Citations for
1NR1D1, SPSB1, SPSB2, SPSB3, SPSB4
The E3 Ligases Spsb1 and Spsb4 Regulate RevErbα Degradation and Circadian Period.
Mekbib T, Suen TC, Rollins-Hairston A, DeBruyne JP.
J Biol Rhythms Dec;34(6):610-621. doi: 10.1177/0748730419878036. Epub 2019 Oct 14. 2019
2NR1D1, STRA8
Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice
Ferder IC, Fung L, Ohguchi Y, Zhang X, Lassen KG, Capen D, Brown D, Xavier RJ, Wang N.
PLoS Genet. May 6;15(5):e1008084. doi: 10.1371/journal.pgen.1008084. 2019
3NR1D1, NR3C1
REV-ERBα influences the stability and nuclear localization of the glucocorticoid receptor.
Okabe T, Chavan R, Fonseca Costa SS, Brenna A, Ripperger JA, Albrecht U.
J Cell Sci 129(21):4143-4154. 2016
4NR1D1
Rev-Erbα modulates retinal visual processing and behavioral responses to light.
Ait-Hmyed Hakkari O, Acar N, Savier E, Spinnhirny P, Bennis M, Felder-Schmittbuhl MP, Mendoza J, Hicks D.
FASEB J 30(11):3690-3701. 2016
5FBXW7, NR1D1
Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation.
Zhao X, Hirota T, Han X, Cho H, Chong LW, Lamia K, Liu S, Atkins AR, Banayo E, Liddle C, Yu RT, Yates JR 3rd, Kay SA, Downes M, Evans RM.
Cell 165(7):1644-57. doi: 10.1016/j.cell.2016.05.012. 2016
6FGF21, NR1D1
The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling.
Jager J, Wang F, Fang B, Lim HW, Peed LC, Steger DJ, Won KJ, Kharitonenkov A, Adams AC, Lazar MA.
J Biol Chem 291(20):10867-75. doi: 10.1074/jbc.M116.719120. 2016
7ARNTL, CLOCK, FABP7, NPAS2, NR1D1
Altered Sleep Homeostasis in Rev-erbα Knockout Mice.
Mang GM, La Spada F, Emmenegger Y, Chappuis S, Ripperger JA, Albrecht U, Franken P.
Sleep 39(3):589-601. doi: 10.5665/sleep.5534. 2016
8NR1D1, NR1D2
Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression.
Amador A, Wang Y, Banerjee S, Kameneka TM, Solt LA, Burris TP.
PLoS One 11(3):e0151014. doi: 10.1371/journal.pone.0151014. Erratum in: PLoS One. 2016;11(5):e0156367. 2016
9NR1D1, SIAH2
Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock.
DeBruyne JP, Baggs JE, Sato TK, Hogenesch JB.
Proc Natl Acad Sci U S A 112(40):12420-5. doi: 10.1073/pnas.1501204112. 2015
10NR1D1
Inhibitory role of REV-ERBα in the expression of bone morphogenetic protein gene family in rat uterus endometrium stromal cells.
Tasaki H, Zhao L, Isayama K, Chen H, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA.
Am J Physiol Cell Physiol 308(7):C528-38. doi: 10.1152/ajpcell.00220.2014. 2015
11APOA4, NR1D1, NR4A1
Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line.
Li X, Xu M, Wang F, Ji Y, DavidsoN WS, Li Z, Tso P.
PLoS One 10(11):e0142098. doi: 10.1371/journal.pone.0142098. 2015
12CACNA1C, NR1D1
A specific role for the REV-ERBα-controlled L-Type Voltage-Gated Calcium Channel CaV1.2 in resetting the circadian clock in the late night.
Schmutz I, Chavan R, Ripperger JA, Maywood ES, Langwieser N, Jurik A, Stauffer A, Delorme JE, Moosmang S, Hastings MH, Hofmann F, Albrecht U.
J Biol Rhythms 29(4):288-98. doi: 10.1177/0748730414540453. 2014
13FABP7, NR1D1
The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis.
Schnell A, Chappuis S, Schmutz I, Brai E, Ripperger JA, Schaad O, Welzl H, Descombes P, Alberi L, Albrecht U.
PLoS One 9(6):e99883. doi: 10.1371/journal.pone.0099883. 2014
14APOA4, NR1D1
Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1.
Li X, Xu M, Wang F, Kohan AB, Haas MK, Yang Q, Lou D, Obici S, Davidson WS, Tso P.
J Biol Chem 289(4):2396-404. doi: 10.1074/jbc.M113.511766. 2014
15CCL2, NR1D1
A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.
Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T.
J Immunol 192(1):407-17. doi: 10.4049/jimmunol.1301982. 2014
16NR1D1, NR1D2
Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour.
Banerjee S, Wang Y, Solt LA, Griffett K, Kazantzis M, Amador A, El-Gendy BM, Huitron-Resendiz S, Roberts AJ, Shin Y, Kamenecka TM, Burris TP.
Nat Commun 5:5759. doi: 10.1038/ncomms6759. 2014
17NAMPT, NR1D1, SIRT1
Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells.
Vieira E, Marroquí L, Figueroa AL, Merino B, Fernandez-Ruiz R, Nadal A, Burris TP, Gomis R, Quesada I.
PLoS One 8(7):e69939. doi: 10.1371/journal.pone.0069939. 2013
18NR1D1
Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy.
