| 1 | NDFIP1, NEDD4L
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| The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation.
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| Yip KH, Kolesnikoff N, Hauschild N, Biggs L, Lopez AF, Galli SJ, Kumar S, Grimbaldeston MA.
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| Nat Commun 7:13198. doi: 10.1038/ncomms13198. 2016
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| 2 | NEDD4L, USP36
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| Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).
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| Anta B, Martín-Rodríguez C, Gomis-Perez C, Calvo L, López-Benito S, Calderón-García AA, Vicente-García C, Villarroel Á, Arévalo JC.
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| J Biol Chem 291(36):19132-45. doi: 10.1074/jbc.M116.722637. Epub 2016 Jul 21.
2016
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| 3 | NEDD4L, SLC12A3, WNK1
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| Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action.
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| Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR.
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| J Clin Invest 125(9):3433-48. doi: 10.1172/JCI75245. Epub 2015 Aug 4.
2015
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| 4 | KCNH2, NDFIP1, NEDD4L
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| Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).
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| Kang Y, Guo J, Yang T, Li W, Zhang S.
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| Biochem J 472(1):71-82. doi: 10.1042/BJ20141282. Epub 2015 Sep 11.
2015
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| 5 | NEDD4L, SLC12A3, WNK3
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| WNK3 abrogates the NEDD4-2-mediated inhibition of the renal Na+-Cl- cotransporter.
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| Lagnaz D, Arroyo JP, Chávez-Canales M, Vázquez N, Rizzo F, Spirlí A, Debonneville A, Staub O, Gamba G.
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| Am J Physiol Renal Physiol 307(3):F275-86. doi: 10.1152/ajprenal.00574.2013. Epub 2014 Jun 11.
2014
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| 6 | NEDD4L
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| Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics.
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| McDonough CW, Burbage SE, Duarte JD, Gong Y, Langaee TY, Turner ST, Gums JG, Chapman AB, Bailey KR, Beitelshees AL, Boerwinkle E, Pepine CJ, Cooper-Dehoff RM, Johnson JA.
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| J Hypertens Hypertens. 2013 Jan 30. [Epub ahead of print]
2013
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| 7 | NEDD4L
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| Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension.
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| Ronzaud C, Loffing-Cueni D, Hausel P, Debonneville A, Malsure SR, Fowler-Jaeger N, Boase NA, Perrier R, Maillard M, Yang B, Stokes JB, Koesters R, Kumar S, Hummler E, Loffing J, Staub O.
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| J Clin Invest Clin Invest. 2013 Jan 25. doi:pii: 61110. 10.1172/JCI61110. [Epub ahead of print]
2013
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| 8 | GLIS3, NDRG1, NEDD4L
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| The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways.
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| Kovacevic Z, Chikhani S, Lui GY, Sivagurunathan S, Richardson DR.
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| Antioxid Redox Signal 18(8):874-87. doi: 10.1089/ars.2011.4273. Epub 2012 May 8.
2013
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| 9 | KCNH2, NEDD4L, RAB4A
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| Regulation of the human ether-a-go-go-related gene (hERG) channel by Rab4 protein through neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2).
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| Cui Z, Zhang S.
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| J Biol Chem 288(30):21876-86. doi: 10.1074/jbc.M113.461715.
2013
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| 10 | CNKSR3, NEDD4L, SCNN1A, SCNN1B, SCNN1D, SGK1
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| Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex.
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| Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D.
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| J Biol Chem 287(39):33014-25. Epub 2012 Jul 31.
2012
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| 11 | NEDD4L, SLC5A7
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| The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2.
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| Yamada H, Imajoh-Ohmi S, Haga T.
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| Biomed Res 33(1):1-8.
2012
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| 12 | NEDD4L
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| Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
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| Gao C, Pang L, Ren C, Ma T.
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| Med Oncol 29(3):1733-8. doi: 10.1007/s12032-011-0061-3. Epub 2011 Sep 11.
2012
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| 13 | AMOT, ITCH, NEDD4, NEDD4L
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| The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation.
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| Wang C, An J, Zhang P, Xu C, Gao K, Wu D, Wang D, Yu H, Liu JO, Yu L.
