Citations for
1NPAS2, NR0B2
Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism.
Lee SM, Zhang Y, Tsuchiya H, Smalling R, Jetten AM, Wang L.
Hepatology 61(2):497-505. doi: 10.1002/hep.27437. 2015
2ABCB11, NR0B2, NR1H4, SLC10A1
The nuclear receptor FXR, but not LXR, up-regulates bile acid transporter expression in non-alcoholic fatty liver disease.
Aguilar-Olivos NE, Carrillo-Córdova D, Oria-Hernández J, Sánchez-Valle V, Ponciano-Rodríguez G, Ramírez-Jaramillo M, Chablé-Montero F, Chávez-Tapia NC, Uribe M, Méndez-Sánchez N.
Ann Hepatol 14(4):487-93. 2015
3CYP7A1, NR0B2, VDR
Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.
Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS.
Gastroenterology 146(4):1048-59. doi: 10.1053/j.gastro.2013.12.027. Epub 2013 Dec 21. 2014
4GLI1, NR0B2
SHP (small heterodimer partner) suppresses the transcriptional activity and nuclear localization of Hedgehog signalling protein Gli1.
Kim K, Kim KH, Cho HK, Kim HY, Kim HH, Cheong J.
Biochem J 427(3):413-22. 2010
5NR0B2, NR5A2, SIRT1
Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation.
Chanda D, Xie YB, Choi HS.
Nucleic Acids Res 38(14):4607-19. Epub 2010 Apr 7. 2010
6FGF19, NR0B2
Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis.
Bhatnagar S, Damron HA, Hillgartner FB.
J Biol Chem 284(15):10023-33. Epub 2009 Feb 20. 2009
7NR0B2
The orphan nuclear receptor SHP inhibits apoptosis during the monocytic differentiation by inducing p21WAF1.
Kim K, Choi YH, Kim HH, Cheong J.
Exp Mol Med 41(6):429-39. 2009
8CREBZF, NR0B2
SMILE, a new orphan nuclear receptor SHP-interacting protein, regulates SHP-repressed estrogen receptor transactivation.
Xie YB, Lee OH, Nedumaran B, Seong HA, Lee KM, Ha H, Lee IK, Yun Y, Choi HS.
Biochem J 416(3):463-73. 2008
9NR0B2, ONECUT1
Orphan nuclear receptor SHP interacts with and represses hepatocyte nuclear factor-6 (HNF-6) transactivation.
Lee YS, Kim DK, Kim YD, Park KC, Shong M, Seong HA, Ha HJ, Choi HS.
Biochem J 413(3):559-69. doi: 10.1042/BJ20071637. 2008
10NR0B2, NR1H4
Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration.
Li YT, Swales KE, Thomas GJ, Warner TD, Bishop-Bailey D.
Arterioscler Thromb Vasc Biol 27(12):2606-11. 2007
11DAX1, NR0B2
LXXLL motifs and AF-2 domain mediate SHP (NR0B2) homodimerization and DAX1 (NR0B1)-DAX1A heterodimerization.
Iyer AK, Zhang YH, McCabe ER.
Mol Genet Metab 92(1-2):151-9. Epub 2007 Aug 7. 2007
12NR0B2
Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.
Boulias K, Katrakili N, Bamberg K, Underhill P, Greenfield A, Talianidis I.
EMBO J 24(14):2624-33. Epub 2005 Jun 23. 2005
13NR0B2
Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus.
Jones ML, Craik JD, Gibbins JM, Poole AW.
J Biol Chem 279(39):40475-83. Epub 2004 Jul 21. 2004
14NR0B2
Orphan nuclear receptor small heterodimer partner represses hepatocyte nuclear factor 3/Foxa transactivation via inhibition of its DNA binding.
Kim JY, Kim HJ, Kim KT, Park YY, Seong HA, Park KC, Lee IK, Ha H, Shong M, Park SC, Choi HS.
Mol Endocrinol 18(12):2880-94. Epub 2004 Sep 9. 2004
15NR0B2
Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects.
Nishigori H, Tomura H, Tonooka N, Kanamori M, Yamada S, Sho K, Inoue I, Kikuchi N, Onigata K, Kojima I, Kohama T, Yamagata K, Yang Q, Matsuzawa Y, Miki T, Seino S, Kim MY, Choi HS, Lee YK, Moore DD, Takeda J.
Proc Natl Acad Sci U S A 98(2):575-80. 2001
16CYP7A1, NR0B2, NR5A2
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.
Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, Galardi C, Wilson JG, Lewis MC, Roth ME, Maloney PR, Willson TM, Kliewer SA.
Mol Cell 6(3):517-26. 2000
17NR0B2, NR1H3, NR5A2
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors.
Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, Mangelsdorf DJ.
Mol Cell 6(3):507-15. 2000
18ABCA1, ABCB11, NR0B2, NR1H3, NR1H4, NR5A2, SCARB1, SLC10A1, SCARB1
Don't know much bile-ology.
