Citations for
1NLRC4, NLRP1, NLRP3
Novel aspects of the assembly and activation of inflammasomes with focus on the NLRC4 inflammasome.
Fusco WG, Duncan JA.
Int Immunol 30(5):183-193. doi: 10.1093/intimm/dxy009. 2018
2NLRP3, PYCARD
Single-Molecule Fluorescence Reveals the Oligomerization and Folding Steps Driving the Prion-like Behavior of ASC.
Gambin Y, Giles N, O'Carroll A, Polinkovsky M, Hunter D, Sierecki E.
J Mol Biol 430(4):491-508. doi: 10.1016/j.jmb.2017.12.013. Epub 2017 Dec 27. Erratum in: J Mol Biol. 2018 Mar 8;:. 2018
3MAP3K5, MAP3K6, NLRP3
ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.
Place DE, Samir P, Karki R, Briard B, Vogel P, Kanneganti TD.
Am J Pathol 188(4):1021-1030. doi: 10.1016/j.ajpath.2017.12.006. Epub 2018 Jan 31. 2018
4HSPD1, NLRP3
HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway.
Swaroop S, Mahadevan A, Shankar SK, Adlakha YK, Basu A.
J Neuroinflammation 15(1):177. doi: 10.1186/s12974-018-1214-5. Erratum in: J Neuroinflammation. 2018 Nov 15;15(1):317. 2018
5NLRP3, NR1H4
Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis.
Hao H, Cao L, Jiang C, Che Y, Zhang S, Takahashi S, Wang G, Gonzalez FJ.
Cell Metab 25(4):856-867.e5. doi: 10.1016/j.cmet.2017.03.007. 2017
6NLRC4, NLRP3
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
Freeman L, Guo H, David CN, Brickey WJ, Jha S, Ting JP.
J Exp Med 214(5):1351-1370. doi: 10.1084/jem.20150237. Epub 2017 Apr 12. 2017
7DFNA34, NLRP3
NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy.
Nakanishi H, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay JS, Chattaraj P, Park YH, Grevich S, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ.
Proc Natl Acad Sci U S A 114(37):E7766-E7775. doi: 10.1073/pnas.1702946114. Epub 2017 Aug 28. 2017
8DFNA34, NLRP3
NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy.
Nakanishi H, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay JS, Chattaraj P, Park YH, Grevich S, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ.
Proc Natl Acad Sci U S A 114(37):E7766-E7775. doi: 10.1073/pnas.1702946114. Epub 2017 Aug 28. 2017
9NLRC3, NLRP3
NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding.
Eren E, Berber M, Özören N.
J Biol Chem 292(30):12691-12701. doi: 10.1074/jbc.M116.769695. Epub 2017 Jun 5. 2017
10CASP1, NLRC3, NLRP3, PYCARD
NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding.
Eren E, Berber M, Özören N.
J Biol Chem 292(30):12691-12701. doi: 10.1074/jbc.M116.769695. Epub 2017 Jun 5. 2017
11CXCL1, CXCL2, CXCR2, NLRP3
CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein-Coupled Receptor CXCR2.
Boro M, Balaji KN.
J Immunol 199(5):1660-1671. doi: 10.4049/jimmunol.1700129. Epub 2017 Jul 24. 2017
12NLRP3, PYCARD
ASC Pyrin Domain Self-associates and Binds NLRP3 Protein Using Equivalent Binding Interfaces.
Oroz J, Barrera-Vilarmau S, Alfonso C, Rivas G, de Alba E.
J Biol Chem 291(37):19487-501. doi: 10.1074/jbc.M116.741082. Epub 2016 Jul 18. 2016
13NLRP1, NLRP3
The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease.
Saresella M, La Rosa F, Piancone F, Zoppis M, Marventano I, Calabrese E, Rainone V, Nemni R, Mancuso R, Clerici M.
Mol Neurodegener 11:23. doi: 10.1186/s13024-016-0088-1. 2016
14NLRP3, TRIM31
The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3.
