| 1 | NOS1, NOS2, NOS3
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| The dual role of iNOS in cancer.
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| Vannini F, Kashfi K, Nath N.
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| Redox Biol 6:334-43. doi: 10.1016/j.redox.2015.08.009. Epub 2015 Aug 24. Review.
2015
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| 2 | HRAS, NOS3
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| Endomembrane H-Ras controls vascular endothelial growth factor-induced nitric-oxide synthase-mediated endothelial cell migration.
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| Haeussler DJ, Pimentel DR, Hou X, Burgoyne JR, Cohen RA, Bachschmid MM.
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| J Biol Chem 288(21):15380-9. doi: 10.1074/jbc.M112.427765. Epub 2013 Apr 2.
2013
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| 3 | NOS3, UBIAD1
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| Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis.
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| Mugoni V, Postel R, Catanzaro V, De Luca E, Turco E, Digilio G, Silengo L, Murphy MP, Medana C, Stainier DY, Bakkers J, Santoro MM.
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| Cell 152(3):504-18. doi: 10.1016/j.cell.2013.01.013.
2013
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| 4 | NOS3
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| Asymmetric dimethylarginine induces endothelial nitric-oxide synthase mitochondrial redistribution through the nitration-mediated activation of Akt1.
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| Rafikov R, Rafikova O, Aggarwal S, Gross C, Sun X, Desai J, Fulton D, Black SM.
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| J Biol Chem 288(9):6212-26. doi: 10.1074/jbc.M112.423269. Epub 2012 Dec 19.
2013
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| 5 | NOS3
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| VEGF-mediated phosphorylation of eNOS regulates angioblast and embryonic endothelial cell proliferation.
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| Gentile C, Muise-Helmericks RC, Drake CJ.
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| Dev Biol 373(1):163-75. doi: 10.1016/j.ydbio.2012.10.020. Epub 2012 Oct 24.
2013
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| 6 | ADH5, NOS3
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| S-nitrosoglutathione reductase (GSNOR) enhances vasculogenesis by mesenchymal stem cells.
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| Gomes SA, Rangel EB, Premer C, Dulce RA, Cao Y, Florea V, Balkan W, Rodrigues CO, Schally AV, Hare JM.
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| Proc Natl Acad Sci U S A 110(8):2834-9. doi: 10.1073/pnas.1220185110. Epub 2013 Jan 3.
2013
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| 7 | GIT1, NOS3
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| G-protein-coupled receptor kinase interactor-1 (GIT1) is a new endothelial nitric-oxide synthase (eNOS) interactor with functional effects on vascular homeostasis.
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| Liu S, Premont RT, Rockey DC.
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| J Biol Chem 287(15):12309-20. doi: 10.1074/jbc.M111.320465. Epub 2012 Jan 31.
2012
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| 8 | NOS3
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| Endothelial nitric oxide synthase inhibits the development of autoimmune-mediated vasculitis in mice.
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| Schoeb TR, Jarmi T, Hicks MJ, Henke S, Zarjou A, Suzuki H, Kramer P, Novak J, Agarwal A, Bullard DC.
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| Arthritis Rheum 64(12):4114-24. doi: 10.1002/art.37683.
2012
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| 9 | NOS3, SRC
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| ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration.
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| Liu G, Place AT, Chen Z, Brovkovych VM, Vogel SM, Muller WA, Skidgel RA, Malik AB, Minshall RD.
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| Blood 120(9):1942-52. doi: 10.1182/blood-2011-12-397430. Epub 2012 Jul 17.
2012
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| 10 | NOS3
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| Endothelial nitric oxide synthase deficiency reduces uterine blood flow, spiral artery elongation, and placental oxygenation in pregnant mice.
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| Kulandavelu S, Whiteley KJ, Qu D, Mu J, Bainbridge SA, Adamson SL.
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| Hypertension 60(1):231-8. doi: 10.1161/HYPERTENSIONAHA.111.187559. Epub 2012 May 21.
2012
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| 11 | NOS3
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| Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition.
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| Chen Z, Bakhshi FR, Shajahan AN, Sharma T, Mao M, Trane A, Bernatchez P, van Nieuw Amerongen GP, Bonini MG, Skidgel RA, Malik AB, Minshall RD.
