1 | NODAL, SHH, TGFB1, TGIF1, TGIF2
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| Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly.
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| Wotton D, Taniguchi K.
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| Am J Med Genet C Semin Med Genet 178(2):128-139. doi: 10.1002/ajmg.c.31612. Epub 2018 May 11.
2018
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2 | MSX2, NODAL, SOX2
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| MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling.
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| Wu Q, Zhang L, Su P, Lei X, Liu X, Wang H, Lu L, Bai Y, Xiong T, Li D, Zhu Z, Duan E, Jiang E, Feng S, Han M, Xu Y, Wang F, Zhou J.
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| Cell Res 25(12):1314-32. doi: 10.1038/cr.2015.118.
2015
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3 | NODAL
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| NODAL secreted by male germ cells regulates the proliferation and function of human Sertoli cells from obstructive azoospermia and nonobstructive azoospermia patients.
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| Tian RH, Yang S, Zhu ZJ, Wang JL, Liu Y, Yao C, Ma M, Guo Y, Yuan Q, Hai Y, Huang YR, He Z, Li Z.
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| Asian J Androl 17(6):996-1005. doi: 10.4103/1008-682X.159722.
2015
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4 | NODAL
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| Increased expression of Nodal correlates with reduced patient survival in pancreatic cancer.
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| Kong B, Wang W, Esposito I, Friess H, Michalski CW, Kleeff J.
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| Pancreatology 15(2):156-61. doi: 10.1016/j.pan.2015.02.001.
2015
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5 | CER1, NODAL
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| Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes.
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| Aykul S, Ni W, Mutatu W, Martinez-Hackert E.
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| PLoS One 10(1):e0114954. doi: 10.1371/journal.pone.0114954.
2015
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6 | NODAL, TDGF1
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| New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding.
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| Focą A, Sanguigno L, Focą G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A.
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| Int J Mol Sci 16(9):21342-62. doi: 10.3390/ijms160921342.
2015
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7 | FOXA2, NODAL
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| Heterozygous deletion of FOXA2 segregates with disease in a family with heterotaxy, panhypopituitarism, and biliary atresia.
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| Tsai EA, Grochowski CM, Falsey AM, Rajagopalan R, Wendel D, Devoto M, Krantz ID, Loomes KM, Spinner NB.
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| Hum Mutat 36(6):631-7. doi: 10.1002/humu.22786. Epub 2015 Apr 21.
2015
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8 | CFC1, GDF1, NODAL
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| Nodal·Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation.
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| Fuerer C, Nostro MC, Constam DB.
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| J Biol Chem 289(25):17854-71. doi: 10.1074/jbc.M114.550301.
2014
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9 | GATA4, NODAL
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| The contribution of de novo and rare inherited copy number changes to congenital heart disease in an unselected sample of children with conotruncal defects or hypoplastic left heart disease.
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| Warburton D, Ronemus M, Kline J, Jobanputra V, Williams I, Anyane-Yeboa K, Chung W, Yu L, Wong N, Awad D, Yu CY, Leotta A, Kendall J, Yamrom B, Lee YH, Wigler M, Levy D.
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| Hum Genet 133(1):11-27. doi: 10.1007/s00439-013-1353-9.
2014
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10 | CER1, NODAL, SMARCD3
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| Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment.
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| Cai W, Albini S, Wei K, Willems E, Guzzo RM, Tsuda M, Giordani L, Spiering S, Kurian L, Yeo GW, Puri PL, Mercola M.
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| Genes Dev 27(21):2332-44. doi: 10.1101/gad.225144.113.
2013
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11 | DAZL, NANOG, NODAL
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| Nodal, Nanog, DAZL and SMAD gene expression in human amniotic fluid stem cells.
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| Stefanidis K, Pergialiotis V, Christakis D, Loutradis D, Antsaklis A.
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| J Stem Cells 8(1):17-23.
2013
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12 | NANOG, NODAL, SMAD3
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| NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway.
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| Sun C, Sun L, Jiang K, Gao DM, Kang XN, Wang C, Zhang S, Huang S, Qin X, Li Y, Liu YK.
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| Int J Biochem Cell Biol 45(6):1099-108. doi: 10.1016/j.biocel.2013.02.017. Epub 2013 Mar 7.
2013
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13 | NODAL, TDGF1
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| TGF-β superfamily member Nodal stimulates human β-cell proliferation while maintaining cellular viability.
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| Boerner BP, George NM, Targy NM, Sarvetnick NE.
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| Endocrinology 154(11):4099-112. doi: 10.1210/en.2013-1197.
