| 1 | NFKB1
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| A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy.
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| Chong AY, Brenner N, Jimenez-Kaufmann A, Cortes A, Hill M, Littlejohns TJ, Gilchrist JJ, Fairfax BP, Knight JC, Hodel F, Fellay J, McVean G, Moreno-Estrada A, Waterboer T, Hill AVS, Mentzer AJ.
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| Am J Hum Genet. Feb 1;111(2):295-308. doi: 10.1016/j.ajhg.2023.12.013. Epub 2024 Jan 16 2024
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| 2 | FHL2, NFKB1
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| LIM-only protein FHL2 attenuates inflammation in vascular smooth muscle cells through inhibition of the NFκB pathway
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| van de Pol V, Vos M, DeRuiter MC, Goumans MJ, de Vries CJM, Kurakula K.
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| Vascul Pharmacol. Feb-Mar;125-126:106634. doi: 10.1016/j.vph.2019.106634. Epub 2019 Dec 19. 2020
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| 3 | NFKB1, TGFA
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| Transforming growth factor alpha promotes tumorigenesis and regulates epithelial-mesenchymal transition modulation in colon cancer
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| Yu CY, Chang WC, Zheng JH, Hung WH, Cho EC.
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| Biochem Biophys Res Commun. Dec 2;506(4):901-906. doi: 10.1016/j.bbrc.2018.10.137. Epub 2018 Nov 2. 2018
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| 4 | NFKB1, TGFA, YY1
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| Transcriptional Regulation of Human Transforming Growth Factor-α in Astrocytes
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| Karki P, Johnson J Jr, Son DS, Aschner M, Lee E.
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| Mol Neurobiol. Mar;54(2):964-976. doi: 10.1007/s12035-016-9705-9. Epub 2016 Jan 21. 2017
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| 5 | CCL18, NFKB1, PITPNM3
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| CCL18/PITPNM3 enhances migration, invasion, and EMT through the NF-κB signaling pathway in hepatocellular carcinoma.
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| Lin Z, Li W, Zhang H, Wu W, Peng Y, Zeng Y, Wan Y, Wang J, Ouyang N.
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| Tumour Biol 37(3):3461-8. doi: 10.1007/s13277-015-4172-x.
2016
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| 6 | GPBAR1, NFKB1
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| Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy.
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| Zhang Y, Pan Y, Lin C, Zheng Y, Sun H, Zhang H, Wang J, Yuan M, Duan T, Du Q, Chen J.
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| J Mol Cell Biol 8(6):530-541. Epub 2016 Jul 8.
2016
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| 7 | MUL1, NFKB1
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| Mitochondrial ubiquitin ligase activator of NF-κB regulates NF-κB signaling in cells subjected to ER stress.
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| Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K, Nakajima T.
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| Int J Mol Med 37(6):1611-8. doi: 10.3892/ijmm.2016.2566. Epub 2016 Apr 14.
2016
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| 8 | CVID12, NFKB1
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| Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency.
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| Fliegauf M, L Bryant V, Frede N, Slade C, Woon ST, Lehnert K, Winzer S, Bulashevska A, Scerri T, Leung E, Jordan A, Keller B, de Vries E, Cao H, Yang F, Schäffer AA, Warnatz K, Browett P, Douglass J, Ameratunga RV, van der Meer JW, Grimbacher B.
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| Am J Hum Genet 97(3):389-403. doi: 10.1016/j.ajhg.2015.07.008. Epub 2015 Aug 13.
2015
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| 9 | ECSIT, NFKB1, RELA
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| Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling.
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| Mi Wi S, Park J, Shim JH, Chun E, Lee KY.
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| Mol Biol Cell 26(1):151-60. doi: 10.1091/mbc.E14-08-1277. Epub 2014 Oct 29.
2015
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| 10 | NFKB1, STAT3, UACA
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| Nucling, a novel apoptosis-associated protein, controls mammary gland involution by regulating NF-κB and STAT3.
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| Dang HV, Sakai T, Pham TA, Tran DH, Yorita K, Shishido Y, Fukui K.
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| J Biol Chem 290(40):24626-35. doi: 10.1074/jbc.M115.673848.
