Citations for
1NR1I2, RXRA
Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα.
Wallace BD, Betts L, Talmage G, Pollet RM, Holman NS, Redinbo MR.
J Mol Biol 425(14):2561-77. doi: 10.1016/j.jmb.2013.04.012. Epub 2013 Apr 16. 2013
2NR1I2
Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress.
Swales KE, Moore R, Truss NJ, Tucker A, Warner TD, Negishi M, Bishop-Bailey D.
Cardiovasc Res 93(4):674-81. doi: 10.1093/cvr/cvr330. Epub 2011 Dec 13. 2012
3NR1I2, SULT1E1
Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure.
Kodama S, Hosseinpour F, Goldstein JA, Negishi M.
Nucleic Acids Res 39(19):8392-403. doi: 10.1093/nar/gkr458. Epub 2011 Jul 14. 2011
4NR1I2
Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma.
van de Winkel A, Menke V, Capello A, Moons LM, Pot RG, van Dekken H, Siersema PD, Kusters JG, van der Laan LJ, Kuipers EJ.
BMC Gastroenterol 11:108. doi: 10.1186/1471-230X-11-108. 2011
5NR1I2
Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease.
Glas J, Seiderer J, Fischer D, Tengler B, Pfennig S, Wetzke M, Beigel F, Olszak T, Weidinger M, Göke B, Ochsenkühn T, Folwaczny M, Müller-Myhsok B, Diegelmann J, Czamara D, Brand S.
Inflamm Bowel Dis 17(9):1917-24. doi: 10.1002/ibd.21562. Epub 2010 Dec 3. 2011
6GADD45B, NR1I2
Pregnane X receptor PXR activates the GADD45beta gene, eliciting the p38 MAPK signal and cell migration.
Kodama S, Negishi M.
J Biol Chem 286(5):3570-8. doi: 10.1074/jbc.M110.179812. Epub 2010 Dec 2. 2011
7CYP3A4, NR1I2, NR2F1, NR2F2, THRA, THRB
Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding.
Istrate MA, Nussler AK, Eichelbaum M, Burk O.
Biochem Biophys Res Commun 393(4):688-93. Epub 2010 Feb 18.PMID: 20171174 2010
8NR1I2
Pregnane X receptor is SUMOylated to repress the inflammatory response.
Hu G, Xu C, Staudinger JL.
J Pharmacol Exp Ther 335(2):342-50. doi: 10.1124/jpet.110.171744. Epub 2010 Aug 18. 2010
9NR1I2
Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes.
Yang J, Hao C, Yang D, Shi D, Song X, Luan X, Hu G, Yan B.
Toxicol Lett 197(3):219-26. doi: 10.1016/j.toxlet.2010.06.003. Epub 2010 Jun 9. 2010
10NR1I2
Steroid and Xenobiotic Receptor (SXR) as a possible prognostic marker in epithelial ovarian cancer.
Yue X, Akahira J, Utsunomiya H, Miki Y, Takahashi N, Niikura H, Ito K, Sasano H, Okamura K, Yaegashi N.
Pathol Int 60(5):400-6. doi: 10.1111/j.1440-1827.2010.02546.x. 2010
11NR1I2
Modulation of T lymphocyte function by the pregnane X receptor.
Dubrac S, Elentner A, Ebner S, Horejs-Hoeck J, Schmuth M.
J Immunol 184(6):2949-57. doi: 10.4049/jimmunol.0902151. Epub 2010 Feb 19. 2010
12NR1I2
Regulation of drug resistance by human pregnane X receptor in breast cancer.
Chen Y, Tang Y, Chen S, Nie D.
Cancer Biol Ther 8(13):1265-72. 2009
13SLCO1B3, NR1I2
Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia.
Kiyotani K, Mushiroda T, Kubo M, Zembutsu H, Sugiyama Y, Nakamura Y.
Cancer Sci 99(5):967-72. Epub 2008 Feb 19. 2008
14NR1I2
Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease.
Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS.
Proc Natl Acad Sci U S A 103(37):13807-12. Epub 2006 Aug 29. 2006
15NR1I2
Identification of regulatory sites in the human PXR (NR1I2) promoter region.
Kurose K, Ikeda S, Koyano S, Tohkin M, Hasegawa R, Sawada J.
Mol Cell Biochem 281(1-2):35-43. 2006
16NR1I2
Human PXR forms a tryptophan zipper-mediated homodimer.
Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR.
Biochemistry 45(28):8579-89. 2006
17NR1I2
Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR.
Kawana K, Ikuta T, Kobayashi Y, Gotoh O, Takeda K, Kawajiri K.
Mol Pharmacol 63(3):524-31. 2003
18NR1I2
Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter.
Uno Y, Sakamoto Y, Yoshida K, Hasegawa T, Hasegawa Y, Koshino T, Inoue I.
J Hum Genet 48(11):594-7. Epub 2003 Oct 29. 2003
19NR1I2
Identification of the novel splicing variants for the hPXR in human livers.
Fukuen S, Fukuda T, Matsuda H, Sumida A, Yamamoto I, Inaba T, Azuma J.
Biochem Biophys Res Commun 298(3):433-8. 2002
20NR1I2
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA.
Proc Natl Acad Sci U S A 98(6):3369-3374. 2001
21NR1I2
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.
Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM.
Proc Natl Acad Sci U S A 98(6):3375-3380. 2001
22NR1I2
Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction.
Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Backman M, Ohlsson R, Postlind H, Blomquist P, Berkenstam A.
Proc Natl Acad Sci U S A 95(21):12208-13. 1998
23NR1I2
SXR, a novel steroid and xenobiotic-sensing nuclear receptor.
Blumberg B, Sabbagh W Jr, Juguilon H, Bolado J Jr, van Meter CM, Ong ES, Evans RM.
Genes Dev 12(20):3195-205. 1998
24NR1I2
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.
Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA.
J Clin Invest 102(5):1016-23. 1998