Citations for
1KIF11, KIFC3, NEK2
The balance between KIFC3 and EG5 tetrameric kinesins controls the onset of mitotic spindle assembly.
Hata S, Pastor Peidro A, Panic M, Liu P, Atorino E, Funaya C, Jškle U, Pereira G, Schiebel E.
Nat Cell Biol 21(9):1138-1151. doi: 10.1038/s41556-019-0382-6. Epub 2019 Sep 2. 2019
2GLI1, GLI2, NEK2, SUFU
Nek2A/SuFu feedback loop regulates Gli-mediated Hedgehog signaling pathway.
Zhou F, Huang D, Li Y, Hu G, Rao H, Lu Q, Luo S, Wang Y.
Int J Oncol 50(2):373-380. doi: 10.3892/ijo.2016.3819. Epub 2016 Dec 23. 2017
3NEK2, SUFU
Nek2A phosphorylates and stabilizes SuFu: A new strategy of Gli2/Hedgehog signaling regulatory mechanism.
Wang Y, Li Y, Hu G, Huang X, Rao H, Xiong X, Luo Z, Lu Q, Luo S.
Cell Signal 28(9):1304-13. doi: 10.1016/j.cellsig.2016.06.010. Epub 2016 Jun 11. 2016
4CEP68, NEK2
Cep68 can be regulated by Nek2 and SCF complex.
Man X, Megraw TL, Lim YP.
Eur J Cell Biol 94(3-4):162-72. doi: 10.1016/j.ejcb.2015.01.004. Epub 2015 Feb 4. 2015
5CNTROB, NEK2
NEK2 phosphorylation antagonizes the microtubule stabilizing activity of centrobin.
Park J, Rhee K.
Biochem Biophys Res Commun iochem Biophys Res Commun. 2013 Jan 3. doi:pii: S0006-291X(12)02466-7. 10.1016/j.bbrc.2012.12.106. [Epub ahead of print] 2013
6FANCA, NEK2
Fanconi anemia complementation group A (FANCA) localizes to centrosomes and functions in the maintenance of centrosome integrity.
Kim S, Hwang SK, Lee M, Kwak H, Son K, Yang J, Kim SH, Lee CH.
Int J Biochem Cell Biol 45(9):1953-61. doi: 10.1016/j.biocel.2013.06.012. Epub 2013 Jun 24. 2013
7EYS, NEK2, RP25, RP67
Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease gene.
Nishiguchi KM, Tearle RG, Liu YP, Oh EC, Miyake N, Benaglio P, Harper S, Koskiniemi-Kuendig H, Venturini G, Sharon D, Koenekoop RK, Nakamura M, Kondo M, Ueno S, Yasuma TR, Beckmann JS, Ikegawa S, Matsumoto N, Terasaki H, Berson EL, Katsanis N, Rivolta C.
Proc Natl Acad Sci U S A 110(40):16139-44. doi: 10.1073/pnas.1308243110. Epub 2013 Sep 16. 2013
8CEP250, CROCC, LRRC45, NEK2
LRRC45 is a centrosome linker component required for centrosome cohesion.
He R, Huang N, Bao Y, Zhou H, Teng J, Chen J.
Cell Rep 4(6):1100-7. doi: 10.1016/j.celrep.2013.08.005. Epub 2013 Sep 12. 2013
9KIF18A, NEK2
Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex.
Sedgwick GG, Hayward DG, Di Fiore B, Pardo M, Yu L, Pines J, Nilsson J.
EMBO J 32(2):303-14. doi: 10.1038/emboj.2012.335. Epub 2013 Jan 4. 2013
10CEP250, NEK2
Nek2 localises to the distal portion of the mother centriole/basal body and is required for timely cilium disassembly at the G2/M transition.
Spalluto C, Wilson DI, Hearn T.
Eur J Cell Biol 91(9):675-86. doi: 10.1016/j.ejcb.2012.03.009. Epub 2012 May 19. 2012
11NEK2
Nek2A contributes to tumorigenic growth and possibly functions as potential therapeutic target for human breast cancer.
Wang S, Li W, Liu N, Zhang F, Liu H, Liu F, Liu J, Zhang T, Niu Y.
J Cell Biochem 113(6):1904-14. doi: 10.1002/jcb.24059. 2012
12NEK1, NEK10, NEK11, NEK2, NEK6, NEK7, NEK9
Cell cycle regulation by the NEK family of protein kinases.
Fry AM, O'Regan L, Sabir SR, Bayliss R.
J Cell Sci 125(Pt 19):4423-33. doi: 10.1242/jcs.111195. Epub 2012 Nov 6. Review. 2012
13NDC80, NEK2
Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.
Wei R, Ngo B, Wu G, Lee WH.
Mol Biol Cell 22(19):3584-94. doi: 10.1091/mbc.E11-01-0012. Epub 2011 Aug 10. 2011
14NEK2, PLK1, PPP1CC
Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction.
Mardin BR, Agircan FG, Lange C, Schiebel E.
