1 | NR1H3, SLC2A5
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| Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR.
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| Zwarts I, van Zutphen T, Kruit JK, Liu W, Oosterveer MH, Verkade HJ, Uhlenhaut NH, Jonker JW.
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| Sci Rep 9(1):9299. doi: 10.1038/s41598-019-45803-x.
2019
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2 | NR1H3, NR1H4
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| Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets.
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| Unsworth AJ, Bye AP, Tannetta DS, Desborough MJR, Kriek N, Sage T, Allan HE, Crescente M, Yaqoob P, Warner TD, Jones CI, Gibbins JM.
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| Arterioscler Thromb Vasc Biol 37(8):1482-1493. doi: 10.1161/ATVBAHA.117.309135. Epub 2017 Jun 15.
2017
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3 | ABCA1, EEPD1, NR1H2, NR1H3
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| EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux.
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| Nelson JK, Koenis DS, Scheij S, Cook EC, Moeton M, Santos A, Lobaccaro JA, Baron S, Zelcer N.
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| Arterioscler Thromb Vasc Biol 37(3):423-432. doi: 10.1161/ATVBAHA.116.308434. Epub 2017 Jan 12.
2017
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4 | CRTC1, NR1H3
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| The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation.
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| Kim H.
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| Sci Rep 6:37280. doi: 10.1038/srep37280.
2016
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5 | NR1H3, OSBPL2
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| Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis.
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| Escajadillo T, Wang H, Li L, Li D, Sewer MB.
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| Mol Cell Endocrinol 427:73-85. doi: 10.1016/j.mce.2016.03.006. Epub 2016 Mar 16.
2016
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6 | NR1H3, UFM1
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| UFM1 Protects Macrophages from oxLDL-Induced Foam Cell Formation Through a Liver X Receptor α Dependent Pathway.
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| Pang Q, Xiong J, Hu XL, He JP, Liu HF, Zhang GY, Li YY, Chen FL.
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| J Atheroscler Thromb 22(11):1124-40. doi: 10.5551/jat.28829. Epub 2015 Jun 4.
2015
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7 | AJUBA, NR1H3
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| Ajuba Preferentially Binds LXRα/RXRγ Heterodimer to Enhance LXR Target Gene Expression in Liver Cells.
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| Fan H, Dong W, Li Q, Zou X, Zhang Y, Wang J, Li S, Liu W, Dong Y, Sun H, Hou Z.
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| Mol Endocrinol 29(11):1608-18. doi: 10.1210/me.2015-1046.
2015
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8 | NR1H3, PRMT3
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| PRMT3 regulates hepatic lipogenesis through direct interaction with LXRα.
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| Kim DI, Park MJ, Lim SK, Park JI, Yoon KC, Han HJ, Gustafsson JÅ, Lim JH, Park SH.
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| Diabetes. Jan;64(1):60-71. doi: 10.2337/db13-1394. Epub 2014 Sep 3. 2015
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9 | IFNG, NR1H3
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| Identification of interferon-γ as a new molecular target of liver X receptor.
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| Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y, Han J.
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| Biochem J 459(2):345-54. doi: 10.1042/BJ20131442.
2014
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10 | ASXL1, ASXL2, NR1H3
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| Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis.
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| Park UH, Seong MR, Kim EJ, Hur W, Kim SW, Yoon SK, Um SJ.
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| Biochem Biophys Res Commun 443(2):489-94. doi: 10.1016/j.bbrc.2013.11.124.
2014
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11 | NR1H2, NR1H3, PIAS1
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| A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors.
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| Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L, Liu Y.
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| J Biol Chem 287(45):37973-85. doi: 10.1074/jbc.M112.403139. Epub 2012 Sep 11.
2012
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12 | IL5, NR1H3
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| Activation of liver X receptor induces macrophage interleukin-5 expression.
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| Chen Y, Duan Y, Kang Y, Yang X, Jiang M, Zhang L, Li G, Yin Z, Hu W, Dong P, Li X, Hajjar DP, Han J.
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| J Biol Chem. Dec 21;287(52):43340-50. doi: 10.1074/jbc.M112.403394. Epub 2012 Nov 13. 2012
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13 | LIPE, NR1H3, PLIN1
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| Liver X receptor (LXR) regulates human adipocyte lipolysis.
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| Stenson BM, Rydén M, Venteclef N, Dahlman I, Pettersson AM, Mairal A, Aström G, Blomqvist L, Wang V, Jocken JW, Clément K, Langin D, Arner P, Laurencikiene J.
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| J Biol Chem 286(1):370-9. Epub 2010 Oct 28.
2011
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14 | LPCAT3, NR1H3
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| Regulation of LPCAT3 by LXR.
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| Demeure O, Lecerf F, Duby C, Desert C, Ducheix S, Guillou H, Lagarrigue S.
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| Gene 470(1-2):7-11. Epub 2010 Sep 15.