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| Biochem J 444(2):279-89. doi: 10.1042/BJ20111983.
2012
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| 14 | CAV3, KCNH2, NEDD4L
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| Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2.
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| Guo J, Wang T, Li X, Shallow H, Yang T, Li W, Xu J, Fridman MD, Yang X, Zhang S.
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| J Biol Chem 287(40):33132-41.
2012
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| 15 | NEDD4L, SCNN1A
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| Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease.
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| Kimura T, Kawabe H, Jiang C, Zhang W, Xiang YY, Lu C, Salter MW, Brose N, Lu WY, Rotin D.
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| Proc Natl Acad Sci U S A 108(8):3216-21. Epub 2011 Feb 7.
2011
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| 16 | NEDD4L
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| Structure and function of a HECT domain ubiquitin-binding site.
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| Kim HC, Steffen AM, Oldham ML, Chen J, Huibregtse JM.
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| EMBO Rep 12(4):334-41. Epub 2011 Mar 11.
2011
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| 17 | NEDD4L
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| A functional variant of the NEDD4L gene is associated with beneficial treatment response with β-blockers and diuretics in hypertensive patients.
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| Svensson-Färbom P, Wahlstrand B, Almgren P, Dahlberg J, Fava C, Kjeldsen S, Hedner T, Melander O.
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| J Hypertens 29(2):388-95. doi: 10.1097/HJH.0b013e3283410390.
2011
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| 18 | NEDD4, NEDD4L, THBS1
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| The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.
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| Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D.
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| J Biol Chem 285(9):6770-80. Epub 2009 Dec 21.PMID: 20026598 2010
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| 19 | NEDD4L, TRPV6
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| Down-regulation of intestinal apical calcium entry channel TRPV6 by ubiquitin E3 ligase Nedd4-2.
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| Zhang W, Na T, Wu G, Jing H, Peng JB.
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| J Biol Chem 285(47):36586-96. Epub 2010 Sep 15.
2010
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| 20 | NEDD4L
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| Human Nedd4L rs4149601 G allele generates evolutionary new isoform I with C2 domain.
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| Ishigami T, Araki N, Umemura S.
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| Hypertension 55(2):e10; author reply e11. doi: 10.1161/HYPERTENSIONAHA.109.146738. Epub 2009 Dec 28. No abstract available.
2010
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| 21 | NEDD4L, SCN8A
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| Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK.
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| Gasser A, Cheng X, Gilmore ES, Tyrrell L, Waxman SG, Dib-Hajj SD.
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| J Biol Chem 285(34):26149-61. doi: 10.1074/jbc.M109.098681. Epub 2010 Jun 8.
2010
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| 22 | NEDD4L
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| Regulation of the RSP5 ubiquitin ligase by an intrinsic ubiquitin-binding site.
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| French ME, Kretzmann BR, Hicke L.
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| J Biol Chem 284(18):12071-9. Epub 2009 Feb 27.
2009
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| 23 | NEDD4L
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| A human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domain.
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| Garrone NF, Blazer-Yost BL, Weiss RB, Lalouel JM, Rohrwasser A.
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| BMC Cell Biol 10:26.
2009
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| 24 | NEDD4L, NPC2, SCNN1A
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| Identification of NPC2 protein as interaction molecule with C2 domain of human Nedd4L.
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| Araki N, Ishigami T, Ushio H, Minegishi S, Umemura M, Miyagi Y, Aoki I, Morinaga H, Tamura K, Toya Y, Uchino K, Umemura S.
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| Biochem Biophys Res Commun 388(2):290-6. Epub 2009 Aug 5.PMID: 19664597 2009
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| 25 | NEDD4L
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| Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.
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| Gao S, Alarcón C, Sapkota G, Rahman S, Chen PY, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P, Massagué J.
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| Mol Cell 36(3):457-68. doi: 10.1016/j.molcel.2009.09.043.
2009
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| 26 | NEDD4L, TNK2
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| Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.
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| Chan W, Tian R, Lee YF, Sit ST, Lim L, Manser E.
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| J Biol Chem 284(12):8185-94. doi: 10.1074/jbc.M806877200. Epub 2009 Jan 14.
2009
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| 27 | NDFIP1, NEDD4, NEDD4L
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| Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins.
