| 1 | ANKS6, INVS, NEK8, NPHP3
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| The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6.
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| Nakajima Y, Kiyonari H, Mukumoto Y, Yokoyama T.
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| Kidney Int 93(5):1108-1117. doi: 10.1016/j.kint.2017.11.016. Epub 2018 Feb 1.
2018
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| 2 | NEK8, RAD51
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| NEK8 regulates DNA damage-induced RAD51 foci formation and replication fork protection.
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| Abeyta A, Castella M, Jacquemont C, Taniguchi T.
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| Cell Cycle 16(4):335-347. doi: 10.1080/15384101.2016.1259038. Epub 2016 Nov 28.
2017
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| 3 | NEK8, RHPD2
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| Genetic spectrum of Saudi Arabian patients with antenatal cystic kidney disease and ciliopathy phenotypes using a targeted renal gene panel.
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| Al-Hamed MH, Kurdi W, Alsahan N, Alabdullah Z, Abudraz R, Tulbah M, Alnemer M, Khan R, Al-Jurayb H, Alahmed A, Tahir AI, Khalil D, Edwards N, Al Abdulaziz B, Binhumaid FS, Majid S, Faquih T, El-Kalioby M, Abouelhoda M, Altassan N, Monies D, Meyer B, Sayer JA, Albaqumi M.
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| J Med Genet 53(5):338-47. doi: 10.1136/jmedgenet-2015-103469. Epub 2016 Feb 9.
2016
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| 4 | NEK8, RHPD2
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| Compound heterozygous mutations in NEK8 in siblings with end-stage renal disease with hepatic and cardiac anomalies.
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| Rajagopalan R, Grochowski CM, Gilbert MA, Falsey AM, Coleman K, Romero R, Loomes KM, Piccoli DA, Devoto M, Spinner NB.
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| Am J Med Genet A 170(3):750-3. doi: 10.1002/ajmg.a.37512. Epub 2015 Dec 24.
2016
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| 5 | NEK8, RHPD2
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| Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation.
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| Grampa V, Delous M, Zaidan M, Odye G, Thomas S, Elkhartoufi N, Filhol E, Niel O, Silbermann F, Lebreton C, Collardeau-Frachon S, Rouvet I, Alessandri JL, Devisme L, Dieux-Coeslier A, Cordier MP, Capri Y, Khung-Savatovsky S, Sigaudy S, Salomon R, Antignac C, Gubler MC, Benmerah A, Terzi F, Attié-Bitach T, Jeanpierre C, Saunier S.
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| PLoS Genet 12(3):e1005894. doi: 10.1371/journal.pgen.1005894. eCollection 2016 Mar.
2016
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| 6 | NEK8, VHL
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| The tumor suppressor pVHL down-regulates never-in-mitosis A-related kinase 8 via hypoxia-inducible factors to maintain cilia in human renal cancer cells.
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| Ding XF, Zhou J, Hu QY, Liu SC, Chen G.
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| J Biol Chem 290(3):1389-94. doi: 10.1074/jbc.M114.589226. Epub 2014 Dec 1.
2015
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| 7 | ANKS6, INVS, NEK8, NPHP16, NPHP3
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| ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3.
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| Hoff S, Halbritter J, Epting D, Frank V, Nguyen TM, van Reeuwijk J, Boehlke C, Schell C, Yasunaga T, Helmstädter M, Mergen M, Filhol E, Boldt K, Horn N, Ueffing M, Otto EA, Eisenberger T, Elting MW, van Wijk JA, Bockenhauer D, Sebire NJ, Rittig S, Vyberg M, Ring T, Pohl M, Pape L, Neuhaus TJ, Elshakhs NA, Koon SJ, Harris PC, Grahammer F, Huber TB, Kuehn EW, Kramer-Zucker A, Bolz HJ, Roepman R, Saunier S, Walz G, Hildebrandt F, Bergmann C, Lienkamp SS.
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| Nat Genet 45(8):951-6. doi: 10.1038/ng.2681. Epub 2013 Jun 23. 2013
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| 8 | NEK8, RHPD2
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| Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression.
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| Frank V, Habbig S, Bartram MP, Eisenberger T, Veenstra-Knol HE, Decker C, Boorsma RA, Göbel H, Nürnberg G, Griessmann A, Franke M, Borgal L, Kohli P, Völker LA, Dötsch J, Nürnberg P, Benzing T, Bolz HJ, Johnson C, Gerkes EH, Schermer B, Bergmann C.
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| Hum Mol Genet 22(11):2177-85. doi: 10.1093/hmg/ddt070. Epub 2013 Feb 14.
2013
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| 9 | NEK8, RHPD2
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| Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.
