| 1 | NOTCH1, NOTCH2, NOTCH3, NOTCH4
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| Notch and the regulation of osteoclast differentiation and function.
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| Yu J, Canalis E.
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| Bone Jun 8:115474. doi: 10.1016/j.bone.2020.115474. Online ahead of print 2020
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| 2 | LEF1, NOTCH1, NOTCH2
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| Lymphoid enhancer-binding factor-1 promotes stemness and poor differentiation of hepatocellular carcinoma by directly activating the NOTCH pathway.
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| Fang S, Liu M, Li L, Zhang FF, Li Y, Yan Q, Cui YZ, Zhu YH, Yuan YF, Guan XY.
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| Oncogene 38(21):4061-4074. doi: 10.1038/s41388-019-0704-y. Epub 2019 Jan 29.
2019
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| 3 | JAG1, NOTCH1
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| Notch ligand Jagged1 promotes mesenchymal stromal cell-based cartilage repair.
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| Sun J, Luo Z, Wang G, Wang Y, Wang Y, Olmedo M, Morandi MM, Barton S, Kevil CG, Shu B, Shang X, Dong Y.
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| Exp Mol Med 50(9):126. doi: 10.1038/s12276-018-0151-9.
2018
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| 4 | JAG1, MFNG, NOTCH1
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| Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells.
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| López-Arribillaga E, Rodilla V, Colomer C, Vert A, Shelton A, Cheng JH, Yan B, Gonzalez-Perez A, Junttila MR, Iglesias M, Torres F, Albanell J, Villanueva A, Bigas A, Siebel CW, Espinosa L.
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| Nat Commun 9(1):2992. doi: 10.1038/s41467-018-05385-0.
2018
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| 5 | LTBP1, NOTCH1, TGFBR1, TGFBR3
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| Bicuspid Aortic Valve: Role of Multiple Gene Variants in Influencing the Clinical Phenotype
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| Sticchi E, De Cario R, Magi A, Giglio S, Provenzano A, Nistri S, Pepe G, Giusti B.
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| Biomed Res Int. Sep 5;2018:8386123. doi: 10.1155/2018/8386123. 2018
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| 6 | NOTCH1, NOTCH2
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| Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis.
|
| Gifford GB, Demitrack ES, Keeley TM, Tam A, La Cunza N, Dedhia PH, Spence JR, Simeone DM, Saotome I, Louvi A, Siebel CW, Samuelson LC.
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| Gut 66(6):1001-1011. doi: 10.1136/gutjnl-2015-310811. Epub 2016 Mar 1.
2017
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| 7 | NOTCH1, RBPJ
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| Regulation of striatal dopamine responsiveness by Notch/RBP-J signaling.
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| Toritsuka M, Kimoto S, Muraki K, Kitagawa M, Kishimoto T, Sawa A, Tanigaki K.
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| Transl Psychiatry 7(3):e1049. doi: 10.1038/tp.2017.21.
2017
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| 8 | KRT18, KRT8, NOTCH1
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| Keratins regulate colonic epithelial cell differentiation through the Notch1 signalling pathway.
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| Lähdeniemi IAK, Misiorek JO, Antila CJM, Landor SK, Stenvall CA, Fortelius LE, Bergström LK, Sahlgren C, Toivola DM.
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| Cell Death Differ 24(6):984-996. doi: 10.1038/cdd.2017.28. Epub 2017 May 5.
2017
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| 9 | DLL1, JAG1, NOTCH1
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| Both Notch1 and its ligands in B cells promote antibody production.
|
| Zhu G, Wang X, Xiao H, Liu X, Fang Y, Zhai B, Xu R, Han G, Chen G, Hou C, Shen B, Li Y, Ma N, Wu H, Liu G, Wang R.
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| Mol Immunol 91:17-23. doi: 10.1016/j.molimm.2017.08.021. Epub 2017 Aug 31.
2017
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| 10 | FBXW7, MAGEA1, NOTCH1
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| MAGEA1 interacts with FBXW7 and regulates ubiquitin ligase-mediated turnover of NICD1 in breast and ovarian cancer cells.
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| Zhao J, Wang Y, Mu C, Xu Y, Sang J.
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| Oncogene 36(35):5023-5034. doi: 10.1038/onc.2017.131. Epub 2017 May 1.
2017
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| 11 | ADAM10, DTX4, NOTCH1
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| Ligand-activated Notch undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing.
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| Chastagner P, Rubinstein E, Brou C.
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| Sci Signal. Jun 13;10(483):eaag2989. doi: 10.1126/scisignal.aag2989 2017
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| 12 | NBEA, NOTCH1
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| Nuclear Localization of the Autism Candidate Gene Neurobeachin and Functional Interaction with the NOTCH1 Intracellular Domain Indicate a Role in Regulating Transcription.
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| Tuand K, Stijnen P, Volders K, Declercq J, Nuytens K, Meulemans S, Creemers J.
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| PLoS One 11(3):e0151954. doi: 10.1371/journal.pone.0151954. eCollection 2016.
2016
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| 13 | ADAM10, CTF1, MAZ, NOTCH1
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| MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis.
|
| Liu B, Ma A, Zhang F, Wang Y, Li Z, Li Q, Xu Z, Zheng Y.
|
| Sci Rep 6:21534. doi: 10.1038/srep21534. Erratum in: Sci Rep. 2016;6:23309.
2016
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| 14 | NOTCH1, TWIST1
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| Notch inhibits chondrogenic differentiation of mesenchymal progenitor cells by targeting Twist1.
|
| Tian Y, Xu Y, Fu Q, Chang M, Wang Y, Shang X, Wan C, Marymont JV, Dong Y.
|
| Mol Cell Endocrinol ol Cell Endocrinol. 2015 Jan 14. pii: S0303-7207(15)00019-2. doi: 10.1016/j.mce.2015.01.015. [Epub ahead of print]
2015
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| 15 | ACVRL1, NOTCH1
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| A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.
|
| Kerr G, Sheldon H, Chaikuad A, Alfano I, von Delft F, Bullock AN, Harris AL.
|
| Angiogenesis ngiogenesis. 2015 Jan 4. [Epub ahead of print]
2015
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| 16 | LOXL2, NOTCH1
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| Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.
|
| Martin A, Salvador F, Moreno-Bueno G, Floristán A, Ruiz-Herguido C, Cuevas EP, Morales S, Santos V, Csiszar K, Dubus P, Haigh JJ, Bigas A, Portillo F, Cano A.
