| 1 | NR2E1
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| Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis
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| Kandel P, Semerci F, Mishra R, Choi W, Bajic A, Baluya D, Ma L, Chen K, Cao AC, Phongmekhin T, Matinyan N, Jiménez-Panizo A, Chamakuri S, Raji IO, Chang L, Fuentes-Prior P, MacKenzie KR, Benn CL, Estébanez-Perpińá E, Venken K, Moore DD, Young DW, Maletic-Savatic M.
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| Proc Natl Acad Sci U S A. Mar 29;119(13):e2023784119. doi: 10.1073/pnas.2023784119. Epub 2022 Mar 25. 2022
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| 2 | NR2E1
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| Nr2e1 deficiency aggravates insulin resistance and chronic inflammation of visceral adipose tissues in a diet-induced obese mice model
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| He G, Gu J, Wang H, Cheng S, Xiong Q, Ke M, Hu Y, Feng J, Song L, Liu Z, Xu Y.
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| Life Sci. Aug 1;278:119562. doi: 10.1016/j.lfs.2021.119562. Epub 2021 Apr 26. 2021
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| 3 | E2F6, NR2E1
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| Nuclear receptor TLX regulates islet beta cell proliferation via E2F6.
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| Shi X, Ma D, Li M, Zeng L, Chen J, Yang Y.
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| Biochem Biophys Res Commun. Jun 4;513(3):560-566. doi: 10.1016/j.bbrc.2019.04.033. Epub 2019 Apr 10. 2019
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| 4 | AR, NR2E1
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| Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription.
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| Jia L, Wu D, Wang Y, You W, Wang Z, Xiao L, Cai G, Xu Z, Zou C, Wang F, Teoh JY, Ng CF, Yu S, Chan FL.
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| Oncogene. Jun;37(25):3340-3355. doi: 10.1038/s41388-018-0198-z. Epub 2018 Mar 20. 2018
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| 5 | NR2E1
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| Nr2e1 Downregulation Is Involved in Excess Retinoic Acid-induced Developmental Abnormality in the Mouse Brain.
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| Yu J, Guo Q, Mu JB, Zhang T, Li RK, Xie J.
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| Biomed Environ Sci. Mar;30(3):185-193. doi: 10.3967/bes2017.026. 2017
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| 6 | NR2E1
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| TLX-Its Emerging Role for Neurogenesis in Health and Disease
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| Sobhan PK, Funa K.
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| Mol Neurobiol. Jan;54(1):272-280. doi: 10.1007/s12035-015-9608-1. Epub 2016 Jan 6. 2017
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| 7 | NR2E1
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| The nuclear receptor Tlx regulates motor, cognitive and anxiety-related behaviours during adolescence and adulthood
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| O'Leary JD, Kozareva DA, Hueston CM, O'Leary OF, Cryan JF, Nolan YM.
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| Behav Brain Res. Jun 1;306:36-47. doi: 10.1016/j.bbr.2016.03.022. Epub 2016 Mar 9. 2016
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| 8 | NR2E1
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| Nr2e1 regulates retinal lamination and the development of Müller glia, S-cones, and glycineric amacrine cells during retinogenesis
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| Corso-Díaz X, Simpson EM.
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| Mol Brain Jun 20;8:37. doi: 10.1186/s13041-015-0126-x. 2015
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| 9 | CBX7, NR2E1
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| The nuclear receptor NR2E1/TLX controls senescence.
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| O'Loghlen A, Martin N, Krusche B, Pemberton H, Alonso MM, Chandler H, Brookes S, Parrinello S, Peters G, Gil J.
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| Oncogene. Jul 30;34(31):4069-4077. doi: 10.1038/onc.2014.335. Epub 2014 Oct 20. 2015
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| 10 | NR2E1
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| Structural basis for corepressor assembly by the orphan nuclear receptor TLX.
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| Zhi X, Zhou XE, He Y, Searose-Xu K, Zhang CL, Tsai CC, Melcher K, Xu HE.
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| Genes Dev. Feb 15;29(4):440-50. doi: 10.1101/gad.254904.114. 2015
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| 11 | NR2E1
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| Role of the nuclear receptor Tailless in adult neural stem cells.
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| Wang Y, Liu HK, Schütz G.
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| Mech Dev. Jun-Aug;130(6-8):388-90. doi: 10.1016/j.mod.2013.02.001. Epub 2013 Feb 13. 2013
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| 12 | NR2E1
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| Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice.
