1 | NR1D1, SPSB1, SPSB2, SPSB3, SPSB4
|
| The E3 Ligases Spsb1 and Spsb4 Regulate RevErbα Degradation and Circadian Period.
|
| Mekbib T, Suen TC, Rollins-Hairston A, DeBruyne JP.
|
| J Biol Rhythms Dec;34(6):610-621. doi: 10.1177/0748730419878036. Epub 2019 Oct 14. 2019
|
2 | NR1D1, STRA8
|
| Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice
|
| Ferder IC, Fung L, Ohguchi Y, Zhang X, Lassen KG, Capen D, Brown D, Xavier RJ, Wang N.
|
| PLoS Genet. May 6;15(5):e1008084. doi: 10.1371/journal.pgen.1008084. 2019
|
3 | NR1D1, NR3C1
|
| REV-ERBα influences the stability and nuclear localization of the glucocorticoid receptor.
|
| Okabe T, Chavan R, Fonseca Costa SS, Brenna A, Ripperger JA, Albrecht U.
|
| J Cell Sci 129(21):4143-4154.
2016
|
4 | NR1D1
|
| Rev-Erbα modulates retinal visual processing and behavioral responses to light.
|
| Ait-Hmyed Hakkari O, Acar N, Savier E, Spinnhirny P, Bennis M, Felder-Schmittbuhl MP, Mendoza J, Hicks D.
|
| FASEB J 30(11):3690-3701.
2016
|
5 | FBXW7, NR1D1
|
| Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation.
|
| Zhao X, Hirota T, Han X, Cho H, Chong LW, Lamia K, Liu S, Atkins AR, Banayo E, Liddle C, Yu RT, Yates JR 3rd, Kay SA, Downes M, Evans RM.
|
| Cell 165(7):1644-57. doi: 10.1016/j.cell.2016.05.012.
2016
|
6 | FGF21, NR1D1
|
| The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling.
|
| Jager J, Wang F, Fang B, Lim HW, Peed LC, Steger DJ, Won KJ, Kharitonenkov A, Adams AC, Lazar MA.
|
| J Biol Chem 291(20):10867-75. doi: 10.1074/jbc.M116.719120.
2016
|
7 | ARNTL, CLOCK, FABP7, NPAS2, NR1D1
|
| Altered Sleep Homeostasis in Rev-erbα Knockout Mice.
|
| Mang GM, La Spada F, Emmenegger Y, Chappuis S, Ripperger JA, Albrecht U, Franken P.
|
| Sleep 39(3):589-601. doi: 10.5665/sleep.5534.
2016
|
8 | NR1D1, NR1D2
|
| Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression.
|
| Amador A, Wang Y, Banerjee S, Kameneka TM, Solt LA, Burris TP.
|
| PLoS One 11(3):e0151014. doi: 10.1371/journal.pone.0151014. Erratum in: PLoS One. 2016;11(5):e0156367.
2016
|
9 | NR1D1, SIAH2
|
| Ubiquitin ligase Siah2 regulates RevErbα degradation and the mammalian circadian clock.
|
| DeBruyne JP, Baggs JE, Sato TK, Hogenesch JB.
|
| Proc Natl Acad Sci U S A 112(40):12420-5. doi: 10.1073/pnas.1501204112.
2015
|
10 | NR1D1
|
| Inhibitory role of REV-ERBα in the expression of bone morphogenetic protein gene family in rat uterus endometrium stromal cells.
|
| Tasaki H, Zhao L, Isayama K, Chen H, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA.
|
| Am J Physiol Cell Physiol 308(7):C528-38. doi: 10.1152/ajpcell.00220.2014.
2015
|
11 | APOA4, NR1D1, NR4A1
|
| Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line.
|
| Li X, Xu M, Wang F, Ji Y, DavidsoN WS, Li Z, Tso P.
|
| PLoS One 10(11):e0142098. doi: 10.1371/journal.pone.0142098.
2015
|
12 | CACNA1C, NR1D1
|
| A specific role for the REV-ERBα-controlled L-Type Voltage-Gated Calcium Channel CaV1.2 in resetting the circadian clock in the late night.
|
| Schmutz I, Chavan R, Ripperger JA, Maywood ES, Langwieser N, Jurik A, Stauffer A, Delorme JE, Moosmang S, Hastings MH, Hofmann F, Albrecht U.
|
| J Biol Rhythms 29(4):288-98. doi: 10.1177/0748730414540453.