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| EMBO J 34(8):1090-109. doi: 10.15252/embj.201489975. Epub 2015 Mar 10.
2015
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| 17 | GLI3, NOTCH1, SMO
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| A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo.
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| Stasiulewicz M, Gray SD, Mastromina I, Silva JC, Björklund M, Seymour PA, Booth D, Thompson C, Green RJ, Hall EA, Serup P, Dale JK.
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| Development 142(13):2291-303. doi: 10.1242/dev.125237. Epub 2015 May 20.
2015
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| 18 | NOTCH1, NOTCH2
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| Notch receptor regulation of intestinal stem cell homeostasis and crypt regeneration.
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| Carulli AJ, Keeley TM, Demitrack ES, Chung J, Maillard I, Samuelson LC.
|
| Dev Biol 402(1):98-108. doi: 10.1016/j.ydbio.2015.03.012. Epub 2015 Mar 30.
2015
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| 19 | MGP, NOTCH1
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| NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium.
|
| White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D.
|
| J Mol Cell Cardiol 84:13-23. doi: 10.1016/j.yjmcc.2015.04.006. Epub 2015 Apr 12.
2015
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| 20 | NOTCH1, ZMIZ1
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| The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia.
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| Pinnell N, Yan R, Cho HJ, Keeley T, Murai MJ, Liu Y, Alarcon AS, Qin J, Wang Q, Kuick R, Elenitoba-Johnson KS, Maillard I, Samuelson LC, Cierpicki T, Chiang MY.
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| Immunity 43(5):870-83. doi: 10.1016/j.immuni.2015.10.007. Epub 2015 Oct 27.
2015
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| 21 | IL1B, NOTCH1, NOTCH4
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| Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β.
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| Verginelli F, Adesso L, Limon I, Alisi A, Gueguen M, Panera N, Giorda E, Raimondi L, Ciarapica R, Campese AF, Screpanti I, Stifani S, Kitajewski J, Miele L, Rota R, Locatelli F.
|
| Oncotarget Dec 22;6(41):43216-29. doi: 10.18632/oncotarget.6456 2015
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| 22 | NOTCH1
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| Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.
|
| Ramasamy SK, Kusumbe AP, Wang L, Adams RH.
|
| Nature 507(7492):376-80. doi: 10.1038/nature13146. Epub 2014 Mar 12.
2014
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| 23 | AOS5, NOTCH1
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| Mutations in NOTCH1 Cause Adams-Oliver Syndrome.
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| Stittrich AB, Lehman A, Bodian DL, Ashworth J, Zong Z, Li H, Lam P, Khromykh A, Iyer RK, Vockley JG, Baveja R, Silva ES, Dixon J, Leon EL, Solomon BD, Glusman G, Niederhuber JE, Roach JC, Patel MS.
|
| Am J Hum Genet 95(3):275-84. doi: 10.1016/j.ajhg.2014.07.011. Epub 2014 Aug 14.
2014
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| 24 | NOTCH1
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| The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.
|
| Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, Epstein JA, Speck N, Bigas A, Pear WS.
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| Genes Dev 28(6):576-93. doi: 10.1101/gad.227496.113.
2014
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| 25 | NOTCH1
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| Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development.
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| Boyle SC, Liu Z, Kopan R.
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| Development 141(2):346-54. doi: 10.1242/dev.100271. Epub 2013 Dec 18.
2014
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| 26 | NOTCH1, PHLPP1, PHLPP2, USP12, WDR20, WDR48
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| Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway.
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| McClurg UL, Summerscales EE, Harle VJ, Gaughan L, Robson CN.
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| Oncotarget 5(16):7081-92.
2014
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| 27 | DLL4, NOTCH1, SNAI1
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| A Snail1/Notch1 signalling axis controls embryonic vascular development.
|
| Wu ZQ, Rowe RG, Lim KC, Lin Y, Willis A, Tang Y, Li XY, Nor JE, Maillard I, Weiss SJ.
|
| Nat Commun 5:3998. doi: 10.1038/ncomms4998.
2014
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| 28 | DLL4, FOXN4, NOTCH1
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| Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFβ signaling to specify V2b interneurons in the spinal cord.
|
| Misra K, Luo H, Li S, Matise M, Xiang M.
|
| Development 141(1):187-98. doi: 10.1242/dev.092536. Epub 2013 Nov 20.
2014
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| 29 | NOTCH1, SLBP
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| Stem-loop binding protein is required for retinal cell proliferation, neurogenesis, and intraretinal axon pathfinding in zebrafish.
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| Imai F, Yoshizawa A, Matsuzaki A, Oguri E, Araragi M, Nishiwaki Y, Masai I.
|
| Dev Biol 394(1):94-109. doi: 10.1016/j.ydbio.2014.07.020. Epub 2014 Aug 5.
2014
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| 30 | NOTCH1, NOTCH2
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| Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture.
|
| Zanotti S, Canalis E.
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| Bone 62:22-8. doi: 10.1016/j.bone.2014.01.023. Epub 2014 Feb 4.
2014
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| 31 | CAMK4, NOTCH1
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| Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability.
|
| Choi YH, Ann EJ, Yoon JH, Mo JS, Kim MY, Park HS.
|
| Biochim Biophys Acta 1833(1):69-79. doi: 10.1016/j.bbamcr.2012.10.018. Epub 2012 Oct 23.
