Citations for
1NR1H3, SLC2A5
Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR.
Zwarts I, van Zutphen T, Kruit JK, Liu W, Oosterveer MH, Verkade HJ, Uhlenhaut NH, Jonker JW.
Sci Rep 9(1):9299. doi: 10.1038/s41598-019-45803-x. 2019
2NR1H3, NR1H4
Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets.
Unsworth AJ, Bye AP, Tannetta DS, Desborough MJR, Kriek N, Sage T, Allan HE, Crescente M, Yaqoob P, Warner TD, Jones CI, Gibbins JM.
Arterioscler Thromb Vasc Biol 37(8):1482-1493. doi: 10.1161/ATVBAHA.117.309135. Epub 2017 Jun 15. 2017
3ABCA1, EEPD1, NR1H2, NR1H3
EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux.
Nelson JK, Koenis DS, Scheij S, Cook EC, Moeton M, Santos A, Lobaccaro JA, Baron S, Zelcer N.
Arterioscler Thromb Vasc Biol 37(3):423-432. doi: 10.1161/ATVBAHA.116.308434. Epub 2017 Jan 12. 2017
4CRTC1, NR1H3
The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation.
Kim H.
Sci Rep 6:37280. doi: 10.1038/srep37280. 2016
5NR1H3, OSBPL2
Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis.
Escajadillo T, Wang H, Li L, Li D, Sewer MB.
Mol Cell Endocrinol 427:73-85. doi: 10.1016/j.mce.2016.03.006. Epub 2016 Mar 16. 2016
6NR1H3, UFM1
UFM1 Protects Macrophages from oxLDL-Induced Foam Cell Formation Through a Liver X Receptor α Dependent Pathway.
Pang Q, Xiong J, Hu XL, He JP, Liu HF, Zhang GY, Li YY, Chen FL.
J Atheroscler Thromb 22(11):1124-40. doi: 10.5551/jat.28829. Epub 2015 Jun 4. 2015
7AJUBA, NR1H3
Ajuba Preferentially Binds LXRα/RXRγ Heterodimer to Enhance LXR Target Gene Expression in Liver Cells.
Fan H, Dong W, Li Q, Zou X, Zhang Y, Wang J, Li S, Liu W, Dong Y, Sun H, Hou Z.
Mol Endocrinol 29(11):1608-18. doi: 10.1210/me.2015-1046. 2015
8IFNG, NR1H3
Identification of interferon-γ as a new molecular target of liver X receptor.
Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y, Han J.
Biochem J 459(2):345-54. doi: 10.1042/BJ20131442. 2014
9ASXL1, ASXL2, NR1H3
Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis.
Park UH, Seong MR, Kim EJ, Hur W, Kim SW, Yoon SK, Um SJ.
Biochem Biophys Res Commun 443(2):489-94. doi: 10.1016/j.bbrc.2013.11.124. 2014
10NR1H2, NR1H3, PIAS1
A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors.
Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L, Liu Y.
J Biol Chem 287(45):37973-85. doi: 10.1074/jbc.M112.403139. Epub 2012 Sep 11. 2012
11LIPE, NR1H3, PLIN1
Liver X receptor (LXR) regulates human adipocyte lipolysis.
Stenson BM, Rydén M, Venteclef N, Dahlman I, Pettersson AM, Mairal A, Aström G, Blomqvist L, Wang V, Jocken JW, Clément K, Langin D, Arner P, Laurencikiene J.
J Biol Chem 286(1):370-9. Epub 2010 Oct 28. 2011
12LPCAT3, NR1H3
Regulation of LPCAT3 by LXR.
Demeure O, Lecerf F, Duby C, Desert C, Ducheix S, Guillou H, Lagarrigue S.
Gene 470(1-2):7-11. Epub 2010 Sep 15. 2011
13CORO2A, NR1H3
Coronin 2A mediates actin-dependent de-repression of inflammatory response genes.
Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK.
Nature 470(7334):414-8. 2011
14CIDEA, NR1H2, NR1H3
CIDEA interacts with liver X receptors in white fat cells.
Kulyté A, Pettersson AT, Antonson P, Stenson BM, Langin D, Gustafsson JA, Staels B, Rydén M, Arner P, Laurencikiene J.