2013
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14 | NODAL
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| Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells.
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| Wu Q, Kanata K, Saba R, Deng CX, Hamada H, Saga Y.
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| Development 140(2):291-300. doi: 10.1242/dev.087882. Epub 2012 Dec 5.
2013
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15 | NBL1, NODAL
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| BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo.
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| Katsu K, Tokumori D, Tatsumi N, Suzuki A, Yokouchi Y.
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| Dev Biol 363(1):15-26. doi: 10.1016/j.ydbio.2011.12.015. Epub 2011 Dec 20.
2012
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16 | CITED2, NODAL, PITX2
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| CITED2 mutation links congenital heart defects to dysregulation of the cardiac gene VEGF and PITX2C expression.
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| Li Q, Pan H, Guan L, Su D, Ma X.
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| Biochem Biophys Res Commun 423(4):895-9. doi: 10.1016/j.bbrc.2012.06.099. Epub 2012 Jun 23.
2012
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17 | NODAL, TDGF1
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| Endogenous Nodal signaling regulates germ cell potency during mammalian testis development.
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| Spiller CM, Feng CW, Jackson A, Gillis AJ, Rolland AD, Looijenga LH, Koopman P, Bowles J.
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| Development 139(22):4123-32. doi: 10.1242/dev.083006. Epub 2012 Oct 3.
2012
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18 | NODAL, PREX1, RAC1
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| Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1
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| Woo S, Housley MP, Weiner OD, Stainier DY.
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| J Cell Biol. Sep 3;198(5):941-52. doi: 10.1083/jcb.201203012. 2012
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19 | CITED2, NODAL
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| Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis.
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| Lopes Floro K, Artap ST, Preis JI, Fatkin D, Chapman G, Furtado MB, Harvey RP, Hamada H, Sparrow DB, Dunwoodie SL.
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| Hum Mol Genet 20(6):1097-110. Epub 2010 Dec 28.
2011
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20 | CCNG2, FOXO3, NODAL
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| Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells.
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| Fu G, Peng C.
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| Oncogene 30(37):3953-66. doi: 10.1038/onc.2011.127. Epub 2011 May 2.
2011
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21 | NODAL, TDGF1
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| Regulation of extra-embryonic endoderm stem cell differentiation by Nodal and Cripto signaling.
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| Kruithof-de Julio M, Alvarez MJ, Galli A, Chu J, Price SM, Califano A, Shen MM.
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| Development 138(18):3885-95. doi: 10.1242/dev.065656.
2011
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22 | NODAL
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| Nodal promotes growth and invasion in human gliomas.
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| Lee CC, Jan HJ, Lai JH, Ma HI, Hueng DY, Lee YC, Cheng YY, Liu LW, Wei HW, Lee HM.
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| Oncogene 29(21):3110-23. Epub 2010 Apr 12.PMID: 20383200 2010
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23 | NODAL, TGIF1, TGIF2
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| Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.
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| Powers SE, Taniguchi K, Yen W, Melhuish TA, Shen J, Walsh CA, Sutherland AE, Wotton D.
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| Development 137(2):249-59.PMID: 20040491 2010
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24 | NODAL
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| Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations.
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| Mohapatra B, Casey B, Li H, Ho-Dawson T, Smith L, Fernbach SD, Molinari L, Niesh SR, Jefferies JL, Craigen WJ, Towbin JA, Belmont JW, Ware SM.
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| Hum Mol Genet 18(5):861-71. Epub 2008 Dec 8.
2009
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25 | NODAL
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| Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly.
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| Roessler E, Pei W, Ouspenskaia MV, Karkera JD, Veléz JI, Banerjee-Basu S, Gibney G, Lupo PJ, Mitchell LE, Towbin JA, Bowers P, Belmont JW, Goldmuntz E, Baxevanis AD, Feldman B, Muenke M.
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| Mol Genet Metab 98(1-2):225-34. Epub 2009 May 27.PMID: 19553149 2009
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26 | HTX5, NODAL
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| Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations.
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| Mohapatra B, Casey B, Li H, Ho-Dawson T, Smith L, Fernbach SD, Molinari L, Niesh SR, Jefferies JL, Craigen WJ, Towbin JA, Belmont JW, Ware SM.
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| Hum Mol Genet 18(5):861-71. doi: 10.1093/hmg/ddn411.
2009
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27 | NODAL, GDF1, TDGF1, FOXH1
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| Reduced NODAL signaling strength via mutation of several pathway members including FOXH1 is linked to human heart defects and holoprosencephaly.