2015
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| 11 | ADAMTS9, IL1B, NFKB1
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| Interleukin-1β induced nuclear factor-κB binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells.
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| Altuntas A, Halacli SO, Cakmak O, Erden G, Akyol S, Ugurcu V, Hirohata S, Demircan K.
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| Mol Med Rep 12(1):595-600. doi: 10.3892/mmr.2015.3444. Epub 2015 Mar 6.
2015
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| 12 | KLF6, NFKB1
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| Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes.
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| Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B, Shu HB.
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| J Biol Chem 289(18):12876-85. doi: 10.1074/jbc.M113.535831. Epub 2014 Mar 14.
2014
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| 13 | IKBKB, IRF5, NFKB1
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| Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.
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| Lopez-Pelaez M, Lamont DJ, Peggie M, Shpiro N, Gray NS, Cohen P.
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| Proc Natl Acad Sci U S A 111(49):17432-7. doi: 10.1073/pnas.1418399111. Epub 2014 Oct 17.
2014
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| 14 | NFKB1, VCAM1
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| NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites.
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| Uchibori R, Tsukahara T, Mizuguchi H, Saga Y, Urabe M, Mizukami H, Kume A, Ozawa K.
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| Cancer Res 73(1):364-72. doi: 10.1158/0008-5472.CAN-12-0088. Epub 2012 Oct 12.
2013
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| 15 | ATF3, NFKB1, NOD2
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| NF-κB1 inhibits NOD2-induced cytokine secretion through ATF3-dependent mechanisms.
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| Zheng S, Abraham C.
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| Mol Cell Biol 33(24):4857-71. doi: 10.1128/MCB.00797-13. Epub 2013 Oct 7.
2013
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| 16 | HOXC4, NFKB1, TNFSF13
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| APRIL stimulates NF-κB-mediated HoxC4 induction for AID expression in mouse B cells.
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| Park SR, Kim PH, Lee KS, Lee SH, Seo GY, Yoo YC, Lee J, Casali P.
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| Cytokine 61(2):608-13. doi: 10.1016/j.cyto.2012.10.018. Epub 2012 Nov 21.
2013
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| 17 | NFKB1, PLK4
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| NFκB regulates expression of Polo-like kinase 4.
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| Ledoux AC, Sellier H, Gillies K, Iannetti A, James J, Perkins ND.
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| Cell Cycle 12(18):3052-62. doi: 10.4161/cc.26086. Epub 2013 Aug 21.
2013
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| 18 | NFKB1, ZAP70
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| Expression of ZAP70 in chronic lymphocytic leukaemia activates NF-κB signalling.
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| Pede V, Rombout A, Vermeire J, Naessens E, Vanderstraeten H, Philippé J, Verhasselt B.
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| Br J Haematol 163(5):621-30. doi: 10.1111/bjh.12588. Epub 2013 Oct 8.
2013
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| 19 | HES6, NFKB1, RELA
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| Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesis.
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| Methot L, Hermann R, Tang Y, Lo R, Al-Jehani H, Jhas S, Svoboda D, Slack RS, Barker PA, Stifani S.
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| Mol Cell Biol. Jul;33(14):2797-808. doi: 10.1128/MCB.01610-12. Epub 2013 May 20. 2013
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| 20 | FAS, NFKB1, VEGFC
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| Correlated expression of Fas, NF-kappaB, and VEGF-C in infiltrating ductal carcinoma of the breast.
|
| Dai XL, Zhou SL, Qiu J, Liu YF, Hua H.
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| Eur J Gynaecol Oncol 33(6):633-9.
2012
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| 21 | BIRC3, NFKB1, TNFSF12
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| TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway.
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| Enwere EK, Holbrook J, Lejmi-Mrad R, Vineham J, Timusk K, Sivaraj B, Isaac M, Uehling D, Al-awar R, LaCasse E, Korneluk RG.
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| Sci Signal 5(246):ra75. doi: 10.1126/scisignal.2003086.
2012
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| 22 | NFKB1, TBK1
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| The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling.
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| Jin J, Xiao Y, Chang JH, Yu J, Hu H, Starr R, Brittain GC, Chang M, Cheng X, Sun SC.
