| 1 | GHRL, NKX2-2
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| Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-κB and Nkx2.2.
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| Shiimura Y, Ohgusu H, Sato T, Kojima M.
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| Int J Endocrinol 2015:580908. doi: 10.1155/2015/580908. Epub 2015 Jan 28.
2015
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| 2 | NKX2-2, PDGFRA
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| Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS.
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| Zhu Q, Zhao X, Zheng K, Li H, Huang H, Zhang Z, Mastracci T, Wegner M, Chen Y, Sussel L, Qiu M.
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| Development 141(3):548-55. doi: 10.1242/dev.095323.
2014
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| 3 | MNX1, NKX2-2
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| Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man.
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| Flanagan SE, De Franco E, Lango Allen H, Zerah M, Abdul-Rasoul MM, Edge JA, Stewart H, Alamiri E, Hussain K, Wallis S, de Vries L, Rubio-Cabezas O, Houghton JA, Edghill EL, Patch AM, Ellard S, Hattersley AT.
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| Cell Metab 19(1):146-54. doi: 10.1016/j.cmet.2013.11.021.
2014
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| 4 | NEUROD1, NKX2-2
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| Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas.
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| Mastracci TL, Anderson KR, Papizan JB, Sussel L.
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| PLoS Genet 9(2):e1003278. doi: 10.1371/journal.pgen.1003278. Epub 2013 Feb 7.
2013
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| 5 | NKX2-2
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| NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma.
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| Yoshida A, Sekine S, Tsuta K, Fukayama M, Furuta K, Tsuda H.
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| Am J Surg Pathol 36(7):993-9. doi: 10.1097/PAS.0b013e31824ee43c.
2012
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| 6 | NKX2-2, TM4SF4
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| The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.
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| Anderson KR, Singer RA, Balderes DA, Hernandez-Lagunas L, Johnson CW, Artinger KB, Sussel L.
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| Development 138(15):3213-24.
2011
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| 7 | NKX2-2
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| Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming.
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| Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L.
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| Genes Dev 25(21):2291-305. doi: 10.1101/gad.173039.111.
2011
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| 8 | ARX, NKX2-2
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| Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression.
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| Mastracci TL, Wilcox CL, Arnes L, Panea C, Golden JA, May CL, Sussel L.
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| Dev Biol 359(1):1-11. doi: 10.1016/j.ydbio.2011.08.001. Epub 2011 Aug 11.
2011
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| 9 | NKX2-2, SIRT2
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| Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation.
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| Ji S, Doucette JR, Nazarali AJ.
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| J Mol Cell Biol 3(6):351-9. doi: 10.1093/jmcb/mjr009. Epub 2011 Jun 13.
2011
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| 10 | GHRL, NKX2-2
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| Nkx2.2 activates the ghrelin promoter in pancreatic islet cells.
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| Hill JT, Chao CS, Anderson KR, Kaufman F, Johnson CW, Sussel L.
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| Mol Endocrinol 24(2):381-90. doi: 10.1210/me.2009-0360. Epub 2009 Dec 4.
2010
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| 11 | NKX2-2, NKX6-2
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| Co-localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes.
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| Cai J, Zhu Q, Zheng K, Li H, Qi Y, Cao Q, Qiu M.
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| Glia 58(4):458-68. doi: 10.1002/glia.20937.
2010
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| 12 | NKX2-2, PAX6
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| Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord.
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| Genethliou N, Panayiotou E, Panayi H, Orford M, Mean R, Lapathitis G, Malas S.
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| Biochem Biophys Res Commun 382(1):69-73. Epub 2009 Mar 1.
2009
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| 13 | NKX2-2
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| Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.
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| Wang YC, Gallego-Arteche E, Iezza G, Yuan X, Matli MR, Choo SP, Zuraek MB, Gogia R, Lynn FC, German MS, Bergsland EK, Donner DB, Warren RS, Nakakura EK.
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| Endocr Relat Cancer 16(1):267-79. Epub 2008 Nov 5.
2009
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| 14 | NKX2-2
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| EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma.
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| Owen LA, Kowalewski AA, Lessnick SL.
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| PLoS One 3(4):e1965.
2008
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| 15 | NEUROD1, NKX2-2
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| Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells.
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| Chao CS, Loomis ZL, Lee JE, Sussel L.
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| Dev Biol 312(2):523-32. Epub 2007 Oct 5.PMID: 17988662 2007
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| 16 | NKX2-2
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| Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma.
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| Smith R, Owen LA, Trem DJ, Wong JS, Whangbo JS, Golub TR, Lessnick SL.
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| Cancer Cell 9(5):405-16. Erratum in: Cancer Cell. 2007 Jan;11(1):97.
2006
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| 17 | LMX1B, NKX2-2
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| Lmx1b is essential for the development of serotonergic neurons.
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| Ding YQ, Marklund U, Yuan W, Yin J, Wegman L, Ericson J, Deneris E, Johnson RL, Chen ZF.
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| Nat Neurosci 6(9):933-8. 2003
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| 18 | NKX2-2, NKX2-4, NKX2-8, NKX2-1
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| Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals.
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| Wang CC, Brodnicki T, Copeland NG, Jenkins NA, Harvey RP.
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| Mamm Genome 11(6):466-8. 2000
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| 19 | NKX2-2
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| Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese.
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| Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI.
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| Diabetes 47(8):1356-8. No abstract available. 1998
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| 20 | NKX2-2, NKX2-4
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| Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain.
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| Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R.
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| Neuron 8(2):241-55. 1992
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