Citations for
1NFKB1
A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy.
Chong AY, Brenner N, Jimenez-Kaufmann A, Cortes A, Hill M, Littlejohns TJ, Gilchrist JJ, Fairfax BP, Knight JC, Hodel F, Fellay J, McVean G, Moreno-Estrada A, Waterboer T, Hill AVS, Mentzer AJ.
Am J Hum Genet. Feb 1;111(2):295-308. doi: 10.1016/j.ajhg.2023.12.013. Epub 2024 Jan 16 2024
2FHL2, NFKB1
LIM-only protein FHL2 attenuates inflammation in vascular smooth muscle cells through inhibition of the NFκB pathway
van de Pol V, Vos M, DeRuiter MC, Goumans MJ, de Vries CJM, Kurakula K.
Vascul Pharmacol. Feb-Mar;125-126:106634. doi: 10.1016/j.vph.2019.106634. Epub 2019 Dec 19. 2020
3NFKB1, TGFA
Transforming growth factor alpha promotes tumorigenesis and regulates epithelial-mesenchymal transition modulation in colon cancer
Yu CY, Chang WC, Zheng JH, Hung WH, Cho EC.
Biochem Biophys Res Commun. Dec 2;506(4):901-906. doi: 10.1016/j.bbrc.2018.10.137. Epub 2018 Nov 2. 2018
4NFKB1, TGFA, YY1
Transcriptional Regulation of Human Transforming Growth Factor-α in Astrocytes
Karki P, Johnson J Jr, Son DS, Aschner M, Lee E.
Mol Neurobiol. Mar;54(2):964-976. doi: 10.1007/s12035-016-9705-9. Epub 2016 Jan 21. 2017
5CCL18, NFKB1, PITPNM3
CCL18/PITPNM3 enhances migration, invasion, and EMT through the NF-κB signaling pathway in hepatocellular carcinoma.
Lin Z, Li W, Zhang H, Wu W, Peng Y, Zeng Y, Wan Y, Wang J, Ouyang N.
Tumour Biol 37(3):3461-8. doi: 10.1007/s13277-015-4172-x. 2016
6GPBAR1, NFKB1
Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy.
Zhang Y, Pan Y, Lin C, Zheng Y, Sun H, Zhang H, Wang J, Yuan M, Duan T, Du Q, Chen J.
J Mol Cell Biol 8(6):530-541. Epub 2016 Jul 8. 2016
7MUL1, NFKB1
Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress.
Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K, Nakajima T.
Int J Mol Med 37(6):1611-8. doi: 10.3892/ijmm.2016.2566. Epub 2016 Apr 14. 2016
8CVID12, NFKB1
Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency.
Fliegauf M, L Bryant V, Frede N, Slade C, Woon ST, Lehnert K, Winzer S, Bulashevska A, Scerri T, Leung E, Jordan A, Keller B, de Vries E, Cao H, Yang F, Schäffer AA, Warnatz K, Browett P, Douglass J, Ameratunga RV, van der Meer JW, Grimbacher B.
Am J Hum Genet 97(3):389-403. doi: 10.1016/j.ajhg.2015.07.008. Epub 2015 Aug 13. 2015
9ECSIT, NFKB1, RELA
Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling.
Mi Wi S, Park J, Shim JH, Chun E, Lee KY.
Mol Biol Cell 26(1):151-60. doi: 10.1091/mbc.E14-08-1277. Epub 2014 Oct 29. 2015
10NFKB1, STAT3, UACA
Nucling, a novel apoptosis-associated protein, controls mammary gland involution by regulating NF-κB and STAT3.
Dang HV, Sakai T, Pham TA, Tran DH, Yorita K, Shishido Y, Fukui K.
J Biol Chem 290(40):24626-35. doi: 10.1074/jbc.M115.673848. 2015
11ADAMTS9, IL1B, NFKB1
Interleukin-1β induced nuclear factor-κB binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells.
Altuntas A, Halacli SO, Cakmak O, Erden G, Akyol S, Ugurcu V, Hirohata S, Demircan K.
Mol Med Rep 12(1):595-600. doi: 10.3892/mmr.2015.3444. Epub 2015 Mar 6. 2015
12KLF6, NFKB1
Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.
Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B, Shu HB.
J Biol Chem 289(18):12876-85. doi: 10.1074/jbc.M113.535831. Epub 2014 Mar 14. 2014
13IKBKB, IRF5, NFKB1
Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.
Lopez-Pelaez M, Lamont DJ, Peggie M, Shpiro N, Gray NS, Cohen P.
