| 1 | NDN
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| Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome.
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| Matarazzo V, Caccialupi L, Schaller F, Shvarev Y, Kourdougli N, Bertoni A, Menuet C, Voituron N, Deneris E, Gaspar P, Bezin L, Durbec P, Hilaire G, Muscatelli F.
|
| Elife 6. pii: e32640. doi: 10.7554/eLife.32640.
2017
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| 2 | MAGED1, NDN
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| Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1.
|
| Ju H, Lee S, Lee J, Ghil S.
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| Biochem Biophys Res Commun 489(2):109-115. doi: 10.1016/j.bbrc.2017.05.101. Epub 2017 May 19.
2017
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| 3 | LRP6, NDN
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| Hypermethylation of NDN promotes cell proliferation by activating the Wnt signaling pathway in colorectal cancer.
|
| Hu YH, Chen Q, Lu YX, Zhang JM, Lin C, Zhang F, Zhang WJ, Li XM, Zhang W, Li XN.
|
| Oncotarget 8(28):46191-46203. doi: 10.18632/oncotarget.17580.
2017
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| 4 | DLX5, MAGED1, NDN
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| Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1.
|
| Ju H, Lee S, Lee J, Ghil S.
|
| Biochem Biophys Res Commun 489(2):109-115. doi: 10.1016/j.bbrc.2017.05.101. Epub 2017 May 19.
2017
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| 5 | MAGED1, MAGED2, MAGED4, MAGEE1, MAGEE2, MAGEF1, MAGEH1, NDN, NSMCE3, TRO
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| Molecular evolution of type II MAGE genes from ancestral MAGED2 gene and their phylogenetic resolution of basal mammalian clades.
|
| De Donato M, Peters SO, Hussain T, Rodulfo H, Thomas BN, Babar ME, Imumorin IG.
|
| Mamm Genome 28(9-10):443-454. doi: 10.1007/s00335-017-9695-6. Epub 2017 May 17.
2017
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| 6 | NDN, PPARGC1A
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| Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.
|
| Hasegawa K, Yasuda T, Shiraishi C, Fujiwara K, Przedborski S, Mochizuki H, Yoshikawa K.
|
| Nat Commun 7:10943. doi: 10.1038/ncomms10943.
2016
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| 7 | NDN
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| NDN is an imprinted tumor suppressor gene that is downregulated in ovarian cancers through genetic and epigenetic mechanisms.
|
| Yang H, Das P, Yu Y, Mao W, Wang Y, Baggerly K, Wang Y, Marquez RT, Bedi A, Liu J, Fishman D, Lu Z, Bast RC Jr.
|
| Oncotarget 7(3):3018-32. doi: 10.18632/oncotarget.6576.
2016
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| 8 | NDN
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| Necdin is a breast cancer metastasis suppressor that regulates the transcription of c-Myc.
|
| Lee M, Beggs SM, Gildea D, Bupp S, Lichtenberg J, Trivedi NS; NISC Comparative Sequencing Program, Hu Y, Bodine DM, Crawford NP.
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| Oncotarget 6(31):31557-68. doi: 10.18632/oncotarget.5230.
2015
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| 9 | GNAO1, NDN
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| The alpha subunit of Go modulates cell proliferation and differentiation through interactions with Necdin.
|
| Ju H, Lee S, Kang S, Kim SS, Ghil S.
|
| Cell Commun Signal 12:39. doi: 10.1186/s12964-014-0039-9.
2014
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| 10 | CBX4, MAGED1, MAGEF1, MAGEL2, NDN, NSMCE2, PIAS1, STAT1
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| Necdin promotes ubiquitin-dependent degradation of PIAS1 SUMO E3 ligase.
|
| Gur I, Fujiwara K, Hasegawa K, Yoshikawa K.
|
| PLoS One 9(6):e99503. doi: 10.1371/journal.pone.0099503. eCollection 2014. 2014
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| 11 | CYS1, MYC, NDN
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| The ciliary protein cystin forms a regulatory complex with necdin to modulate Myc expression.
|
| Wu M, Yang C, Tao B, Bu S, Guay-Woodford LM.
|
| PLoS One 8(12):e83062. doi: 10.1371/journal.pone.0083062. eCollection 2013.
