Citations for
1DLL4, JAG1, NR4A1
DLL4 and Jagged1 are angiogenic targets of orphan nuclear receptor TR3/Nur77.
Peng J, Zhao S, Li Y, Niu G, Chen C, Ye T, Zhao D, Zeng H.
Microvasc Res 124:67-75. doi: 10.1016/j.mvr.2019.03.006. Epub 2019 Mar 28. 2019
2NR4A1, WT1
The stress-response molecule NR4A1 resists ROS-induced pancreatic β-cells apoptosis via WT1.
Zong C, Qin D, Yu C, Gao P, Chen J, Lu S, Zhang Y, Liu Y, Yang Y, Pu Z, Li X, Fu Y, Guan Q, Wang X.
Cell Signal 35:129-139. doi: 10.1016/j.cellsig.2017.03.012. [Epub ahead of print] 2017
3NR4A1, RXRA
Effect of retinoid X receptor-α nuclear export inhibition on apoptosis of neurons in vivo and in vitro.
Liu Y, Tang J, Gao X, Wang M, Shen J, You X.
Mol Med Rep 16(2):2037-2044. doi: 10.3892/mmr.2017.6766. Epub 2017 Jun 14. 2017
4NR4A1
Calcium-induced apoptosis of developing cerebellar granule neurons depends causally on NGFI-B.
Austdal LP, Mathisen GH, Lřberg EM, Paulsen RE.
Int J Dev Neurosci 55:82-90. doi: 10.1016/j.ijdevneu.2016.10.003. Epub 2016 Oct 18. 2016
5NR4A1
Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance.
Hamers AA, Argmann C, Moerland PD, Koenis DS, Marinković G, Sokolović M, de Vos AF, de Vries CJ, van Tiel CM.
BMC Genomics 17:162. doi: 10.1186/s12864-016-2469-9. 2016
6NR4A1
Differential function and regulation of orphan nuclear receptor TR3 isoforms in endothelial cells.
Zhou L, Cui P, Zhao S, Ye T, Li Y, Peng J, Niu G, Zhao D, Zeng H.
Tumour Biol 37(3):3307-20. doi: 10.1007/s13277-015-4157-9. Epub 2015 Oct 6. 2016
7APOA4, NR1D1, NR4A1
Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line.
Li X, Xu M, Wang F, Ji Y, DavidsoN WS, Li Z, Tso P.
PLoS One 10(11):e0142098. doi: 10.1371/journal.pone.0142098. 2015
8IGFBP3, NR4A1
IGFBP-3 may trigger osteoarthritis by inducing apoptosis of chondrocytes through Nur77 translocation.
Wei Z, Li HH.
Int J Clin Exp Pathol 8(12):15599-610. eCollection 2015. 2015
9NR4A1
Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation.
Shaked I, Hanna RN, Shaked H, Chodaczek G, Nowyhed HN, Tweet G, Tacke R, Basat AB, Mikulski Z, Togher S, Miller J, Blatchley A, Salek-Ardakani S, Darvas M, Kaikkonen MU, Thomas GD, Lai-Wing-Sun S, Rezk A, Bar-Or A, Glass CK, Bandukwala H, Hedrick CC.
Nat Immunol 16(12):1228-34. doi: 10.1038/ni.3321. Epub 2015 Nov 2. 2015
10NR4A1
Cutting Edge: The Orphan Nuclear Receptor Nr4a1 Regulates CD8+ T Cell Expansion and Effector Function through Direct Repression of Irf4.
Nowyhed HN, Huynh TR, Thomas GD, Blatchley A, Hedrick CC.
J Immunol 195(8):3515-9. doi: 10.4049/jimmunol.1403027. Epub 2015 Sep 11. 2015
11GATA4, NFATC3, NR4A1
Orphan Nuclear Receptor Nur77 Inhibits Cardiac Hypertrophic Response to Beta-Adrenergic Stimulation.
Yan G, Zhu N, Huang S, Yi B, Shang X, Chen M, Wang N, Zhang GX, Talarico JA, Tilley DG, Gao E, Sun J.
Mol Cell Biol 35(19):3312-23. doi: 10.1128/MCB.00229-15. Epub 2015 Jul 20. 2015
12BIRC5, DDIT3, NR4A1
The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis.
Yu C, Cui S, Zong C, Gao W, Xu T, Gao P, Chen J, Qin D, Guan Q, Liu Y, Fu Y, Li X, Wang X.
J Biol Chem 290(34):20687-99. doi: 10.1074/jbc.M115.654863. Epub 2015 Jul 8. 2015
13NR4A1
The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus.