Song H, Liu B, Huai W, Yu Z, Wang W, Zhao J, Han L, Jiang G, Zhang L, Gao C, Zhao W.
Nat Commun 7:13727. doi: 10.1038/ncomms13727. 2016
15BTK, NLRP3
Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.
Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, Morita R.
Nat Commun 6:7360. doi: 10.1038/ncomms8360. 2015
16ARRB1, NLRC4, NLRP3
β-arrestin1 is critical for the full activation of NLRP3 and NLRC4 inflammasomes.
Mao K, Chen S, Wang Y, Zeng Y, Ma Y, Hu Y, Zhang H, Sun S, Wu X, Meng G, Pei G, Sun B.
J Immunol 194(4):1867-73. doi: 10.4049/jimmunol.1401989. Epub 2015 Jan 12. 2015
17CASP1, IL1B, NLRP3, PLIN2
PLIN2 inhibits insulin-induced glucose uptake in myoblasts through the activation of the NLRP3 inflammasome.
Cho KA, Kang PB.
Int J Mol Med 36(3):839-44. doi: 10.3892/ijmm.2015.2276. Epub 2015 Jul 8. 2015
18CASP4, NLRP3
Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells.
Schmid-Burgk JL, Gaidt MM, Schmidt T, Ebert TS, Bartok E, Hornung V.
Eur J Immunol 45(10):2911-7. doi: 10.1002/eji.201545523. Epub 2015 Aug 6. 2015
19NLRP3, NR1I2
Xenobiotic receptor PXR regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells.
Wang S, Lei T, Zhang K, Zhao W, Fang L, Lai B, Han J, Xiao L, Wang N.
J Biol Chem Biol Chem. 2014 Sep 8. pii: jbc.M114.578781. [Epub ahead of print] 2014
20NLRP3
Mechanism of NLRP3 inflammasome activation.
Sutterwala FS, Haasken S, Cassel SL.
Ann N Y Acad Sci 1319:82-95. doi: 10.1111/nyas.12458. Epub 2014 May 19. Review. 2014
21NLRP3
NLRP3 regulates neutrophil functions and contributes to hepatic ischemia-reperfusion injury independently of inflammasomes.
Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K, Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, Yada T, Yasuda Y, Takahashi M.
J Immunol 192(9):4342-51. doi: 10.4049/jimmunol.1302039. Epub 2014 Apr 2. 2014
22ARRB2, HCAR1, NLRP3
Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity.
Hoque R, Farooq A, Ghani A, Gorelick F, Mehal WZ.
Gastroenterology 146(7):1763-74. doi: 10.1053/j.gastro.2014.03.014. Epub 2014 Mar 20. 2014
23DHX33, NLRP3, TRIM33
The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation.
Weng L, Mitoma H, Trichot C, Bao M, Liu Y, Zhang Z, Liu YJ.
J Immunol 193(7):3676-82. doi: 10.4049/jimmunol.1401448. Epub 2014 Aug 29. Erratum in: J Immunol. 2014 Nov 15;193(10):5351. Tricot, Coline 2014
24DHX33, NLRP3
The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome.
Mitoma H, Hanabuchi S, Kim T, Bao M, Zhang Z, Sugimoto N, Liu YJ.
Immunity 39(1):123-35. doi: 10.1016/j.immuni.2013.07.001. Epub 2013 Jul 18. 2013
25MFN2, NLRP3
Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infection.
Ichinohe T, Yamazaki T, Koshiba T, Yanagi Y.
Proc Natl Acad Sci U S A 110(44):17963-8. doi: 10.1073/pnas.1312571110. Epub 2013 Oct 14. 2013
26ATG7, CTSB, NLRP3
Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line.
Li S, Du L, Zhang L, Hu Y, Xia W, Wu J, Zhu J, Chen L, Zhu F, Li C, Yang S.
J Biol Chem 288(42):30094-104. doi: 10.1074/jbc.M113.494286. Epub 2013 Aug 28. 2013
27BRCC3, NLRP3
Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity.
Py BF, Kim MS, Vakifahmetoglu-Norberg H, Yuan J.
