Citations for
1GPBAR1, NR1H4
Bile acid receptors and the kidney.
Herman-Edelstein M, Weinstein T, Levi M.
Curr Opin Nephrol Hypertens 27(1):56-62. doi: 10.1097/MNH.0000000000000374. 2018
2FGF19, NR1H4
Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis.
Byun S, Kim DH, Ryerson D, Kim YC, Sun H, Kong B, Yau P, Guo G, Xu HE, Kemper B, Kemper JK.
Nat Commun 9(1):2590. doi: 10.1038/s41467-018-04697-5. 2018
3GPBAR1, NR1H4
A dual agonist of farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice.
Wang XX, Luo Y, Wang D, Adorini L, Pruzanski M, Dobrinskikh E, Levi M.
J Biol Chem 292(29):12018-12024. doi: 10.1074/jbc.C117.794982. Epub 2017 Jun 8. 2017
4GPBAR1, NR1H4
Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism.
Pathak P, Liu H, Boehme S, Xie C, Krausz KW, Gonzalez F, Chiang JYL.
J Biol Chem 292(26):11055-11069. doi: 10.1074/jbc.M117.784322. Epub 2017 May 6. 2017
5NR1H4
Activation of FXR pathway does not alter glial cell function.
Albrecht S, Fleck AK, Kirchberg I, Hucke S, Liebmann M, Klotz L, Kuhlmann T.
J Neuroinflammation 14(1):66. doi: 10.1186/s12974-017-0833-6. 2017
6DDIT3, NR1H4
FXR controls CHOP expression in steatohepatitis.
Fuchs CD, Claudel T, Scharnagl H, Stojakovic T, Trauner M.
FEBS Lett 591(20):3360-3368. doi: 10.1002/1873-3468.12845. Epub 2017 Oct 11. 2017
7NR1H3, NR1H4
Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets.
Unsworth AJ, Bye AP, Tannetta DS, Desborough MJR, Kriek N, Sage T, Allan HE, Crescente M, Yaqoob P, Warner TD, Jones CI, Gibbins JM.
Arterioscler Thromb Vasc Biol 37(8):1482-1493. doi: 10.1161/ATVBAHA.117.309135. Epub 2017 Jun 15. 2017
8NLRP3, NR1H4
Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis.
Hao H, Cao L, Jiang C, Che Y, Zhang S, Takahashi S, Wang G, Gonzalez FJ.
Cell Metab 25(4):856-867.e5. doi: 10.1016/j.cmet.2017.03.007. 2017
9GPBAR1, NR1H4
Role of Bile Acid-Regulated Nuclear Receptor FXR and G Protein-Coupled Receptor TGR5 in Regulation of Cardiorenal Syndrome (Cardiovascular Disease and Chronic Kidney Disease).
Levi M.
Hypertension 67(6):1080-4. doi: 10.1161/HYPERTENSIONAHA.115.06417. Epub 2016 Apr 4. Review. No abstract available. 2016
10NR1H4
The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion.
Hucke S, Herold M, Liebmann M, Freise N, Lindner M, Fleck AK, Zenker S, Thiebes S, Fernandez-Orth J, Buck D, Luessi F, Meuth SG, Zipp F, Hemmer B, Engel DR, Roth J, Kuhlmann T, Wiendl H, Klotz L.
Acta Neuropathol 132(3):413-31. doi: 10.1007/s00401-016-1593-6. Epub 2016 Jul 6. 2016
11NR1H4, PFIC5
Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis.
Gomez-Ospina N, Potter CJ, Xiao R, Manickam K, Kim MS, Kim KH, Shneider BL, Picarsic JL, Jacobson TA, Zhang J, He W, Liu P, Knisely AS, Finegold MJ, Muzny DM, Boerwinkle E, Lupski JR, Plon SE, Gibbs RA, Eng CM, Yang Y, Washington GC, Porteus MH, Berquist WE, Kambham N, Singh RJ, Xia F, Enns GM, Moore DD.
Nat Commun 7:10713. doi: 10.1038/ncomms10713. 2016
12NR1H4
Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.
