1 | IL1B, NLRC4, NLRP12
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| Epigenetic hypomethylation and upregulation of NLRC4 and NLRP12 in Kawasaki disease.
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| Huang YH, Lo MH, Cai XY, Kuo HC.
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| Oncotarget 9(27):18939-18948. doi: 10.18632/oncotarget.24851. eCollection 2018 Apr 10.
2018
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2 | NLRC4, NLRP1, NLRP3
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| Novel aspects of the assembly and activation of inflammasomes with focus on the NLRC4 inflammasome.
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| Fusco WG, Duncan JA.
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| Int Immunol 30(5):183-193. doi: 10.1093/intimm/dxy009.
2018
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3 | IRF8, NAIP, NLRC4
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| IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.
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| Karki R, Lee E, Place D, Samir P, Mavuluri J, Sharma BR, Balakrishnan A, Malireddi RKS, Geiger R, Zhu Q, Neale G, Kanneganti TD.
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| Cell 173(4):920-933.e13. doi: 10.1016/j.cell.2018.02.055. Epub 2018 Mar 22. 2018
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4 | NLRC4
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| ASC- and caspase-8-dependent apoptotic pathway diverges from the NLRC4 inflammasome in macrophages.
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| Lee BL, Mirrashidi KM, Stowe IB, Kummerfeld SK, Watanabe C, Haley B, Cuellar TL, Reichelt M, Kayagaki N.
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| Sci Rep 8(1):3788. doi: 10.1038/s41598-018-21998-3.
2018
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5 | NLRC4, NLRP3
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| NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes.
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| Freeman L, Guo H, David CN, Brickey WJ, Jha S, Ting JP.
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| J Exp Med 214(5):1351-1370. doi: 10.1084/jem.20150237. Epub 2017 Apr 12.
2017
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6 | NLRC4, PSMC5
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| A Disease-associated Mutant of NLRC4 Shows Enhanced Interaction with SUG1 Leading to Constitutive FADD-dependent Caspase-8 Activation and Cell Death.
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| Raghawan AK, Sripada A, Gopinath G, Pushpanjali P, Kumar Y, Radha V, Swarup G.
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| J Biol Chem 292(4):1218-1230. doi: 10.1074/jbc.M116.763979. Epub 2016 Dec 14.
2017
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7 | IL1B, NLRC4
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| Involvement of the NLRC4-Inflammasome in Diabetic Nephropathy.
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| Yuan F, Kolb R, Pandey G, Li W, Sun L, Liu F, Sutterwala FS, Liu Y, Zhang W.
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| PLoS One 11(10):e0164135. doi: 10.1371/journal.pone.0164135. eCollection 2016.
2016
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8 | NLRC4, TLR5
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| Activation of NLRC4 downregulates TLR5-mediated antibody immune responses against flagellin.
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| Li W, Yang J, Zhang E, Zhong M, Xiao Y, Yu J, Zhou D, Cao Y, Yang Y, Li Y, Yan H.
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| Cell Mol Immunol 13(4):514-23. doi: 10.1038/cmi.2015.33. Epub 2015 Apr 27.
2016
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9 | NLRC4
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| Structural and biochemical basis for induced self-propagation of NLRC4.
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| Hu Z, Zhou Q, Zhang C, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF, Chai J.
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| Science 350(6259):399-404. doi: 10.1126/science.aac5489. Epub 2015 Oct 8.
2015
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10 | AIM2, NLRC4
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| AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.
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| Denes A, Coutts G, Lénárt N, Cruickshank SM, Pelegrin P, Skinner J, Rothwell N, Allan SM, Brough D.
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| Proc Natl Acad Sci U S A 112(13):4050-5. doi: 10.1073/pnas.1419090112. Epub 2015 Mar 16.
2015
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11 | ARRB1, NLRC4, NLRP3
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| β-arrestin1 is critical for the full activation of NLRP3 and NLRC4 inflammasomes.
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| Mao K, Chen S, Wang Y, Zeng Y, Ma Y, Hu Y, Zhang H, Sun S, Wu X, Meng G, Pei G, Sun B.
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| J Immunol 194(4):1867-73. doi: 10.4049/jimmunol.1401989. Epub 2015 Jan 12.