Mol Cell 49(2):331-8. doi: 10.1016/j.molcel.2012.11.009. Epub 2012 Dec 13. 2013
28NLRP3
Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging.
Youm YH, Grant RW, McCabe LR, Albarado DC, Nguyen KY, Ravussin A, Pistell P, Newman S, Carter R, Laque A, Münzberg H, Rosen CJ, Ingram DK, Salbaum JM, Dixit VD.
Cell Metab 18(4):519-32. doi: 10.1016/j.cmet.2013.09.010. 2013
29NLRP3, VEGFA
NLRP3 inflammasome blockade inhibits VEGF-A-induced age-related macular degeneration.
Marneros AG.
Cell Rep 4(5):945-58. doi: 10.1016/j.celrep.2013.08.002. Epub 2013 Sep 5. 2013
30NLRP3
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation.
Iyer SS, He Q, Janczy JR, Elliott EI, Zhong Z, Olivier AK, Sadler JJ, Knepper-Adrian V, Han R, Qiao L, Eisenbarth SC, Nauseef WM, Cassel SL, Sutterwala FS.
Immunity 39(2):311-23. doi: 10.1016/j.immuni.2013.08.001. Epub 2013 Aug 15. 2013
31NLRP3
Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death.
Lima H Jr, Jacobson LS, Goldberg MF, Chandran K, Diaz-Griffero F, Lisanti MP, Brojatsch J.
Cell Cycle 12(12):1868-78. doi: 10.4161/cc.24903. Epub 2013 May 20. 2013
32NLRP3
The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells.
Licandro G, Ling Khor H, Beretta O, Lai J, Derks H, Laudisi F, Conforti-Andreoni C, Liang Qian H, Teng GG, Ricciardi-Castagnoli P, Mortellaro A.
Eur J Immunol 43(8):2126-37. doi: 10.1002/eji.201242918. Epub 2013 May 24. 2013
33NLRP3
Reduced expression of NLRP3 and MEFV in human ischemic heart tissue.
Hermansson C, Lundqvist A, Wasslavik C, Palmqvist L, Jeppsson A, Hultén LM.
Biochem Biophys Res Commun 430(1):425-8. doi: 10.1016/j.bbrc.2012.11.070. Epub 2012 Dec 1. 2013
34CASP1, NLRP3
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT.
Nature 493(7434):674-8. doi: 10.1038/nature11729. Epub 2012 Dec 19. 2013
35MAVS, NLRP3
The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity.
Park S, Juliana C, Hong S, Datta P, Hwang I, Fernandes-Alnemri T, Yu JW, Alnemri ES.
J Immunol 191(8):4358-66. doi: 10.4049/jimmunol.1301170. Epub 2013 Sep 18. 2013
36GBP5, NLRP3
GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals.
Shenoy AR, Wellington DA, Kumar P, Kassa H, Booth CJ, Cresswell P, MacMicking JD.
Science 336(6080):481-5. doi: 10.1126/science.1217141. Epub 2012 Mar 29. 2012
37NLRP3
Cell volume regulation modulates NLRP3 inflammasome activation.
Compan V, Baroja-Mazo A, López-Castejón G, Gomez AI, Martínez CM, Angosto D, Montero MT, Herranz AS, Bazán E, Reimers D, Mulero V, Pelegrín P.
Immunity 37(3):487-500. doi: 10.1016/j.immuni.2012.06.013. Epub 2012 Sep 13. 2012
38NLRP3
Critical role for calcium mobilization in activation of the NLRP3 inflammasome.
Murakami T, Ockinger J, Yu J, Byles V, McColl A, Hofer AM, Horng T.
Proc Natl Acad Sci U S A 109(28):11282-7. doi: 10.1073/pnas.1117765109. Epub 2012 Jun 25. 2012
39NLRP3
NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis.
Inoue M, Williams KL, Gunn MD, Shinohara ML.
Proc Natl Acad Sci U S A 109(26):10480-5. doi: 10.1073/pnas.1201836109. Epub 2012 Jun 13. 2012
40EIF2AK2, HMGB1, NLRP3
Novel role of PKR in inflammasome activation and HMGB1 release.
Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ.
Nature 488(7413):670-4. doi: 10.1038/nature11290. 2012
41DICER1, MYD88, NLRP3
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núńez G, Baffi JZ, Kleinman ME, Ambati J.
Cell 149(4):847-59. doi: 10.1016/j.cell.2012.03.036. Epub 2012 Apr 26. 2012
42CASP1, CASR, NLRP3
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Lee GS, Subramanian N, Kim AI, Aksentijevich I, Goldbach-Mansky R, Sacks DB, Germain RN, Kastner DL, Chae JJ.
Nature 492(7427):123-7. doi: 10.1038/nature11588. Epub 2012 Nov 11. 2012
43NLRP3, PYCARD
Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.
Vajjhala PR, Mirams RE, Hill JM.
J Biol Chem 287(50):41732-43. doi: 10.1074/jbc.M112.381228. Epub 2012 Oct 12. 2012
44NLRP3
A role for mitochondria in NLRP3 inflammasome activation.
Zhou R, Yazdi AS, Menu P, Tschopp J.
Nature. 469(7329):221-5. 2011
45NLRP3
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance.
Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL, Ravussin E, Stephens JM, Dixit VD.
Nat Med 17(2):179-88. Epub 2011 Jan 9. 2011
46CASP1, NLRC4, NLRP3, PYCARD
Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity.
Motani K, Kushiyama H, Imamura R, Kinoshita T, Nishiuchi T, Suda T.
J Biol Chem 286(39):33963-72. Epub 2011 Aug 8. 2011
47NLRC4, NLRP1, NLRP3, NLRP6
NOD-like receptors and the innate immune system: coping with danger, damage and death.
Kersse K, Bertrand MJ, Lamkanfi M, Vandenabeele P.
Cytokine Growth Factor Rev 22(5-6):257-76. Epub 2011 Oct 12. 2011
48AIM2, CASP1, NLRP3, PYCARD
Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection.
Fang R, Tsuchiya K, Kawamura I, Shen Y, Hara H, Sakai S, Yamamoto T, Fernandes-Alnemri T, Yang R, Hernandez-Cuellar E, Dewamitta SR, Xu Y, Qu H, Alnemri ES, Mitsuyama M.
J Immunol 187(9):4890-9. Epub 2011 Sep 28. 2011
49NLRP3, TLR4
The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3.
Tannahill GM, O'Neill LA.
FEBS Lett 585(11):1568-72. Epub 2011 May 6. Review. 2011
50NLRP3
Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair.
Schlaweck S, Zimmer S, Struck R, Bartok E, Werner N, Bauernfeind F, Latz E, Nickenig G, Hornung V, Ghanem A.
Biochem Biophys Res Commun 411(3):627-31. Epub 2011 Jul 13. 2011
51NLRP3
NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy.
Jin C, Frayssinet P, Pelker R, Cwirka D, Hu B, Vignery A, Eisenbarth SC, Flavell RA.
Proc Natl Acad Sci U S A 108(36):14867-72. Epub 2011 Aug 19. 2011
52NLRP3
Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome.
Busillo JM, Azzam KM, Cidlowski JA.
J Biol Chem 286(44):38703-13. doi: 10.1074/jbc.M111.275370. Epub 2011 Sep 22. 2011
53NLRP3
The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency.
Pontillo A, Paoluzzi E, Crovella S.
Eur J Hum Genet 18(7):844-7. Epub 2010 Feb 24.PMID: 20179743 2010
54IL18, NLRP3
The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18.
Jha S, Srivastava SY, Brickey WJ, Iocca H, Toews A, Morrison JP, Chen VS, Gris D, Matsushima GK, Ting JP.
J Neurosci 30(47):15811-20. 2010
55NLRC4, NLRP3
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella.
Broz P, Newton K, Lamkanfi M, Mariathasan S, Dixit VM, Monack DM.
J Exp Med 207(8):1745-55. Epub 2010 Jul 5. 2010
56NLRC4, NLRP2, NLRP3, NLRP6
Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice.
