| 1 | NR2F1, PTEN
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| PTEN decreases NR2F1 expression to inhibit ciliogenesis during EGFRL858R-induced lung cancer progression.
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| Tran TTT, Hung JJ.
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| Cell Death Dis. Mar 18;15(3):225. doi: 10.1038/s41419-024-06610-z. 2024
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| 2 | NR2F1, OAID
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| NR2F1 shapes mitochondria in the mouse brain, providing new insights into Bosch-Boonstra-Schaaf optic atrophy syndrome.
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| Bonzano S, Dallorto E, Molineris I, Michelon F, Crisci I, Gambarotta G, Neri F, Oliviero S, Beckervordersandforth R, Lie DC, Peretto P, Bovetti S, Studer M, De Marchis S.
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| Dis Model Mech. Jun 1;16(6):dmm049854. doi: 10.1242/dmm.049854. Epub 2023 Jun 26. 2023
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| 3 | NR2F1
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| NR2F1 Is a Barrier to Dissemination of Early-Stage Breast Cancer Cells.
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| Rodriguez-Tirado C, Kale N, Carlini MJ, Shrivastava N, Rodrigues AA, Khalil BD, Bravo-Cordero JJ, Hong Y, Alexander M, Ji J, Behbod F, Sosa MS.
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| Cancer Res. Jun 15;82(12):2313-2326. doi: 10.1158/0008-5472.CAN-21-4145. 2022
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| 4 | NR2F1
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| NR2F1 regulates a Schwann cell precursor-vs-melanocyte cell fate switch in a mouse model of Waardenburg syndrome type IV.
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| Bonnamour G, Charrier B, Sallis S, Leduc E, Pilon N.
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| Pigment Cell Melanoma Res. Sep;35(5):506-516. doi: 10.1111/pcmr.13054. Epub 2022 Jul 16. 2022
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| 5 | NR2F1
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| Structural and Functional Aspects of the Neurodevelopmental Gene NR2F1: From Animal Models to Human Pathology.
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| Tocco C, Bertacchi M, Studer M.
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| Front Mol Neurosci. Dec 15;14:767965. doi: 10.3389/fnmol.2021.767965. 2021
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| 6 | NR2F1
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| COUP-TFI/Nr2f1 Orchestrates Intrinsic Neuronal Activity during Development of the Somatosensory Cortex.
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| Leinekugel X, Frick A, Studer M.
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| Cereb Cortex. Oct 1;30(11):5667-5685. doi: 10.1093/cercor/bhaa137. 2020
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| 7 | NR2F1, OAID
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| Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.
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| Chen CA, Wang W, Pedersen SE, Raman A, Seymour ML, Ruiz FR, Xia A, van der Heijden ME, Wang L, Yin J, Lopez J, Rech ME, Lewis RA, Wu SM, Liu Z, Pereira FA, Pautler RG, Zoghbi HY, Schaaf CP.
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| Hum Mol Genet. Mar 27;29(5):705-715. doi: 10.1093/hmg/ddz233. 2020
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| 8 | BMP2, NR2F1
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| NR2F1 mediated down-regulation of osteoblast differentiation was rescued by bone morphogenetic protein-2 (BMP-2) in human MSC.
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| Manikandan M, Abuelreich S, Elsafadi M, Alsalman H, Almalak H, Siyal A, Hashmi JA, Aldahmash A, Kassem M, Alfayez M, Mahmood A.
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| Differentiation. Nov-Dec;104:36-41. doi: 10.1016/j.diff.2018.10.003. Epub 2018 Oct 29. 2018
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| 9 | CXCR4, NR2F1
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| COUP-TFI mitotically regulates production and migration of dentate granule cells and modulates hippocampal Cxcr4 expression.
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| Parisot J, Flore G, Bertacchi M, Studer M.
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| Development. Jun 1;144(11):2045-2058. doi: 10.1242/dev.139949. Epub 2017 May 15. 2017
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| 10 | NR2F1, OAID
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| NR2F1 Mutations Cause Optic Atrophy with Intellectual Disability.
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| Bosch DG, Boonstra FN, Gonzaga-Jauregui C, Xu M, de Ligt J, Jhangiani S, Wiszniewski W, Muzny DM, Yntema HG, Pfundt R, Vissers LE, Spruijt L, Blokland EA, Chen CA; Baylor-Hopkins Center for Mendelian Genomics, Lewis RA, Tsai SY, Gibbs RA, Tsai MJ, Lupski JR, Zoghbi HY, Cremers FP, de Vries BB, Schaaf CP.
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| Am J Hum Genet 94(2):303-9. doi: 10.1016/j.ajhg.2014.01.002. Epub 2014 Jan 23.
2014
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| 11 | NR2F1, OAID
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| NR2F1 Mutations Cause Optic Atrophy with Intellectual Disability.