Proc Natl Acad Sci U S A 111(49):17432-7. doi: 10.1073/pnas.1418399111. Epub 2014 Oct 17. 2014
14NFKB1, VCAM1
NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.
Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A, Ozawa K.
Cancer Res 73(1):364-72. doi: 10.1158/0008-5472.CAN-12-0088. Epub 2012 Oct 12. 2013
15ATF3, NFKB1, NOD2
NF-κB1 inhibits NOD2-induced cytokine secretion through ATF3-dependent mechanisms.
Zheng S, Abraham C.
Mol Cell Biol 33(24):4857-71. doi: 10.1128/MCB.00797-13. Epub 2013 Oct 7. 2013
16HOXC4, NFKB1, TNFSF13
APRIL stimulates NF-κB-mediated HoxC4 induction for AID expression in mouse B cells.
Park SR, Kim PH, Lee KS, Lee SH, Seo GY, Yoo YC, Lee J, Casali P.
Cytokine 61(2):608-13. doi: 10.1016/j.cyto.2012.10.018. Epub 2012 Nov 21. 2013
17NFKB1, PLK4
NFκB regulates expression of Polo-like kinase 4.
Ledoux AC, Sellier H, Gillies K, Iannetti A, James J, Perkins ND.
Cell Cycle 12(18):3052-62. doi: 10.4161/cc.26086. Epub 2013 Aug 21. 2013
18NFKB1, ZAP70
Expression of ZAP70 in chronic lymphocytic leukaemia activates NF-κB signalling.
Pede V, Rombout A, Vermeire J, Naessens E, Vanderstraeten H, Philippé J, Verhasselt B.
Br J Haematol 163(5):621-30. doi: 10.1111/bjh.12588. Epub 2013 Oct 8. 2013
19HES6, NFKB1, RELA
Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.
Methot L, Hermann R, Tang Y, Lo R, Al-Jehani H, Jhas S, Svoboda D, Slack RS, Barker PA, Stifani S.
Mol Cell Biol. Jul;33(14):2797-808. doi: 10.1128/MCB.01610-12. Epub 2013 May 20. 2013
20FAS, NFKB1, VEGFC
Correlated expression of Fas, NF-kappaB, and VEGF-C in infiltrating ductal carcinoma of the breast.
Dai XL, Zhou SL, Qiu J, Liu YF, Hua H.
Eur J Gynaecol Oncol 33(6):633-9. 2012
21BIRC3, NFKB1, TNFSF12
TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway.
Enwere EK, Holbrook J, Lejmi-Mrad R, Vineham J, Timusk K, Sivaraj B, Isaac M, Uehling D, Al-awar R, LaCasse E, Korneluk RG.
Sci Signal 5(246):ra75. doi: 10.1126/scisignal.2003086. 2012
22NFKB1, TBK1
The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling.
Jin J, Xiao Y, Chang JH, Yu J, Hu H, Starr R, Brittain GC, Chang M, Cheng X, Sun SC.
Nat Immunol 13(11):1101-9. doi: 10.1038/ni.2423. Epub 2012 Sep 30. 2012
23FGFR2, NFKB1
The breast cancer susceptibility gene product fibroblast growth factor receptor 2 serves as a scaffold for regulation of NF-κB signaling.
Wei W, Liu W, Cassol CA, Zheng W, Asa SL, Ezzat S.
Mol Cell Biol 32(22):4662-73. doi: 10.1128/MCB.00935-12. Epub 2012 Sep 17. 2012
24GNB2, NFKB1
Serum starvation activates NF-κB through G protein β2 subunit-mediated signal.
Kohno T, Kubo Y, Yasui K, Haraguchi M, Shigematsu S, Chua KJ, Matsuyama T, Hayashi H.
DNA Cell Biol 31(11):1636-44. doi: 10.1089/dna.2012.1666. Epub 2012 Aug 23. 2012
25NFKB1, NLRC3
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.
Schneider M, Zimmermann AG, Roberts RA, Zhang L, Swanson KV, Wen H, Davis BK, Allen IC, Holl EK, Ye Z, Rahman AH, Conti BJ, Eitas TK, Koller BH, Ting JP.
Nat Immunol 13(9):823-31. doi: 10.1038/ni.2378. Epub 2012 Aug 5. 2012
26CCL5, IL15, IL15RA, NFKB1
IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.
Chenoweth MJ, Mian MF, Barra NG, Alain T, Sonenberg N, Bramson J, Lichty BD, Richards CD, Ma A, Ashkar AA.
