Citations for
1ESR1, NFATC1, WNT5B
Estrogen receptor alpha and NFATc1 bind to a bone mineral density-associated SNP to repress WNT5B in osteoblasts
Suthon S, Lin J, Perkins RS, Crockarell JR Jr, Miranda-Carboni GA, Krum SA.
Am J Hum Genet. Jan 6;109(1):97-115. doi: 10.1016/j.ajhg.2021.11.018. Epub 2021 Dec 13. 2022
2DYRK1A, NFATC1
DYRK1A activates NFATC1 to increase glioblastoma migration
Liu H, Sun Q, Chen S, Chen L, Jia W, Zhao J, Sun X.
Cancer Med. Sep;10(18):6416-6427. doi: 10.1002/cam4.4159. Epub 2021 Jul 26. 2021
3NFATC1
Lack of NFATc1 SUMOylation prevents autoimmunity and alloreactivity.
Xiao Y, Qureischi M, Dietz L, Vaeth M, Vallabhapurapu SD, Klein-Hessling S, Klein M, Liang C, König A, Serfling E, Mottok A, Bopp T, Rosenwald A, Buttmann M, Berberich I, Beilhack A, Berberich-Siebelt F.
J Exp Med. Jan 4;218(1):e20181853. doi: 10.1084/jem.20181853. 2021
4GAP43, NFATC1
GAP-43 ameliorates Podocyte injury by decreasing nuclear NFATc1 expression.
Lian Z, Ke G, Zhang H, Dou C, Chen X, Li B, Zhang F, Wen S, Wu Q, Xia Y, Jiang N, Li Z, Li S, Zhao X, Ma J, Lin T, Wen F, Xu L, Li Z, Liang H, Dong W, Chen Y, Li R, Ye Z, Wang W, Liang X, Shi W, Zhang L, Liu S.
Biochem Biophys Rep. Oct 21;28:101145. doi: 10.1016/j.bbrep.2021.101145. 2021
5NFATC1
Role of NFATc1 in the Bone-Vascular Axis Calcification Paradox
Gu W, Wang Z, Sun Z, Bao Z, Zhang L, Geng Y, Jing L, Mao X, Li L.
J Cardiovasc Pharmacol. Mar;75(3):200-207. doi: 10.1097/FJC.0000000000000788. 2020
6NFATC1
The Role of Ca2+-NFATc1 Signaling and Its Modulation on Osteoclastogenesis.
Kang JY, Kang N, Yang YM, Hong JH, Shin DM.
Int J Mol Sci. May 21;21(10):3646. doi: 10.3390/ijms21103646. 2020
7CDK1, NFATC1
Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation.
Kim HM, He L, Lee S, Park C, Kim DH, Han HJ, Han J, Hwang J, Cha-Molstad H, Lee KH, Ko SK, Jang JH, Ryoo IJ, Blenis J, Lee HG, Ahn JS, Kwon YT, Soung NK, Kim BY.
Bone. Feb;131:115153. doi: 10.1016/j.bone.2019.115153. Epub 2019 Nov 12 2020
8NFATC1, STAT3
STAT3 controls osteoclast differentiation and bone homeostasis by regulating NFATc1 transcription
Yang Y, Chung MR, Zhou S, Gong X, Xu H, Hong Y, Jin A, Huang X, Zou W, Dai Q, Jiang L.
J Biol Chem. Oct 18;294(42):15395-15407. doi: 10.1074/jbc.RA119.010139. Epub 2019 Aug 28. 2019
9NFATC1
NFATc1 Promotes Antitumoral Effector Functions and Memory CD8+ T-cell Differentiation during Non-Small Cell Lung Cancer Development.
Heim L, Friedrich J, Engelhardt M, Trufa DI, Geppert CI, Rieker RJ, Sirbu H, Finotto S.
Cancer Res. Jul 1;78(13):3619-3633. doi: 10.1158/0008-5472.CAN-17-3297. Epub 2018 Apr 24. 2018
10NFATC1
Induction of Short NFATc1/αA Isoform Interferes with Peripheral B Cell Differentiation.
Muhammad K, Rudolf R, Pham DAT, Klein-Hessling S, Takata K, Matsushita N, Ellenrieder V, Kondo E, Serfling E.
Front Immunol. Jan 24;9:32. doi: 10.3389/fimmu.2018.00032. 2018
11MTOR, NFATC1
mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1
Huynh H, Wan Y.