2014
|
13 | FABP7, NR1D1
|
| The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis.
|
| Schnell A, Chappuis S, Schmutz I, Brai E, Ripperger JA, Schaad O, Welzl H, Descombes P, Alberi L, Albrecht U.
|
| PLoS One 9(6):e99883. doi: 10.1371/journal.pone.0099883.
2014
|
14 | APOA4, NR1D1
|
| Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1.
|
| Li X, Xu M, Wang F, Kohan AB, Haas MK, Yang Q, Lou D, Obici S, Davidson WS, Tso P.
|
| J Biol Chem 289(4):2396-404. doi: 10.1074/jbc.M113.511766.
2014
|
15 | CCL2, NR1D1
|
| A circadian clock gene, Rev-erbα, modulates the inflammatory function of macrophages through the negative regulation of Ccl2 expression.
|
| Sato S, Sakurai T, Ogasawara J, Takahashi M, Izawa T, Imaizumi K, Taniguchi N, Ohno H, Kizaki T.
|
| J Immunol 192(1):407-17. doi: 10.4049/jimmunol.1301982.
2014
|
16 | NR1D1, NR1D2
|
| Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour.
|
| Banerjee S, Wang Y, Solt LA, Griffett K, Kazantzis M, Amador A, El-Gendy BM, Huitron-Resendiz S, Roberts AJ, Shin Y, Kamenecka TM, Burris TP.
|
| Nat Commun 5:5759. doi: 10.1038/ncomms6759.
2014
|
17 | NAMPT, NR1D1, SIRT1
|
| Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells.
|
| Vieira E, Marroquí L, Figueroa AL, Merino B, Fernandez-Ruiz R, Nadal A, Burris TP, Gomis R, Quesada I.
|
| PLoS One 8(7):e69939. doi: 10.1371/journal.pone.0069939.
2013
|
18 | NR1D1
|
| Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy.
|
| Woldt E, Sebti Y, Solt LA, Duhem C, Lancel S, Eeckhoute J, Hesselink MK, Paquet C, Delhaye S, Shin Y, Kamenecka TM, Schaart G, Lefebvre P, Nevière R, Burris TP, Schrauwen P, Staels B, Duez H.
|
| Nat Med 19(8):1039-46. doi: 10.1038/nm.3213.
2013
|
19 | CCAR2, NR1D1
|
| DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα.
|
| Chini CC, Escande C, Nin V, Chini EN.
|
| Biochem J 451(3):453-61. doi: 10.1042/BJ20121085. 2013
|
20 | GJA1, NR1D1, SP1
|
| Role of Rev-erbα domains for transactivation of the connexin43 promoter with Sp1.
|
| Negoro H, Okinami T, Kanematsu A, Imamura M, Tabata Y, Ogawa O.
|
| FEBS Lett 587(1):98-103. doi: 10.1016/j.febslet.2012.11.021.
2013
|
21 | NR1D1, NR1D2
|
| Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function.
|
| Bugge A, Feng D, Everett LJ, Briggs ER, Mullican SE, Wang F, Jager J, Lazar MA.
|
| Genes Dev 26(7):657-67. doi: 10.1101/gad.186858.112.
2012
|
22 | NR1D1
|
| The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines.
|
| Gibbs JE, Blaikley J, Beesley S, Matthews L, Simpson KD, Boyce SH, Farrow SN, Else KJ, Singh D, Ray DW, Loudon AS.
|
| Proc Natl Acad Sci U S A 109(2):582-7. doi: 10.1073/pnas.1106750109.
2012
|
23 | NR1D1
|
| Direct regulation of CLOCK expression by REV-ERB.
|
| Crumbley C, Burris TP.
|
| PLoS One 6(3):e17290.
2011
|
24 | HDAC3, NR1D1
|
| A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism.
|
| Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, Liu XS, Lazar MA.
|
| Science 331(6022):1315-9.