2013
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| 32 | NOTCH1
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| Blockage of Notch signaling inhibits the migration and proliferation of retinal pigment epithelial cells.
|
| Liu W, Jin G, Long C, Zhou X, Tang Y, Huang S, Kuang X, Wu L, Zhang Q, Shen H.
|
| ScientificWorldJournal 2013:178708. doi: 10.1155/2013/178708. eCollection 2013.
2013
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| 33 | CCN3, NOTCH1
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| The matricellular protein CCN3 regulates NOTCH1 signalling in chronic myeloid leukaemia.
|
| Suresh S, McCallum L, Crawford LJ, Lu WH, Sharpe DJ, Irvine AE.
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| J Pathol 231(3):378-87. 2013
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| 34 | NOTCH1, ROCK1
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| Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation.
|
| Yugawa T, Nishino K, Ohno S, Nakahara T, Fujita M, Goshima N, Umezawa A, Kiyono T.
|
| Mol Cell Biol 33(22):4434-47. doi: 10.1128/MCB.00577-13. Epub 2013 Sep 9.
2013
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| 35 | NOTCH1
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| NOTCH1 gain of function in germ cells causes failure of spermatogenesis in male mice.
|
| Huang Z, Rivas B, Agoulnik AI.
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| PLoS One 8(7):e71213. doi: 10.1371/journal.pone.0071213. Print 2013.
2013
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| 36 | NOTCH1
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| Notch activation promotes endothelial survival through a PI3K-Slug axis.
|
| Chang L, Wong F, Niessen K, Karsan A.
|
| Microvasc Res 89:80-5. doi: 10.1016/j.mvr.2013.05.007. Epub 2013 Jun 3.
2013
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| 37 | NOTCH1
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| Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.
|
| Bosse K, Hans CP, Zhao N, Koenig SN, Huang N, Guggilam A, LaHaye S, Tao G, Lucchesi PA, Lincoln J, Lilly B, Garg V.
|
| J Mol Cell Cardiol 60:27-35. doi: 10.1016/j.yjmcc.2013.04.001. Epub 2013 Apr 11.
2013
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| 38 | NOTCH1
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| Notch signaling imparts and preserves neural stem characteristics in the adult brain.
|
| Piccin D, Yu F, Morshead CM.
|
| Stem Cells Dev 22(10):1541-50. doi: 10.1089/scd.2012.0390. Epub 2013 Feb 19.
2013
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| 39 | NOTCH1
|
| Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction.
|
| Del Papa B, Sportoletti P, Cecchini D, Rosati E, Balucani C, Baldoni S, Fettucciari K, Marconi P, Martelli MF, Falzetti F, Di Ianni M.
|
| Eur J Immunol 43(1):182-7. doi: 10.1002/eji.201242643. Epub 2012 Dec 5.
2013
|
| 40 | NOTCH1, RBPJ
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| Notch/Rbpjκ signaling regulates progenitor maintenance and differentiation of hypothalamic arcuate neurons.
|
| Aujla PK, Naratadam GT, Xu L, Raetzman LT.
|
| Development 140(17):3511-21. doi: 10.1242/dev.098681. Epub 2013 Jul 24.
2013
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| 41 | NOTCH1, ZMIZ1
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| Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias.
|
| Rakowski LA, Garagiola DD, Li CM, Decker M, Caruso S, Jones M, Kuick R, Cierpicki T, Maillard I, Chiang MY.
|
| Cancer Res 73(2):930-41. doi: 10.1158/0008-5472.CAN-12-1389. Epub 2012 Nov 16.
2013
|
| 42 | APBB1, ITCH, NOTCH1
|
| Dual regulation of notch1 signaling pathway by adaptor protein fe65.
|
| Kim MY, Mo JS, Ann EJ, Yoon JH, Park HS.
|
| J Biol Chem 287(7):4690-701. doi: 10.1074/jbc.M111.289637. Epub 2011 Dec 23.
2012
|
| 43 | NOTCH1
|
| Notch1 intracellular domain increases cytoplasmic EZH2 levels during early megakaryopoiesis.
|
| Roy A, Basak NP, Banerjee S.
|
| Cell Death Dis 3:e380. doi: 10.1038/cddis.2012.119.
2012
|
| 44 | NOTCH1
|
| The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation.
|
| Moretti J, Chastagner P, Liang CC, Cohn MA, Israël A, Brou C.
|
| J Biol Chem 287(35):29429-41. doi: 10.1074/jbc.M112.366807. Epub 2012 Jul 9.
2012
|
| 45 | NOTCH1
|
| Notch controls the magnitude of T helper cell responses by promoting cellular longevity.
|
| Helbig C, Gentek R, Backer RA, de Souza Y, Derks IA, Eldering E, Wagner K, Jankovic D, Gridley T, Moerland PD, Flavell RA, Amsen D.
|
| Proc Natl Acad Sci U S A 109(23):9041-6. doi: 10.1073/pnas.1206044109. Epub 2012 May 21.
2012
|
| 46 | EIF6, NOTCH1
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| The translation factor eIF6 is a Notch-dependent regulator of cell migration and invasion.
|
| Benelli D, Cialfi S, Pinzaglia M, Talora C, Londei P.
|
| PLoS One 7(2):e32047. doi: 10.1371/journal.pone.0032047. Epub 2012 Feb 14.
2012
|
| 47 | NOTCH1
|
| Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis.
|
| Obata Y, Takahashi D, Ebisawa M, Kakiguchi K, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, Hase K, Ohno H.
|
| J Immunol 188(5):2427-36. doi: 10.4049/jimmunol.1101128. Epub 2012 Jan 25.
2012
|
| 48 | DLL4, FLT4, KDR, NOTCH1
|
| Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling.
|
| Benedito R, Rocha SF, Woeste M, Zamykal M, Radtke F, Casanovas O, Duarte A, Pytowski B, Adams RH.
|
| Nature 484(7392):110-4. doi: 10.1038/nature10908.
