| 1 | MUC5AC, NOX4, TGFB3
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| TGF-β3 Induces Autophagic Activity by Increasing ROS Generation in a NOX4-Dependent Pathway.
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| Zhang Y, Tang HM, Liu CF, Yuan XF, Wang XY, Ma N, Xu GF, Wang SP, Deng J, Wang X.
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| Mediators Inflamm. Dec 31;2019:3153240. doi: 10.1155/2019/3153240. 2019
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| 2 | NOX4, POLDIP2
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| NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion.
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| Vukelic S, Xu Q, Seidel-Rogol B, Faidley EA, Dikalova AE, Hilenski LL, Jorde U, Poole LB, Lassègue B, Zhang G, Griendling KK.
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| Arterioscler Thromb Vasc Biol 38(10):2423-2434. doi: 10.1161/ATVBAHA.118.311668.
2018
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| 3 | EIF2S1, NOX4, PPP1R15A
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| Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2α-mediated stress signaling.
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| Santos CX, Hafstad AD, Beretta M, Zhang M, Molenaar C, Kopec J, Fotinou D, Murray TV, Cobb AM, Martin D, Zeh Silva M, Anilkumar N, Schröder K, Shanahan CM, Brewer AC, Brandes RP, Blanc E, Parsons M, Belousov V, Cammack R, Hider RC, Steiner RA, Shah AM.
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| EMBO J 35(3):319-34. doi: 10.15252/embj.201592394. Epub 2016 Jan 7.
2016
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| 4 | DUOX1, DUOX2, NOX4, PDGFA
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| Nox4 and Duox1/2 Mediate Redox Activation of Mesenchymal Cell Migration by PDGF.
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| Tyurin-Kuzmin PA, Zhdanovskaya ND, Sukhova AA, Sagaradze GD, Albert EA, Ageeva LV, Sharonov GV, Vorotnikov AV, Tkachuk VA.
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| PLoS One 11(4):e0154157. doi: 10.1371/journal.pone.0154157. eCollection 2016. 2016
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| 5 | CTH, NOX4
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| Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling.
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| Mistry RK, Murray TV, Prysyazhna O, Martin D, Burgoyne JR, Santos C, Eaton P, Shah AM, Brewer AC.
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| J Biol Chem 291(4):1774-88. doi: 10.1074/jbc.M115.685578. Epub 2015 Nov 30.
2016
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| 6 | CTH, NOX4
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| Transcriptional Regulation of Cystathionine-γ-Lyase in Endothelial Cells by NADPH Oxidase 4-Dependent Signaling.
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| Mistry RK, Murray TV, Prysyazhna O, Martin D, Burgoyne JR, Santos C, Eaton P, Shah AM, Brewer AC.
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| J Biol Chem 291(4):1774-88. doi: 10.1074/jbc.M115.685578. Epub 2015 Nov 30.
2016
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| 7 | NLRP5, NOX4
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| NADPH oxidase-4 and MATER expressions in granulosa cells: Relationships with ovarian aging.
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| Maraldi T, Resca E, Nicoli A, Beretti F, Zavatti M, Capodanno F, Morini D, Palomba S, La Sala GB, De Pol A.
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| Life Sci. Oct 1;162:108-14. doi: 10.1016/j.lfs.2016.08.007. Epub 2016 Aug 8 2016
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| 8 | HSPB1, HSPB2, NOX4, TGFB1I1
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| Hic-5 Mediates TGFβ-Induced Adhesion in Vascular Smooth Muscle Cells by a Nox4-Dependent Mechanism.
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| Fernandez I, Martin-Garrido A, Zhou DW, Clempus RE, Seidel-Rogol B, Valdivia A, Lassègue B, García AJ, Griendling KK, San Martin A.
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| Arterioscler Thromb Vasc Biol 35(5):1198-206. doi: 10.1161/ATVBAHA.114.305185. Epub 2015 Mar 26.
2015
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| 9 | NOX4, TGFB1I1
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| Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein.
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| Desai LP, Zhou Y, Estrada AV, Ding Q, Cheng G, Collawn JF, Thannickal VJ.
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| J Biol Chem 289(26):18270-8. doi: 10.1074/jbc.M114.562249. Epub 2014 May 15.
2014
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| 10 | NOX4, PODIP2
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| Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization.
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| Datla SR, McGrail DJ, Vukelic S, Huff LP, Lyle AN, Pounkova L, Lee M, Seidel-Rogol B, Khalil MK, Hilenski LL, Terada LS, Dawson MR, Lassègue B, Griendling KK.