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| Bosch DG, Boonstra FN, Gonzaga-Jauregui C, Xu M, de Ligt J, Jhangiani S, Wiszniewski W, Muzny DM, Yntema HG, Pfundt R, Vissers LE, Spruijt L, Blokland EA, Chen CA; Baylor-Hopkins Center for Mendelian Genomics, Lewis RA, Tsai SY, Gibbs RA, Tsai MJ, Lupski JR, Zoghbi HY, Cremers FP, de Vries BB, Schaaf CP.
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| Am J Hum Genet 94(2):303-9. doi: 10.1016/j.ajhg.2014.01.002. Epub 2014 Jan 23.
2014
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| 12 | NR2F1, OAID
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| NR2F1 haploinsufficiency is associated with optic atrophy, dysmorphism and global developmental delay.
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| Al-Kateb H, Shimony JS, Vineyard M, Manwaring L, Kulkarni S, Shinawi M.
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| Am J Med Genet A 161A(2):377-81. doi: 10.1002/ajmg.a.35650. Epub 2013 Jan 8. No abstract available.
2013
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| 13 | HOXA5, NR2F1
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| Polycomb recruitment attenuates retinoic acid-induced transcription of the bivalent NR2F1 gene.
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| Laursen KB, Mongan NP, Zhuang Y, Ng MM, Benoit YD, Gudas LJ.
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| Nucleic Acids Res 41(13):6430-43. doi: 10.1093/nar/gkt367. Epub 2013 May 10.
2013
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| 14 | NR2F1
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| COUP-TFI controls activity-dependent tyrosine hydroxylase expression in adult dopaminergic olfactory bulb interneurons.
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| Bovetti S, Bonzano S, Garzotto D, Giannelli SG, Iannielli A, Armentano M, Studer M, De Marchis S.
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| Development 140(24):4850-9. doi: 10.1242/dev.089961. Epub 2013 Nov 13.
2013
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| 15 | NR2F1
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| CoupTFI interacts with retinoic acid signaling during cortical development.
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| Harrison-Uy SJ, Siegenthaler JA, Faedo A, Rubenstein JL, Pleasure SJ.
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| PLoS One 8(3):e58219. doi: 10.1371/journal.pone.0058219. Epub 2013 Mar 5. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/f9bd989 2013
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| 16 | CYP26A1, HOXA1, NR2F1
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| Role of COUP-TFI during retinoic acid-induced differentiation of P19 cells to endodermal cells.
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| Pickens BS, Teets BW, Soprano KJ, Soprano DR.
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| J Cell Physiol 228(4):791-800. doi: 10.1002/jcp.24228.
2013
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| 17 | MTTP, NR2F1
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| NR2F1 disrupts synergistic activation of the MTTP gene transcription by HNF-4α and HNF-1α.
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| Dai K, Hussain MM.
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| J Lipid Res 53(5):901-8. doi: 10.1194/jlr.M025130. Epub 2012 Feb 22.
2012
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| 18 | NR2F1, RND2
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| COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression.
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| Alfano C, Viola L, Heng JI, Pirozzi M, Clarkson M, Flore G, De Maio A, Schedl A, Guillemot F, Studer M.
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| Development. 138(21):4685-97. 2011
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| 19 | NR2F1
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| Thyroid hormone and COUP-TF1 regulate kallikrein-binding protein (KBP) gene expression.
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| Liu YY, Nakatani T, Kogai T, Mody K, Brent GA.
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| Endocrinology 152(3):1143-53. doi: 10.1210/en.2010-0580. Epub 2011 Jan 25.
2011
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| 20 | CYP3A4, NR1I2, NR2F1, NR2F2, THRA, THRB
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| Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding.
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| Istrate MA, Nussler AK, Eichelbaum M, Burk O.
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| Biochem Biophys Res Commun 393(4):688-93. Epub 2010 Feb 18.PMID: 20171174 2010
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| 21 | NR2F1, NR2F2
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| COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis.
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| Tang K, Xie X, Park JI, Jamrich M, Tsai S, Tsai MJ.
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| Development 137(5):725-34.PMID: 20147377 2010
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| 22 | NR2F1
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| Area-specific temporal control of corticospinal motor neuron differentiation by COUP-TFI.
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| Tomassy GS, De Leonibus E, Jabaudon D, Lodato S, Alfano C, Mele A, Macklis JD, Studer M.
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| Proc Natl Acad Sci U S A 107(8):3576-81. Epub 2010 Feb 2.PMID: 20133588 2010
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| 23 | NR2F1, NR2F2
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| COUP-TFI and -TFII nuclear receptors are expressed in amacrine cells and play roles in regulating the differentiation of retinal progenitor cells.
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| Inoue M, Iida A, Satoh S, Kodama T, Watanabe S.
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| Exp Eye Res 90(1):49-56. Epub 2009 Sep 17.PMID: 19766631 2010
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| 24 | ERN2, MTTP, NR2F1
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| NR2F1 and IRE1beta suppress microsomal triglyceride transfer protein expression and lipoprotein assembly in undifferentiated intestinal epithelial cells.