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| Mol Biol Cell 23(7):1388-98. doi: 10.1091/mbc.E11-09-0811. Epub 2012 Feb 9.
2012
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| 12 | NOS3
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| Evaluation of methylation status of the eNOS promoter at birth in relation to childhood bone mineral content.
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| Harvey NC, Lillycrop KA, Garratt E, Sheppard A, McLean C, Burdge G, Slater-Jefferies J, Rodford J, Crozier S, Inskip H, Emerald BS, Gale CR, Hanson M, Gluckman P, Godfrey K, Cooper C.
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| Calcif Tissue Int 90(2):120-7. doi: 10.1007/s00223-011-9554-5. Epub 2011 Dec 8.
2012
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| 13 | NOS3
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| c-Jun N-terminal kinase 2 phosphorylates endothelial nitric oxide synthase at serine 116 and regulates nitric oxide production.
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| Park JH, Park M, Byun CJ, Jo I.
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| Biochem Biophys Res Commun 417(1):340-5. doi: 10.1016/j.bbrc.2011.11.112. Epub 2011 Dec 1.
2012
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| 14 | NOS3
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| eNOS, a pressure-dependent regulator of intraocular pressure.
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| Stamer WD, Lei Y, Boussommier-Calleja A, Overby DR, Ethier CR.
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| Invest Ophthalmol Vis Sci 52(13):9438-44. doi: 10.1167/iovs.11-7839.
2011
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| 15 | NOS3
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| Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2.
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| MacLauchlan S, Yu J, Parrish M, Asoulin TA, Schleicher M, Krady MM, Zeng J, Huang PL, Sessa WC, Kyriakides TR.
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| Proc Natl Acad Sci U S A 108(46):E1137-45. doi: 10.1073/pnas.1104357108. Epub 2011 Sep 26.
2011
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| 16 | MAPK7, NOS3, PRKCZ
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| PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.
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| Nigro P, Abe J, Woo CH, Satoh K, McClain C, O'Dell MR, Lee H, Lim JH, Li JD, Heo KS, Fujiwara K, Berk BC.
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| Blood 116(11):1971-9. doi: 10.1182/blood-2010-02-269134. Epub 2010 Jun 10.
2010
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| 17 | NOS3
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| Endothelial nitric oxide synthase deficiency in mice results in reduced chondrocyte proliferation and endochondral bone growth.
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| Yan Q, Feng Q, Beier F.
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| Arthritis Rheum 62(7):2013-22. doi: 10.1002/art.27486.
2010
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| 18 | NOS3
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| eNOS plays a major role in adiponectin synthesis in adipocytes.
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| Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn JH, Lee KU.
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| Am J Physiol Endocrinol Metab 298(4):E846-53. doi: 10.1152/ajpendo.00008.2010. Epub 2010 Feb 2.
2010
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| 19 | NOS3
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| eNOS uncoupling and endothelial dysfunction in aged vessels.
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| Yang YM, Huang A, Kaley G, Sun D.
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| Am J Physiol Heart Circ Physiol 297(5):H1829-36. doi: 10.1152/ajpheart.00230.2009. Epub 2009 Sep 18.
2009
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| 20 | CETP, LPL, MTHFR, NOS3, OLR1, PAPPA, SERPINE1
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| Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes.
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| Tousoulis D, Briasoulis A, Papageorgiou N, Antoniades C, Stefanadis C.
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| Trends Mol Med rends Mol Med. 2008 Sep 9. [Epub ahead of print]
2008
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| 21 | NOS3
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| The 894G>T variant in the endothelial nitric oxide synthase gene and spina bifida risk.
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| van der Linden IJ, Heil SG, den Heijer M, Blom HJ.
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| J Hum Genet 52(6):516-20. Epub 2007 May 4. 2007
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| 22 | SIRT1, NOS3
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| SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase.
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| Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, Jung SB, Dericco J, Kasuno K, Irani K.
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| Proc Natl Acad Sci U S A 104(37):14855-60. Epub 2007 Sep 4. 2007
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| 23 | NOS3, NAT1
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| Risk of limb deficiency defects associated with NAT1, NAT2, GSTT1, GSTM1, and NOS3 genetic variants, maternal smoking, and vitamin supplement intake.
