurosci 18(7):1731-8. 2003
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| 43 | NR4A2
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| Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem.
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| Wallen A A, Castro DS, Zetterstrom RH, Karlen M, Olson L, Ericson J, Perlmann T.
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| Mol Cell Neurosci 18(6):649-63. 2001
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| 44 | NR2F1, NR2F6, NR4A2
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| Identification of nuclear orphan receptors as regulators of expression of a neurotransmitter receptor gene.
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| Chew LJ, Huang F, Boutin JM, Gallo V.
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| J Biol Chem 274(41):29366-75. 1999
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| 45 | NR4A2
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| cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line.
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| Okabe T, et al.
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| J Immunol 154 : 3871-3879. 1995
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| 46 | NR4A2
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| NOT, a human immediate-early response gene closely related to the steroid/thyroid hormone receptor NAK1/TR3.
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| Mages HW, et al.
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| Mol Endocrinol 8 : 1583-1591. 1994
|