| 1 | NPPA, NSD3
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| Protective effect of histone methyltransferase NSD3 on ISO-induced cardiac hypertrophy
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| Chen K, Jian D, Zhao L, Zang X, Song W, Ma J, Jia Z, Wang X, Gao C.
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| FEBS Lett. Sep;593(18):2556-2565. doi: 10.1002/1873-3468.13515. Epub 2019 Jul 12. 2019
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| 2 | CCM2, NPPA, NPR1, PAK4
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| CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading.
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| Miura K, Nojiri T, Akitake Y, Ando K, Fukuhara S, Zenitani M, Kimura T, Hino J, Miyazato M, Hosoda H, Kangawa K.
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| Biochem J 474(11):1897-1918. doi: 10.1042/BCJ20160841.
2017
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| 3 | KLF10, NPPA, NPR1
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| Klf10 deficiency in mice exacerbates pulmonary inflammation by increasing expression of the proinflammatory molecule NPRA.
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| Huang LT, Chang HW, Wu MJ, Lai YT, Wu WC, Yu WCY, Chang VHS.
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| Int J Biochem Cell Biol 79:231-238. doi: 10.1016/j.biocel.2016.08.027. Epub 2016 Aug 31.
2016
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| 4 | NPPA, NPPB, NPR1
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| Importance of Endogenous Atrial and Brain Natriuretic Peptides in Murine Embryonic Vascular and Organ Development.
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| Tokudome T, Kishimoto I, Shindo T, Kawakami H, Koyama T, Otani K, Nishimura H, Miyazato M, Kohno M, Nakao K, Kangawa K.
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| Endocrinology 157(1):358-67. doi: 10.1210/en.2015-1344. Epub 2015 Oct 30.
2016
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| 5 | NPPA
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| The Expression of NPPA Splice Variants During Mouse Cardiac Development.
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| Taha MF, Javeri A.
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| DNA Cell Biol 34(1):19-28. doi: 10.1089/dna.2014.2600.
2015
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| 6 | NPPA, NPR1
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| Atrial natriuretic peptide inhibits cell cycle activity of embryonic cardiac progenitor cells via its NPRA receptor signaling axis.
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| Hotchkiss A, Feridooni T, Baguma-Nibasheka M, McNeil K, Chinni S, Pasumarthi KB.
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| Am J Physiol Cell Physiol 308(7):C557-69. doi: 10.1152/ajpcell.00323.2014. Epub 2015 Jan 28.
2015
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| 7 | NPPA
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| Correlations of ANP genetic polymorphisms and serum levels with ischemic stroke risk: a meta-analysis.
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| Xing DG, Zhang DY, Wang ZF, Ding DL, Wang J, Wang YJ.
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| Genet Test Mol Biomarkers 18(5):349-56. doi: 10.1089/gtmb.2013.0498. Epub 2014 Mar 21.
2014
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| 8 | ARHGEF2, NPPA
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| Control of vascular permeability by atrial natriuretic peptide via a GEF-H1-dependent mechanism.
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| Tian X, Tian Y, Gawlak G, Sarich N, Wu T, Birukova AA.
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| J Biol Chem 289(8):5168-83. doi: 10.1074/jbc.M113.493924. Epub 2013 Dec 18.
2014
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| 9 | ANXA6, NPPA
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| Cytosolic dynamics of annexin A6 trigger feedback regulation of hypertrophy via atrial natriuretic peptide in cardiomyocytes.
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| Banerjee P, Bandyopadhyay A.
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| J Biol Chem 289(9):5371-85. doi: 10.1074/jbc.M113.514810. Epub 2014 Jan 8.
2014
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| 10 | DRD1, NPPA
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| Concerted action of ANP and dopamine D1-receptor to regulate sodium homeostasis in nephrotic syndrome.
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| Fernandes-Cerqueira C, Sampaio-Maia B, Quelhas-Santos J, Moreira-Rodrigues M, Simões-Silva L, Blazquez-Medela AM, Martinez-Salgado C, Lopez-Novoa JM, Pestana M.
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| Biomed Res Int 2013:397391. doi: 10.1155/2013/397391. Epub 2013 Jul 15.
2013
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| 11 | NPPA
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| Atrial natriuretic peptide presence in parotid gland of human fetus at 13th week of development and in adult man.
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| Lipari L, Farina EV, Buscemi M, Gerbino A.
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| Folia Histochem Cytobiol 51(1):55-8. doi: 10.5603/FHC.2013.008.
2013
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| 12 | NPPA
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| Atrial natriuretic peptide as a marker of heart failure in children with left ventricular volume overload.