Lech M, Avila-Ferrufino A, Skuginna V, Susanti HE, Anders HJ.
Int Immunol 22(9):717-28. Epub 2010 Jun 28. 2010
57NLRP3
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility.
Villani AC, Lemire M, Fortin G, Louis E, Silverberg MS, Collette C, Baba N, Libioulle C, Belaiche J, Bitton A, Gaudet D, Cohen A, Langelier D, Fortin PR, Wither JE, Sarfati M, Rutgeerts P, Rioux JD, Vermeire S, Hudson TJ, Franchimont D.
Nat Genet 41(1):71-6. Epub 2008 Dec 21. 2009
58NLRP1, NLRP10, NLRP11, NLRP12, NLRP13, NLRP14, NLRP2, NLRP3, NLRP4, NLRP5, NLRP6, NLRP7, NLRP8, NLRP9
Evolution and functional divergence of NLRP genes in mammalian reproductive systems.
Tian X, Pascal G, Monget P.
BMC Evol Biol 9:202. 2009
59NLRP3
Evaluation of Nod-like receptor (NLR) effector domain interactions.
Wagner RN, Proell M, Kufer TA, Schwarzenbacher R.
PLoS One. 4(4):e4931. 2009
60NLRP3
A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.
Meng G, Zhang F, Fuss I, Kitani A, Strober W.
Immunity. 30(6):860-74. 2009
61NLRP3
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1.
Thomas PG, Dash P, Aldridge JR Jr, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD.
Immunity. 30(4):566-75. 2009
62NLRP3
Autoinflammatory genes and susceptibility to psoriatic juvenile idiopathic arthritis.
Day TG, Ramanan AV, Hinks A, Lamb R, Packham J, Wise C, Punaro M, Donn RP.
Arthritis Rheum 58(7):2142-6. 2008
63NLRP3
Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response.
Kummer JA, Broekhuizen R, Everett H, Agostini L, Kuijk L, Martinon F, van Bruggen R, Tschopp J.
J Histochem Cytochem. 55(5):443-52. 2007
64NLRP3, CINCA
Neonatal-onset multisystem inflammatory disease (NOMID) due to a novel S331R mutation of the CIAS1 gene and response to interleukin-1 receptor antagonist treatment.
Boschan C, Witt O, Lohse P, Foeldvari I, Zappel H, Schweigerer L.
Am J Med Genet A 140(8):883-6. 2006
65NLRP3, NME8, RHOB
Cis- and trans-acting gene regulation is associated with osteoarthritis.
Mahr S, Burmester GR, Hilke D, Gobel U, Grutzkau A, Haupl T, Hauschild M, Koczan D, Krenn V, Neidel J, Perka C, Radbruch A, Thiesen HJ, Muller B.
Am J Hum Genet 78(5):793-803. Epub 2006 Mar 22. 2006
66MBS2, MBS3, NLRP3
An intronic variable number of tandem repeat polymorphisms of the cold-induced autoinflammatory syndrome 1 (CIAS1) gene modifies gene expression and is associated with essential hypertension.
Omi T, Kumada M, Kamesaki T, Okuda H, Munkhtulga L, Yanagisawa Y, Utsumi N, Gotoh T, Hata A, Soma M, Umemura S, Ogihara T, Takahashi N, Tabara Y, Shimada K, Mano H, Kajii E, Miki T, Iwamoto S.
Eur J Hum Genet 14(12):1295-305. Epub 2006 Jul 26. 2006
67NLRP3
Phenotype, genotype, and sustained response to anakinra in 22 patients with autoinflammatory disease associated with CIAS-1/NALP3 mutations.
Leslie KS, Lachmann HJ, Bruning E, McGrath JA, Bybee A, Gallimore JR, Roberts PF, Woo P, Grattan CE, Hawkins PN.
Arch Dermatol 142(12):1591-7. 2006
68CINCA, NLRP3, MWS
Intrafamilial variable phenotypic expression of a CIAS1 mutation: from Muckle-Wells to chronic infantile neurological cutaneous and articular syndrome.