Chawla A, Saez E, Evans RM.
Cell 103(1):1-4. No abstract available. 2000
19HHG, NR0B2
Hypogonadotropic Hypogonadism in a Female Caused by an X-Linked Recessive Mutation in the DAX1 Gene.
Merke DP, Tajima T, Baron J, Cutler GB Jr.
N Engl J Med 340(16):1248-1252. No abstract available 1999
20AHC, NR0B2
Clinical and functional effects of mutations in the DAX-1 gene in patients with adrenal hypoplasia congenita.
Reutens AT, et al.
J Clin Endocrinol Metab 84(2):504-11. 1999
21NR0B2, WT1
The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation.
Kim J, et al.
Mol Cell Biol 19(3):2289-99. 1999
22AHC, NR0B2
DAX1 mutations map to putative structural domains in a deduced three-dimensional model.
Zhang YH, et al.
Am J Hum Genet 62 : 855-864. 1998
23NR0B2, DDS, NR5A1, WT1
Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression.
Nachtigal MW, et al.
Cell 93 : 445-454. 1998
24NR0B2
Role of Ahch in gonadal development and gametogenesis.
Yu RN, et al.
Nat Genet 20 : 353-357. 1998
25NR0B2
Structure and expression of the orphan nuclear receptor SHP gene.
Lee HK, et al.
J Biol Chem 273(23):14398-402 1998
26NR0B2, DSS, SRY, NR0B1
Dax1 antagonizes Sry action in mammalian sex determination.
Swain A, Narvaez V, Burgoyne P, Camerino G, Lovell-Badge R.
Nature 391(6669):761-7. 1998
27AHC, NR0B2
X-linked adrenal hypoplasia in a large Greenlandic family. Detection of a missense mutation (N440I) in the DAX-1 gene; implication for genetic counselling and carrier diagnosis.
Schwartz M, et al.
Hum Genet 99 : 83-87. 1997
28NR0B2, NR5A1
DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita.
Ito M, et al.
Mol Cell Biol 17 : 1476-1483. 1997
29AHC, DAX1, NR0B1, NR0B2, STAR
DNA binding and transcriptional repression by DAX-1 blocks steroidogenesis.
Zazopoulos E, Lalli E, Stocco DM, Sassone-Corsi P.
Nature 390(6657):311-5. 1997
30AHC, NR0B2
Three novel mutations and a De Novo deletion mutation of the DAX-1 gene in patients with X-linked adrenal hypoplasia congenita.
Nakae J, Abe S, Tajima T, Shinohara N, Murashita M, Igarashi Y, Kusuda S, Suzuki J, Fujieda K.
J Clin Endocrinol Metab 82(11):3835-41. 1997
31NR0B2
A transcriptional silencing domain in DAX-1 whose mutation causes adrenal hypoplasia congenita.
Lalli E, Bardoni B, Zazopoulos E, Wurtz JM, Strom TM, Moras D, Sassone-Corsi P.
Mol Endocrinol 11(13):1950-60. 1997
32NR0B2
An orphan nuclear receptor lacking a zinc-finger DNA-binding domain: interaction with several nuclear receptors.
Masuda N, et al.
Biochim Biophys Acta 1350(1):27-32 1997
33AHC, NR0B2
New mutations of DAX-1 genes in two Japanese patients with X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
Yanase T, et al.
J Clin Endocrinol Metab 81 : 530-535. 1996
34NR0B2
Genomic sequence of the DAX1 gene : an orphan nuclear receptor responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism.
Guo W, et al.
J Clin Endocrinol Metab 81 : 2481-2486. 1996
35AHC, NR0B2, HHG
Adrenal hypoplasia congenita with hypogonadotropic hypogonadism. Evidence that DAX-1 mutations lead to combined hypothalamic and pituitary defects in gonadotropin production.
Habiby RL, et al.
J Clin Invest 98 : 1055-1062. 1996
36NR0B2
An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors.
Seol W, et al.
Science 272(5266):1336-9 1996
37AHC, NR0B2, HHG
Expression of DAX-1, the gene responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism, in the hypothalamic-pituitary-adrenal/gonadal axis.
Guo W, et al.
Biochem Mol Med 56 : 8-13. 1995
38AHC, DSS, MAGEB1, MAGEB2, NR0B2
A family of rapidly evolving genes from the sex reversal critical regionin Xp21.
Dabovic B, et al.
Mamm Genome 6 : 571-580. 1995
39NR0B2
A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.
Luo X, et al.
Cell 77 : 481-490. 1994
40NR0B2, DSS, AHC
An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita.
Zanaria E, et al.
Nature 372 : 635-641. 1994
41NR0B2, AHC, HHG
Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism.
Muscatelli F, et al.
Nature 372 : 672-676. 1994