Commun Biol. Apr 5;1:29. doi: 10.1038/s42003-018-0028-4. 2018
12NFATC1
NFATc1 controls the cytotoxicity of CD8+ T cells
Klein-Hessling S, Muhammad K, Klein M, Pusch T, Rudolf R, Flöter J, Qureischi M, Beilhack A, Vaeth M, Kummerow C, Backes C, Schoppmeyer R, Hahn U, Hoth M, Bopp T, Berberich-Siebelt F, Patra A, Avots A, Müller N, Schulze A, Serfling E.
Nat Commun. Sep 11;8(1):511. doi: 10.1038/s41467-017-00612-6. 2017
13NFATC1
NFATc1 phosphorylation by DYRK1A increases its protein stability
Liu H, Wang K, Chen S, Sun Q, Zhang Y, Chen L, Sun X.
PLoS One. Feb 24;12(2):e0172985. doi: 10.1371/journal.pone.0172985. 2017
14BSG, NFATC1
CD147 promotes the formation of functional osteoclasts through NFATc1 signalling.
Nishioku T, Terasawa M, Baba M, Yamauchi A, Kataoka Y.
Biochem Biophys Res Commun 473(2):620-4. doi: 10.1016/j.bbrc.2016.03.147. Epub 2016 Mar 31. 2016
15LDHA, LDHB, NFATC1, TNFSF11
Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling.
Ahn H, Lee K, Kim JM, Kwon SH, Lee SH, Lee SY, Jeong D.
PLoS One 11(4):e0153886. doi: 10.1371/journal.pone.0153886. eCollection 2016. 2016
16IKBKE, NFATC1
IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response.
Zhang J, Feng H, Zhao J, Feldman ER, Chen SY, Yuan W, Huang C, Akbari O, Tibbetts SA, Feng P.
Cell Rep. Jul 12;16(2):405-418. doi: 10.1016/j.celrep.2016.05.083. Epub 2016 Jun 23. 2016
17IL31, JUNB, NFATC1
NFAT1 and JunB cooperatively regulate IL-31 gene expression in CD4+ T cells in health and disease.
Hwang JS, Kim GC, Park E, Kim JE, Chae CS, Hwang W, Lee C, Hwang SM, Wang HS, Jun CD, Rudra D, Im SH.
J Immunol 194(4):1963-74. doi: 10.4049/jimmunol.1401862. Epub 2015 Jan 16. 2015
18FHL1, NFATC1, UTRN
Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy.
D'Arcy CE, Feeney SJ, McLean CA, Gehrig SM, Lynch GS, Smith JE, Cowling BS, Mitchell CA, McGrath MJ.
Hum Mol Genet 23(3):618-36. doi: 10.1093/hmg/ddt449. Epub 2013 Sep 18. 2014
19GRK5, NFATC1
GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity.
Hullmann JE, Grisanti LA, Makarewich CA, Gao E, Gold JI, Chuprun JK, Tilley DG, Houser SR, Koch WJ.
Circ Res 115(12):976-85. doi: 10.1161/CIRCRESAHA.116.304475. Epub 2014 Oct 20. 2014
20CALM1, EDF1, NFATC1, PPP3CA
EDF-1 downregulates the CaM/Cn/NFAT signaling pathway during adipogenesis.
López-Victorio CJ, Velez-delValle C, Beltrán-Langarica A, Kuri-Harcuch W.
Biochem Biophys Res Commun 432(1):146-51. doi: 10.1016/j.bbrc.2013.01.069. Epub 2013 Feb 1. 2013
21ETS1, IL2, NFATC1, PRDM1
Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter.
Tsao HW, Tai TS, Tseng W, Chang HH, Grenningloh R, Miaw SC, Ho IC.
Proc Natl Acad Sci U S A 110(39):15776-81. doi: 10.1073/pnas.1304343110. Epub 2013 Sep 9. 2013
22FN1, NFATC1, RHOA
Nuclear factor of activated T cells mediates RhoA-induced fibronectin upregulation in glomerular podocytes.
Zhu L, Qi XY, Aoudjit L, Mouawad F, Baldwin C, Nattel S, Takano T.
Am J Physiol Renal Physiol 304(7):F849-62. doi: 10.1152/ajprenal.00495.2012. Epub 2013 Feb 6. 2013
23NFATC1, SERPINA12
Vaspin attenuates RANKL-induced osteoclast formation in RAW264.7 cells.
Kamio N, Kawato T, Tanabe N, Kitami S, Morita T, Ochiai K, Maeno M.
