Citations for
1IKBKG, NMRAL1, USP7
HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination.
Li T, Guan J, Li S, Zhang X, Zheng X.
Cell Death Dis 5:e1229. doi: 10.1038/cddis.2014.197. 2014
2NMRAL1, OTUB1, TRAF3
HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1.
Peng Y, Xu R, Zheng X.
PLoS Pathog 10(4):e1004041. doi: 10.1371/journal.ppat.1004041. eCollection 2014 Apr. 2014
3NMRAL1, USP7
HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation.
Hu B, Li S, Zhang X, Zheng X.
Nucleic Acids Res 42(9):5582-93. doi: 10.1093/nar/gku230. Epub 2014 Apr 7. 2014
4NCF1, NMRAL1
HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation.
Hu B, Li S, Zhang X, Zheng X.
Nucleic Acids Res 42(9):5582-93. doi: 10.1093/nar/gku230. Epub 2014 Apr 7. 2014
5NMRAL1
A CRM1-dependent nuclear export signal controls nucleocytoplasmic translocation of HSCARG, which regulates NF-κB activity.
Zhang M, Hu B, Li T, Peng Y, Guan J, Lai S, Zheng X.
Traffic 13(6):790-9. doi: 10.1111/j.1600-0854.2012.01346.x. Epub 2012 Mar 14. 2012
6NMRAL1
HSCARG inhibits activation of NF-kappaB by interacting with IkappaB kinase-beta.
Gan Q, Li T, Hu B, Lian M, Zheng X.
J Cell Sci 122(Pt 22):4081-8. doi: 10.1242/jcs.054007. Epub 2009 Oct 20. 2009
7COMMD1, NMRAL1
HSCARG regulates NF-kappaB activation by promoting the ubiquitination of RelA or COMMD1.
Lian M, Zheng X.
J Biol Chem 284(27):17998-8006. doi: 10.1074/jbc.M809752200. Epub 2009 May 11. 2009
8NMRAL1
NADPH is an allosteric regulator of HSCARG.
Dai X, Li Y, Meng G, Yao S, Zhao Y, Yu Q, Zhang J, Luo M, Zheng X.
J Mol Biol 387(5):1277-85. doi: 10.1016/j.jmb.2009.02.049. Epub 2009 Feb 28. 2009
9NMRAL1
An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability.
Zhao Y, Zhang J, Li H, Li Y, Ren J, Luo M, Zheng X.
J Biol Chem 283(16):11004-13. doi: 10.1074/jbc.M708697200. Epub 2008 Feb 8. 2008
10NMRAL1
Protein expression, crystallization and preliminary X-ray crystallographic studies on HSCARG from Homo sapiens.
Dai X, Gu X, Luo M, Zheng X.
Protein Pept Lett 13(9):955-7. 2006