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| Manning DK, Sergeev M, van Heesbeen RG, Wong MD, Oh JH, Liu Y, Henkelman RM, Drummond I, Shah JV, Beier DR.
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| J Am Soc Nephrol 24(1):100-12. doi: 10.1681/ASN.2012050490.
2013
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| 10 | NEK8
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| NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.
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| Choi HJ, Lin JR, Vannier JB, Slaats GG, Kile AC, Paulsen RD, Manning DK, Beier DR, Giles RH, Boulton SJ, Cimprich KA.
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| Mol Cell 51(4):423-39. doi: 10.1016/j.molcel.2013.08.006.
2013
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| 11 | NEK8, NPHP4, TAZ
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| The ciliopathy disease protein NPHP9 promotes nuclear delivery and activation of the oncogenic transcriptional regulator TAZ.
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| Habbig S, Bartram MP, Sägmüller JG, Griessmann A, Franke M, Müller RU, Schwarz R, Hoehne M, Bergmann C, Tessmer C, Reinhardt HC, Burst V, Benzing T, Schermer B.
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| Hum Mol Genet 21(26):5528-38. doi: 10.1093/hmg/dds408. Epub 2012 Oct 1.
2012
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| 12 | NEK8, NPHP9
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| The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis.
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| Zalli D, Bayliss R, Fry AM.
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| Hum Mol Genet 21(5):1155-71. doi: 10.1093/hmg/ddr544. Epub 2011 Nov 21.
2012
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| 13 | ARL13B, CC2D2A, CEP290, GLIS2, INPP5E, INVS, NEK8, NPHP2, NPHP4, TMEM67, TTC21B, XPNPEP3
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| Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.
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| Otto EA, Ramaswami G, Janssen S, Chaki M, Allen SJ, Zhou W, Airik R, Hurd TW, Ghosh AK, Wolf MT, Hoppe B, Neuhaus TJ, Bockenhauer D, Milford DV, Soliman NA, Antignac C, Saunier S, Johnson CA, Hildebrandt F; GPN Study Group.
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| J Med Genet 48(2):105-16. Epub 2010 Nov 10. 2011
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| 14 | INVS, NEK8, NPHP3
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| Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia.
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| Shiba D, Manning DK, Koga H, Beier DR, Yokoyama T.
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| Cytoskeleton (Hoboken) 67(2):112-9. doi: 10.1002/cm.20428.
2010
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| 15 | NEK8, NPHP9
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| Primary cilia and the cell cycle.
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| Plotnikova OV, Pugacheva EN, Golemis EA.
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| Methods Cell Biol 94:137-60. Epub 2009 Dec 23.PMID: 20362089 2009
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| 16 | NEK8, NPHP9
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| Too much of a good thing: does Nek8 link polycystic kidney disease and nephronophthisis?
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| Cai Y, Somlo S.
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| J Am Soc Nephrol 19(3):418-20. Epub 2008 Feb 13. No abstract available. PMID: 18272836 2008
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| 17 | NEK8, NPHP9
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| Nek8 regulates the expression and localization of polycystin-1 and polycystin-2.
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| Sohara E, Luo Y, Zhang J, Manning DK, Beier DR, Zhou J.
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| J Am Soc Nephrol 19(3):469-76. Epub 2008 Jan 30.PMID: 18235101 2008
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| 18 | NEK8, NPHP9
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| Defects in ciliary localization of Nek8 is associated with cystogenesis.
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| Trapp ML, Galtseva A, Manning DK, Beier DR, Rosenblum ND, Quarmby LM.
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| Pediatr Nephrol 23(3):377-87. Epub 2008 Jan 9.PMID: 18189147 2008
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| 19 | NEK8
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| Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures.
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| Natoli TA, Gareski TC, Dackowski WR, Smith L, Bukanov NO, Russo RJ, Husson H, Matthews D, Piepenhagen P, Ibraghimov-Beskrovnaya O.
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| Am J Physiol Renal Physiol 294(1):F73-83. Epub 2007 Oct 10.PMID: 17928412 2008
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| 20 | NEK6, NEK7, NEK8, NEK9
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| Caught Nek-ing: cilia and centrioles.
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| Quarmby LM, Mahjoub MR.
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| J Cell Sci 118(Pt 22):5161-9. Review.PMID: 16280549 2005
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| 21 | NEK8
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| Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.
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| Bowers AJ, Boylan JF.
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| Gene 328:135-42.PMID: 15019993 2004
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| 22 | NEK8
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| Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2.
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| Holland PM, Milne A, Garka K, Johnson RS, Willis C, Sims JE, Rauch CT, Bird TA, Virca GD.
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| J Biol Chem 277(18):16229-40. Epub 2002 Feb 25.PMID: 11864968 2002
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