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| Kotby AA, Taman KH, Sedky HT, Habeeb NM, El-Hadidi ES, Yosseif HS.
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| J Paediatr Child Health 49(1):43-7. doi: 10.1111/jpc.12012. Epub 2012 Dec 28.
2013
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| 13 | ATRST2, NPPA
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| Autosomal recessive atrial dilated cardiomyopathy with standstill evolution associated with mutation of Natriuretic Peptide Precursor A.
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| Disertori M, Quintarelli S, Grasso M, Pilotto A, Narula N, Favalli V, Canclini C, Diegoli M, Mazzola S, Marini M, Del Greco M, Bonmassari R, Masè M, Ravelli F, Specchia C, Arbustini E.
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| Circ Cardiovasc Genet 6(1):27-36. doi: 10.1161/CIRCGENETICS.112.963520. Epub 2012 Dec 29.
2013
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| 14 | NPPA, NPR1
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| Gradients of natriuretic peptide precursor A (NPPA) in oviduct and of natriuretic peptide receptor 1 (NPR1) in spermatozoon are involved in mouse sperm chemotaxis and fertilization.
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| Bian F, Mao G, Guo M, Mao G, Wang J, Li J, Han Y, Chen X, Zhang M, Xia G.
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| J Cell Physiol 227(5):2230-9. doi: 10.1002/jcp.22962.
2012
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| 15 | CORIN, NPPA
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| Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.
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| Cui Y, Wang W, Dong N, Lou J, Srinivasan DK, Cheng W, Huang X, Liu M, Fang C, Peng J, Chen S, Wu S, Liu Z, Dong L, Zhou Y, Wu Q.
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| Nature 484(7393):246-50. doi: 10.1038/nature10897.
2012
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| 16 | NPPA
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| Potential association between frequent nonsynonymous variant of NPPA and cardioembolic stroke.
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| Kim JH, Jang BH, Go HY, Park S, Shin YC, Kim SH, Ko SG.
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| DNA Cell Biol 31(6):993-1000. doi: 10.1089/dna.2011.1463. Epub 2012 Mar 8.
2012
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| 17 | NPPA, NPR1, PDE2A
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| Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity.
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| Hu F, Ren J, Zhang JE, Zhong W, Luo M.
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| Proc Natl Acad Sci U S A 109(43):17681-6. doi: 10.1073/pnas.1209185109. Epub 2012 Oct 8.
2012
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| 18 | CAMTA1, NPPA
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| CAMTA1 is a novel tumour suppressor regulated by miR-9/9* in glioblastoma stem cells.
|
| Schraivogel D, Weinmann L, Beier D, Tabatabai G, Eichner A, Zhu JY, Anton M, Sixt M, Weller M, Beier CP, Meister G.
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| EMBO J 30(20):4309-22. doi: 10.1038/emboj.2011.301.
2011
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| 19 | NPPA, PRKAA2
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| Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK.
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| Souza SC, Chau MD, Yang Q, Gauthier MS, Clairmont KB, Wu Z, Gromada J, Dole WP.
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| Biochem Biophys Res Commun 410(3):398-403. Epub 2011 Jun 6.
2011
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| 20 | NKX265, NPPA
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| Differential role of Nkx2-5 in activation of the atrial natriuretic factor gene in the developing versus failing heart.
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| Warren SA, Terada R, Briggs LE, Cole-Jeffrey CT, Chien WM, Seki T, Weinberg EO, Yang TP, Chin MT, Bungert J, Kasahara H.
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| Mol Cell Biol 31(22):4633-45. Epub 2011 Sep 19.
2011
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| 21 | NPPA, NPR1
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| NPR-A regulates self-renewal and pluripotency of embryonic stem cells.
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| Abdelalim EM, Tooyama I.
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| Cell Death Dis 2:e127.
2011
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| 22 | NPPA, NPR1
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| Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase.
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| Misono KS, Philo JS, Arakawa T, Ogata CM, Qiu Y, Ogawa H, Young HS.
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| FEBS J 278(11):1818-29. doi: 10.1111/j.1742-4658.2011.08083.x. Epub 2011 Apr 7. Review.
2011
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| 23 | CORIN, NPPA
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| Decompensated heart failure is associated with reduced corin levels and decreased cleavage of pro-atrial natriuretic peptide.
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| Ibebuogu UN, Gladysheva IP, Houng AK, Reed GL.
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| Circ Heart Fail 4(2):114-20. doi: 10.1161/CIRCHEARTFAILURE.109.895581. Epub 2011 Jan 7.
2011
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| 24 | NPPA, NPPB, NPPC
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| Characterization and functional expression of the natriuretic peptide system in human lens epithelial cells.