Connect Tissue Res 54(2):147-52. doi: 10.3109/03008207.2012.761978. 2013
24ASIC1, NFATC1
Acid-sensing ion channel 1a is involved in acid-induced osteoclastogenesis by regulating activation of the transcription factor NFATc1.
Li X, Xu RS, Jiang DL, He XL, Jin C, Lu WG, Su Q, Yuan FL.
FEBS Lett 587(19):3236-42. doi: 10.1016/j.febslet.2013.08.017. Epub 2013 Aug 28. 2013
25NFATC1, RARRES2
Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis.
Muruganandan S, Dranse HJ, Rourke JL, McMullen NM, Sinal CJ.
Stem Cells 31(10):2172-82. doi: 10.1002/stem.1450. 2013
26FAM102A, NFATC1, PLCG2, TNFRSF11A
Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis.
Choi HK, Kang HR, Jung E, Kim TE, Lin JJ, Lee SY.
Cell Res 23(4):524-36. doi: 10.1038/cr.2013.33. Epub 2013 Mar 12. 2013
27MMP2, MMP9, NFATC1, SKIL, SMAD3
Cooperative involvement of NFAT and SnoN mediates transforming growth factor-β (TGF-β) induced EMT in metastatic breast cancer (MDA-MB 231) cells.
Sengupta S, Jana S, Biswas S, Mandal PK, Bhattacharyya A.
Clin Exp Metastasis 30(8):1019-31. doi: 10.1007/s10585-013-9600-y. Epub 2013 Jul 6. 2013
28KDM8, NFATC1
JMJD5, a Jumonji C (JmjC) domain-containing protein, negatively regulates osteoclastogenesis by facilitating NFATc1 protein degradation.
Youn MY, Yokoyama A, Fujiyama-Nakamura S, Ohtake F, Minehata K, Yasuda H, Suzuki T, Kato S, Imai Y.
J Biol Chem 287(16):12994-3004. doi: 10.1074/jbc.M111.323105. Epub 2012 Feb 28. 2012
29FN1, FOS, NFATC1, SP7
Inorganic phosphate stimulates fibronectin expression in renal fibroblasts.
Chen Z, Chen D, McCarthy TL, Centrella M, Zhang Y, Moeckel GW.
Cell Physiol Biochem 30(1):151-9. doi: 10.1159/000339054. Epub 2012 Jun 18. 2012
30AKT2, NFATC1
Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores.
Martin VA, Wang WH, Lipchik AM, Parker LL, He Y, Zhang S, Zhang ZY, Geahlen RL.
Cell Signal 24(5):1064-73. doi: 10.1016/j.cellsig.2012.01.001. Epub 2012 Jan 11. 2012
31CD86, IL2, NFATC1
IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells.
Paine A, Kirchner H, Immenschuh S, Oelke M, Blasczyk R, Eiz-Vesper B.
J Immunol 188(4):1620-9. doi: 10.4049/jimmunol.1100181. Epub 2012 Jan 13. 2012
32APOBECG, NFATC1, NFATC2
NFAT and IRF proteins regulate transcription of the anti-HIV gene, APOBEC3G.
Farrow MA, Kim EY, Wolinsky SM, Sheehy AM.
J Biol Chem 286(4):2567-77. Epub 2010 Nov 15. 2011
33NFATC1, TNFSF11
NFATC1 promotes epicardium-derived cell invasion into myocardium.
Combs MD, Braitsch CM, Lange AW, James JF, Yutzey KE.
Development 138(9):1747-57. Epub 2011 Mar 29. 2011
34ACP5, NFATC1, OSCAR, TNFSF11
RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation.
Kim JH, Kim K, Youn BU, Jin HM, Kim JY, Moon JB, Ko A, Seo SB, Lee KY, Kim N.
Biochem J 436(2):253-62. 2011
35NFATC1, OSCAR
The role of osteoclast-associated receptor in osteoimmunology.
Nemeth K, Schoppet M, Al-Fakhri N, Helas S, Jessberger R, Hofbauer LC, Goettsch C.
J Immunol 186(1):13-8. Review. 2011
36GPC6, NFATC1, NFATC2, NFATC3, NFATC4
NFAT promotes carcinoma invasive migration through glypican-6.
Yiu GK, Kaunisto A, Chin YR, Toker A.
Biochem J 440(1):157-66. doi: 10.1042/BJ20110530. 2011
37KDM6B, NFATC1
Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1.
Yasui T, Hirose J, Tsutsumi S, Nakamura K, Aburatani H, Tanaka S.