FEBS Lett 585(5):744-8. Epub 2011 Feb 22. 2011
15NR1H2, NR1H3
Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity.
Korach-André M, Archer A, Barros RP, Parini P, Gustafsson JÅ.
Proc Natl Acad Sci U S A 108(1):403-8. Epub 2010 Dec 20. 2011
16NR1H2, NR1H3
Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes.
Ketterer C, Müssig K, Machicao F, Stefan N, Fritsche A, Häring HU, Staiger H.
J Mol Med (Berl) 89(1):75-81. Epub 2010 Nov 2. 2011
17NR1H3, PPARA
PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status.
Caton PW, Holness MJ, Bishop-Bailey D, Sugden MC.
Biochem J 437(3):521-30. 2011
18NR1H3
Activation of liver X receptor (LXR) inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation in an LXRβ-dependent mechanism.
Remen KM, Henning P, Lerner UH, Gustafsson JÅ, Andersson G.
J Biol Chem 286(38):33084-94. Epub 2011 Jul 22. 2011
19MID1IP1, NR1H2, NR1H3
Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation.
Inoue J, Yamasaki K, Ikeuchi E, Satoh S, Fujiwara Y, Nishimaki-Mogami T, Shimizu M, Sato R.
Mol Endocrinol 25(6):995-1005. doi: 10.1210/me.2011-0070. Epub 2011 Apr 7. 2011
20NCOA1, NR1H3, RXRA
Molecular determinants of the interactions between SRC-1 and LXR/RXR heterodimers.
Son YL, Lee YC.
FEBS Lett 584(18):3862-6. Epub 2010 Aug 1. 2010
21NR1H2, NR1H3
Expression of liver X receptors in pregnancies complicated by preeclampsia.
Weedon-Fekjær MS, Johnsen GM, Anthonisen EH, Sugulle M, Nebb HI, Duttaroy AK, Staff AC.
Placenta 31(9):818-24. Epub 2010 Jul 22. 2010
22NR1H2, NR1H3
LXR{beta} is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux.
Hessvik NP, Boekschoten MV, Baltzersen MA, Kersten S, Xu X, Andersén H, Rustan AC, Thoresen GH.
Am J Physiol Endocrinol Metab 298(3):E602-13. Epub 2009 Dec 8. 2010
23NR1H2, NR1H3
Liver X receptor in cholesterol metabolism.
Zhao C, Dahlman-Wright K.
J Endocrinol 204(3):233-40. Epub 2009 Oct 16. Review. 2010
24NR0B1, NR1H3
Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis.
Nedumaran B, Kim GS, Hong S, Yoon YS, Kim YH, Lee CH, Lee YC, Koo SH, Choi HS.
J Biol Chem 285(12):9221-32. Epub 2010 Jan 15. 2010
25AEBP1, NR1H3, PPARG
PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1.
Majdalawieh A, Ro HS.
Nucl Recept Signal 8:e004. doi: 10.1621/nrs.08004. Review. 2010
26HD, HTT, NR1H3
Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors.
Futter M, Diekmann H, Schoenmakers E, Sadiq O, Chatterjee K, Rubinsztein DC.
J Med Genet 46(7):438-46. Epub 2009 May 17. 2009
27NR1H2, NR1H3
Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.
Sacchetti P, Sousa KM, Hall AC, Liste I, Steffensen KR, Theofilopoulos S, Parish CL, Hazenberg C, Richter LA, Hovatta O, Gustafsson JA, Arenas E.
Cell Stem Cell 5(4):409-19. 2009
28NR1H2, NR1H3
Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.
A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, Díaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, Andujar M, Tontonoz P, Castrillo A.
Immunity 31(2):245-58. Epub 2009 Jul 30. 2009
29NR1H2, NR1H3
Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kappaB signalling.
Wu S, Yin R, Ernest R, Li Y, Zhelyabovska O, Luo J, Yang Y, Yang Q.
Cardiovasc Res 84(1):119-26. Epub 2009 Jun 1. 2009
30OSBP, NR1H3
OSBP Negatively Regulates ABCA1 Protein Stability.
Bowden K, Ridgway ND.
