| 1 | NR1I2
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| Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress.
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| Swales KE, Moore R, Truss NJ, Tucker A, Warner TD, Negishi M, Bishop-Bailey D.
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| Cardiovasc Res 93(4):674-81. doi: 10.1093/cvr/cvr330. Epub 2011 Dec 13.
2012
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| 2 | NR1I2, SULT1E1
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| Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure.
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| Kodama S, Hosseinpour F, Goldstein JA, Negishi M.
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| Nucleic Acids Res 39(19):8392-403. doi: 10.1093/nar/gkr458. Epub 2011 Jul 14.
2011
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| 3 | NR1I2
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| Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma.
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| van de Winkel A, Menke V, Capello A, Moons LM, Pot RG, van Dekken H, Siersema PD, Kusters JG, van der Laan LJ, Kuipers EJ.
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| BMC Gastroenterol 11:108. doi: 10.1186/1471-230X-11-108.
2011
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| 4 | NR1I2
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| Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease.
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| Glas J, Seiderer J, Fischer D, Tengler B, Pfennig S, Wetzke M, Beigel F, Olszak T, Weidinger M, Göke B, Ochsenkühn T, Folwaczny M, Müller-Myhsok B, Diegelmann J, Czamara D, Brand S.
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| Inflamm Bowel Dis 17(9):1917-24. doi: 10.1002/ibd.21562. Epub 2010 Dec 3.
2011
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| 5 | GADD45B, NR1I2
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| Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.
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| Kodama S, Negishi M.
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| J Biol Chem 286(5):3570-8. doi: 10.1074/jbc.M110.179812. Epub 2010 Dec 2.
2011
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| 6 | CYP3A4, NR1I2, NR2F1, NR2F2, THRA, THRB
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| Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding.
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| Istrate MA, Nussler AK, Eichelbaum M, Burk O.
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| Biochem Biophys Res Commun 393(4):688-93. Epub 2010 Feb 18.PMID: 20171174 2010
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| 7 | NR1I2
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| Pregnane X receptor is SUMOylated to repress the inflammatory response.
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| Hu G, Xu C, Staudinger JL.
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| J Pharmacol Exp Ther 335(2):342-50. doi: 10.1124/jpet.110.171744. Epub 2010 Aug 18.
2010
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| 8 | NR1I2
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| Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes.
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| Yang J, Hao C, Yang D, Shi D, Song X, Luan X, Hu G, Yan B.
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| Toxicol Lett 197(3):219-26. doi: 10.1016/j.toxlet.2010.06.003. Epub 2010 Jun 9.
2010
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| 9 | NR1I2
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| Steroid and Xenobiotic Receptor (SXR) as a possible prognostic marker in epithelial ovarian cancer.
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| Yue X, Akahira J, Utsunomiya H, Miki Y, Takahashi N, Niikura H, Ito K, Sasano H, Okamura K, Yaegashi N.
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| Pathol Int 60(5):400-6. doi: 10.1111/j.1440-1827.2010.02546.x.
2010
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| 10 | NR1I2
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| Modulation of T lymphocyte function by the pregnane X receptor.
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| Dubrac S, Elentner A, Ebner S, Horejs-Hoeck J, Schmuth M.
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| J Immunol 184(6):2949-57. doi: 10.4049/jimmunol.0902151. Epub 2010 Feb 19.
2010
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| 11 | NR1I2
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| Regulation of drug resistance by human pregnane X receptor in breast cancer.
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| Chen Y, Tang Y, Chen S, Nie D.
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| Cancer Biol Ther 8(13):1265-72.
2009
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| 12 | SLCO1B3, NR1I2
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| Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia.
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| Kiyotani K, Mushiroda T, Kubo M, Zembutsu H, Sugiyama Y, Nakamura Y.
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| Cancer Sci 99(5):967-72. Epub 2008 Feb 19. 2008
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| 13 | NR1I2
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| Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease.
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| Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS.
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| Proc Natl Acad Sci U S A 103(37):13807-12. Epub 2006 Aug 29. 2006
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| 14 | NR1I2
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| Identification of regulatory sites in the human PXR (NR1I2) promoter region.
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| Kurose K, Ikeda S, Koyano S, Tohkin M, Hasegawa R, Sawada J.
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| Mol Cell Biochem 281(1-2):35-43. 2006
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| 15 | NR1I2
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| Human PXR forms a tryptophan zipper-mediated homodimer.
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| Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR.
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| Biochemistry 45(28):8579-89. 2006
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| 16 | NR1I2
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| Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR.
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| Kawana K, Ikuta T, Kobayashi Y, Gotoh O, Takeda K, Kawajiri K.
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| Mol Pharmacol 63(3):524-31. 2003
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| 17 | NR1I2
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| Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter.
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| Uno Y, Sakamoto Y, Yoshida K, Hasegawa T, Hasegawa Y, Koshino T, Inoue I.
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| J Hum Genet 48(11):594-7. Epub 2003 Oct 29. 2003
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| 18 | NR1I2
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| Identification of the novel splicing variants for the hPXR in human livers.
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| Fukuen S, Fukuda T, Matsuda H, Sumida A, Yamamoto I, Inaba T, Azuma J.
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| Biochem Biophys Res Commun 298(3):433-8. 2002
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| 19 | NR1I2
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| The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
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| Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA.
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| Proc Natl Acad Sci U S A 98(6):3369-3374. 2001
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| 20 | NR1I2
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| An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.
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| Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM.
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| Proc Natl Acad Sci U S A 98(6):3375-3380. 2001
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| 21 | NR1I2
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| Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.
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| Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Backman M, Ohlsson R, Postlind H, Blomquist P, Berkenstam A.
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| Proc Natl Acad Sci U S A 95(21):12208-13. 1998
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| 22 | NR1I2
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| SXR, a novel steroid and xenobiotic-sensing nuclear receptor.
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| Blumberg B, Sabbagh W Jr, Juguilon H, Bolado J Jr, van Meter CM, Ong ES, Evans RM.
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| Genes Dev 12(20):3195-205. 1998
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| 23 | NR1I2
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| The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
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| Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA.
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| J Clin Invest 102(5):1016-23. 1998
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