Tacke R, Hilgendorf I, Garner H, Waterborg C, Park K, Nowyhed H, Hanna RN, Wu R, Swirski FK, Geissmann F, Hedrick CC.
Sci Rep 5:10055. doi: 10.1038/srep10055. 2015
14NR4A1, RUNX3
The nuclear receptor nr4a1 controls CD8 T cell development through transcriptional suppression of runx3.
Nowyhed HN, Huynh TR, Blatchley A, Wu R, Thomas GD, Hedrick CC.
Sci Rep 5:9059. doi: 10.1038/srep09059. 2015
15NKX6-1, NR4A1, NR4A3
Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.
Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB.
Proc Natl Acad Sci U S A 111(14):5242-7. doi: 10.1073/pnas.1320953111. Epub 2014 Mar 24. 2014
16EDN1, NR4A1
Orphan nuclear receptor Nur77 is a novel negative regulator of endothelin-1 expression in vascular endothelial cells.
Qin Q, Chen M, Yi B, You X, Yang P, Sun J.
J Mol Cell Cardiol 77:20-8. doi: 10.1016/j.yjmcc.2014.09.027. Epub 2014 Oct 2. 2014
17NR4A1
The nuclear receptor Nr4a1 mediates anti-inflammatory effects of apoptotic cells.
Ipseiz N, Uderhardt S, Scholtysek C, Steffen M, Schabbauer G, Bozec A, Schett G, Krönke G.
J Immunol 192(10):4852-8. doi: 10.4049/jimmunol.1303377. Epub 2014 Apr 16. 2014
18NR4A1, NR4A2, NR4A3
Regulation of NR4A by nutritional status, gender, postnatal development and hormonal deficiency.
Pérez-Sieira S, López M, Nogueiras R, Tovar S.
Sci Rep 4:4264. doi: 10.1038/srep04264. 2014
19CRH, NR4A1, NR4A2, TYRP1, UCN
Involvement of Nurr-1/Nur77 in corticotropin-releasing factor/urocortin1-induced tyrosinase-related protein 1 gene transcription in human melanoma HMV-II cells.
Watanuki Y, Takayasu S, Kageyama K, Iwasaki Y, Sakihara S, Terui K, Nigawara T, Suda T.
Mol Cell Endocrinol 370(1-2):42-51. doi: 10.1016/j.mce.2013.01.022. Epub 2013 Feb 14. 2013
20NR4A1, SSR3
The orphan nuclear receptor TR3/Nur77 regulates ER stress and induces apoptosis via interaction with TRAPγ.
Chen HZ, Wen Q, Wang WJ, He JP, Wu Q.
Int J Biochem Cell Biol 45(8):1600-9. doi: 10.1016/j.biocel.2013.04.026. Epub 2013 May 6. 2013
21NR4A1, NR4A2, NR4A3
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis.
Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, Morita R, Kimura A, Ichinose H, Metzger D, Chambon P, Yoshimura A.
Nat Immunol 14(3):230-7. doi: 10.1038/ni.2520. Epub 2013 Jan 20. 2013
22NR4A1, NR4A2, NR4A3, PIN1
Dual function of Pin1 in NR4A nuclear receptor activation: enhanced activity of NR4As and increased Nur77 protein stability.
van Tiel CM, Kurakula K, Koenis DS, van der Wal E, de Vries CJ.
Biochim Biophys Acta 1823(10):1894-904. doi: 10.1016/j.bbamcr.2012.06.030. Epub 2012 Jul 10. 2012
23NR4A1, NR4A2
Differential roles for Nr4a1 and Nr4a2 in object location vs. object recognition long-term memory.
McNulty SE, Barrett RM, Vogel-Ciernia A, Malvaez M, Hernandez N, Davatolhagh MF, Matheos DP, Schiffman A, Wood MA.
Learn Mem 19(12):588-92. doi: 10.1101/lm.026385.112. 2012
24NR4A1, NR4A2, NR4A3
The Nuclear Orphan Receptors NR4A as Therapeutic Target in Cancer Therapy.
Deutsch AJ, Angerer H, Fuchs TE, Neumeister P.
Anticancer Agents Med Chem 12(9):1001-14. 2012
25NR4A1, NR4A2
Nuclear receptors Nur77 and Nurr1 modulate mesenchymal stromal cell migration.
Maijenburg MW, Gilissen C, Melief SM, Kleijer M, Weijer K, Ten Brinke A, Roelofs H, Van Tiel CM, Veltman JA, de Vries CJ, van der Schoot CE, Voermans C.