J Bone Miner Res 26(11):2665-71. doi: 10.1002/jbmr.464. 2011
38FOXP3, NFATC1, SIVA1
Regulation of IL-2 gene expression by Siva and FOXP3 in human T cells.
Hench VK, Su L.
BMC Immunol MC Immunol. 2011 2011
39NFATC1, PRDM1, TM7SF4
Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.
Nishikawa K, Nakashima T, Hayashi M, Fukunaga T, Kato S, Kodama T, Takahashi S, Calame K, Takayanagi H.
Proc Natl Acad Sci U S A 107(7):3117-22. Epub 2010 Jan 28.PMID: 20133620 2010
40NFATC1
Regulatory mechanism of NFATc1 in RANKL-induced osteoclast activation.
Song I, Kim JH, Kim K, Jin HM, Youn BU, Kim N.
FEBS Lett 583(14):2435-40. Epub 2009 Jul 2. 2009
41CTSK, NFATC1, TNFSF11
Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand.
Balkan W, Martinez AF, Fernandez I, Rodriguez MA, Pang M, Troen BR.
Gene 446(2):90-8. Epub 2009 Jun 27. 2009
42MYH4, NFATC1, NFATC2, NFATC3, NFATC4
NFAT isoforms control activity-dependent muscle fiber type specification.
Calabria E, Ciciliot S, Moretti I, Garcia M, Picard A, Dyar KA, Pallafacchina G, Tothova J, Schiaffino S, Murgia M.
Proc Natl Acad Sci U S A 106(32):13335-40. Epub 2009 Jul 24.PMID: 19633193 2009
43ATP6V0D2, MEF2A, MITF, NFATC1
Myocyte enhancer factor 2 and microphthalmia-associated transcription factor cooperate with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis.
Feng H, Cheng T, Steer JH, Joyce DA, Pavlos NJ, Leong C, Kular J, Liu J, Feng X, Zheng MH, Xu J.
J Biol Chem 284(21):14667-76. Epub 2009 Mar 25.PMID: 19321441 2009
44NFATC1, SH3BP2
Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFAT.
Shukla U, Hatani T, Nakashima K, Ogi K, Sada K.
J Biol Chem 284(49):33719-28. doi: 10.1074/jbc.M109.049999. Epub 2009 Oct 15. 2009
45NFATC1
NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells.
Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E.
Cell 132(2):299-310. 2008
46SPI1, NFATC1
PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter.
Crotti TN, Sharma SM, Fleming JD, Flannery MR, Ostrowski MC, Goldring SR, McHugh KP.
J Cell Physiol 215(3):636-44. 2008
47NFATC1
Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis.
Kuroda Y, Hisatsune C, Nakamura T, Matsuo K, Mikoshiba K.
Proc Natl Acad Sci U S A 105(25):8643-8. Epub 2008 Jun 13. 2008
48NFATC1, NFATC2, NFATC3, NFATC4
Alternative splicing and expression of human and mouse NFAT genes.
Vihma H, Pruunsild P, Timmusk T.
Genomics 92(5):279-91. Epub 2008 Aug 26. 2008
49ATP6V0D2, NFATC1
NFATc1 induces osteoclast fusion via up-regulation of Atp6v0d2 and the dendritic cell-specific transmembrane protein (DC-STAMP).
Kim K, Lee SH, Ha Kim J, Choi Y, Kim N.
Mol Endocrinol 22(1):176-85. Epub 2007 Sep 20.PMID: 17885208 2008
50GPR68, NFATC1, RGS18, TNFSF11
RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway.
Iwai K, Koike M, Ohshima S, Miyatake K, Uchiyama Y, Saeki Y, Ishii M.
J Bone Miner Res 22(10):1612-20. 2007
51RCAN1, NFATC1
Down Syndrome Critical Region-1 Is a Transcriptional Target of Nuclear Factor of Activated T Cells-c1 within the Endocardium during Heart Development.
Wu H, Kao SC, Barrientos T, Baldwin SH, Olson EN, Crabtree GR, Zhou B, Chang CP.
J Biol Chem 282(42):30673-9. Epub 2007 Aug 10. 2007
52NFATC1
NFATc is required for TGFbeta-mediated transcriptional regulation of fibronectin.
Cobbs SL, Gooch JL.
Biochem Biophys Res Commun 362(2):288-94. Epub 2007 Aug 13. 2007
53PTPN11, NS1, NFATC1
Gain-of-function/Noonan syndrome SHP-2/Ptpn11 mutants enhance calcium oscillations and impair NFAT signaling.
