1 | KIF11, KIFC3, NEK2
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| The balance between KIFC3 and EG5 tetrameric kinesins controls the onset of mitotic spindle assembly.
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| Hata S, Pastor Peidro A, Panic M, Liu P, Atorino E, Funaya C, Jäkle U, Pereira G, Schiebel E.
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| Nat Cell Biol 21(9):1138-1151. doi: 10.1038/s41556-019-0382-6. Epub 2019 Sep 2.
2019
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2 | GLI1, GLI2, NEK2, SUFU
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| Nek2A/SuFu feedback loop regulates Gli-mediated Hedgehog signaling pathway.
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| Zhou F, Huang D, Li Y, Hu G, Rao H, Lu Q, Luo S, Wang Y.
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| Int J Oncol 50(2):373-380. doi: 10.3892/ijo.2016.3819. Epub 2016 Dec 23.
2017
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3 | NEK2, SUFU
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| Nek2A phosphorylates and stabilizes SuFu: A new strategy of Gli2/Hedgehog signaling regulatory mechanism.
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| Wang Y, Li Y, Hu G, Huang X, Rao H, Xiong X, Luo Z, Lu Q, Luo S.
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| Cell Signal 28(9):1304-13. doi: 10.1016/j.cellsig.2016.06.010. Epub 2016 Jun 11.
2016
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4 | CEP68, NEK2
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| Cep68 can be regulated by Nek2 and SCF complex.
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| Man X, Megraw TL, Lim YP.
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| Eur J Cell Biol 94(3-4):162-72. doi: 10.1016/j.ejcb.2015.01.004. Epub 2015 Feb 4.
2015
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5 | CNTROB, NEK2
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| NEK2 phosphorylation antagonizes the microtubule stabilizing activity of centrobin.
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| Park J, Rhee K.
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| Biochem Biophys Res Commun iochem Biophys Res Commun. 2013 Jan 3. doi:pii: S0006-291X(12)02466-7. 10.1016/j.bbrc.2012.12.106. [Epub ahead of print]
2013
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6 | FANCA, NEK2
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| Fanconi anemia complementation group A (FANCA) localizes to centrosomes and functions in the maintenance of centrosome integrity.
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| Kim S, Hwang SK, Lee M, Kwak H, Son K, Yang J, Kim SH, Lee CH.
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| Int J Biochem Cell Biol 45(9):1953-61. doi: 10.1016/j.biocel.2013.06.012. Epub 2013 Jun 24.
2013
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7 | EYS, NEK2, RP25, RP67
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| Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease gene.
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| Nishiguchi KM, Tearle RG, Liu YP, Oh EC, Miyake N, Benaglio P, Harper S, Koskiniemi-Kuendig H, Venturini G, Sharon D, Koenekoop RK, Nakamura M, Kondo M, Ueno S, Yasuma TR, Beckmann JS, Ikegawa S, Matsumoto N, Terasaki H, Berson EL, Katsanis N, Rivolta C.
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| Proc Natl Acad Sci U S A 110(40):16139-44. doi: 10.1073/pnas.1308243110. Epub 2013 Sep 16.
2013
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8 | CEP250, CROCC, LRRC45, NEK2
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| LRRC45 is a centrosome linker component required for centrosome cohesion.
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| He R, Huang N, Bao Y, Zhou H, Teng J, Chen J.
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| Cell Rep 4(6):1100-7. doi: 10.1016/j.celrep.2013.08.005. Epub 2013 Sep 12.
2013
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9 | KIF18A, NEK2
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| Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex.
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| Sedgwick GG, Hayward DG, Di Fiore B, Pardo M, Yu L, Pines J, Nilsson J.
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| EMBO J 32(2):303-14. doi: 10.1038/emboj.2012.335. Epub 2013 Jan 4.
2013
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10 | CEP250, NEK2
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| Nek2 localises to the distal portion of the mother centriole/basal body and is required for timely cilium disassembly at the G2/M transition.
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| Spalluto C, Wilson DI, Hearn T.
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| Eur J Cell Biol 91(9):675-86. doi: 10.1016/j.ejcb.2012.03.009. Epub 2012 May 19.
2012
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11 | NEK2
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| Nek2A contributes to tumorigenic growth and possibly functions as potential therapeutic target for human breast cancer.
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| Wang S, Li W, Liu N, Zhang F, Liu H, Liu F, Liu J, Zhang T, Niu Y.
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| J Cell Biochem 113(6):1904-14. doi: 10.1002/jcb.24059.
2012
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12 | NEK1, NEK10, NEK11, NEK2, NEK6, NEK7, NEK9
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| Cell cycle regulation by the NEK family of protein kinases.
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| Fry AM, O'Regan L, Sabir SR, Bayliss R.
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| J Cell Sci 125(Pt 19):4423-33. doi: 10.1242/jcs.111195. Epub 2012 Nov 6. Review.
2012
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13 | NDC80, NEK2
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| Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.
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| Wei R, Ngo B, Wu G, Lee WH.
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| Mol Biol Cell 22(19):3584-94. doi: 10.1091/mbc.E11-01-0012. Epub 2011 Aug 10.
2011
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14 | NEK2, PLK1, PPP1CC
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| Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction.
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| Mardin BR, Agircan FG, Lange C, Schiebel E.