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| Schmouth JF, Banks KG, Mathelier A, Gregory-Evans CY, Castellarin M, Holt RA, Gregory-Evans K, Wasserman WW, Simpson EM.
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| Mol Cell Biol. 32(7):1296-311 2012
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| 13 | BCL11A, NR2E1
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| The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function.
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| Estruch SB, Buzón V, Carbó LR, Schorova L, Lüders J, Estébanez-Perpińá E.
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| PLoS One 7(6):e37963. doi: 10.1371/journal.pone.0037963. Epub 2012 Jun 4.
2012
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| 14 | NR2E1
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| The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche
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| Zou Y, Niu W, Qin S, Downes M, Burns DK, Zhang CL.
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| Mol Cell Biol. Dec;32(23):4811-20. doi: 10.1128/MCB.01122-12. Epub 2012 Oct 1. 2012
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| 15 | KDM1A, NR2E1
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| Histone demethylase LSD1 regulates neural stem cell proliferation.
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| Sun G, Alzayady K, Stewart R, Ye P, Yang S, Li W, Shi Y.
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| Mol Cell Biol 30(8):1997-2005. Epub 2010 Feb 1.
2010
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| 16 | NR2E1, SIRT1
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| Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX.
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| Iwahara N, Hisahara S, Hayashi T, Horio Y.
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| Biochem Biophys Res Commun 386(4):671-5. Epub 2009 Jun 23.PMID: 19555662 2009
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| 17 | NR2E1
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| Transrepressive function of TLX requires the histone demethylase LSD1.
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| Yokoyama A, Takezawa S, Schle R, Kitagawa H, Kato S.
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| Mol Cell Biol 28(12):3995-4003. Epub 2008 Apr 7. 2008
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| 18 | NR2E1
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| Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain.
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| Li W, Sun G, Yang S, Qu Q, Nakashima K, Shi Y.
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| Mol Endocrinol. 22(1):56-64. 2008
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| 19 | NR2E1
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| Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation.
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| Sun G, Yu RT, Evans RM, Shi Y.
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| Proc Natl Acad Sci U S A 104(39):15282-7. Epub 2007 Sep 14. 2007
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| 20 | NR2E1
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| Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1
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| Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM.
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| Genes Dev. 20(10):1308-20. 2006
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| 21 | NR2E1
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| Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes.
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| Uemura A, Kusuhara S, Wiegand SJ, Yu RT, Nishikawa S.
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| J Clin Invest. 116(2):369-77 2006
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| 22 | NR2E1
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| Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors.
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| Wang L, Rajan H, Pitman JL, McKeown M, Tsai CC.
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| Genes Dev. 20(5):525-30 2006
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| 23 | NR2E1
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| Expression and function of orphan nuclear receptor TLX in adult neural stem cells.
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| Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM.
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| Nature 427(6969):78-83. 2004
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| 24 | NR2E1
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| Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina.
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| Miyawaki T, Uemura A, Dezawa M, Yu RT, Ide C, Nishikawa S, Honda Y, Tanabe Y, Tanabe T.
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| J Neurosci. 24(37):8124-34. 2004
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| 25 | NR2E1
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| Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent.
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| Young KA, Berry ML, Mahaffey CL, Saionz JR, Hawes NL, Chang B, Zheng QY, Smith RS, Bronson RT, Nelson RJ, Simpson EM.
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| Behav Brain Res. 132(2):145-58. 2002
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| 26 | PAX2, NR2E1
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| The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision.
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| Yu RT, Chiang MY, Tanabe T, Kobayashi M, Yasuda K, Evans RM, Umesono K.
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| Proc Natl Acad Sci U S A 97(6):2621-5. 2000
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| 27 | NR2E1
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| The human homologue of the Drosophila tailless gene (TLX) : characterization and mapping to a region of common deletion in human lymphoid leukemia on chromosome 6q21.
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| Jackson A, et al.
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| Genomics 50 : 34-43. 1998
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| 28 | NR2E1
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| Defective limbic system in mice lacking the tailless gene.
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| Monaghan AP, Bock D, Gass P, Schwager A, Wolfer DP, Lipp HP, Schutz G.
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| Nature 390(6659):515-7. 1997
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| 29 | NR2E1
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| Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx.
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| Yu RT, McKeown M, Evans RM, Umesono K.
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| Nature 370(6488):375-9. 1994
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