2011
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15 | CORO2A, NR1H3
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| Coronin 2A mediates actin-dependent de-repression of inflammatory response genes.
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| Huang W, Ghisletti S, Saijo K, Gandhi M, Aouadi M, Tesz GJ, Zhang DX, Yao J, Czech MP, Goode BL, Rosenfeld MG, Glass CK.
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| Nature 470(7334):414-8. 2011
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16 | CIDEA, NR1H2, NR1H3
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| CIDEA interacts with liver X receptors in white fat cells.
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| Kulyté A, Pettersson AT, Antonson P, Stenson BM, Langin D, Gustafsson JA, Staels B, Rydén M, Arner P, Laurencikiene J.
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| FEBS Lett 585(5):744-8. Epub 2011 Feb 22.
2011
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17 | NR1H2, NR1H3
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| Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity.
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| Korach-André M, Archer A, Barros RP, Parini P, Gustafsson JÅ.
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| Proc Natl Acad Sci U S A 108(1):403-8. Epub 2010 Dec 20.
2011
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18 | NR1H2, NR1H3
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| Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes.
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| Ketterer C, Müssig K, Machicao F, Stefan N, Fritsche A, Häring HU, Staiger H.
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| J Mol Med (Berl) 89(1):75-81. Epub 2010 Nov 2.
2011
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19 | NR1H3, PPARA
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| PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status.
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| Caton PW, Holness MJ, Bishop-Bailey D, Sugden MC.
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| Biochem J 437(3):521-30.
2011
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20 | NR1H3
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| Activation of liver X receptor (LXR) inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation in an LXRβ-dependent mechanism.
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| Remen KM, Henning P, Lerner UH, Gustafsson JÅ, Andersson G.
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| J Biol Chem 286(38):33084-94. Epub 2011 Jul 22.
2011
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21 | MID1IP1, NR1H2, NR1H3
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| Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation.
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| Inoue J, Yamasaki K, Ikeuchi E, Satoh S, Fujiwara Y, Nishimaki-Mogami T, Shimizu M, Sato R.
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| Mol Endocrinol 25(6):995-1005. doi: 10.1210/me.2011-0070. Epub 2011 Apr 7.
2011
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22 | NCOA1, NR1H3, RXRA
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| Molecular determinants of the interactions between SRC-1 and LXR/RXR heterodimers.
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| Son YL, Lee YC.
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| FEBS Lett 584(18):3862-6. Epub 2010 Aug 1.
2010
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23 | NR1H2, NR1H3
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| Expression of liver X receptors in pregnancies complicated by preeclampsia.
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| Weedon-Fekjær MS, Johnsen GM, Anthonisen EH, Sugulle M, Nebb HI, Duttaroy AK, Staff AC.
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| Placenta 31(9):818-24. Epub 2010 Jul 22.
2010
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24 | NR1H2, NR1H3
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| LXR{beta} is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux.
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| Hessvik NP, Boekschoten MV, Baltzersen MA, Kersten S, Xu X, Andersén H, Rustan AC, Thoresen GH.
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| Am J Physiol Endocrinol Metab 298(3):E602-13. Epub 2009 Dec 8.
2010
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25 | NR1H2, NR1H3
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| Liver X receptor in cholesterol metabolism.
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| Zhao C, Dahlman-Wright K.
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| J Endocrinol 204(3):233-40. Epub 2009 Oct 16. Review.
2010
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26 | NR0B1, NR1H3
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| Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis.
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| Nedumaran B, Kim GS, Hong S, Yoon YS, Kim YH, Lee CH, Lee YC, Koo SH, Choi HS.
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| J Biol Chem 285(12):9221-32. Epub 2010 Jan 15.
2010
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27 | AEBP1, NR1H3, PPARG
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| PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1.
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| Majdalawieh A, Ro HS.
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| Nucl Recept Signal 8:e004. doi: 10.1621/nrs.08004. Review.
2010
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28 | HD, HTT, NR1H3
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| Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors.
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| Futter M, Diekmann H, Schoenmakers E, Sadiq O, Chatterjee K, Rubinsztein DC.
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| J Med Genet 46(7):438-46. Epub 2009 May 17.
2009
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29 | NR1H2, NR1H3
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| Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.
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| Sacchetti P, Sousa KM, Hall AC, Liste I, Steffensen KR, Theofilopoulos S, Parish CL, Hazenberg C, Richter LA, Hovatta O, Gustafsson JA, Arenas E.
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| Cell Stem Cell 5(4):409-19.
2009
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30 | NR1H2, NR1H3
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| Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.
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| A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, Díaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, Andujar M, Tontonoz P, Castrillo A.
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| Immunity 31(2):245-58. Epub 2009 Jul 30.
2009
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31 | NR1H2, NR1H3
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| Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kappaB signalling.
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| Wu S, Yin R, Ernest R, Li Y, Zhelyabovska O, Luo J, Yang Y, Yang Q.