J Biol Chem 283(26):18210-7. Epub 2008 May 1. 2008
31NR1H2,NR1H3
Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells.
Delvecchio CJ, Bilan P, Radford K, Stephen J, Trigatti BL, Cox G, Parameswaran K, Capone JP.
Mol Endocrinol 21(6):1324-34. Epub 2007 Apr 3. 2007
32NR1H3, NR1H2
Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity.
Dahlman I, Nilsson M, Jiao H, Hoffstedt J, Lindgren CM, Humphreys K, Kere J, Gustafsson JA, Arner P, Dahlman-Wright K.
Pharmacogenet Genomics 16(12):881-9. 2006
33LDLR,NR1H3
Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.
Ishimoto K, Tachibana K, Sumitomo M, Omote S, Hanano I, Yamasaki D, Watanabe Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.
FEBS Lett 580(20):4929-33. Epub 2006 Aug 14. 2006
34NR1H3
Phosphorylation of the liver X receptors.
Chen M, Bradley MN, Beaven SW, Tontonoz P.
FEBS Lett 580(20):4835-41. Epub 2006 Aug 4. 2006
35MPO, NR1H3, PPARA
The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands.
Reynolds WF, Kumar AP, Piedrafita FJ.
Biochem Biophys Res Commun 349(2):846-54. Epub 2006 Aug 31. 2006
36NR1H3
Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha.
Chen M, Beaven S, Tontonoz P.
J Lipid Res 46(12):2570-9. Epub 2005 Sep 16. 2005
37NR1H2, NR1H3
LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function.
Gerin I, Dolinsky VW, Shackman JG, Kennedy RT, Chiang SH, Burant CF, Steffensen KR, Gustafsson JA, MacDougald OA.
J Biol Chem 280(24):23024-31. Epub 2005 Apr 13. 2005
38FABP6, NR1H4, NR1H3
FXRE can function as an LXRE in the promoter of human ileal bile acid-binding protein (I-BABP) gene.
Landrier JF, Grober J, Demydchuk J, Besnard P.
FEBS Lett 553(3):299-303. 2003
39NR1H3, RXRA
Liver X receptor and retinoic X receptor mediated ABCA1 regulation and cholesterol efflux in macrophage cells-messenger RNA measured by branched DNA technology.
Zhang Y, Beyer T, Bramlett K, Yao S, Burris T, Schmidt R, Eacho P, Cao G.
Mol Genet Metab 77(1-2):150. 2002
40APOE, NR1H3, APOC1, APOC2, APOC4
Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA.
J Biol Chem 277(35):31900-8. 2002
41NR1H3, PPARA
Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha ) in HEK293 cells.
Pawar A, Xu J, Jerks E, Mangelsdorf DJ, Jump DB.
J Biol Chem 277(42):39243-50. 2002
42NR1H3, NR1H2
Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG.
Proc Natl Acad Sci U S A 99(18):11896-901. Epub 2002 Aug 22. 2002
43NR1H3
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P.
Proc Natl Acad Sci U S A 98(2):507-12. 2001
44CYP7A1, NR1H3
Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
Chiang JY, Kimmel R, Stroup D.
Gene 262(1-2):257-65. 2001
45NR1H2, NR1H3, SREBF1
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter.
Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N.
Mol Cell Biol 21(9):2991-3000. 2001
46NR1H3, NR1H4
Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages
Whitney KD, Watson MA, Goodwin B, Galardi CM, Maglich JM, Wilson JG, Willson TM, Collins JL, Kliewer SA.
J Biol Chem 276(47):43509-15. 2001
47NR0B2, NR1H3, NR5A2
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.
Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, Mangelsdorf DJ.
Mol Cell 6(3):507-15. 2000
48ABCA1, ABCB11, NR0B2, NR1H3, NR1H4, NR5A2, SCARB1, SLC10A1, SCARB1
Don't know much bile-ology.
Chawla A, Saez E, Evans RM.
Cell 103(1):1-4. No abstract available. 2000
49NR1H3
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha.
Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, Mangelsdorf DJ.
Cell 93(5):693-704. 1998
50NR1H3
LXR, a nuclear receptor that defines a distinct retinoid response pathway.
Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ.
Genes Dev 9(9):1033-45. 1995