Moraes LA, Unsworth AJ, Vaiyapuri S, Ali MS, Sasikumar P, Sage T, Flora GD, Bye AP, Kriek N, Dorchies E, Molendi-Coste O, Dombrowicz D, Staels B, Bishop-Bailey D, Gibbins JM.
Arterioscler Thromb Vasc Biol 36(12):2324-2333. doi: 10.1161/ATVBAHA.116.308093. Epub 2016 Oct 6. 2016
13NR1H4
An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease.
Gonzalez FJ, Jiang C, Patterson AD.
Gastroenterology 151(5):845-859. doi: 10.1053/j.gastro.2016.08.057. Epub 2016 Sep 14. Review. 2016
14NR1H4
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.
Jiang C, Xie C, Lv Y, Li J, Krausz KW, Shi J, Brocker CN, Desai D, Amin SG, Bisson WH, Liu Y, Gavrilova O, Patterson AD, Gonzalez FJ.
Nat Commun 6:10166. doi: 10.1038/ncomms10166. 2015
15NR1H4, SOCS3
FXR induces SOCS3 and suppresses hepatocellular carcinoma.
Guo F, Xu Z, Zhang Y, Jiang P, Huang G, Chen S, Lyu X, Zheng P, Zhao X, Zeng Y, Wang S, He F.
Oncotarget 6(33):34606-16. doi: 10.18632/oncotarget.5314. 2015
16KDM1A, NR1H4
Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity.
Kim YC, Fang S, Byun S, Seok S, Kemper B, Kemper JK.
Hepatology 62(1):220-31. doi: 10.1002/hep.27677. Epub 2015 Feb 27. 2015
17HRG, NR1H4
The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein.
Deuschle U, Birkel M, Hambruch E, Hornberger M, Kinzel O, Perović-Ottstadt S, Schulz A, Hahn U, Burnet M, Kremoser C.
Int J Cancer 136(11):2693-704. doi: 10.1002/ijc.29312. Epub 2014 Nov 13. 2015
18ABCB11, NR0B2, NR1H4, SLC10A1
The nuclear receptor FXR, but not LXR, up-regulates bile acid transporter expression in non-alcoholic fatty liver disease.
Aguilar-Olivos NE, Carrillo-Córdova D, Oria-Hernández J, Sánchez-Valle V, Ponciano-Rodríguez G, Ramírez-Jaramillo M, Chablé-Montero F, Chávez-Tapia NC, Uribe M, Méndez-Sánchez N.
Ann Hepatol 14(4):487-93. 2015
19CDX2, NR1H4
Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2).
Modica S, Cariello M, Morgano A, Gross I, Vegliante MC, Murzilli S, Salvatore L, Freund JN, Sabbŕ C, Moschetta A.
J Biol Chem 289(41):28421-32. doi: 10.1074/jbc.M114.571513. Epub 2014 Aug 19. 2014
20AQP2, NR1H4
Farnesoid X receptor (FXR) gene deficiency impairs urine concentration in mice.
Zhang X, Huang S, Gao M, Liu J, Jia X, Han Q, Zheng S, Miao Y, Li S, Weng H, Xia X, Du S, Wu W, Gustafsson JĹ, Guan Y.
Proc Natl Acad Sci U S A 111(6):2277-82. doi: 10.1073/pnas.1323977111. Epub 2014 Jan 24. 2014
21CES1, NR1H4
Hepatic carboxylesterase 1 is essential for both normal and farnesoid X receptor-controlled lipid homeostasis.
Xu J, Li Y, Chen WD, Xu Y, Yin L, Ge X, Jadhav K, Adorini L, Zhang Y.
Hepatology 59(5):1761-1771. doi: 10.1002/hep.26714. Epub 2014 Apr 1. 2014
22NR1H4
Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?
Baptissart M, Vega A, Martinot E, Baron S, Lobaccaro JM, Volle DH.
Cell Mol Life Sci 70(23):4511-26. doi: 10.1007/s00018-013-1387-0. Epub 2013 Jun 20. Review. 2013
23NR1H4
Positive regulation of osteogenesis by bile acid through FXR.
Cho SW, An JH, Park H, Yang JY, Choi HJ, Kim SW, Park YJ, Kim SY, Yim M, Baek WY, Kim JE, Shin CS.