Uhlen P, Burch PM, Zito CI, Estrada M, Ehrlich BE, Bennett AM.
Proc Natl Acad Sci U S A 103(7):2160-5. Epub 2006 Feb 3. 2006
54NFATC1, ITGB3
NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiation.
Crotti TN, Flannery M, Walsh NC, Fleming JD, Goldring SR, McHugh KP.
Gene 372:92-102. Epub 2006 Mar 2. 2006
55RCAN1, DYRK1A, NFATC1, NFATC2, NFATC3, NFATC4, TRI21
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.
Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR.
Nature 441(7093):595-600. Epub 2006 Mar 22. 2006
56DYRK1A,NFATC1,NFATC2,NFATC3,NFATC4
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT.
Gwack Y, Sharma S, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A.
Nature 441(7093):646-50. Epub 2006 Mar 1. 2006
57NFATC1, TNFSF11, CTSK
NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K.
Lange AW, Yutzey KE.
Dev Biol 292(2):407-17. 2006
58NFATC1
Differential duplication of an intronic region in the NFATC1 gene in patients with congenital heart disease.
Yehya A, Souki R, Bitar F, Nemer G.
Genome 49(9):1092-8. 2006
59NFATC1, SP7
NFAT and Osterix cooperatively regulate bone formation.
Koga T, Matsui Y, Asagiri M, Kodama T, de Crombrugghe B, Nakashima K, Takayanagi H.
Nat Med 11(8):880-885. Epub 2005 Jul 24. 2005
60TNFSF11, NFATC1
RANK-L induces the expression of NFATc1, but not of NFkappaB subunits during osteoclast formation.
Zhu LL, Zaidi S, Moonga BS, Troen BR, Sun L.
Biochem Biophys Res Commun 326(1):131-5. 2005
61NFATC1
Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart.
Zhou B, Wu B, Tompkins KL, Boyer KL, Grindley JC, Baldwin HS.
Development 132(5):1137-46. Epub 2005 Feb 2. 2005
62NFATC1, SOX9
Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.
Akiyama H, Chaboissier MC, Behringer RR, Rowitch DH, Schedl A, Epstein JA, De Crombrugghe B.
Proc Natl Acad Sci U S A 101(17):6502-7. Epub 2004 Apr 19. 2004
63NFATC1, NFATC2, NFATC3, NFATC4
NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching.
McCullagh KJ, Calabria E, Pallafacchina G, Ciciliot S, Serrano AL, Argentini C, Kalhovde JM, Lomo T, Schiaffino S.
Proc Natl Acad Sci U S A 101(29):10590-5. Epub 2004 Jul 09. 2004
64NFATC1
Role of NFAT proteins in IL13 gene transcription in mast cells.
Monticelli S, Solymar DC, Rao A.
J Biol Chem 279(35):36210-8. Epub 2004 Jun 30. 2004
65NFATC1, NFATC2
NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription.
Monticelli S, Rao A.
Eur J Immunol 32(10):2971-8. 2002
66NFATC1, NFATC2, CD3G
Identification of three NFAT binding motifs in the 5'-upstream region of the human CD3gamma gene that differentially bind NFATc1, NFATc2, and NF-kappa B p50.
Badran BM, Wolinsky SM, Burny A, Willard-Gallo KE.
J Biol Chem 277(49):47136-48. Epub 2002 Oct 08. 2002
67NFATC1, NFATC2, NFATC3
A second calcineurin binding site on the NFAT regulatory domain.
Park S, Uesugi M, Verdine GL.
Proc Natl Acad Sci U S A 97(13):7130-5. 2000
68GATA2, IGF1, NFATC1
Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway.
Semsarian C, et al.
Nature 400(6744):576-81 1999
69GATA2, IGF1, NFATC1
IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1.
Musaro A, McCullagh KJ, Naya FJ, Olson EN, Rosenthal N.
Nature 400(6744):581-5. 1999
70NFATC1
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.
Beals CR, et al.
Science 275 : 1930-1933. 1997
71NFATC1, NFATC2
Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp.
Li X, et al.
Cytogenet Cell Genet 68 : 185-191. 1995
72NFATC1, NFATC2
A similar DNA-binding motif in NFAT family proteins and the Rel homology region.
Jain J, Burgeon E, Badalian TM, Hogan PG, Rao A.
J Biol Chem 270(8):4138-45. 1995
73NFATC1, NFATC2
NF-AT components define a family of transcription factors targeted in T-cell activation.
Northrop JP, et al.
Nature 369 : 497-502. 1994