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| Cammarata PR, Braun B, Dimitrijevich SD, Pack J.
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| Mol Vis 16:630-8.
2010
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| 25 | C10orf107, NPPA, NPPB
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| Genome-wide association study identifies eight loci associated with blood pressure.
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| Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL; Wellcome Trust Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth DM, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, Döring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS, Subirana I, Freimer NB, Hartikainen AL, McCarthy MI, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder H, van Gilst WH, Clarke R, Goel A, Hamsten A, Peden JF, Seedorf U, Syvänen AC, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, Dörr M, Ernst F, Felix SB, Homuth G, Lorbeer R, Reffelmann T, Rettig R, Völker U, Galan P, Gut IG, Hercberg S, Lathrop GM, Zelenika D, Deloukas P, Soranzo N, Williams FM, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi NG, Völzke H, Uiterwaal CS, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bingham SA, Kooner JS, Connell JM, Bandinelli S, Ferrucci L, Watkins H, Spector TD, Tuomilehto J, Altshuler D, Strachan DP, Laan M, Meneton P, Wareham NJ, Uda M, Jarvelin MR, Mooser V, Melander O, Loos RJ, Elliott P, Abecasis GR, Caulfield M, Munroe PB.
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| Nat Genet at Genet. 2009 May 10. [Epub ahead of print] 2009
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| 26 | NPPA, NPPB
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| Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure.
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| Newton-Cheh C, Larson MG, Vasan RS, Levy D, Bloch KD, Surti A, Guiducci C, Kathiresan S, Benjamin EJ, Struck J, Morgenthaler NG, Bergmann A, Blankenberg S, Kee F, Nilsson P, Yin X, Peltonen L, Vartiainen E, Salomaa V, Hirschhorn JN, Melander O, Wang TJ.
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| Nat Genet 41(3):348-53. Epub 2009 Feb 15.
2009
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| 27 | ATFB6, NPPA
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| A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation.
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| Dickey DM, Yoder AR, Potter LR.
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| J Biol Chem 284(29):19196-202. Epub 2009 May 19.
2009
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| 28 | NPPA, NPR3, OSTN
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| Competitive binding of musclin to natriuretic peptide receptor 3 with atrial natriuretic peptide
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| Kita S, Nishizawa H, Okuno Y, Tanaka M, Yasui A, Matsuda M, Yamada Y, Shimomura I.
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| J Endocrinol. May;201(2):287-95. doi: 10.1677/JOE-08-0551. Epub 2009 Feb 25. 2009
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| 29 | ATFB6, NPPA
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| Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation.
|
| Hodgson-Zingman DM, Karst ML, Zingman LV, Heublein DM, Darbar D, Herron KJ, Ballew JD, de Andrade M, Burnett JC Jr, Olson TM.
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| N Engl J Med 359(2):158-65.
2008
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| 30 | NPPA,SRF,ZIC3
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| Identification of a novel role of ZIC3 in regulating cardiac development.
|
| Zhu L, Harutyunyan KG, Peng JL, Wang J, Schwartz RJ, Belmont JW.
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| Hum Mol Genet 16(14):1649-60. Epub 2007 Apr 27. 2007
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| 31 | NPPA, TBX5, WWTR1, YY1AP1
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| A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome.
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| Murakami M, Nakagawa M, Olson EN, Nakagawa O.
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| Proc Natl Acad Sci U S A 102(50):18034-9. Epub 2005 Dec 6. 2005
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| 32 | TBX5, TBX20, NPPA
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| Differential expression and function of Tbx5 and Tbx20 in cardiac development.
|
| Plageman TF Jr, Yutzey KE.
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| J Biol Chem 279(18):19026-34. Epub 2004 Feb 20. 2004
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| 33 | NPPA
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| Investigation of the human ANP gene in type 1 diabetic nephropathy: case-control and follow-up studies.
|
| Roussel R, Tregouet DA, Hadjadj S, Jeunemaitre X, Marre M.
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| Diabetes 53(5):1394-8. 2004
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| 34 | NPPA, JARID2, GATA4, NKX2-5
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| Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors.
|
| Kim TG, Chen J, Sadoshima J, Lee Y.
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| Mol Cell Biol 24(23):10151-60. 2004
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| 35 | NKX2-5, NPPA, PLOD1, PITX2
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| PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5.
|
| Ganga M, Espinoza HM, Cox CJ, Morton L, Hjalt TA, Lee Y, Amendt BA.
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| J Biol Chem 278(25):22437-45. Epub 2003 Apr 11. 2003
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| 36 | NPPA
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| Polymorphisms in the hANP (human atrial natriuretic peptide) gene, albuminuria, and hypertension.
|
| Nannipieri M, Manganiello M, Pezzatini A, De Bellis A, Seghieri G, Ferrannini E.