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| Nat Immunol 13(11):1101-9. doi: 10.1038/ni.2423. Epub 2012 Sep 30.
2012
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| 23 | FGFR2, NFKB1
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| The breast cancer susceptibility gene product fibroblast growth factor receptor 2 serves as a scaffold for regulation of NF-κB signaling.
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| Wei W, Liu W, Cassol CA, Zheng W, Asa SL, Ezzat S.
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| Mol Cell Biol 32(22):4662-73. doi: 10.1128/MCB.00935-12. Epub 2012 Sep 17.
2012
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| 24 | GNB2, NFKB1
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| Serum starvation activates NF-κB through G protein β2 subunit-mediated signal.
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| Kohno T, Kubo Y, Yasui K, Haraguchi M, Shigematsu S, Chua KJ, Matsuyama T, Hayashi H.
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| DNA Cell Biol 31(11):1636-44. doi: 10.1089/dna.2012.1666. Epub 2012 Aug 23.
2012
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| 25 | NFKB1, NLRC3
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| The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.
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| Schneider M, Zimmermann AG, Roberts RA, Zhang L, Swanson KV, Wen H, Davis BK, Allen IC, Holl EK, Ye Z, Rahman AH, Conti BJ, Eitas TK, Koller BH, Ting JP.
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| Nat Immunol 13(9):823-31. doi: 10.1038/ni.2378. Epub 2012 Aug 5.
2012
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| 26 | CCL5, IL15, IL15RA, NFKB1
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| IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.
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| Chenoweth MJ, Mian MF, Barra NG, Alain T, Sonenberg N, Bramson J, Lichty BD, Richards CD, Ma A, Ashkar AA.
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| J Immunol 188(9):4149-57. doi: 10.4049/jimmunol.1101883. Epub 2012 Mar 23.
2012
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| 27 | NFKB1, USP6
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| Atypical mechanism of NF-κB activation by TRE17/ubiquitin-specific protease 6 (USP6) oncogene and its requirement in tumorigenesis.
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| Pringle LM, Young R, Quick L, Riquelme DN, Oliveira AM, May MJ, Chou MM.
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| Oncogene 31(30):3525-35. doi: 10.1038/onc.2011.520. Epub 2011 Nov 14.
2012
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| 28 | IL6, NFKB1, STAT3
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| NF-κB and STAT3 cooperatively induce IL6 in starved cancer cells.
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| Yoon S, Woo SU, Kang JH, Kim K, Shin HJ, Gwak HS, Park S, Chwae YJ.
|
| Oncogene ncogene. 2012 2012
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| 29 | ARNTL, CLOCK, NFKB1
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| Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription.
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| Spengler ML, Kuropatwinski KK, Comas M, Gasparian AV, Fedtsova N, Gleiberman AS, Gitlin II, Artemicheva NM, Deluca KA, Gudkov AV, Antoch MP.
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| Proc Natl Acad Sci U S A 109(37):E2457-65. doi: 10.1073/pnas.1206274109.
2012
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| 30 | EGFR, NFKB1
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| FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.
|
| Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, Moonsamy P, Dahlman K, Miller VA, Costa C, Hannon G, Sawyers CL.
|
| Nature 471(7339):523-6.
2011
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| 31 | IKBKG, NFKB1, SENP2
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| NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress.
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| Lee MH, Mabb AM, Gill GB, Yeh ET, Miyamoto S.
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| Mol Cell 43(2):180-91. 2011
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| 32 | IL15, NFKB1
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| NFĸB is an unexpected major mediator of interleukin-15 signaling in cerebral endothelia.
|
| Stone KP, Kastin AJ, Pan W.
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| Cell Physiol Biochem 28(1):115-24. doi: 10.1159/000331720. Epub 2011 Aug 16.
2011
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| 33 | CASP3, HIF1A, NFKB1, TGM2
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| Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells.
|
| Jang GY, Jeon JH, Cho SY, Shin DM, Kim CW, Jeong EM, Bae HC, Kim TW, Lee SH, Choi Y, Lee DS, Park SC, Kim IG.
|
| Oncogene 29(3):356-67. Epub 2009 Oct 19.