Stem Cells Dev 21(2):228-38. doi: 10.1089/scd.2011.0076. Epub 2011 Jun 1. 2012
26AR, NR4A1
Testicular steroidogenesis is locally regulated by androgen via suppression of Nur77.
Song CH, Gong EY, Park Js, Lee K.
Biochem Biophys Res Commun 422(2):327-32. doi: 10.1016/j.bbrc.2012.04.161. Epub 2012 May 7. 2012
27NR4A1, PIN1
Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis.
Chen HZ, Li L, Wang WJ, Du XD, Wen Q, He JP, Zhao BX, Li GD, Zhou W, Xia Y, Yang QY, Hew CL, Liou YC, Wu Q.
Oncogene 31(23):2876-87. doi: 10.1038/onc.2011.463. Epub 2011 Oct 17. 2012
28NR4A1
The orphan nuclear receptor Nur77 regulates decidual prolactin expression in human endometrial stromal cells.
Jiang Y, Hu Y, Zhao J, Zhen X, Yan G, Sun H.
Biochem Biophys Res Commun 404(2):628-33. Epub 2010 Dec 10. 2011
29NR4A1
Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells.
Wu H, Lin Y, Li W, Sun Z, Gao W, Zhang H, Xie L, Jiang F, Qin B, Yan T, Chen L, Zhao Y, Cao X, Wu Y, Lin B, Zhou H, Wong AS, Zhang XK, Zeng JZ.
FASEB J 25(1):192-205. Epub 2010 Sep 16. 2011
30GDNF, NR4A1
FSH acts on the proliferation of type A spermatogonia via Nur77 that increases GDNF expression in the Sertoli cells.
Ding LJ, Yan GJ, Ge QY, Yu F, Zhao X, Diao ZY, Wang ZQ, Yang ZZ, Sun HX, Hu YL.
FEBS Lett 585(15):2437-44. Epub 2011 Jun 30. 2011
31NR4A1, NR4A2, NR4A3
Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation.
Lundequist A, Calounova G, Wensman H, Rönnberg E, Pejler G.
Mol Immunol 48(15-16):1753-61. doi: 10.1016/j.molimm.2011.04.017. Epub 2011 May 31. 2011
32NR4A1, NR4A2, PRKDC
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair.
Malewicz M, Kadkhodaei B, Kee N, Volakakis N, Hellman U, Viktorsson K, Leung CY, Chen B, Lewensohn R, van Gent DC, Chen DJ, Perlmann T.
Genes Dev 25(19):2031-40. doi: 10.1101/gad.16872411. 2011
33FHL2, NR4A1
FHL2 protein is a novel co-repressor of nuclear receptor Nur77.
Kurakula K, van der Wal E, Geerts D, van Tiel CM, de Vries CJ.
J Biol Chem 286(52):44336-43. doi: 10.1074/jbc.M111.308999. Epub 2011 Nov 2. 2011
34APOA5, NR4A1
Orphan nuclear receptor Nur77 participates in human apolipoprotein A5 gene expression.
Song KH.
Biochem Biophys Res Commun 392(1):63-6. Epub 2010 Jan 7.PMID: 20059973 2010
35DAP3, NR4A1
Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction.
Tosa N, Iwai A, Tanaka T, Kumagai T, Nitta T, Chiba S, Maeda M, Takahama Y, Uede T, Miyazaki T.
Biochem Biophys Res Commun 395(3):356-60. Epub 2010 Apr 8.PMID: 20381457 2010
36CREB1, NR4A1, NR4A2, NR4A3
NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.
Volakakis N, Kadkhodaei B, Joodmardi E, Wallis K, Panman L, Silvaggi J, Spiegelman BM, Perlmann T.
Proc Natl Acad Sci U S A 107(27):12317-22. Epub 2010 Jun 21. 2010
37EP300, HDAC1, NR4A1
Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1.
Kang SA, Na H, Kang HJ, Kim SH, Lee MH, Lee MO.
Biochem Pharmacol 80(6):867-73. Epub 2010 May 11. 2010
38NR4A1
Regulation of vascular smooth muscle cell proliferation by nuclear orphan receptor Nur77.
Wang L, Gong F, Dong X, Zhou W, Zeng Q.
Mol Cell Biochem 341(1-2):159-66. Epub 2010 Apr 22. 2010
39NR4A1
Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia.
Novak G, Gallo A, Zai CC, Meltzer HY, Lieberman JA, Potkin SG, Voineskos AN, Remington G, Kennedy JL, Levesque D, Le Foll B.