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| Am J Physiol Heart Circ Physiol 307(7):H945-57. doi: 10.1152/ajpheart.00918.2013. Epub 2014 Jul 25.
2014
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| 11 | NOX4, TGFB1
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| Nox4 modulates collagen production stimulated by transforming growth factor β1 in vivo and in vitro.
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| Chan EC, Peshavariya HM, Liu GS, Jiang F, Lim SY, Dusting GJ.
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| Biochem Biophys Res Commun 430(3):918-25. doi: 10.1016/j.bbrc.2012.11.138. Epub 2012 Dec 19.
2013
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| 12 | NOX4, SESN2
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| Sestrin 2 and AMPK connect hyperglycemia to Nox4-dependent endothelial nitric oxide synthase uncoupling and matrix protein expression.
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| Eid AA, Lee DY, Roman LJ, Khazim K, Gorin Y.
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| Mol Cell Biol 33(17):3439-60. doi: 10.1128/MCB.00217-13. Epub 2013 Jul 1.
2013
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| 13 | HDAC4, NOX4
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| Increased Oxidative Stress in the Nucleus Caused by Nox4 Mediates Oxidation of HDAC4 and Cardiac Hypertrophy.
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| Matsushima S, Kuroda J, Ago T, Zhai P, Park JY, Xie LH, Tian B, Sadoshima J.
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| Circ Res irc Res. 2012 Dec 27. [Epub ahead of print]
2012
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| 14 | NOX4
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| ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence.
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| Weyemi U, Lagente-Chevallier O, Boufraqech M, Prenois F, Courtin F, Caillou B, Talbot M, Dardalhon M, Al Ghuzlan A, Bidart JM, Schlumberger M, Dupuy C.
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| Oncogene 31(9):1117-29. doi: 10.1038/onc.2011.327. Epub 2011 Aug 15.
2012
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| 15 | NOX4, PDE4A, PDE4B, PDE4D
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| NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells.
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| Muzaffar S, Jeremy JY, Angelini GD, Shukla N.
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| J Cell Physiol 227(5):1941-50. doi: 10.1002/jcp.22922.
2012
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| 16 | FOXO3, MMP2, NOX4, UTS2
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| NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II.
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| Diebold I, Petry A, Burger M, Hess J, Görlach A.
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| Mol Biol Cell 22(22):4424-34. doi: 10.1091/mbc.E10-12-0971. Epub 2011 Sep 30.
2011
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| 17 | NOX4
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| NOX-4 is expressed in thickened pulmonary arteries in idiopathic pulmonary fibrosis.
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| Pache JC, Carnesecchi S, Deffert C, Donati Y, Herrmann FR, Barazzone-Argiroffo C, Krause KH.
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| Nat Med 17(1):31-2; author reply 32-3. No abstract available.
2011
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| 18 | CYBB, NOX4
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| X-ROS signaling: rapid mechano-chemo transduction in heart.
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| Prosser BL, Ward CW, Lederer WJ.
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| Science 333(6048):1440-5. 2011
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| 19 | NOX4, SP3
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| Sp3 transcription factor is crucial for transcriptional activation of the human NOX4 gene.
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| Katsuyama M, Hirai H, Iwata K, Ibi M, Matsuno K, Matsumoto M, Yabe-Nishimura C.
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| FEBS J 278(6):964-72. doi: 10.1111/j.1742-4658.2011.08018.x. Epub 2011 Feb 5.
2011
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| 20 | NOX1, NOX4
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| Transcriptional regulation of NADPH oxidase isoforms, Nox1 and Nox4, by nuclear factor-kappaB in human aortic smooth muscle cells.
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| Manea A, Tanase LI, Raicu M, Simionescu M.
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| Biochem Biophys Res Commun 396(4):901-7. Epub 2010 May 10.PMID: 20457132 2010
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| 21 | NOX4
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| NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart.
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| Kuroda J, Ago T, Matsushima S, Zhai P, Schneider MD, Sadoshima J.
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| Proc Natl Acad Sci U S A 107(35):15565-70. Epub 2010 Aug 16.PMID: 20713697 2010
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| 22 | DUOX2, NOX4
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| The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway.
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| Salmeen A, Park BO, Meyer T.
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| Oncogene 29(31):4473-84. Epub 2010 Jun 7.
2010
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| 23 | CYBB, NOX1, NOX4
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| Reactive oxygen species generated by NADPH oxidase 2 and 4 are required for chondrogenic differentiation.
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| Kim KS, Choi HW, Yoon HE, Kim IY.
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| J Biol Chem 285(51):40294-302. Epub 2010 Oct 15.