2010
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| 34 | AGER, CAMK4, NFKB1, PLCB1
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| PLC/CAMK IV-NF-kappaB involved in the receptor for advanced glycation end products mediated signaling pathway in human endothelial cells.
|
| You J, Peng W, Lin X, Huang QL, Lin JY.
|
| Mol Cell Endocrinol 320(1-2):111-7. doi: 10.1016/j.mce.2010.01.036. Epub 2010 Feb 18.
2010
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| 35 | NFKB1, UACA
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| NF-kappaB regulates the expression of Nucling, a novel apoptosis regulator, with involvement of proteasome and caspase for its degradation.
|
| Tran NH, Sakai T, Kim SM, Fukui K.
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| J Biochem 148(5):573-80. doi: 10.1093/jb/mvq089.
2010
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| 36 | CSF2RB, NFKB1, TRAF6
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| A novel TNF receptor-associated factor 6 binding domain mediates NF-kappa B signaling by the common cytokine receptor beta subunit.
|
| Meads MB, Li ZW, Dalton WS.
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| J Immunol 185(3):1606-15. doi: 10.4049/jimmunol.0902026. Epub 2010 Jul 9.
2010
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| 37 | NF-kappa-B, NFKB1
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| Glutamate-induced NFkappaB activation in the retina
|
| Fan W, Cooper NG.
|
| Invest Ophthalmol Vis Sci. 50(2):917-25 2009
|
| 38 | NFKB1, TNIP1
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| ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor.
|
| Cohen S, Ciechanover A, Kravtsova-Ivantsiv Y, Lapid D, Lahav-Baratz S.
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| Biochem Biophys Res Commun 389(2):205-10. Epub 2009 Aug 18.PMID: 19695220 2009
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| 39 | NFKB1, RELB
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| RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.
|
| Gasparini C, Foxwell BM, Feldmann M.
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| Eur J Immunol 39(8):2215-23.PMID: 19655301 2009
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| 40 | NFKB1, NFKB2
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| The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes.
|
| Savinova OV, Hoffmann A, Ghosh G.
|
| Mol Cell 34(5):591-602. doi: 10.1016/j.molcel.2009.04.033.
2009
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| 41 | NFKB1, HOXA9
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| Differential regulation of HOXA9 expression by nuclear factor kappa B (NF-kappaB) and HOXA9.
|
| Trivedi CM, Patel RC, Patel CV.
|
| Gene 408(1-2):187-95. Epub 2007 Nov 13. 2008
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| 42 | NFKB1
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| Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence.
|
| Edenberg HJ, Xuei X, Wetherill LF, Bierut L, Bucholz K, Dick DM, Hesselbrock V, Kuperman S, Porjesz B, Schuckit MA, Tischfield JA, Almasy LA, Nurnberger JI Jr, Foroud T.
|
| Hum Mol Genet 17(7):963-70. Epub 2007 Dec 12. 2008
|
| 43 | IRF2, NFKB1
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| IRF-2 regulates NF-kappaB activity by modulating the subcellular localization of NF-kappaB.
|
| Chae M, Kim K, Park SM, Jang IS, Seo T, Kim DM, Kim IC, Lee JH, Park J.
|
| Biochem Biophys Res Commun 370(3):519-24. Epub 2008 Apr 3. 2008
|
| 44 | NFKB1, RELB
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| The mitochondrial localization of RelB and NFATx in immature T cells.
|
| Stasik I, Rapak A, Zioło E, Strzadała L.
|
| Cell Mol Biol Lett 13(4):493-501. Epub 2008 May 6.PMID: 18463795 2008
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| 45 | FSTL3, NFKB1,TNF
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| Identification of NF-kappaB responsive elements in follistatin related gene (FLRG) promoter.
|
| Bartholin L, Guindon S, Martel S, Corbo L, Rimokh R.
|
| Gene 393(1-2):153-62. Epub 2007 Mar 1. 2007
|
| 46 | NFKB1
|
| Sulfasalazine inhibits activation of nuclear factor-kappaB in patients with ulcerative colitis.
|
| Gan HT, Chen YQ, Ouyang Q.
|
| J Gastroenterol Hepatol 20(7):1016-24. 2005
|
| 47 | NFKB1, MUC6
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| Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors.