Woldt E, Sebti Y, Solt LA, Duhem C, Lancel S, Eeckhoute J, Hesselink MK, Paquet C, Delhaye S, Shin Y, Kamenecka TM, Schaart G, Lefebvre P, Nevière R, Burris TP, Schrauwen P, Staels B, Duez H.
Nat Med 19(8):1039-46. doi: 10.1038/nm.3213. 2013
19CCAR2, NR1D1
DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα.
Chini CC, Escande C, Nin V, Chini EN.
Biochem J 451(3):453-61. doi: 10.1042/BJ20121085. 2013
20GJA1, NR1D1, SP1
Role of Rev-erbα domains for transactivation of the connexin43 promoter with Sp1.
Negoro H, Okinami T, Kanematsu A, Imamura M, Tabata Y, Ogawa O.
FEBS Lett 587(1):98-103. doi: 10.1016/j.febslet.2012.11.021. 2013
21NR1D1, NR1D2
Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function.
Bugge A, Feng D, Everett LJ, Briggs ER, Mullican SE, Wang F, Jager J, Lazar MA.
Genes Dev 26(7):657-67. doi: 10.1101/gad.186858.112. 2012
22NR1D1
The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines.
Gibbs JE, Blaikley J, Beesley S, Matthews L, Simpson KD, Boyce SH, Farrow SN, Else KJ, Singh D, Ray DW, Loudon AS.
Proc Natl Acad Sci U S A 109(2):582-7. doi: 10.1073/pnas.1106750109. 2012
23NR1D1
Direct regulation of CLOCK expression by REV-ERB.
Crumbley C, Burris TP.
PLoS One 6(3):e17290. 2011
24HDAC3, NR1D1
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.
Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, Liu XS, Lazar MA.
Science 331(6022):1315-9. 2011
25NR1D1, RORA
Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene.
Crumbley C, Wang Y, Kojetin DJ, Burris TP.
J Biol Chem 285(46):35386-92. Epub 2010 Sep 3. 2010
26ID1, NR1D1
Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.
Phelan CA, Gampe RT Jr, Lambert MH, Parks DJ, Montana V, Bynum J, Broderick TM, Hu X, Williams SP, Nolte RT, Lazar MA.
Nat Struct Mol Biol 17(7):808-14. Epub 2010 Jun 27. 2010
27DGKH, NR1D1
Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients.
Manchia M, Squassina A, Congiu D, Chillotti C, Ardau R, Severino G, Del Zompo M.
Neurosci Lett 467(2):67-71. Epub 2009 Oct 7.PMID: 1981838 2009
28NR1D1
REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.
Le Martelot G, Claudel T, Gatfield D, Schaad O, Kornmann B, Sasso GL, Moschetta A, Schibler U.
PLoS Biol 7(9):e1000181. Epub 2009 Sep 1. 2009
29NR1D1
Rev-erb-alpha: an integrator of circadian rhythms and metabolism.
Duez H, Staels B.
J Appl Physiol 107(6):1972-80. Epub 2009 Aug 20. Review. 2009
30NR1D1, NR1D2
The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter.
Wang J, Liu N, Liu Z, Li Y, Song C, Yuan H, Li YY, Zhao X, Lu H.
Biochim Biophys Acta 1783(2):224-36. Epub 2007 Oct 4. 2008
31NR1D1
Bifunctional role of Rev-erbalpha in adipocyte differentiation.
Wang J, Lazar MA.
Mol Cell Biol 28(7):2213-20. Epub 2008 Jan 28. 2008
32NR1D1, NR1D2
Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms.
Liu AC, Tran HG, Zhang EE, Priest AA, Welsh DK, Kay SA.
PLoS Genet 4(2):e1000023. doi: 10.1371/journal.pgen.1000023. 2008
33NR1D2, NR1D1
Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta.
Raghuram S, Stayrook KR, Huang P, Rogers PM, Nosie AK, McClure DB, Burris LL, Khorasanizadeh S, Burris TP, Rastinejad F.
Nat Struct Mol Biol 14(12):1207-13. Epub 2007 Nov 25. 2007
34ARNTL, CRY1, CRY2, NR1D1, PER1, PER3
Localization of a circadian clock in mammalian photoreceptors.
Tosini G, Davidson AJ, Fukuhara C, Kasamatsu M, Castanon-Cervantes O.
FASEB J 21(14):3866-71. Epub 2007 Jul 9. Erratum in: FASEB J. 2008 Mar;22(3):941. 2007
35NR2E3, NR1D1, CRX, NRL
Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors.
Cheng H, Khanna H, Oh EC, Hicks D, Mitton KP, Swaroop A.
Hum Mol Genet 13(15):1563-75. Epub 2004 Jun 09. 2004
36RORA, NR1D1
Identification of Reverb(alpha) as a novel ROR(alpha) target gene.
Delerive P, Chin WW, Suen CS.
J Biol Chem 277(38):35013-8. Epub 2002 Jul 11. 2002
37NR1D1
Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha.
Burke LJ, Downes M, Laudet V, Muscat GE.
Mol Endocrinol 12(2):248-62. 1998
38NR1D1
A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity.
Adelmant G, Begue A, Stehelin D, Laudet V.
Proc Natl Acad Sci U S A 93(8):3553-8. 1996
39NR1D1
Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone.
Lazar MA, Jones KE, Chin WW.
DNA Cell Biol 9(2):77-83. 1990
40NR1D1, THRA
Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.
Miyajima N, et al.
Cell 57 : 31-39. 1989