Citations for
1NR2E1
Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis
Kandel P, Semerci F, Mishra R, Choi W, Bajic A, Baluya D, Ma L, Chen K, Cao AC, Phongmekhin T, Matinyan N, Jiménez-Panizo A, Chamakuri S, Raji IO, Chang L, Fuentes-Prior P, MacKenzie KR, Benn CL, Estébanez-Perpińá E, Venken K, Moore DD, Young DW, Maletic-Savatic M.
Proc Natl Acad Sci U S A. Mar 29;119(13):e2023784119. doi: 10.1073/pnas.2023784119. Epub 2022 Mar 25. 2022
2NR2E1
Nr2e1 deficiency aggravates insulin resistance and chronic inflammation of visceral adipose tissues in a diet-induced obese mice model
He G, Gu J, Wang H, Cheng S, Xiong Q, Ke M, Hu Y, Feng J, Song L, Liu Z, Xu Y.
Life Sci. Aug 1;278:119562. doi: 10.1016/j.lfs.2021.119562. Epub 2021 Apr 26. 2021
3E2F6, NR2E1
Nuclear receptor TLX regulates islet beta cell proliferation via E2F6.
Shi X, Ma D, Li M, Zeng L, Chen J, Yang Y.
Biochem Biophys Res Commun. Jun 4;513(3):560-566. doi: 10.1016/j.bbrc.2019.04.033. Epub 2019 Apr 10. 2019
4AR, NR2E1
Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription.
Jia L, Wu D, Wang Y, You W, Wang Z, Xiao L, Cai G, Xu Z, Zou C, Wang F, Teoh JY, Ng CF, Yu S, Chan FL.
Oncogene. Jun;37(25):3340-3355. doi: 10.1038/s41388-018-0198-z. Epub 2018 Mar 20. 2018
5NR2E1
Nr2e1 Downregulation Is Involved in Excess Retinoic Acid-induced Developmental Abnormality in the Mouse Brain.
Yu J, Guo Q, Mu JB, Zhang T, Li RK, Xie J.
Biomed Environ Sci. Mar;30(3):185-193. doi: 10.3967/bes2017.026. 2017
6NR2E1
TLX-Its Emerging Role for Neurogenesis in Health and Disease
Sobhan PK, Funa K.
Mol Neurobiol. Jan;54(1):272-280. doi: 10.1007/s12035-015-9608-1. Epub 2016 Jan 6. 2017
7NR2E1
The nuclear receptor Tlx regulates motor, cognitive and anxiety-related behaviours during adolescence and adulthood
O'Leary JD, Kozareva DA, Hueston CM, O'Leary OF, Cryan JF, Nolan YM.
Behav Brain Res. Jun 1;306:36-47. doi: 10.1016/j.bbr.2016.03.022. Epub 2016 Mar 9. 2016
8NR2E1
Nr2e1 regulates retinal lamination and the development of Müller glia, S-cones, and glycineric amacrine cells during retinogenesis
Corso-Díaz X, Simpson EM.
Mol Brain Jun 20;8:37. doi: 10.1186/s13041-015-0126-x. 2015
9CBX7, NR2E1
The nuclear receptor NR2E1/TLX controls senescence.
O'Loghlen A, Martin N, Krusche B, Pemberton H, Alonso MM, Chandler H, Brookes S, Parrinello S, Peters G, Gil J.
Oncogene. Jul 30;34(31):4069-4077. doi: 10.1038/onc.2014.335. Epub 2014 Oct 20. 2015
10NR2E1
Structural basis for corepressor assembly by the orphan nuclear receptor TLX.
Zhi X, Zhou XE, He Y, Searose-Xu K, Zhang CL, Tsai CC, Melcher K, Xu HE.
Genes Dev. Feb 15;29(4):440-50. doi: 10.1101/gad.254904.114. 2015
11NR2E1
Role of the nuclear receptor Tailless in adult neural stem cells.
Wang Y, Liu HK, Schütz G.