Curr Biol 21(13):1145-51. doi: 10.1016/j.cub.2011.05.047. Epub 2011 Jun 30. 2011
15NEK2
An undecided coiled coil: the leucine zipper of Nek2 kinase exhibits atypical conformational exchange dynamics.
Croasdale R, Ivins FJ, Muskett F, Daviter T, Scott DJ, Hardy T, Smerdon SJ, Fry AM, Pfuhl M.
J Biol Chem 286(31):27537-47. doi: 10.1074/jbc.M110.196972. Epub 2011 Jun 13. 2011
16NEK2, PCNT
Involvement of a centrosomal protein kendrin in the maintenance of centrosome cohesion by modulating Nek2A kinase activity.
Matsuo K, Nishimura T, Hayakawa A, Ono Y, Takahashi M.
Biochem Biophys Res Commun 398(2):217-23. Epub 2010 Jun 18. 2010
17NEK2, SAV1, STK3
Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.
Mardin BR, Lange C, Baxter JE, Hardy T, Scholz SR, Fry AM, Schiebel E.
Nat Cell Biol 12(12):1166-76. doi: 10.1038/ncb2120. Epub 2010 Nov 14. 2010
18NEK2
Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.
Liu Q, Hirohashi Y, Du X, Greene MI, Wang Q.
Exp Mol Pathol 88(2):225-33. doi: 10.1016/j.yexmp.2009.12.004. Epub 2009 Dec 23. 2010
19NEK2
Nek2 as a novel molecular target for the treatment of breast carcinoma.
Tsunoda N, Kokuryo T, Oda K, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M.
Cancer Sci 100(1):111-6. 2009
20NEK2
The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability.
Du J, Cai X, Yao J, Ding X, Wu Q, Pei S, Jiang K, Zhang Y, Wang W, Shi Y, Lai Y, Shen J, Teng M, Huang H, Fei Q, Reddy ES, Zhu J, Jin C, Yao X.
Oncogene 27(29):4107-14. Epub 2008 Feb 25. 2008
21CEP250, CROCC, NEK2
beta-Catenin is a Nek2 substrate involved in centrosome separation.
Bahmanyar S, Kaplan DD, Deluca JG, Giddings TH Jr, O'Toole ET, Winey M, Salmon ED, Casey PJ, Nelson WJ, Barth AI.
Genes Dev 22(1):91-105. Epub 2007 Dec 17.PMID: 18086858 2008
22NEK2
Structure and regulation of the human Nek2 centrosomal kinase.
Rellos P, Ivins FJ, Baxter JE, Pike A, Nott TJ, Parkinson DM, Das S, Howell S, Fedorov O, Shen QY, Fry AM, Knapp S, Smerdon SJ.
J Biol Chem 282(9):6833-42. Epub 2006 Dec 31. 2007
23MXD1, NEK2, SGOL1
Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis.
Fu G, Ding X, Yuan K, Aikhionbare F, Yao J, Cai X, Jiang K, Yao X.
Cell Res 17(7):608-18. 2007
24CNTROB, NEK2
Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization.
Jeong Y, Lee J, Kim K, Yoo JC, Rhee K.
J Cell Sci 120(Pt 12):2106-16. Epub 2007 May 29.PMID: 17535851 2007
25NEK1, NEK11, NEK2, NEK6, NEK7, NEK9
Mitotic regulation by NIMA-related kinases.
O'regan L, Blot J, Fry AM.
Cell Div 2:25.PMID: 17727698 2007
26NEK2, PCM1
Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.
Hames RS, Crookes RE, Straatman KR, Merdes A, Hayes MJ, Faragher AJ, Fry AM.
Mol Biol Cell 16(4):1711-24. Epub 2005 Jan 19. 2005
27NECAB3, NEK2
NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi.
Yoo JC, Chang JR, Kim SH, Jang SK, Wolgemuth DJ, Kim K, Rhee K.
Exp Cell Res 292(2):393-402. 2004
28MXD1, NEK2
NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.
Lou Y, Yao J, Zereshki A, Dou Z, Ahmed K, Wang H, Hu J, Wang Y, Yao X.
J Biol Chem 279(19):20049-57. Epub 2004 Feb 20. 2004
29NEK2
Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis.
Hames RS, Fry AM.
Biochem J 361(Pt 1):77-85. 2002
30NEK2
Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.
Eto M, Elliott E, Prickett TD, Brautigan DL.
J Biol Chem 277(46):44013-20. 2002
31NEK1, NEK2, NEK3, NEK4
NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3.
Chen A, Yanai A, Arama E, Kilfin G, Motro B.
Gene 234(1):127-37. 1999
32NEK2
A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.
Fry AM, et al.
EMBO J 17(2):470-81 1998
33NEK2
Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.
Schultz SJ, et al.
Cell Growth Differ 5(6):625-35 1994
34NEK2, NEK3, MAP4K5
Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.
Schultz SJ, et al.
Cell Growth Differ 4(10):821-30 1993