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| Roessler E, Ouspenskaia MV, Karkera JD, Vlez JI, Kantipong A, Lacbawan F, Bowers P, Belmont JW, Towbin JA, Goldmuntz E, Feldman B, Muenke M.
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| Am J Hum Genet 83(1):18-29. Epub 2008 Jun 5. 2008
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28 | NODAL, TDGF1
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| Activation of a Nodal-independent signaling pathway by Cripto-1 mutants with impaired activation of a Nodal-dependent signaling pathway.
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| Bianco C, Mysliwiec M, Watanabe K, Mancino M, Nagaoka T, Gonzales M, Salomon DS.
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| FEBS Lett 582(29):3997-4002. Epub 2008 Nov 18.
2008
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29 | NODAL
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| Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells.
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| Wu Z, Zhang W, Chen G, Cheng L, Liao J, Jia N, Gao Y, Dai H, Yuan J, Cheng L, Xiao L.
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| J Biol Chem 283(36):24991-5002. Epub 2008 Jul 2.
2008
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30 | NODAL
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| TGFbeta/Activin/Nodal pathway in inhibition of human embryonic stem cell differentiation by mechanical strain.
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| Saha S, Ji L, de Pablo JJ, Palecek SP.
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| Biophys J 94(10):4123-33. Epub 2008 Jan 30.
2008
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31 | NODAL, TDGF1
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| Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal.
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| Kelber JA, Shani G, Booker EC, Vale WW, Gray PC.
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| J Biol Chem 283(8):4490-500. Epub 2007 Dec 18.
2008
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32 | LEMD3, NODAL
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| Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner.
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| Ishimura A, Chida S, Osada S.
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| Dev Dyn 237(12):3565-76. doi: 10.1002/dvdy.21663.
2008
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33 | GDF1, NODAL
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| Long-range action of Nodal requires interaction with GDF1.
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| Tanaka C, Sakuma R, Nakamura T, Hamada H, Saijoh Y.
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| Genes Dev 21(24):3272-82.PMID: 18079174 2007
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34 | NODAL
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| Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness.
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| Topczewska JM, Postovit LM, Margaryan NV, Sam A, Hess AR, Wheaton WW, Nickoloff BJ, Topczewski J, Hendrix MJ.
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| Nat Med 12(8):925-32. Epub 2006 Jul 30. 2006
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35 | DAND5, CER1, NODAL, GREM1
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| CER1 is a common target of WNT and NODAL signaling pathways in human embryonic stem cells.
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| Katoh M, Katoh M.
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| Int J Mol Med 17(5):795-9. 2006
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36 | NODAL
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| Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.
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| Vallier L, Alexander M, Pedersen RA.
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| J Cell Sci 118(Pt 19):4495-509.
2005
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37 | CITED2, PITX2, TFAP2A, NODAL
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| Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.
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| Bamforth SD, Braganca J, Farthing CR, Schneider JE, Broadbent C, Michell AC, Clarke K, Neubauer S, Norris D, Brown NA, Anderson RH, Bhattacharya S.
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| Nat Genet 36(11):1189-96. Epub 2004 Oct 10. 2004
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38 | NODAL, LEFTY1, LEFTY2
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| Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.
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| Besser D.
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| J Biol Chem 279(43):45076-84. Epub 2004 Aug 11. 2004
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39 | NODAL, NCLN, NOMO1, NOMO2, NOMO3
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| Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.
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| Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C.
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| EMBO J 23(15):3041-50. Epub 2004 Jul 15. 2004
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40 | MED15,NODAL,TGFB1,TGFB2,TGFB3
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| A component of the ARC/Mediator complex required for TGFbeta/Nodal signalling.
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| Kato Y, Habas R, Katsuyama Y, Naar AM, He X.
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| Nature 418(6898):641-6. 2002
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41 | NODAL, TDGF1
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| Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway.
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| Yan YT, Liu JJ, Luo Y, E C, Haltiwanger RS, Abate-Shen C, Shen MM.
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| Mol Cell Biol 22(13):4439-49. 2002
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42 | ACVR1C, NODAL
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| cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C).
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| Bondestam J, Huotari MA, Moren A, Ustinov J, Kaivo-Oja N, Kallio J, Horelli-Kuitunen N, Aaltonen J, Fujii M, Moustakas A, Ten Dijke P, Otonkoski T, Ritvos O.
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| Cytogenet Cell Genet 95(3-4):157-62. 2001
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43 | NODAL
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| Molecular pathways controlling heart development.
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| Olson EN, et al.
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| Science 272(5262):671-6. Review 1996
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44 | NODAL
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| Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation.
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| Zhou X, et al.
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| Nature 361(6412):543-7 1993
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