2012
|
| 49 | FURIN, NOTCH1, SRC
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| The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells.
|
| Ma YC, Shi C, Zhang YN, Wang LG, Liu H, Jia HT, Zhang YX, Sarkar FH, Wang ZS.
|
| PLoS One 7(3):e33414. doi: 10.1371/journal.pone.0033414. Epub 2012 Mar 30.
2012
|
| 50 | ACVRL1, NOTCH1
|
| ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.
|
| Larrivée B, Prahst C, Gordon E, del Toro R, Mathivet T, Duarte A, Simons M, Eichmann A.
|
| Dev Cell 22(3):489-500. doi: 10.1016/j.devcel.2012.02.005.
2012
|
| 51 | NOTCH1, USP12, WDR48
|
| The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation.
|
| Moretti J, Chastagner P, Liang CC, Cohn MA, Israël A, Brou C.
|
| J Biol Chem 287(35):29429-41. doi: 10.1074/jbc.M112.366807. Epub 2012 Jul 9.
2012
|
| 52 | MIB1, NOTCH1
|
| Mind bomb 1 is required for pancreatic β-cell formation.
|
| Horn S, Kobberup S, Jørgensen MC, Kalisz M, Klein T, Kageyama R, Gegg M, Lickert H, Lindner J, Magnuson MA, Kong YY, Serup P, Ahnfelt-Rønne J, Jensen JN.
|
| Proc Natl Acad Sci U S A 109(19):7356-61. doi: 10.1073/pnas.1203605109. Epub 2012 Apr 23.
2012
|
| 53 | ID2, NOTCH1, RORC
|
| Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
|
| Cherrier M, Sawa S, Eberl G.
|
| J Exp Med 209(4):729-40. doi: 10.1084/jem.20111594. Epub 2012 Mar 19.
2012
|
| 54 | CAMK2A, NCOR2, NOTCH1, RBPJ, WNT5A
|
| Wnt5a controls Notch1 signaling through CaMKII-mediated degradation of the SMRT corepressor protein.
|
| Ann EJ, Kim HY, Seo MS, Mo JS, Kim MY, Yoon JH, Ahn JS, Park HS.
|
| J Biol Chem 287(44):36814-29. doi: 10.1074/jbc.M112.356048. Epub 2012 Aug 10.
2012
|
| 55 | NOTCH1, NRG1
|
| A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth.
|
| Zhang K, Wong P, Zhang L, Jacobs B, Borden EC, Aster JC, Bedogni B.
|
| Oncogene 31(43):4609-18. doi: 10.1038/onc.2011.606. Epub 2012 Jan 16.
2012
|
| 56 | FRYL, KDM1A, NOTCH1, RBPJ
|
| NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.
|
| Yatim A, Benne C, Sobhian B, Laurent-Chabalier S, Deas O, Judde JG, Lelievre JD, Levy Y, Benkirane M.
|
| Mol Cell 48(3):445-58. doi: 10.1016/j.molcel.2012.08.022. Epub 2012 Sep 27.
2012
|
| 57 | IL7R, NOTCH1
|
| Notch1 and IL-7 receptor signalling in early T-cell development and leukaemia.
|
| González-García S, García-Peydró M, Alcain J, Toribio ML.
|
| Curr Top Microbiol Immunol 360:47-73. doi: 10.1007/82_2012_231. Review.
2012
|
| 58 | AKT1, FOXM1, NOTCH1
|
| Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells.
|
| Wang Z, Li Y, Ahmad A, Banerjee S, Azmi AS, Kong D, Wojewoda C, Miele L, Sarkar FH.
|
| J Cell Biochem 112(1):78-88.
2011
|
| 59 | NOTCH1, SGK1
|
| Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase.
|
| Mo JS, Ann EJ, Yoon JH, Jung J, Choi YH, Kim HY, Ahn JS, Kim SM, Kim MY, Hong JA, Seo MS, Lang F, Choi EJ, Park HS.
|
| J Cell Sci 124(Pt 1):100-12. Epub 2010 Dec 8.
2011
|
| 60 | NOTCH1, RUNX3
|
| RUNX3 maintains the mesenchymal phenotype after termination of the Notch signal.
|
| Fu Y, Chang AC, Fournier M, Chang L, Niessen K, Karsan A.
|
| J Biol Chem 286(13):11803-13. Epub 2011 Feb 2.
2011
|
| 61 | DLL1, NOTCH1
|
| NOTCH, a new signaling pathway implicated in holoprosencephaly.
|
| Dupé V, Rochard L, Mercier S, Le Pétillon Y, Gicquel I, Bendavid C, Bourrouillou G, Kini U, Thauvin-Robinet C, Bohan TP, Odent S, Dubourg C, David V.
|
| Hum Mol Genet 20(6):1122-31. Epub 2010 Dec 31.
2011
|
| 62 | HJCYS, NOTCH1, NOTCH2
|
| Mutations in NOTCH2 in families with Hajdu-Cheney syndrome.
|
| Majewski J, Schwartzentruber JA, Caqueret A, Patry L, Marcadier J, Fryns JP, Boycott KM, Ste-Marie LG, McKiernan FE, Marik I, Van Esch H; FORGE Canada Consortium, Michaud JL, Samuels ME.
|
| Hum Mutat 32(10):1114-7. doi: 10.1002/humu.21546. Epub 2011 Sep 9. 2011
|
| 63 | NOTCH1
|
| Neural crest regulates myogenesis through the transient activation of NOTCH.
|
| Rios AC, Serralbo O, Salgado D, Marcelle C.
|
| Nature 473(7348):532-5. Epub 2011 May 15.
2011
|
| 64 | JARID2, NOTCH1
|
| Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression.
|
| Mysliwiec MR, Bresnick EH, Lee Y.
|
| J Biol Chem 286(19):17193-204. Epub 2011 Mar 14.