J Bone Miner Res 28(10):2109-21. doi: 10.1002/jbmr.1961. 2013
24NR1H4
Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes.
Caron S, Huaman Samanez C, Dehondt H, Ploton M, Briand O, Lien F, Dorchies E, Dumont J, Postic C, Cariou B, Lefebvre P, Staels B.
Mol Cell Biol 33(11):2202-11. doi: 10.1128/MCB.01004-12. Epub 2013 Mar 25. 2013
25NR1H4
FXR signaling in the enterohepatic system.
Matsubara T, Li F, Gonzalez FJ.
Mol Cell Endocrinol 368(1-2):17-29. doi: 10.1016/j.mce.2012.05.004. Epub 2012 May 17. Review. 2013
26NR1H4, PFIC5
A novel heterozygous NR1H4 termination codon mutation in idiopathic infantile cholestasis.
Chen XQ, Wang LL, Shan QW, Tang Q, Deng YN, Lian SJ, Yun X.
World J Pediatr 8(1):67-71. doi: 10.1007/s12519-011-0299-z. Epub 2011 Jun 1. 2012
27CISH, NR1H4
Activation of farnesoid X receptor increases the expression of cytokine inducible SH2-containing protein in HepG2 cells.
Xu Z, Huang G, Gong W, Zhao Y, Zhou P, Zeng Y, He F.
J Interferon Cytokine Res Nov;32(11):517-23. doi: 10.1089/jir.2012.0008. Epub 2012 Jul 20 2012
28NR0B1, NR1H4
DAX1 suppresses FXR transactivity as a novel co-repressor.
Li J, Lu Y, Liu R, Xiong X, Zhang Z, Zhang X, Ning G, Li X.
Biochem Biophys Res Commun 412(4):660-6. Epub 2011 Aug 12. 2011
29NR1H4
Role of farnesoid X receptor (FXR) in the process of differentiation of bone marrow stromal cells into osteoblasts.
Id Boufker H, Lagneaux L, Fayyad-Kazan H, Badran B, Najar M, Wiedig M, Ghanem G, Laurent G, Body JJ, Journé F.
Bone 49(6):1219-31. doi: 10.1016/j.bone.2011.08.013. Epub 2011 Aug 26. 2011
30NR1H4
The farnesoid X receptor regulates adipocyte differentiation and function by promoting peroxisome proliferator-activated receptor-gamma and interfering with the Wnt/beta-catenin pathways.
Abdelkarim M, Caron S, Duhem C, Prawitt J, Dumont J, Lucas A, Bouchaert E, Briand O, Brozek J, Kuipers F, Fievet C, Cariou B, Staels B.
J Biol Chem 285(47):36759-67. doi: 10.1074/jbc.M110.166231. Epub 2010 Sep 17. 2010
31NR1H4
Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation.
Renga B, Mencarelli A, Migliorati M, Distrutti E, Fiorucci S.
World J Gastroenterol 15(17):2097-108. 2009
32NR1H4, PTK2
FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9.
Das A, Yaqoob U, Mehta D, Shah VH.
Arterioscler Thromb Vasc Biol 29(4):562-70. Epub 2009 Jan 15. 2009
33NR1H4
The farnesoid X receptor regulates transcription of 3beta-hydroxysteroid dehydrogenase type 2 in human adrenal cells.
Xing Y, Saner-Amigh K, Nakamura Y, Hinshelwood MM, Carr BR, Mason JI, Rainey WE.
Mol Cell Endocrinol 299(2):153-62. Epub 2008 Nov 18. 2009
34DCN, NR1H4
Upregulation of decorin by FXR in vascular smooth muscle cells.
He F, Zhang Q, Kuruba R, Gao X, Li J, Li Y, Gong W, Jiang Y, Xie W, Li S.
Biochem Biophys Res Commun 372(4):746-51. Epub 2008 Jun 2. 2008
35NR1H4
The role of FXR in disorders of bile acid homeostasis.
Eloranta JJ, Kullak-Ublick GA.
Physiology (Bethesda) 23:286-95. Review. 2008
36NR1H4, PRKCA
Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.