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| Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, Tan SS.
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| J Biol Chem 283(47):32621-7. Epub 2008 Sep 25.
2008
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| 28 | CYTH1, NEDD4L
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| A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.
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| Dehring DA, Adler AS, Hosseini A, Hicke L.
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| J Biol Chem 283(49):34188-96. Epub 2008 Oct 2.
2008
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| 29 | NEDD4L, TTYH1, TTYH2, TTYH3
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| The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels.
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| He Y, Hryciw DH, Carroll ML, Myers SA, Whitbread AK, Kumar S, Poronnik P, Hooper JD.
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| J Biol Chem 283(35):24000-10. Epub 2008 Jun 24.
2008
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| 30 | NEDD4L, SCNN1A
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| Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension.
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| Araki N, Umemura M, Miyagi Y, Yabana M, Miki Y, Tamura K, Uchino K, Aoki R, Goshima Y, Umemura S, Ishigami T.
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| Hypertension 51(3):773-7. Epub 2008 Feb 11.PMID: 18268134 2008
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| 31 | ADRBK1, NEDD4, NEDD4L
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| GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.
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| Sanchez-Perez A, Kumar S, Cook DI.
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| Biochem Biophys Res Commun 359(3):611-5. Epub 2007 May 29. 2007
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| 32 | PSALD, SCNN1B, NEDD4L, SCNN1G
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| Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.
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| Knight KK, Olson DR, Zhou R, Snyder PM.
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| Proc Natl Acad Sci U S A [Epub ahead of print] 2006
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| 33 | NEDD4L, SCNN1G
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| 14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase.
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| Ichimura T, Yamamura H, Sasamoto K, Tominaga Y, Taoka M, Kakiuchi K, Shinkawa T, Takahashi N, Shimada S, Isobe T.
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| J Biol Chem 280(13):13187-94. Epub 2005 Jan 26. 2005
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| 34 | NEDD4L
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| Association of NEDD4L ubiquitin ligase with essential hypertension.
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| Russo CJ, Melista E, Cui J, DeStefano AL, Bakris GL, Manolis AJ, Gavras H, Baldwin CT.
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| Hypertension 46(3):488-91. Epub 2005 Aug 15. 2005
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| 35 | NEDD4, NEDD4L, SGK3, SGK1, SLC5A1
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| Regulation of glucose transporter SGLT1 by ubiquitin ligase Nedd4-2 and kinases SGK1, SGK3, and PKB.
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| Dieter M, Palmada M, Rajamanickam J, Aydin A, Busjahn A, Boehmer C, Luft FC, Lang F.
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| Obes Res 12(5):862-70. 2004
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| 36 | SCN5A, NEDD4, NEDD4L
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| Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.
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| van Bemmelen MX, Rougier JS, Gavillet B, Apotheloz F, Daidie D, Tateyama M, Rivolta I, Thomas MA, Kass RS, Staub O, Abriel H.
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| Circ Res 95(3):284-91. Epub 2004 Jun 24. 2004
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| 37 | NEDD4L
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| Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells.
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| Qi H, Grenier J, Fournier A, Labrie C.
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| Mol Cell Endocrinol 210(1-2):51-62. 2003
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| 38 | NEDD4L
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| NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene.
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| Chen H, Ross CA, Wang N, Huo Y, MacKinnon DF, Potash JB, Simpson SG, McMahon FJ, DePaulo Jr JR, McInnis MG.
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| Eur J Hum Genet 9(12):922-30. 2001
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| 39 | NEDD4L
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| The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.
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| Harvey KF, Dinudom A, Cook DI, Kumar S.
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| J Biol Chem 276(11):8597-601. 2001
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| 40 | NEDD4L
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| Rsp5, a ubiquitin-protein ligase, is involved in degradation of the single-stranded-DNA binding protein rfa1 in Saccharomyces cerevisiae.
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| Erdeniz N, Rothstein R.
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| Mol Cell Biol 20(1):224-32. 2000
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| 41 | FMNL1, NEDD4L
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| FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages.
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| Yayoshi-Yamamoto S, Taniuchi I, Watanabe T.
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| Mol Cell Biol 20(18):6872-81. 2000
|