1 | NKX3-2, SOX9
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| Interplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells.
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| Cairns DM, Liu R, Sen M, Canner JP, Schindeler A, Little DG, Zeng L.
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| PLoS One 7(7):e39642. doi: 10.1371/journal.pone.0039642. Epub 2012 Jul 2.
2012
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2 | NKX3-2
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| Nkx3.2 promotes primary chondrogenic differentiation by upregulating Col2a1 transcription.
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| Kawato Y, Hirao M, Ebina K, Shi K, Hashimoto J, Honjo Y, Yoshikawa H, Myoui A.
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| PLoS One 7(4):e34703. doi: 10.1371/journal.pone.0034703. Epub 2012 Apr 12.
2012
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3 | NKX3-2
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| Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.
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| Choi SW, Jeong DU, Kim JA, Lee B, Joeng KS, Long F, Kim DW.
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| Biochem J 443(3):789-98. doi: 10.1042/BJ20112062.
2012
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4 | IHH, NKX3-2
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| Indian Hedgehog signalling triggers Nkx3.2 protein degradation during chondrocyte maturation.
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| Choi SW, Jeong DU, Kim JA, Lee B, Joeng KS, Long F, Kim DW.
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| Biochem J 443(3):789-98. doi: 10.1042/BJ20112062.
2012
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5 | NKX3-2, RUNX2
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| Nkx3.2-induced suppression of Runx2 is a crucial mediator of hypoxia-dependent maintenance of chondrocyte phenotypes.
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| Kawato Y, Hirao M, Ebina K, Tamai N, Shi K, Hashimoto J, Yoshikawa H, Myoui A.
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| Biochem Biophys Res Commun 416(1-2):205-10. doi: 10.1016/j.bbrc.2011.11.026. Epub 2011 Nov 10.
2011
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6 | IKBKG, NKX3-2
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| Exogenous signal-independent nuclear IkappaB kinase activation triggered by Nkx3.2 enables constitutive nuclear degradation of IkappaB-alpha in chondrocytes.
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| Yong Y, Choi SW, Choi HJ, Nam HW, Kim JA, Jeong DU, Kim DY, Kim YS, Kim DW.
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| Mol Cell Biol 31(14):2802-16. doi: 10.1128/MCB.00253-10. Epub 2011 May 23.
2011
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7 | NKX3-2, SMMD
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| Homozygous inactivating mutations in the NKX3-2 gene result in spondylo-megaepiphyseal-metaphyseal dysplasia.
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| Hellemans J, Simon M, Dheedene A, Alanay Y, Mihci E, Rifai L, Sefiani A, van Bever Y, Meradji M, Superti-Furga A, Mortier G.
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| Am J Hum Genet 85(6):916-22.PMID: 20004766 2009
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8 | NKX3-2
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| Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes.
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| Yamashita S, Andoh M, Ueno-Kudoh H, Sato T, Miyaki S, Asahara H.
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| Exp Cell Res 315(13):2231-40. doi: 10.1016/j.yexcr.2009.03.008. Epub 2009 Mar 21.
2009
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9 | NKX3-2, RELA
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| Constitutive RelA activation mediated by Nkx3.2 controls chondrocyte viability.
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| Park M, Yong Y, Choi SW, Kim JH, Lee JE, Kim DW.
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| Nat Cell Biol 9(3):287-98. Epub 2007 Feb 18.PMID: 17310243 2007
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10 | NKX3-2
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| Histone acetylation dependent allelic expression imbalance of BAPX1 in patients with the oculo-auriculo-vertebral spectrum.
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| Fischer S, Ludecke HJ, Wieczorek D, Bohringer S, Gillessen-Kaesbach G, Horsthemke B.
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| Hum Mol Genet 15(4):581-7. Epub 2006 Jan 11. 2006
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11 | MEOX1, NKX3-2
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| Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter.
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| Rodrigo I, Bovolenta P, Mankoo BS, Imai K.
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| Mol Cell Biol 24(7):2757-66.
2004
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12 | NKX3-2
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| The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen.
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| Tribioli C, Lufkin T.
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| Development 126(24):5699-711. 1999
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13 | NKX3-2
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| Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia.
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| Yoshiura KI, Murray JC.
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| Genomics 45(2):425-8. 1997
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14 | NKX3-2
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| Molecular cloning, chromosomal mapping and developmental expression of BAPX1, a novel human homeobox-containing gene homologous to Drosophila bagpipe.
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| Tribioli C, Lufkin T.
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| Gene 203(2):225-33. 1997
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15 | NKX3-2
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| Bapx1: an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton.
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| Tribioli C, Frasch M, Lufkin T.
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| Mech Dev 65(1-2):145-62. 1997
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