2015
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12 | FCAS4, NLRC4
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| An inherited mutation in NLRC4 causes autoinflammation in human and mice.
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| Kitamura A, Sasaki Y, Abe T, Kano H, Yasutomo K.
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| J Exp Med 211(12):2385-96. doi: 10.1084/jem.20141091. Epub 2014 Nov 10.
2014
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13 | AIFEC, NLRC4
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| An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.
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| Canna SW, de Jesus AA, Gouni S, Brooks SR, Marrero B, Liu Y, DiMattia MA, Zaal KJ, Sanchez GA, Kim H, Chapelle D, Plass N, Huang Y, Villarino AV, Biancotto A, Fleisher TA, Duncan JA, O'Shea JJ, Benseler S, Grom A, Deng Z, Laxer RM, Goldbach-Mansky R.
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| Nat Genet 46(10):1140-6. doi: 10.1038/ng.3089. Epub 2014 Sep 14.
2014
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14 | AIFEC, NLRC4
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| Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation.
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| Romberg N, Al Moussawi K, Nelson-Williams C, Stiegler AL, Loring E, Choi M, Overton J, Meffre E, Khokha MK, Huttner AJ, West B, Podoltsev NA, Boggon TJ, Kazmierczak BI, Lifton RP.
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| Nat Genet 46(10):1135-1139. doi: 10.1038/ng.3066. Epub 2014 Sep 14.
2014
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15 | NLRC4
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| NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen.
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| Nordlander S, Pott J, Maloy KJ.
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| Mucosal Immunol 7(4):775-85. doi: 10.1038/mi.2013.95. Epub 2013 Nov 27.
2014
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16 | NLRC4
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| Crystal structure of NLRC4 reveals its autoinhibition mechanism.
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| Hu Z, Yan C, Liu P, Huang Z, Ma R, Zhang C, Wang R, Zhang Y, Martinon F, Miao D, Deng H, Wang J, Chang J, Chai J.
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| Science 341(6142):172-5. doi: 10.1126/science.1236381. Epub 2013 Jun 13.
2013
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17 | NLRC4
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| Phosphorylation of NLRC4 is critical for inflammasome activation.
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| Qu Y, Misaghi S, Izrael-Tomasevic A, Newton K, Gilmour LL, Lamkanfi M, Louie S, Kayagaki N, Liu J, Kömüves L, Cupp JE, Arnott D, Monack D, Dixit VM.
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| Nature 490(7421):539-42. doi: 10.1038/nature11429. Epub 2012 Aug 12.
2012
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18 | NLRC4
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| Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges.
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| Carvalho FA, Nalbantoglu I, Aitken JD, Uchiyama R, Su Y, Doho GH, Vijay-Kumar M, Gewirtz AT.
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| Mucosal Immunol 5(3):288-98. doi: 10.1038/mi.2012.8. Epub 2012 Feb 8.
2012
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19 | CASP1, NLRC4, NLRP3, PYCARD
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| Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity.
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| Motani K, Kushiyama H, Imamura R, Kinoshita T, Nishiuchi T, Suda T.
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| J Biol Chem 286(39):33963-72. Epub 2011 Aug 8. 2011
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20 | NLRC4, PYCARD
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| Asc modulates the function of NLRC4 in response to infection of macrophages by Legionella pneumophila.
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| Case CL, Roy CR.
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| MBio 2(4). pii: e00117-11. doi: 10.1128/mBio.00117-11. Print 2011.
2011
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21 | NAIP, NLRC4
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| Differential requirements for NAIP5 in activation of the NLRC4 inflammasome.
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| Lightfield KL, Persson J, Trinidad NJ, Brubaker SW, Kofoed EM, Sauer JD, Dunipace EA, Warren SE, Miao EA, Vance RE.
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| Infect Immun 79(4):1606-14. Epub 2011 Jan 31.
2011
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22 | NLRC4, NLRP1, NLRP3, NLRP6
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| NOD-like receptors and the innate immune system: coping with danger, damage and death.
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| Kersse K, Bertrand MJ, Lamkanfi M, Vandenabeele P.
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| Cytokine Growth Factor Rev 22(5-6):257-76. Epub 2011 Oct 12.