2011
|
25 | NR1D1, RORA
|
| Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene.
|
| Crumbley C, Wang Y, Kojetin DJ, Burris TP.
|
| J Biol Chem 285(46):35386-92. Epub 2010 Sep 3.
2010
|
26 | ID1, NR1D1
|
| Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction.
|
| Phelan CA, Gampe RT Jr, Lambert MH, Parks DJ, Montana V, Bynum J, Broderick TM, Hu X, Williams SP, Nolte RT, Lazar MA.
|
| Nat Struct Mol Biol 17(7):808-14. Epub 2010 Jun 27.
2010
|
27 | DGKH, NR1D1
|
| Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients.
|
| Manchia M, Squassina A, Congiu D, Chillotti C, Ardau R, Severino G, Del Zompo M.
|
| Neurosci Lett 467(2):67-71. Epub 2009 Oct 7.PMID: 1981838 2009
|
28 | NR1D1
|
| REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.
|
| Le Martelot G, Claudel T, Gatfield D, Schaad O, Kornmann B, Sasso GL, Moschetta A, Schibler U.
|
| PLoS Biol 7(9):e1000181. Epub 2009 Sep 1.
2009
|
29 | NR1D1
|
| Rev-erb-alpha: an integrator of circadian rhythms and metabolism.
|
| Duez H, Staels B.
|
| J Appl Physiol 107(6):1972-80. Epub 2009 Aug 20. Review.
2009
|
30 | NR1D1, NR1D2
|
| The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter.
|
| Wang J, Liu N, Liu Z, Li Y, Song C, Yuan H, Li YY, Zhao X, Lu H.
|
| Biochim Biophys Acta 1783(2):224-36. Epub 2007 Oct 4. 2008
|
31 | NR1D1
|
| Bifunctional role of Rev-erbalpha in adipocyte differentiation.
|
| Wang J, Lazar MA.
|
| Mol Cell Biol 28(7):2213-20. Epub 2008 Jan 28. 2008
|
32 | NR1D1, NR1D2
|
| Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms.
|
| Liu AC, Tran HG, Zhang EE, Priest AA, Welsh DK, Kay SA.
|
| PLoS Genet 4(2):e1000023. doi: 10.1371/journal.pgen.1000023.
2008
|
33 | NR1D2, NR1D1
|
| Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta.
|
| Raghuram S, Stayrook KR, Huang P, Rogers PM, Nosie AK, McClure DB, Burris LL, Khorasanizadeh S, Burris TP, Rastinejad F.
|
| Nat Struct Mol Biol 14(12):1207-13. Epub 2007 Nov 25. 2007
|
34 | ARNTL, CRY1, CRY2, NR1D1, PER1, PER3
|
| Localization of a circadian clock in mammalian photoreceptors.
|
| Tosini G, Davidson AJ, Fukuhara C, Kasamatsu M, Castanon-Cervantes O.
|
| FASEB J 21(14):3866-71. Epub 2007 Jul 9. Erratum in: FASEB J. 2008 Mar;22(3):941.
2007
|
35 | NR2E3, NR1D1, CRX, NRL
|
| Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors.
|
| Cheng H, Khanna H, Oh EC, Hicks D, Mitton KP, Swaroop A.
|
| Hum Mol Genet 13(15):1563-75. Epub 2004 Jun 09. 2004
|
36 | RORA, NR1D1
|
| Identification of Reverb(alpha) as a novel ROR(alpha) target gene.
|
| Delerive P, Chin WW, Suen CS.
|
| J Biol Chem 277(38):35013-8. Epub 2002 Jul 11. 2002
|
37 | NR1D1
|
| Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha.
|
| Burke LJ, Downes M, Laudet V, Muscat GE.
|
| Mol Endocrinol 12(2):248-62. 1998
|
38 | NR1D1
|
| A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity.
|
| Adelmant G, Begue A, Stehelin D, Laudet V.
|
| Proc Natl Acad Sci U S A 93(8):3553-8. 1996
|
39 | NR1D1
|
| Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone.
|
| Lazar MA, Jones KE, Chin WW.
|
| DNA Cell Biol 9(2):77-83. 1990
|
40 | NR1D1, THRA
|
| Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.
|
| Miyajima N, et al.
|
| Cell 57 : 31-39. 1989
|