Citations for
1IL1B, NLRC4, NLRP12
Epigenetic hypomethylation and upregulation of NLRC4 and NLRP12 in Kawasaki disease.
Huang YH, Lo MH, Cai XY, Kuo HC.
Oncotarget 9(27):18939-18948. doi: 10.18632/oncotarget.24851. eCollection 2018 Apr 10. 2018
2NLRC4, NLRP1, NLRP3
Novel aspects of the assembly and activation of inflammasomes with focus on the NLRC4 inflammasome.
Fusco WG, Duncan JA.
Int Immunol 30(5):183-193. doi: 10.1093/intimm/dxy009. 2018
3IRF8, NAIP, NLRC4
IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.
Karki R, Lee E, Place D, Samir P, Mavuluri J, Sharma BR, Balakrishnan A, Malireddi RKS, Geiger R, Zhu Q, Neale G, Kanneganti TD.
Cell 173(4):920-933.e13. doi: 10.1016/j.cell.2018.02.055. Epub 2018 Mar 22. 2018
4NLRC4
ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages.
Lee BL, Mirrashidi KM, Stowe IB, Kummerfeld SK, Watanabe C, Haley B, Cuellar TL, Reichelt M, Kayagaki N.
Sci Rep 8(1):3788. doi: 10.1038/s41598-018-21998-3. 2018
5NLRC4, NLRP3
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
Freeman L, Guo H, David CN, Brickey WJ, Jha S, Ting JP.
J Exp Med 214(5):1351-1370. doi: 10.1084/jem.20150237. Epub 2017 Apr 12. 2017
6NLRC4, PSMC5
A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death.
Raghawan AK, Sripada A, Gopinath G, Pushpanjali P, Kumar Y, Radha V, Swarup G.
J Biol Chem 292(4):1218-1230. doi: 10.1074/jbc.M116.763979. Epub 2016 Dec 14. 2017
7IL1B, NLRC4
Involvement of the NLRC4-Inflammasome in Diabetic Nephropathy.
Yuan F, Kolb R, Pandey G, Li W, Sun L, Liu F, Sutterwala FS, Liu Y, Zhang W.
PLoS One 11(10):e0164135. doi: 10.1371/journal.pone.0164135. eCollection 2016. 2016
8NLRC4, TLR5
Activation of NLRC4 downregulates TLR5-mediated antibody immune responses against flagellin.
Li W, Yang J, Zhang E, Zhong M, Xiao Y, Yu J, Zhou D, Cao Y, Yang Y, Li Y, Yan H.
Cell Mol Immunol 13(4):514-23. doi: 10.1038/cmi.2015.33. Epub 2015 Apr 27. 2016
9NLRC4
Structural and biochemical basis for induced self-propagation of NLRC4.
Hu Z, Zhou Q, Zhang C, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF, Chai J.
Science 350(6259):399-404. doi: 10.1126/science.aac5489. Epub 2015 Oct 8. 2015
10AIM2, NLRC4
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.
Denes A, Coutts G, Lénárt N, Cruickshank SM, Pelegrin P, Skinner J, Rothwell N, Allan SM, Brough D.
Proc Natl Acad Sci U S A 112(13):4050-5. doi: 10.1073/pnas.1419090112. Epub 2015 Mar 16. 2015
11ARRB1, NLRC4, NLRP3
β-arrestin1 is critical for the full activation of NLRP3 and NLRC4 inflammasomes.
Mao K, Chen S, Wang Y, Zeng Y, Ma Y, Hu Y, Zhang H, Sun S, Wu X, Meng G, Pei G, Sun B.
J Immunol 194(4):1867-73. doi: 10.4049/jimmunol.1401989. Epub 2015 Jan 12. 2015
12FCAS4, NLRC4
An inherited mutation in NLRC4 causes autoinflammation in human and mice.
Kitamura A, Sasaki Y, Abe T, Kano H, Yasutomo K.
J Exp Med 211(12):2385-96. doi: 10.1084/jem.20141091. Epub 2014 Nov 10. 2014
13AIFEC, NLRC4
An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.
Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O'Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R.
Nat Genet 46(10):1140-6. doi: 10.1038/ng.3089. Epub 2014 Sep 14. 2014
14AIFEC, NLRC4
Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation.
Romberg N, Al Moussawi K, Nelson-Williams C, Stiegler AL, Loring E, Choi M, Overton J, Meffre E, Khokha MK, Huttner AJ, West B, Podoltsev NA, Boggon TJ, Kazmierczak BI, Lifton RP.
Nat Genet 46(10):1135-1139. doi: 10.1038/ng.3066. Epub 2014 Sep 14. 2014
15NLRC4
NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen.
Nordlander S, Pott J, Maloy KJ.
Mucosal Immunol 7(4):775-85. doi: 10.1038/mi.2013.95. Epub 2013 Nov 27. 2014
16NLRC4
Crystal structure of NLRC4 reveals its autoinhibition mechanism.
Hu Z, Yan C, Liu P, Huang Z, Ma R, Zhang C, Wang R, Zhang Y, Martinon F, Miao D, Deng H, Wang J, Chang J, Chai J.
Science 341(6142):172-5. doi: 10.1126/science.1236381. Epub 2013 Jun 13. 2013
17NLRC4
Phosphorylation of NLRC4 is critical for inflammasome activation.
Qu Y, Misaghi S, Izrael-Tomasevic A, Newton K, Gilmour LL, Lamkanfi M, Louie S, Kayagaki N, Liu J, Kömüves L, Cupp JE, Arnott D, Monack D, Dixit VM.