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| Curr Biol 21(13):1145-51. doi: 10.1016/j.cub.2011.05.047. Epub 2011 Jun 30.
2011
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15 | NEK2
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| An undecided coiled coil: the leucine zipper of Nek2 kinase exhibits atypical conformational exchange dynamics.
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| Croasdale R, Ivins FJ, Muskett F, Daviter T, Scott DJ, Hardy T, Smerdon SJ, Fry AM, Pfuhl M.
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| J Biol Chem 286(31):27537-47. doi: 10.1074/jbc.M110.196972. Epub 2011 Jun 13.
2011
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16 | NEK2, PCNT
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| Involvement of a centrosomal protein kendrin in the maintenance of centrosome cohesion by modulating Nek2A kinase activity.
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| Matsuo K, Nishimura T, Hayakawa A, Ono Y, Takahashi M.
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| Biochem Biophys Res Commun 398(2):217-23. Epub 2010 Jun 18. 2010
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17 | NEK2, SAV1, STK3
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| Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.
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| Mardin BR, Lange C, Baxter JE, Hardy T, Scholz SR, Fry AM, Schiebel E.
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| Nat Cell Biol 12(12):1166-76. doi: 10.1038/ncb2120. Epub 2010 Nov 14. 2010
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18 | NEK2
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| Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.
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| Liu Q, Hirohashi Y, Du X, Greene MI, Wang Q.
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| Exp Mol Pathol 88(2):225-33. doi: 10.1016/j.yexmp.2009.12.004. Epub 2009 Dec 23.
2010
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19 | NEK2
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| Nek2 as a novel molecular target for the treatment of breast carcinoma.
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| Tsunoda N, Kokuryo T, Oda K, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M.
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| Cancer Sci 100(1):111-6.
2009
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20 | NEK2
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| The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability.
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| Du J, Cai X, Yao J, Ding X, Wu Q, Pei S, Jiang K, Zhang Y, Wang W, Shi Y, Lai Y, Shen J, Teng M, Huang H, Fei Q, Reddy ES, Zhu J, Jin C, Yao X.
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| Oncogene 27(29):4107-14. Epub 2008 Feb 25.
2008
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21 | CEP250, CROCC, NEK2
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| beta-Catenin is a Nek2 substrate involved in centrosome separation.
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| Bahmanyar S, Kaplan DD, Deluca JG, Giddings TH Jr, O'Toole ET, Winey M, Salmon ED, Casey PJ, Nelson WJ, Barth AI.
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| Genes Dev 22(1):91-105. Epub 2007 Dec 17.PMID: 18086858 2008
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22 | NEK2
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| Structure and regulation of the human Nek2 centrosomal kinase.
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| Rellos P, Ivins FJ, Baxter JE, Pike A, Nott TJ, Parkinson DM, Das S, Howell S, Fedorov O, Shen QY, Fry AM, Knapp S, Smerdon SJ.
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| J Biol Chem 282(9):6833-42. Epub 2006 Dec 31. 2007
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23 | MXD1, NEK2, SGOL1
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| Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis.
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| Fu G, Ding X, Yuan K, Aikhionbare F, Yao J, Cai X, Jiang K, Yao X.
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| Cell Res 17(7):608-18. 2007
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24 | CNTROB, NEK2
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| Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization.
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| Jeong Y, Lee J, Kim K, Yoo JC, Rhee K.
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| J Cell Sci 120(Pt 12):2106-16. Epub 2007 May 29.PMID: 17535851 2007
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25 | NEK1, NEK11, NEK2, NEK6, NEK7, NEK9
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| Mitotic regulation by NIMA-related kinases.
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| O'regan L, Blot J, Fry AM.
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| Cell Div 2:25.PMID: 17727698 2007
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26 | NEK2, PCM1
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| Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.
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| Hames RS, Crookes RE, Straatman KR, Merdes A, Hayes MJ, Faragher AJ, Fry AM.
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| Mol Biol Cell 16(4):1711-24. Epub 2005 Jan 19. 2005
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27 | NECAB3, NEK2
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| NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi.
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| Yoo JC, Chang JR, Kim SH, Jang SK, Wolgemuth DJ, Kim K, Rhee K.
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| Exp Cell Res 292(2):393-402.
2004
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28 | MXD1, NEK2
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| NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.
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| Lou Y, Yao J, Zereshki A, Dou Z, Ahmed K, Wang H, Hu J, Wang Y, Yao X.
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| J Biol Chem 279(19):20049-57. Epub 2004 Feb 20.
2004
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29 | NEK2
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| Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis.
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| Hames RS, Fry AM.
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| Biochem J 361(Pt 1):77-85. 2002
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30 | NEK2
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| Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.
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| Eto M, Elliott E, Prickett TD, Brautigan DL.
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| J Biol Chem 277(46):44013-20. 2002
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31 | NEK1, NEK2, NEK3, NEK4
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| NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3.
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| Chen A, Yanai A, Arama E, Kilfin G, Motro B.
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| Gene 234(1):127-37.
1999
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32 | NEK2
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| A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.
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| Fry AM, et al.
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| EMBO J 17(2):470-81 1998
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33 | NEK2
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| Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.
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| Schultz SJ, et al.
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| Cell Growth Differ 5(6):625-35 1994
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34 | NEK2, NEK3, MAP4K5
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| Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.
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| Schultz SJ, et al.
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| Cell Growth Differ 4(10):821-30 1993
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