Mech Dev. Jun-Aug;130(6-8):388-90. doi: 10.1016/j.mod.2013.02.001. Epub 2013 Feb 13. 2013
12NR2E1
Retina restored and brain abnormalities ameliorated by single-copy knock-in of human NR2E1 in null mice.
Schmouth JF, Banks KG, Mathelier A, Gregory-Evans CY, Castellarin M, Holt RA, Gregory-Evans K, Wasserman WW, Simpson EM.
Mol Cell Biol. 32(7):1296-311 2012
13BCL11A, NR2E1
The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function.
Estruch SB, Buzón V, Carbó LR, Schorova L, Lüders J, Estébanez-Perpińá E.
PLoS One 7(6):e37963. doi: 10.1371/journal.pone.0037963. Epub 2012 Jun 4. 2012
14NR2E1
The nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche
Zou Y, Niu W, Qin S, Downes M, Burns DK, Zhang CL.
Mol Cell Biol. Dec;32(23):4811-20. doi: 10.1128/MCB.01122-12. Epub 2012 Oct 1. 2012
15KDM1A, NR2E1
Histone demethylase LSD1 regulates neural stem cell proliferation.
Sun G, Alzayady K, Stewart R, Ye P, Yang S, Li W, Shi Y.
Mol Cell Biol 30(8):1997-2005. Epub 2010 Feb 1. 2010
16NR2E1, SIRT1
Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX.
Iwahara N, Hisahara S, Hayashi T, Horio Y.
Biochem Biophys Res Commun 386(4):671-5. Epub 2009 Jun 23.PMID: 19555662 2009
17NR2E1
Transrepressive function of TLX requires the histone demethylase LSD1.
Yokoyama A, Takezawa S, SchŸle R, Kitagawa H, Kato S.
Mol Cell Biol 28(12):3995-4003. Epub 2008 Apr 7. 2008
18NR2E1
Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain.
Li W, Sun G, Yang S, Qu Q, Nakashima K, Shi Y.
Mol Endocrinol. 22(1):56-64. 2008
19NR2E1
Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation.
Sun G, Yu RT, Evans RM, Shi Y.
Proc Natl Acad Sci U S A 104(39):15282-7. Epub 2007 Sep 14. 2007
20NR2E1
Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1
Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM.
Genes Dev. 20(10):1308-20. 2006
21NR2E1
Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes.
Uemura A, Kusuhara S, Wiegand SJ, Yu RT, Nishikawa S.
J Clin Invest. 116(2):369-77 2006
22NR2E1
Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors.
Wang L, Rajan H, Pitman JL, McKeown M, Tsai CC.
Genes Dev. 20(5):525-30 2006
23NR2E1
Expression and function of orphan nuclear receptor TLX in adult neural stem cells.
Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM.
Nature 427(6969):78-83. 2004
24NR2E1
Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina.
Miyawaki T, Uemura A, Dezawa M, Yu RT, Ide C, Nishikawa S, Honda Y, Tanabe Y, Tanabe T.
J Neurosci. 24(37):8124-34. 2004
25NR2E1
Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent.
Young KA, Berry ML, Mahaffey CL, Saionz JR, Hawes NL, Chang B, Zheng QY, Smith RS, Bronson RT, Nelson RJ, Simpson EM.
Behav Brain Res. 132(2):145-58. 2002
26PAX2, NR2E1
The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision.
Yu RT, Chiang MY, Tanabe T, Kobayashi M, Yasuda K, Evans RM, Umesono K.
Proc Natl Acad Sci U S A 97(6):2621-5. 2000
27NR2E1
The human homologue of the Drosophila tailless gene (TLX) : characterization and mapping to a region of common deletion in human lymphoid leukemia on chromosome 6q21.
Jackson A, et al.
Genomics 50 : 34-43. 1998
28NR2E1
Defective limbic system in mice lacking the tailless gene.
Monaghan AP, Bock D, Gass P, Schwager A, Wolfer DP, Lipp HP, Schutz G.
Nature 390(6659):515-7. 1997
29NR2E1
Relationship between Drosophila gap gene tailless and a vertebrate nuclear receptor Tlx.
Yu RT, McKeown M, Evans RM, Umesono K.
Nature 370(6488):375-9. 1994