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| Dai K, Khatun I, Hussain MM.
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| Arterioscler Thromb Vasc Biol 30(3):568-74. doi: 10.1161/ATVBAHA.109.198135. Epub 2009 Dec 10.
2010
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| 25 | NR2F1, TNFAIP8
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| A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8).
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| Zhang LJ, Liu X, Gafken PR, Kioussi C, Leid M.
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| J Biol Chem 284(10):6156-68. Epub 2008 Dec 26.
2009
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| 26 | NR2F1
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| COUP-TFI modulates estrogen signaling and influences proliferation, survival and migration of breast cancer cells.
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| Le Dily F, Métivier R, Guéguen MM, Le Péron C, Flouriot G, Tas P, Pakdel F.
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| Breast Cancer Res Treat 110(1):69-83. Epub 2007 Aug 3.
2008
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| 27 | NR2F1
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| COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.
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| Faedo A, Tomassy GS, Ruan Y, Teichmann H, Krauss S, Pleasure SJ, Tsai SY, Tsai MJ, Studer M, Rubenstein JL.
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| Cereb Cortex 18(9):2117-31. Epub 2007 Dec 28.PMID: 18165280 2008
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| 28 | NR2F1
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| Genotype-dependent activation or repression of HBV enhancer II by transcription factor COUP-TF1.
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| Fischer SF, Schmidt K, Fiedler N, Glebe D, Schüttler C, Sun J, Gerlich WH, Repp R, Schaefer S.
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| World J Gastroenterol 12(37):6054-8.
2006
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| 29 | NR2F1
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| COUP-TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth.
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| Armentano M, Filosa A, Andolfi G, Studer M.
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| Development 133(21):4151-62. Epub 2006 Oct 4.PMID: 17021036 2006
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| 30 | CYP11A1, CYP11B1, CYP11B2, CYP17A1D, CYP19A1, GATA4, NR0B1, NR2F1, NR2F2, NR5A1, PCNA, COPS2
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| DAX1 and its network partners: exploring complexity in development.
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| Clipsham R, McCabe ER.
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| Mol Genet Metab 80(1-2):81-120. 2003
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| 31 | MAPK1, NR2F1
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| Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK.
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| Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F.
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| EMBO J. 21(13):3443-53. 2002
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| 32 | CALR, NKX2-5, NR2F1
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| COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development.
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| Guo L, Lynch J, Nakamura K, Fliegel L, Kasahara H, Izumo S, Komuro I, Agellon LB, Michalak M.
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| J Biol Chem 276(4):2797-801. 2001
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| 33 | NR2F1, NR2F6
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| Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor.
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| Zhang Y, Dufau ML.
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| J Biol Chem 275(4):2763-70. 2000
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| 34 | NR2F1
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| The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.
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| Klinge CM, Kaur K, Swanson HI.
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| Arch Biochem Biophys. 373(1):163-74. 2000
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| 35 | NR2F1
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| Transcription activation by the orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI). Definition of the domain involved in the glucocorticoid response of the phosphoenolpyruvate carboxykinase gene
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| Sugiyama T, Wang JC, Scott DK, Granner DK.
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| J Biol Chem. 275(5):3446-54. 2000
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| 36 | NR2F1, NR2F6, NR4A2
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| Identification of nuclear orphan receptors as regulators of expression of a neurotransmitter receptor gene.
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| Chew LJ, Huang F, Boutin JM, Gallo V.
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| J Biol Chem 274(41):29366-75. 1999
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| 37 | COPS2, NR2F1
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| Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily.
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| Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A.
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| Mol Cell Biol 19(5):3383-94. 1999
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| 38 | NR2F1
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| COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells.
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| Rohr O, Aunis D, Schaeffer E.
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| J Biol Chem. 272(49):31149-55. 1997
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| 39 | NR2F1
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| Chicken ovalbumin upstream promoter-transcription factor interacts with estrogen receptor, binds to estrogen response elements and half-sites, and inhibits estrogen-induced gene expression.
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| Klinge CM, Silver BF, Driscoll MD, Sathya G, Bambara RA, Hilf R.
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| J Biol Chem. 272(50):31465-74. 1997
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| 40 | NR2F1, NR2F2
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| Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes.
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| Qiu Y, et al.
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| Genomics 29 : 240-246. 1995
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| 41 | NR2F1
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| Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).
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| Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW.
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| J Biol Chem. 267(25):17617-23. 1992
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| 42 | NR2F1
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| Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.
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| Kliewer SA, Umesono K, Heyman RA, Mangelsdorf DJ, Dyck JA, Evans RM.
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| Proc Natl Acad Sci U S A. 89(4):1448-52. 1992
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| 43 | NR2F1
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| Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein.
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| Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA.
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| Mol Endocrinol. 6(9):1468-78. 1992
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| 44 | NR2F1, NR2F6
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| Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.
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| Miyajima N, et al.
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| Nucleic Acids Res 16 : 11057-11074. 1988
|