2010
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| 24 | NOX4
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| NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis.
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| Zhang M, Brewer AC, Schröder K, Santos CX, Grieve DJ, Wang M, Anilkumar N, Yu B, Dong X, Walker SJ, Brandes RP, Shah AM.
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| Proc Natl Acad Sci U S A 107(42):18121-6. Epub 2010 Oct 4.
2010
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| 25 | CYBB, NOX4
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| Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization.
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| von Löhneysen K, Noack D, Wood MR, Friedman JS, Knaus UG.
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| Mol Cell Biol 30(4):961-75. Epub 2009 Dec 7.
2010
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| 26 | CYBA, MAPK14, NOX4
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| Nox4 overexpression activates reactive oxygen species and p38 MAPK in human endothelial cells.
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| Goettsch C, Goettsch W, Muller G, Seebach J, Schnittler HJ, Morawietz H.
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| Biochem Biophys Res Commun iochem Biophys Res Commun. 2009 Jan 23. [Epub ahead of print]
2009
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| 27 | NOX4
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| Subcellular localization of Nox4 and regulation in diabetes.
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| Block K, Gorin Y, Abboud HE.
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| Proc Natl Acad Sci U S A 106(34):14385-90. Epub 2009 Aug 17.
2009
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| 28 | NOX4
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| The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells.
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| Lener B, Kozieł R, Pircher H, Hütter E, Greussing R, Herndler-Brandstetter D, Hermann M, Unterluggauer H, Jansen-Dürr P.
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| Biochem J 423(3):363-74.
2009
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| 29 | NOX1, NOX4
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| Identification of structural elements in Nox1 and Nox4 controlling localization and activity.
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| Helmcke I, Heumüller S, Tikkanen R, Schröder K, Brandes RP.
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| Antioxid Redox Signal 11(6):1279-87.PMID: 19061439 2009
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| 30 | KCNK3, NOX4
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| Identification of subdomains in NADPH oxidase-4 critical for the oxygen-dependent regulation of TASK-1 K+ channels.
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| Park SJ, Chun YS, Park KS, Kim SJ, Choi SO, Kim HL, Park JW.
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| Am J Physiol Cell Physiol 297(4):C855-64. Epub 2009 Aug 5.PMID: 19657056 2009
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| 31 | NOX4, CYBB
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| HIV-1 Tat activates dual Nox pathways leading to independent activation of ERK and JNK MAP kinases.
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| Wu RF, Ma Z, Myers DP, Terada LS.
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| J Biol Chem 282(52):37412-9. Epub 2007 Oct 16. 2007
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| 32 | NOX4
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| Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression.
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| McKallip RJ, Jia W, Schlomer J, Warren JW, Nagarkatti PS, Nagarkatti M.
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| Mol Pharmacol 70(3):897-908. Epub 2006 Jun 5. 2006
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| 33 | NOX4
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| Differential upregulation of Nox homologues of NADPH oxidase by tumor necrosis factor-alpha in human aortic smooth muscle and embryonic kidney cells.
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| Moe KT, Aulia S, Jiang F, Chua YL, Koh TH, Wong MC, Dusting GJ.
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| J Cell Mol Med 10(1):231-9. 2006
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| 34 | CYBB, NOX1, NOX4
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| NOX2 and NOX4 mediate proliferative response in endothelial cells.
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| Petry A, Djordjevic T, Weitnauer M, Kietzmann T, Hess J, Görlach A.
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| Antioxid Redox Signal 8(9-10):1473-84.
2006
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| 35 | NOX4
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| Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells.
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| Goyal P, Weissmann N, Rose F, Grimminger F, Schafers HJ, Seeger W, Hanze J.
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| Biochem Biophys Res Commun 329(1):32-9. 2005
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| 36 | NOX4
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| A novel superoxide-producing NAD(P)H oxidase in kidney.
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| Shiose A, Kuroda J, Tsuruya K, Hirai M, Hirakata H, Naito S, Hattori M, Sakaki Y, Sumimoto H.
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| J Biol Chem 276(2):1417-23. 2001
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| 37 | NOX1, NOX3, NOX4, NOX5
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| Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.
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| Cheng G, Cao Z, Xu X, van Meir EG, Lambeth JD.
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| Gene 269(1-2):131-40. 2001
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| 38 | NOX4
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| Identification of renox, an NAD(P)H oxidase in kidney.
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| Geiszt M, Kopp JB, Varnai P, Leto TL.
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| Proc Natl Acad Sci U S A 97(14):8010-4. 2000
|