Gineste R, Sirvent A, Paumelle R, Helleboid S, Aquilina A, Darteil R, Hum DW, Fruchart JC, Staels B.
Mol Endocrinol 22(11):2433-47. Epub 2008 Aug 28. 2008
37ATP8B1, NR1H4
The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor.
Frankenberg T, Miloh T, Chen FY, Ananthanarayanan M, Sun AQ, Balasubramaniyan N, Arias I, Setchell KD, Suchy FJ, Shneider BL.
Hepatology 48(6):1896-905. 2008
38AGTR2, NR1H4
FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells.
Zhang Q, He F, Kuruba R, Gao X, Wilson A, Li J, Billiar TR, Pitt BR, Xie W, Li S.
Cardiovasc Res 77(3):560-9. Epub 2007 Nov 13.PMID: 18006431 2008
39NR0B2, NR1H4
Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration.
Li YT, Swales KE, Thomas GJ, Warner TD, Bishop-Bailey D.
Arterioscler Thromb Vasc Biol 27(12):2606-11. 2007
40ALAS1, NR1H4
Regulation of human liver delta-aminolevulinic acid synthase by bile acids.
Peyer AK, Jung D, Beer M, Gnerre C, Keogh A, Stroka D, Zavolan M, Meyer UA.
Hepatology 46(6):1960-70. 2007
41VIPR1, NR1H4
VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium.
Chignard N, Mergey M, Barbu V, Finzi L, Tiret E, Paul A, Housset C.
Hepatology 42(3):549-57. 2005
42NR1H4,RXRG,SLC1A5
Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR/RXR dimers.
Bungard CI, McGivan JD.
Arch Biochem Biophys 443(1-2):53-9. Epub 2005 Sep 15. 2005
43NR1H4, ATP8B1
Reduced hepatic expression of farnesoid X receptor in hereditary cholestasis associated to mutation in ATP8B1.
Alvarez L, Jara P, Sanchez-Sabate E, Hierro L, Larrauri J, Diaz MC, Camarena C, De la Vega A, Frauca E, Lopez-Collazo E, Lapunzina P.
Hum Mol Genet 13(20):2451-60. Epub 2004 Aug 18. 2004
44MED1, NR1H4
Identification of DRIP205 as a coactivator for the Farnesoid X receptor.
Pineda Torra I, Freedman LP, Garabedian MJ.
J Biol Chem 279(35):36184-91. Epub 2004 Jun 8. 2004
45FABP6, NR1H4, NR1H3
FXRE can function as an LXRE in the promoter of human ileal bile acid-binding protein (I-BABP) gene.
Landrier JF, Grober J, Demydchuk J, Besnard P.
FEBS Lett 553(3):299-303. 2003
46NR1H3, NR1H4
Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages
Whitney KD, Watson MA, Goodwin B, Galardi CM, Maglich JM, Wilson JG, Willson TM, Collins JL, Kliewer SA.
J Biol Chem 276(47):43509-15. 2001
47NR1H4, NR5A2
Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydroxylase transcription.
del Castillo-Olivares A, Gil G.
Nucleic Acids Res 28(18):3587-93. 2000
48ABCA1, ABCB11, NR0B2, NR1H3, NR1H4, NR5A2, SCARB1, SLC10A1, SCARB1
Don't know much bile-ology.
Chawla A, Saez E, Evans RM.
Cell 103(1):1-4. No abstract available. 2000
49NR1H4
Identification of a nuclear receptor for bile acids.
Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, Shan B.
Science 284(5418):1362-5. 1999
50NR1H4
Bile acids: natural ligands for an orphan nuclear receptor.
Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM.
Science 284(5418):1365-8. 1999
51NR1H4
Activation of the orphan receptor RIP14 by retinoids.
Zavacki AM, Lehmann JM, Seol W, Willson TM, Kliewer SA, Moore DD.
Proc Natl Acad Sci U S A 94(15):7909-14. 1997
52NR1H4
Identification of a nuclear receptor that is activated by farnesol metabolites.
Forman BM, Goode E, Chen J, Oro AE, Bradley DJ, Perlmann T, Noonan DJ, Burka LT, McMorris T, Lamph WW, et al.
Cell 81(5):687-93. 1995