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| Cardiovasc Res 84(1):119-26. Epub 2009 Jun 1.
2009
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32 | OSBP, NR1H3
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| OSBP Negatively Regulates ABCA1 Protein Stability.
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| Bowden K, Ridgway ND.
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| J Biol Chem 283(26):18210-7. Epub 2008 May 1. 2008
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33 | NR1H2,NR1H3
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| Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells.
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| Delvecchio CJ, Bilan P, Radford K, Stephen J, Trigatti BL, Cox G, Parameswaran K, Capone JP.
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| Mol Endocrinol 21(6):1324-34. Epub 2007 Apr 3. 2007
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34 | NR1H3, NR1H2
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| Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity.
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| Dahlman I, Nilsson M, Jiao H, Hoffstedt J, Lindgren CM, Humphreys K, Kere J, Gustafsson JA, Arner P, Dahlman-Wright K.
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| Pharmacogenet Genomics 16(12):881-9. 2006
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35 | LDLR,NR1H3
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| Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.
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| Ishimoto K, Tachibana K, Sumitomo M, Omote S, Hanano I, Yamasaki D, Watanabe Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.
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| FEBS Lett 580(20):4929-33. Epub 2006 Aug 14. 2006
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36 | NR1H3
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| Phosphorylation of the liver X receptors.
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| Chen M, Bradley MN, Beaven SW, Tontonoz P.
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| FEBS Lett 580(20):4835-41. Epub 2006 Aug 4. 2006
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37 | MPO, NR1H3, PPARA
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| The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands.
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| Reynolds WF, Kumar AP, Piedrafita FJ.
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| Biochem Biophys Res Commun 349(2):846-54. Epub 2006 Aug 31. 2006
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38 | NR1H3
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| Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha.
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| Chen M, Beaven S, Tontonoz P.
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| J Lipid Res 46(12):2570-9. Epub 2005 Sep 16. 2005
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39 | NR1H2, NR1H3
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| LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function.
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| Gerin I, Dolinsky VW, Shackman JG, Kennedy RT, Chiang SH, Burant CF, Steffensen KR, Gustafsson JA, MacDougald OA.
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| J Biol Chem 280(24):23024-31. Epub 2005 Apr 13. 2005
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40 | FABP6, NR1H4, NR1H3
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| FXRE can function as an LXRE in the promoter of human ileal bile acid-binding protein (I-BABP) gene.
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| Landrier JF, Grober J, Demydchuk J, Besnard P.
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| FEBS Lett 553(3):299-303. 2003
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41 | NR1H3, RXRA
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| Liver X receptor and retinoic X receptor mediated ABCA1 regulation and cholesterol efflux in macrophage cells-messenger RNA measured by branched DNA technology.
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| Zhang Y, Beyer T, Bramlett K, Yao S, Burris T, Schmidt R, Eacho P, Cao G.
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| Mol Genet Metab 77(1-2):150. 2002
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42 | APOE, NR1H3, APOC1, APOC2, APOC4
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| Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
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| Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA.
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| J Biol Chem 277(35):31900-8. 2002
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43 | NR1H3, PPARA
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| Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha ) in HEK293 cells.
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| Pawar A, Xu J, Jerks E, Mangelsdorf DJ, Jump DB.
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| J Biol Chem 277(42):39243-50. 2002
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44 | NR1H3, NR1H2
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| Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
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| Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG.
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| Proc Natl Acad Sci U S A 99(18):11896-901. Epub 2002 Aug 22. 2002
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45 | NR1H3
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| LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
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| Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P.
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| Proc Natl Acad Sci U S A 98(2):507-12. 2001
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46 | CYP7A1, NR1H3
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| Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
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| Chiang JY, Kimmel R, Stroup D.
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| Gene 262(1-2):257-65. 2001
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47 | NR1H2, NR1H3, SREBF1
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| Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter.
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| Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N.
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| Mol Cell Biol 21(9):2991-3000. 2001
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48 | NR1H3, NR1H4
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| Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages
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| Whitney KD, Watson MA, Goodwin B, Galardi CM, Maglich JM, Wilson JG, Willson TM, Collins JL, Kliewer SA.
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| J Biol Chem 276(47):43509-15. 2001
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49 | NR0B2, NR1H3, NR5A2
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| Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.
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| Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, Mangelsdorf DJ.
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| Mol Cell 6(3):507-15. 2000
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50 | ABCA1, ABCB11, NR0B2, NR1H3, NR1H4, NR5A2, SCARB1, SLC10A1, SCARB1
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| Don't know much bile-ology.
|
| Chawla A, Saez E, Evans RM.
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| Cell 103(1):1-4. No abstract available. 2000
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51 | NR1H3
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| Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha.
|
| Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, Mangelsdorf DJ.
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| Cell 93(5):693-704. 1998
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52 | NR1H3
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| LXR, a nuclear receptor that defines a distinct retinoid response pathway.
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| Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ.
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| Genes Dev 9(9):1033-45. 1995
|