| 1 | CREB3, HCFC1, NR3C1
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| LUMAN/CREB3 is a key regulator of glucocorticoid-mediated stress responses.
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| Penney J, Mendell A, Zeng M, Tran K, Lymer J, Turner PV, Choleris E, MacLusky N, Lu R.
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| Mol Cell Endocrinol 439:95-104. doi: 10.1016/j.mce.2016.10.022.
2017
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| 2 | MDFIC, NR3C1
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| Cross-talk between the glucocorticoid receptor and MyoD family inhibitor domain-containing protein provides a new mechanism for generating tissue-specific responses to glucocorticoids.
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| Oakley RH, Busillo JM, Cidlowski JA.
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| J Biol Chem 292(14):5825-5844. doi: 10.1074/jbc.M116.758888. Epub 2017 Feb 21.
2017
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| 3 | NR1D1, NR3C1
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| REV-ERBα influences the stability and nuclear localization of the glucocorticoid receptor.
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| Okabe T, Chavan R, Fonseca Costa SS, Brenna A, Ripperger JA, Albrecht U.
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| J Cell Sci 129(21):4143-4154.
2016
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| 4 | ANGPTL4, FOXO1, NR3C1
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| Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin.
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| Kuo T, Chen TC, Yan S, Foo F, Ching C, McQueen A, Wang JC.
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| J Lipid Res 55(5):919-28. doi: 10.1194/jlr.M047860. Epub 2014 Feb 24.
2014
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| 5 | BUD23, NR3C1
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| The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer.
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| Jangani M, Poolman TM, Matthews L, Yang N, Farrow SN, Berry A, Hanley N, Williamson AJ, Whetton AD, Donn R, Ray DW.
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| J Biol Chem 289(13):8931-46. doi: 10.1074/jbc.M113.540906. Epub 2014 Jan 31.
2014
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| 6 | NR3C1
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| Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle.
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| Gupte R, Muse GW, Chinenov Y, Adelman K, Rogatsky I.
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| Proc Natl Acad Sci U S A 110(36):14616-21. doi: 10.1073/pnas.1309898110. Epub 2013 Aug 15.
2013
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| 7 | NR3C1, NR4A3
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| Control of energy balance by hypothalamic gene circuitry involving two nuclear receptors, neuron-derived orphan receptor 1 and glucocorticoid receptor.
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| Kim SG, Lee B, Kim DH, Kim J, Lee S, Lee SK, Lee JW.
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| Mol Cell Biol 33(19):3826-34. doi: 10.1128/MCB.00385-13. Epub 2013 Jul 29.
2013
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| 8 | AGRP, BSX, NR3C1
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| Brain-specific homeobox factor as a target selector for glucocorticoid receptor in energy balance.
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| Lee B, Kim SG, Kim J, Choi KY, Lee S, Lee SK, Lee JW.
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| Mol Cell Biol 33(14):2650-8. doi: 10.1128/MCB.00094-13. Epub 2013 May 13.
2013
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| 9 | NR3C1
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| Glucocorticoid receptor is required for foetal heart maturation.
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| Rog-Zielinska EA, Thomson A, Kenyon CJ, Brownstein DG, Moran CM, Szumska D, Michailidou Z, Richardson J, Owen E, Watt A, Morrison H, Forrester LM, Bhattacharya S, Holmes MC, Chapman KE.
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| Hum Mol Genet 22(16):3269-82. doi: 10.1093/hmg/ddt182. Epub 2013 Apr 16.
2013
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| 10 | NR3C1
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| Glucocorticoid receptor protein expression in human hippocampus; stability with age.
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| Wang Q, Van Heerikhuize J, Aronica E, Kawata M, Seress L, Joels M, Swaab DF, Lucassen PJ.
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| Neurobiol Aging 34(6):1662-73. doi: 10.1016/j.neurobiolaging.2012.11.019. Epub 2013 Jan 3.
2013
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| 11 | NR3C1
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| Endothelial glucocorticoid receptor is required for protection against sepsis.
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| Goodwin JE, Feng Y, Velazquez H, Sessa WC.
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| Proc Natl Acad Sci U S A 110(1):306-11. doi: 10.1073/pnas.1210200110. Epub 2012 Dec 17.
2013
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| 12 | HNF4A, NR3C1, SLC22A1
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| Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α upregulation in primary human hepatocytes.
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| Rulcova A, Krausova L, Smutny T, Vrzal R, Dvorak Z, Jover R, Pavek P.
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| Pharmacol Rep 65(5):1322-35.
2013
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| 13 | FOXA1, NR3C1
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| FoxA1 and glucocorticoid receptor crosstalk via histone H4K16 acetylation at a hormone regulated enhancer.
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| Belikov S, Holmqvist PH, Astrand C, Wrange Ö.
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| Exp Cell Res 318(1):61-74. doi: 10.1016/j.yexcr.2011.09.016. Epub 2011 Oct 6.
2012
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| 14 | FOXO3, NR3C1
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| FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop.
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| Lützner N, Kalbacher H, Krones-Herzig A, Rösl F.
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| PLoS One 7(7):e42166. doi: 10.1371/journal.pone.0042166. Epub 2012 Jul 27.
2012
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| 15 | GSK3B, NR3C1
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| Glycogen synthase kinase-3β is involved in ligand-dependent activation of transcription and cellular localization of the glucocorticoid receptor.
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| Rubio-Patińo C, Palmeri CM, Pérez-Perarnau A, Cosialls AM, Moncunill-Massaguer C, González-Girončs DM, Pons-Hernández L, López JM, Ventura F, Gil J, Pons G, Iglesias-Serret D.
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| Mol Endocrinol 26(9):1508-20. doi: 10.1210/me.2011-1366. Epub 2012 Jul 6.
2012
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| 16 | MEF2A, NR3C1
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| Glucocorticoid receptor and myocyte enhancer factor 2 cooperate to regulate the expression of c-JUN in a neuronal context.
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| Speksnijder N, Christensen KV, Didriksen M, De Kloet ER, Datson NA.
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| J Mol Neurosci 48(1):209-18. doi: 10.1007/s12031-012-9809-2. Epub 2012 May 24.
2012
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| 17 | NCOA2, NR3C1
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| Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid receptor is accompanied by conformational reorganizations.
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| Khan SH, Awasthi S, Guo C, Goswami D, Ling J, Griffin PR, Simons SS Jr, Kumar R.
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| J Biol Chem 287(53):44546-60. doi: 10.1074/jbc.M112.411330. Epub 2012 Nov 6.
2012
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| 18 | GPR50, KAT5, NR3C1
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| GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling.
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| Li J, Hand LE, Meng QJ, Loudon AS, Bechtold DA.
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| PLoS One 6(8):e23725. doi: 10.1371/journal.pone.0023725. Epub 2011 Aug 17.
2011
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| 19 | NR3C1
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| Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes.
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| Rao NA, McCalman MT, Moulos P, Francoijs KJ, Chatziioannou A, Kolisis FN, Alexis MN, Mitsiou DJ, Stunnenberg HG.
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| Genome Res 21(9):1404-16. doi: 10.1101/gr.118042.110. Epub 2011 Jul 12.
2011
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| 20 | NR3C1
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| A novel point mutation in helix 10 of the human glucocorticoid receptor causes generalized glucocorticoid resistance by disrupting the structure of the ligand-binding domain.
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| Nader N, Bachrach BE, Hurt DE, Gajula S, Pittman A, Lescher R, Kino T.
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| J Clin Endocrinol Metab 95(5):2281-5. Epub 2010 Mar 24.PMID: 20335448 2010
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| 21 | NR3C1
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| Human glucocorticoid receptor alpha gene (NR3C1) pharmacogenomics: gene resequencing and functional genomics.
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| Niu N, Manickam V, Kalari KR, Moon I, Pelleymounter LL, Eckloff BW, Wieben ED, Schaid DJ, Wang L.
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| J Clin Endocrinol Metab 94(8):3072-84. Epub 2009 May 12.
2009
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| 22 | NR3C1
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| Human glucocorticoid receptor isoform beta: recent understanding of its potential implications in physiology and pathophysiology.
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| Kino T, Su YA, Chrousos GP.
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| Cell Mol Life Sci 66(21):3435-48. Epub 2009 Jul 26. Review.PMID: 19633971 2009
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| 23 | ANGPTL4, NR3C1
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| Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.
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| Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV Jr, Wang JC.
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| J Biol Chem 284(38):25593-601. Epub 2009 Jul 23.PMID: 19628874 2009
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| 24 | NR3C1
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| Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells.
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| Stellacci E, Di Noia A, Di Baldassarre A, Migliaccio G, Battistini A, Migliaccio AR.
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| Exp Hematol 37(5):559-72.PMID: 19375647 2009
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| 25 | NR3C1
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| DNA binding site sequence directs glucocorticoid receptor structure and activity.
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| Meijsing SH, Pufall MA, So AY, Bates DL, Chen L, Yamamoto KR.
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| Science 324(5925):407-10.PMID: 19372434 2009
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| 26 | NR3C1
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| Mutation screen and association analysis of the glucocorticoid receptor gene (NR3C1) in childhood-onset mood disorders (COMD).
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| Mill J, Wigg K, Burcescu I, Vetró A, Kiss E, Kapornai K, Tamás Z, Baji I, Gádoros J, Kennedy JL, Kovacs M, Barr CL; International Consortium for Childhood-Onset Mood Disorders.
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| Am J Med Genet B Neuropsychiatr Genet 150B(6):866-73.PMID: 19089807 2009
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| 27 | NR3C1, NUP62
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| Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta.
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| Echeverría PC, Mazaira G, Erlejman A, Gomez-Sanchez C, Piwien Pilipuk G, Galigniana MD.
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| Mol Cell Biol 29(17):4788-97. Epub 2009 Jul 6.
2009
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| 28 | HEXIM1, NR3C1
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| Role of the hinge region of glucocorticoid receptor for HEXIM1-mediated transcriptional repression.
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| Yoshikawa N, Shimizu N, Sano M, Ohnuma K, Iwata S, Hosono O, Fukuda K, Morimoto C, Tanaka H.
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| Biochem Biophys Res Commun 371(1):44-9. Epub 2008 Apr 11. 2008
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| 29 | BCL2, DLEC1, HOXA1, HOXA10, KL, NR3C1, SEZ6L, SFRP4, SFRP5, SMAD9, TWIST1
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| DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis.
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| Kang GH, Lee S, Cho NY, Gandamihardja T, Long TI, Weisenberger DJ, Campan M, Laird PW.
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| Lab Invest 88(2):161-70. Epub 2007 Dec 24.
2008
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| 30 | NR3C1, SKA2
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| Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor.
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| Rice L, Waters CE, Eccles J, Garside H, Sommer P, Kay P, Blackhall FH, Zeef L, Telfer B, Stratford I, Clarke R, Singh D, Stevens A, White A, Ray DW.
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| J Endocrinol 198(3):499-509. Epub 2008 Jun 26.PMID: 18583474 2008
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| 31 | NR3C1
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| Glucocorticoid receptor phosphorylation differentially affects target gene expression.
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| Chen W, Dang T, Blind RD, Wang Z, Cavasotto CN, Hittelman AB, Rogatsky I, Logan SK, Garabedian MJ.
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| Mol Endocrinol 22(8):1754-66. Epub 2008 May 15.PMID: 18483179 2008
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| 32 | NR3C1
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| Proteasome activity modulates chromatin modifications and RNA polymerase II phosphorylation to enhance glucocorticoid receptor-mediated transcription.
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| Kinyamu HK, Archer TK.
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| Mol Cell Biol 27(13):4891-904. Epub 2007 Apr 16. 2007
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| 33 | NR3C1, GRL
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| A novel point mutation in helix 11 of the ligand-binding domain of the human glucocorticoid receptor gene causing generalized glucocorticoid resistance.
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| Charmandari E, Kino T, Ichijo T, Jubiz W, Mejia L, Zachman K, Chrousos GP.
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| J Clin Endocrinol Metab 92(10):3986-90. Epub 2007 Jul 17. 2007
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| 34 | NCOA2, NR3C1, TTLL5
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| STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression.
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| He Y, Simons SS Jr.
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| Mol Cell Biol 27(4):1467-85. Epub 2006 Nov 20.
2007
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| 35 | NR3C1, PMF1
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| Polyamine-modulated factor 1 represses glucocorticoid receptor activity.
|
| Shoji Y, Osman W, Zilliacus J.
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| Biochem Biophys Res Commun 361(1):176-81. Epub 2007 Jul 16.
2007
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| 36 | ADAMTS1, CRABP1, NR3C1
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| ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis.
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| Lind GE, Kleivi K, Meling GI, Teixeira MR, Thiis-Evensen E, Rognum TO, Lothe RA.
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| Cell Oncol 28(5-6):259-72. 2006
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| 37 | NR3C1, RARB, THRA
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| Spatial and temporal expression of glucocorticoid, retinoid, and thyroid hormone receptors is not altered in lungs of congenital diaphragmatic hernia.
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| Rajatapiti P, Keijzer R, Blommaart PE, Lamers WH, DE Krijger RR, Visser TJ, Tibboel D, Rottier R.
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| Pediatr Res 60(6):693-8. Epub 2006 Oct 25. 2006
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| 38 | NR3C1
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| Functional analysis of the LXXLL motifs of the human glucocorticoid receptor: association with altered ligand affinity.
|
| Dong DD, Jewell CM, Bienstock RJ, Cidlowski JA.
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| J Steroid Biochem Mol Biol 101(2-3):106-17. Epub 2006 Aug 17. 2006
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| 39 | NR3C1
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| Genetic variations of the NR3C1 gene in children with sporadic nephrotic syndrome.
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| Ye J, Yu Z, Ding J, Chen Y, Huang J, Yao Y, Xiao H, Yang J, Shen Y, Meng Q.
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| Biochem Biophys Res Commun 348(2):507-13. Epub 2006 Jul 28. 2006
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| 40 | NR3C1
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| Overrepresentation of the N363S variant of the glucocorticoid receptor gene in patients with bilateral adrenal incidentalomas.
|
| Majnik J, Patocs A, Balogh K, Toth M, Gergics P, Szappanos A, Mondok A, Borgulya G, Panczel P, Prohaszka Z, Racz K.
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| J Clin Endocrinol Metab 91(7):2796-9. Epub 2006 Apr 24. 2006
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| 41 | NR3C1
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| The glucocorticoid receptor N363S polymorphism and steroid response in Duchenne dystrophy.
|
| Bonifati DM, Witchel SF, Ermani M, Hoffman EP, Angelini C, Pegoraro E.
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| J Neurol Neurosurg Psychiatry 77(10):1177-9. 2006
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| 42 | NR3C1
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| Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1.
|
| Turner JD, Muller CP.
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| J Mol Endocrinol 35(2):283-92. 2005
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| 43 | GNB2, NR3C1
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| G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus.
|
| Kino T, Tiulpakov A, Ichijo T, Chheng L, Kozasa T, Chrousos GP.
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| J Cell Biol 169(6):885-96. Epub 2005 Jun 13. 2005
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| 44 | NR3C1, SMARCA4, SMARCC1, SMARCC2, SMARCD1, SMARCE1
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| BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation.
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| Hsiao PW, Fryer CJ, Trotter KW, Wang W, Archer TK.
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| Mol Cell Biol 23(17):6210-20. 2003
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| 45 | DAP3, NR3C1
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| Functional interaction between the pro-apoptotic DAP3 and the glucocorticoid receptor.
|
| Hulkko SM, Zilliacus J.
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| Biochem Biophys Res Commun 295(3):749-55. 2002
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| 46 | NR3C1
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| Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation.
|
| Itoh M, Adachi M, Yasui H, Takekawa M, Tanaka H, Imai K.
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| Mol Endocrinol 16(10):2382-92.PMID: 12351702 2002
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| 47 | NR3C1
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| Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety.
|
| Tronche F, et al.
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| Nat Genet 23(1):99-103 1999
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| 48 | NR3C1
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| Inhibition by insulin of glucocorticoid-induced gene transcription: involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways.
|
| Pierreux CE, et al.
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| Mol Endocrinol 12(9):1343-54 1998
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| 49 | NR3C1
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| Familial glucocorticoid resistance caused by a splice site deletion in the human glucocorticoid receptor gene.
|
| Karl M, et al.
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| J Clin Endocrinol Metab 76 : 683-689. 1993
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| 50 | NR3C1, GRL
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| A mutation of the glucocorticoid receptor in primary cortisol resistance.
|
| Malchoff DM, et al.
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| J Clin Invest 91 : 1918-1925. 1993
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| 51 | ESR1, ESR2, ESRRA, ESRRB, ESRRG, NR3C1
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| The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements.
|
| Schwabe JW, et al.
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| Cell 75(3):567-78 1993
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| 52 | NR3C1
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| A TthIII1 polymorphism on the 5' flanking region of glucocorticoid receptor gene (GRL).
|
| Detera-Wadleigh SD, et al.
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| Nucleic Acids Res 19 : 1960. 1991
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| 53 | NR3C1, DRD1, GRL
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| Physical linkage of glucocorticoid receptor (GRL) and dopamine D1 receptor (DRD1) on the long arm of chromosome 5.
|
| Boultwood J, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 1894. 1991
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| 54 | NR3C1, GRL
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| Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial clucocorticoid resistance.
|
| Hurley DM, et al.
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| J Clin Invest 87 : 680-686. 1991
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| 55 | NR3C1
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| A glucocorticoid receptor mutation in a subject with primary cortisol resistance.
|
| Brufsky AM, et al.
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| Trans Assoc Am Physicians 103 : 53-63. 1990
|
| 56 | NR3C1
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| The glucocorticoid receptor gene is in 5q31-q32.
|
| Francke U, Foellmer BE.
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| Genomics 4 : 610-612. 1989
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| 57 | NR3C1
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| Regional chromosomal assignment of the human glucocorticoid receptor gene to 5q31.
|
| Theriault A, et al.
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| Hum Genet 83 : 289-291. 1989
|
| 58 | NR3C1
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| Glucocorticoid receptor maps to the distal long arm of chromosome 5.
|
| Giuffra LA, Kennedy JL, Castiglione CM, Evans RM, Wasmuth JJ, Kidd KK.
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| Cytogenet Cell Genet 49 : 313-314. 1988
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| 59 | NR3C1, EGFR, GRL
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| RFLPs for the glucocorticoid receptor (GRL) on chromosome 5 and the epidermal growth factor receptor (EGFR) on chromosome 7.
|
| Smith R, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 695. 1987
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| 60 | NR3C1, GRL
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| RFLP for the glucocorticoid receptor (GRL) located at 5q11-5q13.
|
| Murray JC, et al.
|
| Nucleic Acids Res 15 : 6765. 1987
|
| 61 | NR3C1, NR3C1P
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| Primary structure and expression of functional human glucocorticoid receptor cDNA.
|
| Hollenberg SM, Weinberger C, Ong ES, Cerelli G, Oro A, Lebo R, Thompson EB, Rosenfeld MG, Evans RM.
|
| Nature 318 : 635-641. 1985
|
| 62 | NR3C1, GRL
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| Chromosome assignment of the human gene for glucocorticoid receptor (GRL).
|
| Gehring U, et al.
|
| (HGM7) Cytogenet Cell Genet 37 : 476. 1984
|
| 63 | NR3C1, GRL
|
| Primary cortisol resistance in man. A glucocorticoid receptor-mediated disease.
|
| Chrousos GP, Vingerhoeds A, Brandon D, Eil C, Pugeat M, DeVroede M, Loriaux DL, Lipsett MB.
|
| J Clin Invest 69 : 1261-1269. 1982
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| 64 | NR3C1
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| Spontaneous hypercortisolism without Cushing's syndrome.
|
| Vingerhoeds ACM, et al.
|
| J Clin Endocrinol Metab 43 : 1128-1133. 1976
|