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| Hypertension 37(6):1416-22. 2001
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| 37 | NPPA, NPPB
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| Gene structure of a new cardiac peptide hormone: a model for heart-specific gene expression.
|
| Majalahti-Palviainen T, Hirvinen M, Tervonen V, Ilves M, Ruskoaho H, Vuolteenaho O.
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| Endocrinology 141(2):731-40. 2000
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| 38 | NPPA
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| Functional deletion mutation of the 5'-flanking region of type A human natriuretic peptide receptor gene and its association with essential hypertension and left ventricular hypertrophy in the Japanese.
|
| Nakayama T, Soma M, Takahashi Y, Rehemudula D, Kanmatsuse K, Furuya K.
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| Circ Res 86(8):841-5. 2000
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| 39 | NPPA
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| Molecular cloning of a regulatory protein for membrane-bound guanylate cyclase GC-A.
|
| Chen ZJ, Miao ZH, Vetter M, Dulin N, Liu S, Che D, Hughes B, Murad F, Douglas J, Chang CH.
|
| Biochem Biophys Res Commun 278(1):106-11. 2000
|
| 40 | NPPA
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| Pronatriodilatin gene polymorphisms, microvascular permeability, and diabetic nephropathy in type 1 diabetes mellitus.
|
| Nannipieri M, et al.
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| J Am Soc Nephrol 10(7):1530-41 1999
|
| 41 | NPPA, NPPB
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| Two cardiac natriuretic peptide genes (atrial natriuretic peptide and brain natriuretic peptide) are organized in tandem in the mouse and human genomes.
|
| Tamura N, et al.
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| J Mol Cell Cardiol 28 : 1811-1815. 1996
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| 42 | NPPA
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| Insertion/deletion polymorphism within a polyadenylate stretch at the human atrial natriuretic peptides (hANP) gene locus.
|
| Ramasawmy R, et al.
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| Hum Genet 93 : 355-356. 1994
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| 43 | NPPA
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| A new polymorphic restriction site at the human atrial natriuretic peptide (hANP) gene locus.
|
| Ramasawmy R, et al.
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| Hum Genet 91 : 509-510. 1993
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| 44 | NPPA
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| Investigation of the polymorphic ScaI site by a PCR-based assay at the human atrial natriuretic peptides (hANP) gene locus.
|
| Ramasawmy R, et al.
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| Hum Genet 90 : 323-324. 1992
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| 45 | NPPA
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| Genetic analysis of the atrial natriuretic factor gene in familial orthostatic intolerance.
|
| Krishnamani MRS, et al.
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| Am J Hum Genet 49S : 194. 1991
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| 46 | NPPA, NPPB
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| Brain natriuretic peptide as a novel cardiac hormone in humans. Evidencefor an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.
|
| Mukoyama M, et al.
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| J Clin Invest 87 : 1402-1412. 1991
|
| 47 | NPPA
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| NsiI and ScaI restriction fragment length polymorphisms at the atrial natriuretic peptides (ANP) gene locus.
|
| Masharani U, et al.
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| Hum Genet 80 : 307. 1988
|
| 48 | NPPA
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| Human natriuretic peptides (ANP) gene locus : BsmI RFLP.
|
| Frossard PM, et al.
|
| Nucleic Acids Res 15 : 7656. 1987
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| 49 | NPPA
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| Human atrial natriuretic peptides (ANP) gene locus : BgII RFLP.
|
| Frossard PM, et al.
|
| Nucleic Acids Res 14 : 9223. 1986
|
| 50 | NPPA
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| BgIII dimorphism at the human atrial natriuretic peptide (ANP) gene locus.
|
| Frossard PM, et al.
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| Nucleic Acids Res 14 : 5121. 1986
|
| 51 | NPPA
|
| Atrial natriuretic peptide elevation in congestive heart failure in the human.
|
| Burnett JC Jr, Kao PC, Hu DC, Heser DW, Heublein D, Granger JP, Opgenorth TJ, Reeder GS.
|
| Science 231(4742):1145-7. 1986
|
| 52 | NPPA
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| The pronatriodilatin gene is located on the distal short arm of human chromosome 1 and on mouse chromosome 4.
|
| Yang-Feng TL, et al.
|
| Am J Hum Genet 37 : 1117-1128. 1985
|
| 53 | NPPA
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| Human pronatriodilantin gene is located on the distal short arm ofchromosome 1 (band 1p36).
|
| Yang-Feng TL, et al.
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| (HGM8) Cytogenet Cell Genet 40 : 783. 1985
|