2011
|
| 65 | NOTCH1
|
| A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.
|
| Klinakis A, Lobry C, Abdel-Wahab O, Oh P, Haeno H, Buonamici S, van De Walle I, Cathelin S, Trimarchi T, Araldi E, Liu C, Ibrahim S, Beran M, Zavadil J, Efstratiadis A, Taghon T, Michor F, Levine RL, Aifantis I.
|
| Nature 473(7346):230-3.
2011
|
| 66 | NOTCH1, SIRT1
|
| Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
|
| Guarani V, Deflorian G, Franco CA, Krüger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M.
|
| Nature 473(7346):234-8. Epub 2011 Apr 17.
2011
|
| 67 | NOTCH1
|
| Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1.
|
| Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Treviño L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN.
|
| Science 333(6046):1154-7. Epub 2011 Jul 28.
2011
|
| 68 | NOTCH1, RBPJ
|
| Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.
|
| Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC.
|
| Proc Natl Acad Sci U S A 108(36):14908-13. Epub 2011 Jul 7.
2011
|
| 69 | ARC, NOTCH1
|
| Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks.
|
| Alberi L, Liu S, Wang Y, Badie R, Smith-Hicks C, Wu J, Pierfelice TJ, Abazyan B, Mattson MP, Kuhl D, Pletnikov M, Worley PF, Gaiano N.
|
| Neuron 69(3):437-44. doi: 10.1016/j.neuron.2011.01.004.
2011
|
| 70 | NOTCH1
|
| Notch signalling and haematopoietic stem cell formation during embryogenesis.
|
| Gering M, Patient R.
|
| J Cell Physiol 222(1):11-6. Review.PMID: 19725072 2010
|
| 71 | NOTCH1, NOTCH2, NOTCH3
|
| Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura.
|
| Ma D, Dai J, Zhu X, Yan S, Zhao P, Zhang J, Zhu Y, Sun J, Peng J, Ji C, Hou M.
|
| Ann Hematol 89(2):155-61. Epub 2009 Jul 15.PMID: 19603167 2010
|
| 72 | CBFA2T3, NOTCH1
|
| Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification.
|
| Engel ME, Nguyen HN, Mariotti J, Hunt A, Hiebert SW.
|
| Mol Cell Biol 30(7):1852-63. Epub 2010 Feb 1.
2010
|
| 73 | NOTCH1, NOTCH2
|
| Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma.
|
| Mazur PK, Einwchter H, Lee M, Sipos B, Nakhai H, Rad R, Zimber-Strobl U, Strobl LJ, Radtke F, Klppel G, Schmid RM, Siveke JT.
|
| Proc Natl Acad Sci U S A 107(30):13438-43. Epub 2010 Jul 12.PMID: 20624967 2010
|
| 74 | NOTCH1, TLX1
|
| TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells.
|
| Riz I, Hawley TS, Luu TV, Lee NH, Hawley RG.
|
| Mol Cancer 9:181.PMID: 20618946 2010
|
| 75 | NOTCH1
|
| Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.
|
| Jeannet R, Mastio J, Macias-Garcia A, Oravecz A, Ashworth T, Geimer Le Lay AS, Jost B, Le Gras S, Ghysdael J, Gridley T, Honjo T, Radtke F, Aster JC, Chan S, Kastner P.
|
| Blood 116(25):5443-54. Epub 2010 Sep 9.
2010
|
| 76 | DLL3, NOTCH1
|
| Expression of Notch receptors, ligands and target genes during development of the mouse mammary gland.
|
| Raafat A, Goldhar AS, Klauzinska M, Xu K, Amirjaz I, McCurdy D, Lashin K, Salomon D, Vonderhaar BK, Egan S, Callahan R.
|
| J Cell Physiol Cell Physiol. 2010 Dec 6. [Epub ahead of print]
2010
|
| 77 | NOTCH1, NOTCH2, RBPJ, SPEN
|
| The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage.
|
| Surendran K, Boyle S, Barak H, Kim M, Stomberski C, McCright B, Kopan R.
|
| Dev Biol 337(2):386-95. doi: 10.1016/j.ydbio.2009.11.017. Epub 2009 Nov 13.
2010
|
| 78 | NOTCH1, PIN1
|
| The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer.
|
| Rustighi A, Tiberi L, Soldano A, Napoli M, Nuciforo P, Rosato A, Kaplan F, Capobianco A, Pece S, Di Fiore PP, Del Sal G.
|
| Nat Cell Biol. 11(2):133-42 2009
|
| 79 | GJA1, HAND1, HLHS1, HLHS2, HLHS3, NKX2-5, NOTCH1
|
| Hypoplastic left heart syndrome: new genetic insights.
|
| Grossfeld P, Ye M, Harvey R.
|
| J Am Coll Cardiol 53(12):1072-4. No abstract available.
2009
|
| 80 | ADAM10, ADAM17, NOTCH1
|
| Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling.
|
| Bozkulak EC, Weinmaster G.
|
| Mol Cell Biol 29(21):5679-95. Epub 2009 Aug 24.
2009
|
| 81 | NOTCH1, NOTCH2
|
| Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.
|
| Gordon WR, Vardar-Ulu D, L'Heureux S, Ashworth T, Malecki MJ, Sanchez-Irizarry C, McArthur DG, Histen G, Mitchell JL, Aster JC, Blacklow SC.
|
| PLoS One 4(8):e6613.PMID: 19701457 2009
|
| 82 | DLL3, HUWE1, MYCN, NOTCH1
|
| The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.
|
| Zhao X, D' Arca D, Lim WK, Brahmachary M, Carro MS, Ludwig T, Cardo CC, Guillemot F, Aldape K, Califano A, Iavarone A, Lasorella A.
|
| Dev Cell 17(2):210-21.