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| Carmichael SL, Shaw GM, Yang W, Iovannisci DM, Lammer E.
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| Am J Med Genet A 140(18):1915-22. 2006
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| 24 | NOS3
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| Genetic variations of the endothelial nitric oxide synthase gene are related to increased levels of C-reactive protein and macrophage-colony stimulating-factor in patients with coronary artery disease.
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| Lekakis JP, Ikonomidis I, Tsibida M, Protogerou A, Papada A, Papapanagiotou A, Revela I, Papamichael CM, Kalofoutis AT, Kremastinos DT.
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| Thromb Haemost 96(4):520-8.
2006
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| 25 | NOS3
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| Modifier effect of ENOS in autosomal dominant polycystic kidney disease.
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| Persu A, Stoenoiu MS, Messiaen T, Davila S, Robino C, El-Khattabi O, Mourad M, Horie S, Feron O, Balligand JL, Wattiez R, Pirson Y, Chauveau D, Lens XM, Devuyst O.
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| Hum Mol Genet 11(3):229-41. 2002
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| 26 | NOS3
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| Endothelial nitric oxide synthase gene polymorphisms in Fabry's disease.
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| Heltianu C, Costache G, Azibi K, Poenaru L, Simionescu M.
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| Clin Genet 61(6):423-9. 2002
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| 27 | NOS3
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| Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis.
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| Guzik TJ, Black E, West NE, McDonald D, Ratnatunga C, Pillai R, Channon KM.
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| Am J Med Genet 100(2):130-7. 2001
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| 28 | NOS3
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| the missense Glu298Asp variant of the endothelial nitric oxide synthase gene is strongly associated with placental abruption.
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| Yoshimura T, Yoshimura M, Tabata A, yasue H, Okamura H.
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| Hum Genet 108 : 181-183. 2001
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| 29 | GRB10, MEST, NOS3, SERPINE1, UPD7M
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| Maternal and paternal chromosomes 7 show differential methylation of many genes in lymphoblast DNA.
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| Hannula K, Lipsanen-Nyman M, Scherer SW, Holmberg C, Hoglund P, Kere J.
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| Genomics 73(1):1-9. 2001
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| 30 | NOS3
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| Endothelial nitric oxide synthase gene (NOS3) variant and hypertension in pregnancy.
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| Kobashi G, Yamada H, Ohta K, Kato EH, Ebina Y, Fujimoto S.
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| Am J Med Genet 103 : 241-244. 2001
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| 31 | NOS3
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| Loss of heterozygosity of the NOS3 dinucleotide repeat marker in atherosclerotic plaques of human carotid arteries.
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| Grati FR, Ghilardi G, Sirchia SM, Massaro F, Cassani B, Scorza R, De Andreis C, Sironi E, Simoni G.
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| Atherosclerosis 159(2):261-7. 2001
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| 32 | NOS3
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| Endothelial nitric oxide synthase gene sequence variations and vascular disease.
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| Wang XL, Wang J.
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| Mol Genet Metab 70(4):241-51. 2000
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| 33 | NOS3, RPA1
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| Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T-->C mutation associated with coronary spastic angina.
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| Miyamoto Y, Saito Y, Nakayama M, Shimasaki Y, Yoshimura T, Yoshimura M, Harada M, Kajiyama N, Kishimoto I, Kuwahara K, Hino J, Ogawa E, Hamanaka I, Kamitani S, Takahashi N, Kawakami R, Kangawa K, Yasue H, Nakao K.
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| Hum Mol Genet 9(18):2629-37. 2000
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| 34 | NOS3
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| Failure to detect linkage of preeclampsia to the region of the NOS3 locus on chromosome 7q.
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| Lewis I, et al.
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| Am J Hum Genet 64 : 310-313. 1999
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| 35 | ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
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| Sequence diversity in 36 candidate genes for cardiovascular disorders.
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| Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
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| Am J Hum Genet 65(1):183-91. 1999
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| 36 | NOS3
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| Nitric oxide synthase type 3 is increased in squamous hyperplasia, dysplasia, and squamous cell carcinoma of the head and neck.
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| Bentz BG, Haines GK 3rd, Lingen MW, Pelzer HJ, Hanson DG, Radosevich JA.