J Immunol 188(9):4149-57. doi: 10.4049/jimmunol.1101883. Epub 2012 Mar 23. 2012
27NFKB1, USP6
Atypical mechanism of NF-κB activation by TRE17/ubiquitin-specific protease 6 (USP6) oncogene and its requirement in tumorigenesis.
Pringle LM, Young R, Quick L, Riquelme DN, Oliveira AM, May MJ, Chou MM.
Oncogene 31(30):3525-35. doi: 10.1038/onc.2011.520. Epub 2011 Nov 14. 2012
28IL6, NFKB1, STAT3
NF-κB and STAT3 cooperatively induce IL6 in starved cancer cells.
Yoon S, Woo SU, Kang JH, Kim K, Shin HJ, Gwak HS, Park S, Chwae YJ.
Oncogene ncogene. 2012 2012
29ARNTL, CLOCK, NFKB1
Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription.
Spengler ML, Kuropatwinski KK, Comas M, Gasparian AV, Fedtsova N, Gleiberman AS, Gitlin II, Artemicheva NM, Deluca KA, Gudkov AV, Antoch MP.
Proc Natl Acad Sci U S A 109(37):E2457-65. doi: 10.1073/pnas.1206274109. 2012
30EGFR, NFKB1
FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.
Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, Moonsamy P, Dahlman K, Miller VA, Costa C, Hannon G, Sawyers CL.
Nature 471(7339):523-6. 2011
31IKBKG, NFKB1, SENP2
NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress.
Lee MH, Mabb AM, Gill GB, Yeh ET, Miyamoto S.
Mol Cell 43(2):180-91. 2011
32IL15, NFKB1
NFĸB is an unexpected major mediator of interleukin-15 signaling in cerebral endothelia.
Stone KP, Kastin AJ, Pan W.
Cell Physiol Biochem 28(1):115-24. doi: 10.1159/000331720. Epub 2011 Aug 16. 2011
33CASP3, HIF1A, NFKB1, TGM2
Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells.
Jang GY, Jeon JH, Cho SY, Shin DM, Kim CW, Jeong EM, Bae HC, Kim TW, Lee SH, Choi Y, Lee DS, Park SC, Kim IG.
Oncogene 29(3):356-67. Epub 2009 Oct 19. 2010
34AGER, CAMK4, NFKB1, PLCB1
PLC/CAMK IV-NF-kappaB involved in the receptor for advanced glycation end products mediated signaling pathway in human endothelial cells.
You J, Peng W, Lin X, Huang QL, Lin JY.
Mol Cell Endocrinol 320(1-2):111-7. doi: 10.1016/j.mce.2010.01.036. Epub 2010 Feb 18. 2010
35NFKB1, UACA
NF-kappaB regulates the expression of Nucling, a novel apoptosis regulator, with involvement of proteasome and caspase for its degradation.
Tran NH, Sakai T, Kim SM, Fukui K.
J Biochem 148(5):573-80. doi: 10.1093/jb/mvq089. 2010
36CSF2RB, NFKB1, TRAF6
A novel TNF receptor-associated factor 6 binding domain mediates NF-kappa B signaling by the common cytokine receptor beta subunit.
Meads MB, Li ZW, Dalton WS.
J Immunol 185(3):1606-15. doi: 10.4049/jimmunol.0902026. Epub 2010 Jul 9. 2010
37NF-kappa-B, NFKB1
Glutamate-induced NFkappaB activation in the retina
Fan W, Cooper NG.
Invest Ophthalmol Vis Sci. 50(2):917-25 2009
38NFKB1, TNIP1
ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor.
Cohen S, Ciechanover A, Kravtsova-Ivantsiv Y, Lapid D, Lahav-Baratz S.
Biochem Biophys Res Commun 389(2):205-10. Epub 2009 Aug 18.PMID: 19695220 2009
39NFKB1, RELB
RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.
Gasparini C, Foxwell BM, Feldmann M.
Eur J Immunol 39(8):2215-23.PMID: 19655301 2009
40NFKB1, NFKB2
The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes.
Savinova OV, Hoffmann A, Ghosh G.
Mol Cell 34(5):591-602. doi: 10.1016/j.molcel.2009.04.033. 2009
41NFKB1, HOXA9
Differential regulation of HOXA9 expression by nuclear factor kappa B (NF-kappaB) and HOXA9.
Trivedi CM, Patel RC, Patel CV.
Gene 408(1-2):187-95. Epub 2007 Nov 13. 2008
42NFKB1
Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence.
Edenberg HJ, Xuei X, Wetherill LF, Bierut L, Bucholz K, Dick DM, Hesselbrock V, Kuperman S, Porjesz B, Schuckit MA, Tischfield JA, Almasy LA, Nurnberger JI Jr, Foroud T.