2009
|
| 83 | ASD2, ASD3, GATA4, ICHD, JAG1, MYH6, NKX2-5, NOTCH1, TBX1, TBX20, TBX5, TFAP2B, THRAP2
|
| The developmental genetics of congenital heart disease.
|
| Bruneau BG.
|
| Nature 451(7181):943-8. 2008
|
| 84 | NOTCH1, NOTCH2, NOTCH3, JAG1, ICHD, PSEN1, PSEN2
|
| The multifaceted role of Notch in cardiac development and disease.
|
| High FA, Epstein JA.
|
| Nat Rev Genet 9(1):49-61. Review. 2008
|
| 85 | NOTCH1
|
| The Notch pathway in podocytes plays a role in the development of glomerular disease.
|
| Niranjan T, Bielesz B, Gruenwald A, Ponda MP, Kopp JB, Thomas DB, Susztak K.
|
| Nat Med 14(3):290-8. Epub 2008 Mar 2. 2008
|
| 86 | NOTCH1
|
| Dimorphic effects of Notch signaling in bone homeostasis.
|
| Engin F, Yao Z, Yang T, Zhou G, Bertin T, Jiang MM, Chen Y, Wang L, Zheng H, Sutton RE, Boyce BF, Lee B.
|
| Nat Med 14(3):299-305. Epub 2008 Feb 24. 2008
|
| 87 | NOTCH1
|
| NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells.
|
| Bai S, Kopan R, Zou W, Hilton MJ, Ong CT, Long F, Ross FP, Teitelbaum SL.
|
| J Biol Chem 283(10):6509-18. Epub 2007 Dec 22. 2008
|
| 88 | EGFR, NOTCH1
|
| EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer.
|
| Kolev V, Mandinova A, Guinea-Viniegra J, Hu B, Lefort K, Lambertini C, Neel V, Dummer R, Wagner EF, Dotto GP.
|
| Nat Cell Biol 10(8):902-11. Epub 2008 Jul 6.
2008
|
| 89 | FAVD1, NOTCH1
|
| NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling.
|
| McBride KL, Riley MF, Zender GA, Fitzgerald-Butt SM, Towbin JA, Belmont JW, Cole SE.
|
| Hum Mol Genet 17(18):2886-93. Epub 2008 Jun 30.
2008
|
| 90 | NKX2-5, NOTCH1
|
| Notch1 regulates the fate of cardiac progenitor cells.
|
| Boni A, Urbanek K, Nascimbene A, Hosoda T, Zheng H, Delucchi F, Amano K, Gonzalez A, Vitale S, Ojaimi C, Rizzi R, Bolli R, Yutzey KE, Rota M, Kajstura J, Anversa P, Leri A.
|
| Proc Natl Acad Sci U S A 105(40):15529-34. Epub 2008 Oct 1. 2008
|
| 91 | FABP7, NOTCH1, RELN
|
| Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1.
|
| Keilani S, Sugaya K.
|
| BMC Dev Biol 8:69.
2008
|
| 92 | NOTCH1
|
| Dimorphic effects of Notch signaling in bone homeostasis
|
| Engin, F.; Yao, Z.; Yang, T.; Zhou, G.; Bertin, T.; Jiang, M. M.; Chen, Y.; Wang, L.; Zheng, H.; Sutton, R. E.; Boyce, B. F.; Lee, B.
|
| Nature Med. 14: 299-305 2008
|
| 93 | NOTCH1
|
| Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
|
| Hilton, M. J.; Tu, X.; Wu, X.; Bai, S.; Zhao, H.; Kobayashi, T.; Kronenberg, H. M.; Teitelbaum, S. L.; Ross, F. P.; Kopan, R.; Long, F.
|
| Nature Med. 14: 306-314 2008
|
| 94 | CDC42BPA,NOTCH1,ROCK1,ROCK2
|
| Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases.
|
| Lefort K, Mandinova A, Ostano P, Kolev V, Calpini V, Kolfschoten I, Devgan V, Lieb J, Raffoul W, Hohl D, Neel V, Garlick J, Chiorino G, Dotto GP.
|
| Genes Dev 21(5):562-77. 2007
|
| 95 | NOTCH1,TP53
|
| Regulation of Notch1 gene expression by p53 in epithelial cells.
|
| Yugawa T, Handa K, Narisawa-Saito M, Ohno S, Fujita M, Kiyono T.
|
| Mol Cell Biol 27(10):3732-42. Epub 2007 Mar 12. 2007
|
| 96 | MYC,NOTCH1
|
| The Notch1/c-Myc pathway in T cell leukemia.
|
| Sharma VM, Draheim KM, Kelliher MA.
|
| Cell Cycle 6(8):927-30. Epub 2007 Apr 11. 2007
|
| 97 | PTEN, NOTCH1
|
| Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
|
| Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zœ–iga-PflŸcker JC, Dominguez M, Ferrando AA.
|
| Nat Med 13(10):1203-10. Epub 2007 Sep 16. 2007
|
| 98 | NOTCH1
|
| Notch1 and its ligand Jagged1 are present in remyelination in a T-cell- and antibody-mediated model of inflammatory demyelination.
|
| Seifert T, Bauer J, Weissert R, Fazekas F, Storch MK.
|
| Acta Neuropathol 113(2):195-203. Epub 2006 Nov 30.
2007
|
| 99 | NOTCH1
|
| Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism
|
| Vauclair, S.; Majo, F.; Durham, A.-D.; Ghyselinck, N. B.; Barrandon, Y.; Radtke, F.
|
| Dev Cell. 13: 242-253 2007
|
| 100 | CEBPA, NOTCH1
|
| Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1.
|
| Wouters BJ, Jordà MA, Keeshan K, Louwers I, Erpelinck-Verschueren CA, Tielemans D, Langerak AW, He Y, Yashiro-Ohtani Y, Zhang P, Hetherington CJ, Verhaak RG, Valk PJ, Löwenberg B, Tenen DG, Pear WS, Delwel R.
|
| Blood 110(10):3706-14. Epub 2007 Aug 1.PMID: 17671232 2007
|
| 101 | NOTCH1, NOTCH2, NOTCH3, NOTCH4
|
| A role for notch signaling in human corneal epithelial cell differentiation and proliferation.
|
| Ma A, Boulton M, Zhao B, Connon C, Cai J, Albon J.
|
| Invest Ophthalmol Vis Sci 48(8):3576-85.PMID: 17652726 2007
|
| 102 | NOTCH1,NOTCH2,NOTCH3,NOTCH4
|
| Multiple functions of Notch signaling in self-renewing organs and cancer.
|
| Wilson A, Radtke F.
|
| FEBS Lett 580(12):2860-8. Epub 2006 Mar 20. 2006
|
| 103 | NOTCH1
|
| Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling.
|
| Deregowski V, Gazzerro E, Priest L, Rydziel S, Canalis E.
|
| J Biol Chem 281(10):6203-10. Epub 2006 Jan 6. 2006
|
| 104 | NOTCH1, FAVD1
|
| Mutations in NOTCH1 cause aortic valve disease.
|
| Garg V, Muth AN, Ransom JF, Schluterman MK, Barnes R, King IN, Grossfeld PD, Srivastava D.
|
| Nature 437(7056):270-4. Epub 2005 Jul 17. 2005
|
| 105 | DLL1,NOTCH1
|
| Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP.
|
| Fischer DF, van Dijk R, Sluijs JA, Nair SM, Racchi M, Levelt CN, van Leeuwen FW, Hol EM.
|
| FASEB J 19(11):1451-8. 2005
|
| 106 | NOTCH1
|
| The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity
|
| Morimoto, M.; Takahashi, Y.; Endo, M.; Saga, Y
|
| Nature 435: 354-359 2005
|
| 107 | NOTCH1
|
| Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
|
| Weng AP, Ferrando AA, Lee W, Morris JP 4th, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC.
|
| Science 306(5694):269-71. 2004
|
| 108 | NOTCH1
|
| The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells
|
| Sade H, Krishna S, Sarin A.
|
| J Biol Chem. 279(4):2937-44 2004
|
| 109 | CADASIL, DLL1, Dll3, DLL4, JAG1, JAG2, NOTCH1, NOTCH2, NOTCH3, NOTCH4 , RBPJ, SCDO1
|
| Notch signaling and inherited disease syndromes.
|
| Gridley T.
|
| Hum Mol Genet 12 Spec No 1:R9-13. Review. 2003
|
| 110 | CNTN1, DTX1, NOTCH1, NOTCH2
|
| F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.
|
| Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Sankar N, Ng YK, Ling EA, Maciag T, Small D, Trifonova R, Kopan R, Okano H, Nakafuku M, Chiba S, Hirai H, Aster JC, Schachner M, Pallen CJ, Watanabe K, Xiao ZC.
|
| Cell 115(2):163-75. 2003
|
| 111 | ALPCA1,ALPCA2,NOTCH1,NOTCH2,NOTCH3,NOTCH4
|
| Notch signaling in development and disease.
|
| Harper JA, Yuan JS, Tan JB, Visan I, Guidos CJ.
|
| Clin Genet 64(6):461-72. 2003
|
| 112 | NOTCH1, NUMB
|
| Notch1 and Numb genes are inversely expressed as oligodendrocytes differentiate.
|
| Givogri MI, Schonmann V, Cole R, De Vellis J, Bongarzone ER.
|
| Dev Neurosci 25(1):50-64. 2003
|
| 113 | NOTCH1
|
| Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain
|
| McGill MA, McGlade CJ.
|
| J Biol Chem. 278(25):23196-203 2003
|
| 114 | NOTCH1
|
| Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3.
|
| Blokzijl A, Dahlqvist C, Reissmann E, Falk A, Moliner A, Lendahl U, Ibáñez CF.
|
| J Cell Biol. 24;163(4):723-8 2003
|
| 115 | NOTCH1
|
| Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch.
|
| Yeh TS, Lin YM, Hsieh RH, Tseng MJ.
|
| J Biol Chem. 278(43):41963-9 2003
|
| 116 | NOTCH1
|
| Notch-mediated restoration of regenerative potential to aged muscle
|
| Conboy, I. M.; Conboy, M. J.; Smythe, G. M.; Rando, T. A
|
| Science. 302: 1575-1577 2003
|
| 117 | NOTCH1
|
| Notch1 functions as a tumor suppressor in mouse skin.
|
| Nicolas, M.; Wolfer, A.; Raj, K.; Kummer, J. A.; Mill, P.; van Noort, M.; Hui, C.; Clevers, H.; Dotto, G. P.; Radtke, F.
|
| Nature Genet. 33: 416-421 2003
|
| 118 | NOTCH1
|
| Notch signaling regulates left-right asymmetry determination by inducing Nodal expression
|
| Krebs, L. T.; Iwai, N.; Nonaka, S.; Welsh, I. C.; Lan, Y.; Jiang, R.; Saijoh, Y.; O'Brien, T. P.; Hamada, H.; Gridley, T.
|
| Genes Dev. 17: 1207-1212 2003
|
| 119 | NOTCH1
|
| Glycogen synthase kinase-3beta modulates notch signaling and stability
|
| Foltz DR, Santiago MC, Berechid BE, Nye JS.
|
| Curr Biol. 12(12):1006-11 2002
|
| 120 | NOTCH1
|
| The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.
|
| Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K.
|
| J Biol Chem 277(33):29399-405 2002
|
| 121 | NOTCH1
|
| Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a notchless-like amino-terminal domain.
|
| Nal B, Mohr E, Silva MI, Tagett R, Navarro C, Carroll P, Depetris D, Verthuy C, Jordan BR, Ferrier P.
|
| Genomics 79(1):77-86 2002
|
| 122 | JAG2, NOTCH1
|
| Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes.
|
| Hayashi T, Kageyama Y, Ishizaka K, Xia G, Kihara K, Oshima H.
|
| J Androl 22(6):999-1011. 2001
|
| 123 | NOTCH1
|
| Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
|
| Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, Six E, Ciechanover A, Israël A.
|
| J Biol Chem. 276(37):34371-8 2001
|
| 124 | NOTCH1
|
| Hyperphosphorylation and association with RBP of the intracellular domain of Notch1.
|
| Foltz DR, Nye JS.
|
| Biochem Biophys Res Commun. 286(3):484-92 2001
|
| 125 | NOTCH1
|
| Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.
|
| Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M.
|
| J Biol Chem. 276(48):45031-40 2001
|
| 126 | NOTCH1
|
| Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate
|
| Tanigaki, K.; Nogaki, F.; Takahashi, J.; Tashiro, K.; Kurooka, H.; Honjo, T.
|
| Neuron. 29: 45-55 2001
|
| 127 | LFNG, MFNG, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NOTCH5, RFNG
|
| Fringe is a glycosyltransferase that modifies Notch.
|
| Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, Wilson R, Wang Y, Stanley P, Irvine KD, Haltiwanger RS, Vogt TF.
|
| Nature 406(6794):369-75. 2000
|
| 128 | LFNG, MFNG, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NOTCH5, RFNG
|
| Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.
|
| Bruckner K, Perez L, Clausen H, Cohen S.
|
| Nature 406(6794):411-5. 2000
|
| 129 | DLL4, NOTCH1
|
| Dll4, a novel Notch ligand expressed in arterial endothelium.
|
| Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL.
|
| Genes Dev 14(11):1313-8. 2000
|
| 130 | NOTCH1, NOTCH4
|
| Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers.
|
| Suzuki T, Aoki D, Susumu N, Udagawa Y, Nozawa S.
|
| Int J Oncol 17(6):1131-9. 2000
|
| 131 | NOTCH1
|
| MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors
|
| Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD.
|
| Nature Genet. 26(4):484-9 2000
|
| 132 | NOTCH1
|
| Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5
|
| Kurooka H, Honjo T.
|
| J Biol Chem 275(22):17211-20 2000
|
| 133 | NOTCH1
|
| Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors
|
| Shimizu K, Chiba S, Saito T, Kumano K, Hirai H.
|
| Biochem Biophys Res Commun. 276(1):385-9 2000
|
| 134 | NOTCH1
|
| Calcium depletion dissociates and activates heterodimeric notch receptors.
|
| Rand MD, Grimm LM, Artavanis-Tsakonas S, Patriub V, Blacklow SC, Sklar J, Aster JC.
|
| Mol Cell Biol. 20(5):1825-35 2000
|
| 135 | NOTCH1
|
| SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.
|
| Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD.
|
| Mol Cell Biol. 20(7):2400-10 2000
|
| 136 | NOTCH1
|
| Mesp2 initiates somite segmentation through the Notch signalling pathway
|
| Takahashi, Y.; Koizumi, K.; Takagi, A.; Kitajima, S.; Inoue, T.; Koseki, H.; Saga, Y.
|
| Nature Genet. 25: 390-396 2000
|
| 137 | JAG2, NOTCH1
|
| Notch signalling pathway mediates hair cell development in mammalian cochlea.
|
| Lanford PJ, et al.
|
| Nat Genet 21(3):289-92. 1999
|
| 138 | NOTCH1
|
| Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics.
|
| Carlesso N, et al.
|
| Blood 93(3):838-48. 1999
|
| 139 | NOTCH1, NOTCH2, NOTCH3, NOTCH4, PSEN1
|
| Presenilin is required for activity and nuclear access of Notch in Drosophila.
|
| Struhl G, et al.
|
| Nature 398(6727):522-5. 1999
|
| 140 | NOTCH1, NOTCH2, NOTCH3, NOTCH4, PSEN1
|
| A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
|
| De Strooper B, et al.
|
| Nature 398(6727):518-22. 1999
|
| 141 | NOTCH1, PSEN1
|
| Evidence for a physical interaction between presenilin and Notch.
|
| Ray WJ, Yao M, Nowotny P, Mumm J, Zhang W, Wu JY, Kopan R, Goate AM.
|
| Proc Natl Acad Sci U S A. 96(6):3263-8 1999
|
| 142 | NOTCH1
|
| Contact-dependent inhibition of cortical neurite growth mediated by Notch signaling
|
| Sestan, N.; Artavanis-Tsakonas, S.; Rakic, P
|
| Science. 286: 741-746 1999
|
| 143 | NOTCH1,NOTCH4,PBX1,PBX2,PBX3,RXRA,RXRB,RXRG
|
| Paralogy mapping : identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci.
|
| Katsanis N, et al.
|
| Genomics 35 : 101-108. 1996
|
| 144 | NOTCH1
|
| T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells
|
| Guan E, Wang J, Laborda J, Norcross M, Baeuerle PA, Hoffman T.
|
| J Exp Med. 183(5):2025-32 1996
|
| 145 | NOTCH1
|
| Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.
|
| Zhong W, Feder JN, Jiang MM, Jan LY, Jan YN.
|
| Neuron 17(1):43-53 1996
|
| 146 | NOTCH1
|
| Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H).
|
| Tamura K, Taniguchi Y, Minoguchi S, Sakai T, Tun T, Furukawa T, Honjo T.
|
| Curr Biol. 5(12):1416-23 1995
|
| 147 | TAN1, NOTCH1
|
| A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors.
|
| Milner LA, et al.
|
| Blood 83 : 2057-2062. 1994
|
| 148 | NOTCH1, NOTCH2, NOTCH3
|
| The human NOTCH1, 2, and 3 genes are located at chromosome positions 9q34, 1p13-p11, and 19p13.2-p13.1 in regions of neoplasia-associated translocation.
|
| Larsson C, et al.
|
| Genomics 24 : 253-258. 1994
|
| 149 | NOTCH1
|
| A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors
|
| Milner, L. A.; Kopan, R.; Martin, D. I. K.; Bernstein, I. D.
|
| Blood 83: 2057-2062 1994
|
| 150 | TAN1, NOTCH1
|
| TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
|
| Ellisen LW, et al.
|
| Cell 66 : 649-661. 1991
|