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| Ann Otol Rhinol Laryngol 108(8):781-7 1999
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| 37 | NOS3
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| Association between Alzheimer's disease and the NOS3 gene.
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| Dahiyat M, Cumming A, Harrington C, Wischik C, Xuereb J, Corrigan F, Breen G, Shaw D, St Clair D.
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| Ann Neurol 46(4):664-7 1999
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| 38 | NOS3, PEE2
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| Genetic susceptibility to pre-eclampsia and chromosome 7q36.
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| Guo G, Lade JA, Wilton AN, Moses EK, Grehan M, Fu Y, Qiu H, Cooper DW, Brennecke SP.
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| Hum Genet 105(6):641-7 1999
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| 39 | NOS3
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| Linkage analysis of endothelial nitric oxide synthase gene with human blood pressure.
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| Takami S, Wong ZY, Stebbing M, Harrap SB.
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| J Hypertens 17(10):1431-6. 1999
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| 40 | GUCY1A2, GUCY1A3, NOS3
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| Guanylate cyclase and the .NO/cGMP signaling pathway.
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| Denninger JW, Marletta MA.
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| Biochim Biophys Acta 1411(2-3):334-50. Review. 1999
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| 41 | NOS3
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| Characterization of the human endothelial nitric-oxide synthase promoter.
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| Karantzoulis-Fegaras F, Antoniou H, Lai SL, Kulkarni G, D'Abreo C, Wong GK, Miller TL, Chan Y, Atkins J, Wang Y, Marsden PA.
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| J Biol Chem 274(5):3076-93. 1999
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| 42 | NOS3
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| Polymorphisms of the endothelial nitric oxide synthase gene - no consistent association with myocardial infarction in the ECTIM study.
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| Poirier O, Mao C, Mallet C, Nicaud V, Herrmann SM, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L, Soubrier F, Cambien F.
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| Eur J Clin Invest 29(4):284-90. 1999
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| 43 | NOS3
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| A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese.
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| Yoshimura M, et al.
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| Hum Genet 103 : 65-69. 1998
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| 44 | NOS3
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| Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction.
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| Shimasaki Y, et al.
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| J Am Coll Cardiol 31 : 1506-1510. 1998
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| 45 | NOS3
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| Mspl polymorphism in the promoter of the human endothelial constitutive NO synthase gene in Australian Caucasian population.
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| Sim AS, et al.
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| Mol Genet Metab 65 : 62. 1998
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| 46 | NOS3
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| Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region.
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| Arngrimsson R, Hayward C, Nadaud S, Baldursdottir A, Walker JJ, Liston WA, Bjarnadottir RI, Brock DJ, Geirsson RT, Connor JM, Soubrier F.
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| Am J Hum Genet 61(2):354-62. 1997
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| 47 | NOS1, NOS2, NOS2B, NOS2C, NOS3
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| Nitric oxide synthases: which, where, how, and why?
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| Michel T, Feron O.
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| J Clin Invest 100(9):2146-52. 1997
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| 48 | NOS3
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| A common base change in the promoter region of the human endothelial NO-synthase (NOS3) gene.
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| Meier J, et al.
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| Hum Mutat 8 : 394. 1996
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| 49 | NOS3
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| Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene.
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| Robinson LJ, et al.
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| Genomics 19 : 350-357. 1994
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| 50 | NOS2, NOS3
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| Mapping of the genes encoding human inducible and endothelial nitric oxide synthase (NOS2 and NOS3) to the pericentric region of chromosome 17 and to chromosome 7, respectively.
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| Xu W, et al.
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| Genomics 21 : 419-422. 1994
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| 51 | NOS3
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| Cloning and structural characterization of the human endothelial nitric-oxide-synthase gene.
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| Miyahara K, et al.
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| Eur J Biochem 223 : 719-726. 1994
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| 52 | NOS3
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| Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene.
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| Nadaud S, et al.
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| Biochem Biophys Res Commun 198 : 1027-1033. 1994
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| 53 | NOS1, NOS2, NOS3
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| Nitric oxide synthases : roles, tolls, and controls.
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| Nathan C, et al.
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| Cell 78 : 915-918. 1994
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| 54 | NOS1, NOS3
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| Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene.
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| Marsden PA, et al.
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| J Biol Chem 268 : 17478-17488. 1993
|