Hentgen V, Despert V, Lepretre AC, Cuisset L, Chevrant-Breton J, Jego P, Chales G, Gall EL, Delpech M, Grateau G.
J Rheumatol 32(4):747-51. 2005
69NLRP12, NLRP2, NLRP3, NLRP6, NLRP7
PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.
Kinoshita T, Wang Y, Hasegawa M, Imamura R, Suda T.
J Biol Chem 280(23):21720-5. Epub 2005 Apr 6. 2005
70NLRP3, CINCA, MWS, FCU
Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU.
Neven B, Callebaut I, Prieur AM, Feldmann J, Bodemer C, Lepore L, Derfalvi B, Benjaponpitak S, Vesely R, Sauvain MJ, Oertle S, Allen R, Morgan G, Borkhardt A, Hill C, Gardner-Medwin J, Fischer A, de Saint Basile G.
Blood 103(7):2809-15. Epub 2003 Nov 20. 2004
71NLRP3
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J.
Immunity. 20(3):319-25. 2004
72NLRP3, FCU
Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P
Hoffman HM, Gregory SG, Mueller JL, Tresierras M, Broide DH, Wanderer AA, Kolodner RD.
Hum Genet 112(2):209-16. 2003
73FMF, MEFV, NLRC5, NLRP11, NLRP3, PYCARD
Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product.
Dowds TA, Masumoto J, Chen FF, Ogura Y, Inohara N, Nunez G.
Biochem Biophys Res Commun 302(3):575-80. 2003
74NOD2, NLRP3
Structural localization of disease-associated sequence variations in the NACHT and LRR domains of PYPAF1 and NOD2.
Albrecht M, Domingues FS, Schreiber S, Lengauer T.
FEBS Lett 554(3):520-8. 2003
75NLRP1, NLRP10, NLRP11, NLRP12, NLRP13, NLRP14, NLRP2, NLRP3, NLRP4, NLRP5, NLRP6, NLRP7, NLRP8, NLRP9
NALPs: a novel protein family involved in inflammation.
Tschopp J, Martinon F, Burns K.
Nat Rev Mol Cell Biol 4(2):95-104. Review. 2003
76NLRP3
Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties.
O'Connor W Jr, Harton JA, Zhu X, Linhoff MW, Ting JP.
J Immunol. 171(12):6329-33. 2003
77NLRP3, FCU, MWS
New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes.
Dode C, Le Du N, Cuisset L, Letourneur F, Berthelot JM, Vaudour G, Meyrier A, Watts RA, Scott DG, Nicholls A, Granel B, Frances C, Garcier F, Edery P, Boulinguez S, Domergues JP, Delpech M, Grateau G.
Am J Hum Genet 70(6):1498-506. 2002
78NLRP3, CINCA
Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes.
Feldmann J, Prieur AM, Quartier P, Berquin P, Cortis E, Teillac-Hamel D, Fischer A.
Am J Hum Genet 71(1):198-203. 2002
79NLRP2, NLRP11, NLRP4, NLRP6, NLRP3
Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.
Grenier JM, Wang L, Manji GA, Huang WJ, Al-Garawi A, Kelly R, Carlson A, Merriam S, Lora JM, Briskin M, DiStefano PS, Bertin J.
FEBS Lett 530(1-3):73-8. 2002
80PYDC1, NLRP3
PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B.
Manji GA, Wang L, Geddes BJ, Brown M, Merriam S, Al-Garawi A, Mak S, Lora JM, Briskin M, Jurman M, Cao J, DiStefano PS, Bertin J.
J Biol Chem 277(13):11570-5. Epub 2002 Jan 10. 2002
81NLRP3, FCU, MWS
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome.
Hoffman HM, Mueller JL, Broide DH, Wanderer AA, Kolodner RD.
Nat Genet 29(3):301-5. 2001
82NLRP3, FCU
Identification of a locus on chromosome 1q44 for familial cold urticaria.
Hoffman HM, Wright FA, Broide DH, Wanderer AA, Kolodner RD.
Am J Hum Genet 66(5):1693-8. 2000