Hum Mol Genet 17(7):963-70. Epub 2007 Dec 12. 2008
43IRF2, NFKB1
IRF-2 regulates NF-kappaB activity by modulating the subcellular localization of NF-kappaB.
Chae M, Kim K, Park SM, Jang IS, Seo T, Kim DM, Kim IC, Lee JH, Park J.
Biochem Biophys Res Commun 370(3):519-24. Epub 2008 Apr 3. 2008
44NFKB1, RELB
The mitochondrial localization of RelB and NFATx in immature T cells.
Stasik I, Rapak A, Zioło E, Strzadała L.
Cell Mol Biol Lett 13(4):493-501. Epub 2008 May 6.PMID: 18463795 2008
45FSTL3, NFKB1,TNF
Identification of NF-kappaB responsive elements in follistatin related gene (FLRG) promoter.
Bartholin L, Guindon S, Martel S, Corbo L, Rimokh R.
Gene 393(1-2):153-62. Epub 2007 Mar 1. 2007
46NFKB1
Sulfasalazine inhibits activation of nuclear factor-kappaB in patients with ulcerative colitis.
Gan HT, Chen YQ, Ouyang Q.
J Gastroenterol Hepatol 20(7):1016-24. 2005
47NFKB1, MUC6
Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors.
Sakai H, Jinawath A, Yamaoka S, Yuasa Y.
Biochem Biophys Res Commun 333(4):1254-60. 2005
48NFKB1
A NFKB1 promoter polymorphism is involved in susceptibility to ulcerative colitis.
Borm ME, van Bodegraven AA, Mulder CJ, Kraal G, Bouma G.
Int J Immunogenet 32(6):401-5. 2005
49NFKB1, IKBKG
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.
Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM.
Nature 427(6970):167-71. Epub 2003 Dec 24. 2004
50NFKB1
Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis.
Karban AS, Okazaki T, Panhuysen CI, Gallegos T, Potter JJ, Bailey-Wilson JE, Silverberg MS, Duerr RH, Cho JH, Gregersen PK, Wu Y, Achkar JP, Dassopoulos T, Mezey E, Bayless TM, Nouvet FJ, Brant SR.
Hum Mol Genet 13(1):35-45. Epub 2003 Nov 12. 2004
51TNIP2, MAP3K8, NFKB1
ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.
Lang V, Symons A, Watton SJ, Janzen J, Soneji Y, Beinke S, Howell S, Ley SC.
Mol Cell Biol 24(12):5235-48. 2004
52CYLD, IKBKG, NFKB1, TRAF2
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.
Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, Courtois G.
Nature 424(6950):801-5. 2003
53CYLD, EDA2R, IKBKG, NFKB1, TRAF2
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.
Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A, Mosialos G.
Nature 424(6950):793-6. 2003
54NFKB1, MALT1
Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase.
Ruefli-Brasse AA, French DM, Dixit VM.
Science 302(5650):1581-4. Epub 2003 Oct 23. 2003
55CREBBP, HDAC1, NFKB1, NFKB2
The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.
Zhong H, May MJ, Jimi E, Ghosh S.
Mol Cell 9(3):625-36. 2002
56MAP3K7, NFKB1, NFKB2, XIAP
Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1.
Hofer-Warbinek R, Schmid JA, Stehlik C, Binder BR, Lipp J, de Martin R.
J Biol Chem 275(29):22064-8. 2000
57JAG1, NFKB1, NFKB2, REL
Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors.
Bash J, et al.
EMBO J 18(10):2803-2811. 1999
58NFKB1
NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes.
Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C.
EMBO J 18(17):4766-78 1999
59NFKB1, NFKB2
New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases.
Chen F, Castranova V, Shi X, Demers LM.
Clin Chem 45(1):7-17. Review. 1999
60NFKB1
IkappaB-NF-kappaB structures: at the interface of inflammation control.
Baeuerle PA.
Cell 95 : 729-731. 1998
61NFKB1
The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-kappaB and IkappaB-gamma : implications for NF-kappaB-mediated signal transduction.
HŽron E, et al.
Genomics 30 : 493-505. 1995
62REL, NFKB1, NFKB2, RELA
Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappaBp50, NF-kappaBp65, and lyt-10 by fluorescence in situ hybridization.
Mathew S, et al.
Oncogene 8 : 191-193. 1993
63NFKB1, NFKB2
Related subunits of NF-kB map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2.
Liptay S, et al.
Genomics 13 : 287-292. 1992
64NFKB1
B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappaB p50.
Neri A, et al.
Cell 67 : 1075-1087. 1991