Nature 490(7421):539-42. doi: 10.1038/nature11429. Epub 2012 Aug 12. 2012
18NLRC4
Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges.
Carvalho FA, Nalbantoglu I, Aitken JD, Uchiyama R, Su Y, Doho GH, Vijay-Kumar M, Gewirtz AT.
Mucosal Immunol 5(3):288-98. doi: 10.1038/mi.2012.8. Epub 2012 Feb 8. 2012
19CASP1, NLRC4, NLRP3, PYCARD
Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity.
Motani K, Kushiyama H, Imamura R, Kinoshita T, Nishiuchi T, Suda T.
J Biol Chem 286(39):33963-72. Epub 2011 Aug 8. 2011
20NLRC4, PYCARD
Asc modulates the function of NLRC4 in response to infection of macrophages by Legionella pneumophila.
Case CL, Roy CR.
MBio 2(4). pii: e00117-11. doi: 10.1128/mBio.00117-11. Print 2011. 2011
21NAIP, NLRC4
Differential requirements for NAIP5 in activation of the NLRC4 inflammasome.
Lightfield KL, Persson J, Trinidad NJ, Brubaker SW, Kofoed EM, Sauer JD, Dunipace EA, Warren SE, Miao EA, Vance RE.
Infect Immun 79(4):1606-14. Epub 2011 Jan 31. 2011
22NLRC4, NLRP1, NLRP3, NLRP6
NOD-like receptors and the innate immune system: coping with danger, damage and death.
Kersse K, Bertrand MJ, Lamkanfi M, Vandenabeele P.
Cytokine Growth Factor Rev 22(5-6):257-76. Epub 2011 Oct 12. 2011
23NAIP, NLRC4
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.
Zhao Y, Yang J, Shi J, Gong YN, Lu Q, Xu H, Liu L, Shao F.
Nature 477(7366):596-600. doi: 10.1038/nature10510. 2011
24NLRC4, NLRP3
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella.
Broz P, Newton K, Lamkanfi M, Mariathasan S, Dixit VM, Monack DM.
J Exp Med 207(8):1745-55. Epub 2010 Jul 5. 2010
25NLRC4
Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome.
Miao EA, Warren SE.
J Clin Immunol 30(4):502-6. Epub 2010 Mar 27. 2010
26NAIP, NLRC4, TLR5
A novel pathway for inducible nitric-oxide synthase activation through inflammasomes.
Buzzo CL, Campopiano JC, Massis LM, Lage SL, Cassado AA, Leme-Souza R, Cunha LD, Russo M, Zamboni DS, Amarante-Mendes GP, Bortoluci KR.
J Biol Chem 285(42):32087-95. Epub 2010 Aug 11. 2010
27NLRC4, TLR5
TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin.
Vijay-Kumar M, Carvalho FA, Aitken JD, Fifadara NH, Gewirtz AT.
Eur J Immunol 40(12):3528-34. 2010
28NLRC4
Nlrc4/Ipaf/CLAN/CARD12: more than a flagellin sensor.
Abdelaziz DH, Amr K, Amer AO.
Int J Biochem Cell Biol 42(6):789-91. Epub 2010 Jan 11. Review. 2010
29NLRC4, NLRP2, NLRP3, NLRP6
Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice.
Lech M, Avila-Ferrufino A, Skuginna V, Susanti HE, Anders HJ.
Int Immunol 22(9):717-28. Epub 2010 Jun 28. 2010
30NLRC4, PSMC5
Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.
Kumar Y, Radha V, Swarup G.
Biochem J 427(1):91-104. doi: 10.1042/BJ20091349. 2010
31NLRC4
Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila.
Case CL, Shin S, Roy CR.
Infect Immun 77(5):1981-91. Epub 2009 Feb 23. 2009
32NLRC4
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages.
Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozören N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, Núñez G.
Nat Immunol 7(6):576-82. Epub 2006 Apr 30. 2006
33NLRC4
Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis.
Thalappilly S, Sadasivam S, Radha V, Swarup G.
FEBS J 273(12):2766-78. 2006
34NLRC4
Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation.
Lu C, Wang A, Wang L, Dorsch M, Ocain TD, Xu Y.
Biochem Biophys Res Commun 331(4):1114-9. 2005
35NLRC4, PYCARD
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.
Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM.
Nature 430(6996):213-8. Epub 2004 Jun 9. 2004
36NLRC4
CLAN, a novel human CED-4-like gene.
Damiano JS, Stehlik C, Pio F, Godzik A, Reed JC.
Genomics 75(1-3):77-83. 2001
37NLRC4
Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis.
Geddes BJ, Wang L, Huang WJ, Lavellee M, Manji GA, Brown M, Jurman M, Cao J, Morgenstern J, Merriam S, Glucksmann MA, DiStefano PS, Bertin J.
Biochem Biophys Res Commun 284(1):77-82. 2001
38NLRC4
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.
Poyet JL, Srinivasula SM, Tnani M, Razmara M, Fernandes-Alnemri T, Alnemri ES.
J Biol Chem 276(30):28309-13. 2001
39BCL10, CARD10, CARD11, NLRC4, CARD14, NOD1, NOD2, CARD9, RIPK2
Caspase recruitment domain (CARD)-dependent cytoplasmic filaments mediate bcl10-induced NF-kappaB activation.
Guiet C, Vito P.
J Cell Biol 148(6):1131-40. 2000