2011
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23 | NAIP, NLRC4
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| The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.
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| Zhao Y, Yang J, Shi J, Gong YN, Lu Q, Xu H, Liu L, Shao F.
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| Nature 477(7366):596-600. doi: 10.1038/nature10510.
2011
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24 | NLRC4, NLRP3
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| Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella.
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| Broz P, Newton K, Lamkanfi M, Mariathasan S, Dixit VM, Monack DM.
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| J Exp Med 207(8):1745-55. Epub 2010 Jul 5.
2010
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25 | NLRC4
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| Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome.
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| Miao EA, Warren SE.
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| J Clin Immunol 30(4):502-6. Epub 2010 Mar 27.
2010
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26 | NAIP, NLRC4, TLR5
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| A novel pathway for inducible nitric-oxide synthase activation through inflammasomes.
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| Buzzo CL, Campopiano JC, Massis LM, Lage SL, Cassado AA, Leme-Souza R, Cunha LD, Russo M, Zamboni DS, Amarante-Mendes GP, Bortoluci KR.
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| J Biol Chem 285(42):32087-95. Epub 2010 Aug 11. 2010
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27 | NLRC4, TLR5
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| TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin.
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| Vijay-Kumar M, Carvalho FA, Aitken JD, Fifadara NH, Gewirtz AT.
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| Eur J Immunol 40(12):3528-34.
2010
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28 | NLRC4
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| Nlrc4/Ipaf/CLAN/CARD12: more than a flagellin sensor.
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| Abdelaziz DH, Amr K, Amer AO.
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| Int J Biochem Cell Biol 42(6):789-91. Epub 2010 Jan 11. Review.
2010
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29 | NLRC4, NLRP2, NLRP3, NLRP6
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| Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice.
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| Lech M, Avila-Ferrufino A, Skuginna V, Susanti HE, Anders HJ.
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| Int Immunol 22(9):717-28. Epub 2010 Jun 28.
2010
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30 | NLRC4, PSMC5
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| Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death.
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| Kumar Y, Radha V, Swarup G.
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| Biochem J 427(1):91-104. doi: 10.1042/BJ20091349.
2010
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31 | NLRC4
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| Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila.
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| Case CL, Shin S, Roy CR.
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| Infect Immun 77(5):1981-91. Epub 2009 Feb 23.
2009
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32 | NLRC4
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| Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages.
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| Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozören N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, Núñez G.
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| Nat Immunol 7(6):576-82. Epub 2006 Apr 30.
2006
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33 | NLRC4
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| Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis.
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| Thalappilly S, Sadasivam S, Radha V, Swarup G.
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| FEBS J 273(12):2766-78.
2006
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34 | NLRC4
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| Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation.
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| Lu C, Wang A, Wang L, Dorsch M, Ocain TD, Xu Y.
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| Biochem Biophys Res Commun 331(4):1114-9. 2005
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35 | NLRC4, PYCARD
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| Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.
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| Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM.
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| Nature 430(6996):213-8. Epub 2004 Jun 9.
2004
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36 | NLRC4
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| CLAN, a novel human CED-4-like gene.
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| Damiano JS, Stehlik C, Pio F, Godzik A, Reed JC.
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| Genomics 75(1-3):77-83. 2001
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37 | NLRC4
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| Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis.
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| Geddes BJ, Wang L, Huang WJ, Lavellee M, Manji GA, Brown M, Jurman M, Cao J, Morgenstern J, Merriam S, Glucksmann MA, DiStefano PS, Bertin J.
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| Biochem Biophys Res Commun 284(1):77-82. 2001
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38 | NLRC4
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| Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.
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| Poyet JL, Srinivasula SM, Tnani M, Razmara M, Fernandes-Alnemri T, Alnemri ES.
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| J Biol Chem 276(30):28309-13. 2001
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39 | BCL10, CARD10, CARD11, NLRC4, CARD14, NOD1, NOD2, CARD9, RIPK2
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| Caspase recruitment domain (CARD)-dependent cytoplasmic filaments mediate bcl10-induced NF-kappaB activation.
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| Guiet C, Vito P.
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| J Cell Biol 148(6):1131-40. 2000
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