2013
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| 12 | NDN
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| Necdin controls proliferation and apoptosis of embryonic neural stem cells in an oxygen tension-dependent manner.
|
| Huang Z, Fujiwara K, Minamide R, Hasegawa K, Yoshikawa K.
|
| J Neurosci 33(25):10362-73. doi: 10.1523/JNEUROSCI.5682-12.2013.
2013
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| 13 | MAGED1, MAGEL2, NDN, OXT
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| Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus.
|
| Dombret C, Nguyen T, Schakman O, Michaud JL, Hardin-Pouzet H, Bertrand MJ, De Backer O.
|
| Hum Mol Genet 21(21):4703-17. doi: 10.1093/hmg/dds310. Epub 2012 Aug 2.
2012
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| 14 | CCAR1, NDN
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| Necdin enhances myoblasts survival by facilitating the degradation of the mediator of apoptosis CCAR1/CARP1.
|
| François S, D'Orlando C, Fatone T, Touvier T, Pessina P, Meneveri R, Brunelli S.
|
| PLoS One 7(8):e43335. doi: 10.1371/journal.pone.0043335. Epub 2012 Aug 14.
2012
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| 15 | NDN
|
| Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells.
|
| Asai T, Liu Y, Di Giandomenico S, Bae N, Ndiaye-Lobry D, Deblasio A, Menendez S, Antipin Y, Reva B, Wevrick R, Nimer SD.
|
| Blood 120(8):1601-12. doi: 10.1182/blood-2011-11-393983. Epub 2012 Jul 9.
2012
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| 16 | FOXO1, NDN, SIRT1, TP53
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| Necdin controls Foxo1 acetylation in hypothalamic arcuate neurons to modulate the thyroid axis.
|
| Hasegawa K, Kawahara T, Fujiwara K, Shimpuku M, Sasaki T, Kitamura T, Yoshikawa K.
|
| J Neurosci 32(16):5562-72. doi: 10.1523/JNEUROSCI.0142-12.2012.
2012
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| 17 | NDN
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| Loss of the Prader-Willi obesity syndrome protein necdin promotes adipogenesis.
|
| Bush JR, Wevrick R.
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| Gene 497(1):45-51. doi: 10.1016/j.gene.2012.01.027. Epub 2012 Jan 27.
2012
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| 18 | NDN, TNFRSF1A
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| Necdin protects embryonic motoneurons from programmed cell death.
|
| Aebischer J, Sturny R, Andrieu D, Rieusset A, Schaller F, Geib S, Raoul C, Muscatelli F.
|
| PLoS One 6(9):e23764. doi: 10.1371/journal.pone.0023764. Epub 2011 Sep 2.
2011
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| 19 | NDN
|
| Loss of Necdin impairs myosin activation and delays cell polarization.
|
| Bush JR, Wevrick R.
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| Genesis 48(9):540-53. doi: 10.1002/dvg.20658.
2010
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| 20 | NDN
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| Necdin promotes tangential migration of neocortical interneurons from basal forebrain.
|
| Kuwajima T, Hasegawa K, Yoshikawa K.
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| J Neurosci 30(10):3709-14. doi: 10.1523/JNEUROSCI.5797-09.2010.
2010
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| 21 | DUP15QP, GABRB3, NDN, SNRPN, UBE3A
|
| Chromosome 15q11-13 duplication syndrome brain reveals epigenetic alterations in gene expression not predicted from copy number.
|
| Hogart A, Leung KN, Wang NJ, Wu DJ, Driscoll J, Vallero RO, Schanen NC, LaSalle JM.
|
| J Med Genet 46(2):86-93. Epub 2008 Oct 7.
2009
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| 22 | GNRH1, MSX1, MSX2, NDN, PWS
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| Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development.
|
| