Citations for
1NR2F2, VCHD
Loss of Function of the Nuclear Receptor NR2F2, Encoding COUP-TF2, Causes Testis Development and Cardiac Defects in 46,XX Children.
Bashamboo A, Eozenou C, Jorgensen A, Bignon-Topalovic J, Siffroi JP, Hyon C, Tar A, Nagy P, Sólyom J, Halász Z, Paye-Jaouen A, Lambert S, Rodriguez-Buritica D, Bertalan R, Martinerie L, Rajpert-De Meyts E, Achermann JC, McElreavey K.
Am J Hum Genet 102(3):487-493. doi: 10.1016/j.ajhg.2018.01.021. Epub 2018 Feb 22. 2018
2FGF2, NR2F2
FGF2 Stimulates COUP-TFII Expression via the MEK1/2 Pathway to Inhibit Osteoblast Differentiation in C3H10T1/2 Cells.
Lee MN, Kim JW, Oh SH, Jeong BC, Hwang YC, Koh JT.
PLoS One 11(7):e0159234. doi: 10.1371/journal.pone.0159234. eCollection 2016. 2016
3NR2F2
Rare Variants in NR2F2 Cause Congenital Heart Defects in Humans.
Al Turki S, Manickaraj AK, Mercer CL, Gerety SS, Hitz MP, Lindsay S, D'Alessandro LC, Swaminathan GJ, Bentham J, Arndt AK, Low J, Breckpot J, Gewillig M, Thienpont B, Abdul-Khaliq H, Harnack C, Hoff K, Kramer HH, Schubert S, Siebert R, Toka O, Cosgrove C, Watkins H, Lucassen AM, O'Kelly IM, Salmon AP, Bu'lock FA, Granados-Riveron J, Setchfield K, Thornborough C, Brook JD, Mulder B, Klaassen S, Bhattacharya S, Devriendt K, Fitzpatrick DF; UK10K Consortium, Wilson DI, Mital S, Hurles ME.
Am J Hum Genet 94(4):574-85. doi: 10.1016/j.ajhg.2014.03.007. 2014
4CYP7A1, NR2F2
The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII.
Yamazaki T, Suehiro J, Miyazaki H, Minami T, Kodama T, Miyazono K, Watabe T.
Biochem J 452(2):345-57. doi: 10.1042/BJ20121200. 2013
5NR2F2, SMAD4, TGFB1
COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.
Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, Ittmann MM, Tsai SJ, Tsai MJ, Tsai SY.
Nature 493(7431):236-40. doi: 10.1038/nature11674. Epub 2012 Nov 28. 2013
6DIH1, DIH2, GATA4, NR2F2
A family-based paradigm to identify candidate chromosomal regions for isolated congenital diaphragmatic hernia.
Arrington CB, Bleyl SB, Matsunami N, Bowles NE, Leppert TI, Demarest BL, Osborne K, Yoder BA, Byrne JL, Schiffman JD, Null DM, Digeronimo R, Rollins M, Faix R, Comstock J, Camp NJ, Leppert MF, Yost HJ, Brunelli L.
Am J Med Genet A 158A(12):3137-47. doi: 10.1002/ajmg.a.35664. Epub 2012 Nov 19. 2012
7EYA1, NR2F2, WT1
COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival.
Yu CT, Tang K, Suh JM, Jiang R, Tsai SY, Tsai MJ.
Development 139(13):2330-9. doi: 10.1242/dev.076299. 2012
8DEL15QD, NR2F2
5.78 Mb terminal deletion of chromosome 15q in a girl, evaluation of NR2F2 as candidate gene for congenital heart defects.
Nakamura E, Makita Y, Okamoto T, Nagaya K, Hayashi T, Sugimoto M, Manabe H, Taketazu G, Kajino H, Fujieda K.
Eur J Med Genet 54(3):354-6. Epub 2010 Dec 21. 2011
9NR2F2, NTS
Characterization of promoter elements regulating the expression of the human neurotensin/neuromedin N gene.
Wang X, Gulhati P, Li J, Dobner PR, Weiss H, Townsend CM Jr, Evers BM.
J Biol Chem 286(1):542-54. Epub 2010 Oct 28. 2011
10CYP3A4, NR1I2, NR2F1, NR2F2, THRA, THRB
Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding.
Istrate MA, Nussler AK, Eichelbaum M, Burk O.
Biochem Biophys Res Commun 393(4):688-93. Epub 2010 Feb 18.PMID: 20171174 2010
11NR2F2
COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis.
Qin J, Chen X, Xie X, Tsai MJ, Tsai SY.
Proc Natl Acad Sci U S A 107(8):3687-92. Epub 2010 Feb 3. 2010
12NR2F1, NR2F2
COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis.
Tang K, Xie X, Park JI, Jamrich M, Tsai S, Tsai MJ.
Development 137(5):725-34.PMID: 20147377 2010
13NR2F1, NR2F2
COUP-TFI and -TFII nuclear receptors are expressed in amacrine cells and play roles in regulating the differentiation of retinal progenitor cells.
Inoue M, Iida A, Satoh S, Kodama T, Watanabe S.
Exp Eye Res 90(1):49-56. Epub 2009 Sep 17.PMID: 19766631 2010
14NR2F2, PROX1
COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction.
Yamazaki T, Yoshimatsu Y, Morishita Y, Miyazono K, Watabe T.
Genes Cells 14(3):425-34. Epub 2009 Feb 4.PMID: 19210544 2009
15NR2F2, PROX1
Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate.
Lee S, Kang J, Yoo J, Ganesan SK, Cook SC, Aguilar B, Ramu S, Lee J, Hong YK.
Blood 113(8):1856-9. Epub 2008 Sep 24.PMID: 18815287 2009
16NR2F2
Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency.
Petit FG, Jamin SP, Kurihara I, Behringer RR, DeMayo FJ, Tsai MJ, Tsai SY.
Proc Natl Acad Sci U S A 104(15):6293-8. Epub 2007 Apr 2. 2007
17NR2F2
Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.
You LR, Lin FJ, Lee CT, DeMayo FJ, Tsai MJ, Tsai SY.
Nature 435(7038):98-104. 2005
18NR0B1, NR2F2, NR5A1
Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle.
Sato Y, Suzuki T, Hidaka K, Sato H, Ito K, Ito S, Sasano H.
J Clin Endocrinol Metab 88(7):3415-20. 2003
19CYP11A1, CYP11B1, CYP11B2, CYP17A1D, CYP19A1, GATA4, NR0B1, NR2F1, NR2F2, NR5A1, PCNA, COPS2
DAX1 and its network partners: exploring complexity in development.
Clipsham R, McCabe ER.
Mol Genet Metab 80(1-2):81-120. 2003
20NR2F2
The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development.
Pereira FA, et al.
Genes Dev 13(8):1037-49 1999
21MYOD1, NR2F2
The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function : COUP-TF II directly interacts with p300 and MyoD.
Bailey P, Sartorelli V, Hamamori Y, Muscat GE.
Nucleic Acids Res 26(23):5501-10. 1998
22NR2F1, NR2F2
Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes.
Qiu Y, et al.
Genomics 29 : 240-246. 1995
23NR2F2
Chromosomal localization of the ARP-1 gene to 15q26.
Modi WS, et al.
(HGM11) Cytogenet Cell Genet 58 : 1995. 1991
24NR2F2
Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily.
Ladias JAA, et al.
Science 251 : 561-565. 1991