|
| Sakai H, Jinawath A, Yamaoka S, Yuasa Y.
|
| Biochem Biophys Res Commun 333(4):1254-60. 2005
|
| 48 | NFKB1
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| A NFKB1 promoter polymorphism is involved in susceptibility to ulcerative colitis.
|
| Borm ME, van Bodegraven AA, Mulder CJ, Kraal G, Bouma G.
|
| Int J Immunogenet 32(6):401-5. 2005
|
| 49 | NFKB1, IKBKG
|
| Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.
|
| Zhou H, Wertz I, O'Rourke K, Ultsch M, Seshagiri S, Eby M, Xiao W, Dixit VM.
|
| Nature 427(6970):167-71. Epub 2003 Dec 24. 2004
|
| 50 | NFKB1
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| Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis.
|
| Karban AS, Okazaki T, Panhuysen CI, Gallegos T, Potter JJ, Bailey-Wilson JE, Silverberg MS, Duerr RH, Cho JH, Gregersen PK, Wu Y, Achkar JP, Dassopoulos T, Mezey E, Bayless TM, Nouvet FJ, Brant SR.
|
| Hum Mol Genet 13(1):35-45. Epub 2003 Nov 12. 2004
|
| 51 | TNIP2, MAP3K8, NFKB1
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| ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.
|
| Lang V, Symons A, Watton SJ, Janzen J, Soneji Y, Beinke S, Howell S, Ley SC.
|
| Mol Cell Biol 24(12):5235-48. 2004
|
| 52 | CYLD, IKBKG, NFKB1, TRAF2
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| The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.
|
| Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, Courtois G.
|
| Nature 424(6950):801-5. 2003
|
| 53 | CYLD, EDA2R, IKBKG, NFKB1, TRAF2
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| CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.
|
| Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A, Mosialos G.
|
| Nature 424(6950):793-6. 2003
|
| 54 | NFKB1, MALT1
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| Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase.
|
| Ruefli-Brasse AA, French DM, Dixit VM.
|
| Science 302(5650):1581-4. Epub 2003 Oct 23. 2003
|
| 55 | CREBBP, HDAC1, NFKB1, NFKB2
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| The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1.
|
| Zhong H, May MJ, Jimi E, Ghosh S.
|
| Mol Cell 9(3):625-36. 2002
|
| 56 | MAP3K7, NFKB1, NFKB2, XIAP
|
| Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1.
|
| Hofer-Warbinek R, Schmid JA, Stehlik C, Binder BR, Lipp J, de Martin R.
|
| J Biol Chem 275(29):22064-8. 2000
|
| 57 | JAG1, NFKB1, NFKB2, REL
|
| Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors.
|
| Bash J, et al.
|
| EMBO J 18(10):2803-2811. 1999
|
| 58 | NFKB1
|
| NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes.
|
| Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C.
|
| EMBO J 18(17):4766-78 1999
|
| 59 | NFKB1, NFKB2
|
| New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases.
|
| Chen F, Castranova V, Shi X, Demers LM.
|
| Clin Chem 45(1):7-17. Review. 1999
|
| 60 | NFKB1
|
| IkappaB-NF-kappaB structures: at the interface of inflammation control.
|
| Baeuerle PA.
|
| Cell 95 : 729-731. 1998
|
| 61 | NFKB1
|
| The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-kappaB and IkappaB-gamma : implications for NF-kappaB-mediated signal transduction.
|
| HŽron E, et al.
|
| Genomics 30 : 493-505. 1995
|
| 62 | REL, NFKB1, NFKB2, RELA
|
| Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappaBp50, NF-kappaBp65, and lyt-10 by fluorescence in situ hybridization.
|
| Mathew S, et al.
|
| Oncogene 8 : 191-193. 1993
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| 63 | NFKB1, NFKB2
|
| Related subunits of NF-kB map to two distinct loci associated with translocations in leukemia, NFKB1 and NFKB2.
|
| Liptay S, et al.
|
| Genomics 13 : 287-292. 1992
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| 64 | NFKB1
|
| B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappaB p50.
|
| Neri A, et al.
|
| Cell 67 : 1075-1087. 1991
|