Psychiatr Genet 20(1):39-43. 2010
40NR4A1
Expression of the nerve growth factor-induced gene B-beta in the developing rat brain and retina.
Li Y, Ohashi R, Naito M.
Arch Histol Cytol 72(1):23-34. 2009
41NR4A1
Phosphorylation of Nur77 by the MEK-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T cells.
Wang A, Rud J, Olson CM Jr, Anguita J, Osborne BA.
J Immunol 183(5):3268-77. Epub 2009 Aug 12. 2009
42NR4A1
The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression.
You B, Jiang YY, Chen S, Yan G, Sun J.
Circ Res 104(6):742-9. Epub 2009 Feb 12. 2009
43NR4A1, MC1R
Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells.
Smith AG, Luk N, Newton RA, Roberts DW, Sturm RA, Muscat GE.
J Biol Chem 283(18):12564-70. Epub 2008 Feb 21. 2008
44CAMK1, NR4A1
The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2+/calmodulin-dependent protein kinase I.
Martin LJ, Boucher N, Brousseau C, Tremblay JJ.
Mol Endocrinol 22(9):2021-37. Epub 2008 Jul 3. 2008
45NR4A1
Involvement of TR3/Nur77 translocation to the endoplasmic reticulum in ER stress-induced apoptosis.
Liang B, Song X, Liu G, Li R, Xie J, Xiao L, Du M, Zhang Q, Xu X, Gan X, Huang D.
Exp Cell Res 313(13):2833-44. Epub 2007 May 10. 2007
46GRIN3A, GRIN3B, NR4A1
Cross-talk between the NR3B and NR4A families of orphan nuclear receptors.
Lammi J, Rajalin AM, Huppunen J, Aarnisalo P.
Biochem Biophys Res Commun 359(2):391-7. Epub 2007 May 25. 2007
47NR4A1, NR4A2, NR4A3
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism.
Pei L, Waki H, Vaitheesvaran B, Wilpitz DC, Kurland IJ, Tontonoz P.
Nat Med 12(9):1048-55. Epub 2006 Aug 13. 2006
48NR4A1
A novel function of Nur77: physical and functional association with protein kinase C.
Kim H, Kim BY, Soh JW, Cho EJ, Liu JO, Youn HD.
Biochem Biophys Res Commun 348(3):950-6. Epub 2006 Aug 4. 2006
49NR4A1
Nur77 forms novel nuclear structures upon DNA damage that cause transcriptional arrest.
de LŽsŽleuc L, Denis F.
Exp Cell Res 312(9):1507-13. Epub 2006 Feb 14. 2006
50NR4A1, NR4A2
The orphan nuclear receptors NURR1 and NGFIB regulate adrenal aldosterone production.
Bassett MH, Suzuki T, Sasano H, White PC, Rainey WE.
Mol Endocrinol 18(2):279-90. Epub 2003 Nov 26. 2004
51NR4A1, PML
Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions.
Wu WS, Xu ZX, Ran R, Meng F, Chang KS.
Oncogene 21(24):3925-33. 2002
52AKT1, NR4A1
Akt phosphorylates and regulates the orphan nuclear receptor Nur77.
Pekarsky Y, Hallas C, Palamarchuk A, Koval A, Bullrich F, Hirata Y, Bichi R, Letofsky J, Croce CM.
Proc Natl Acad Sci U S A 98(7):3690-4. 2001
53NR4A1
LH induces orphan nuclear receptor Nur77 gene expression in testicular Leydig cells
Song KH, Park JI, Lee MO, Soh J, Lee K, Choi HS.
Endocrinology 142(12):5116-23. 2001
54CITED1, CITED2, MEF2A, NR4A1
Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis.
Youn HD, Chatila TA, Liu JO.
EMBO J 19(16):4323-31. 2000
55CABIN1, NR4A1
Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2.
Youn HD, Sun L, Prywes R, Liu JO.
Science 286(5440):790-3. 1999
56EGR3, FOS, NR4A1
A screen for genes induced in the suprachiasmatic nucleus by light.
Morris ME, Viswanathan N, Kuhlman S, Davis FC, Weitz CJ.
Science 279(5356):1544-7. 1998
57NR4A1
Cloning and sequence of a secretory protein induced by growth factors in mouse fibroblats.
Ryseck RP, et al.
Exp Cell Res 180 : 266-275. 1989
58NR4A1
Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily.
Chang C, et al.
J Steroid Biochem 34(1-6):391-5 1989
59NR4A1
Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor.
Ryseck RP, et al.
EMBO J 8(11):3327-35 1989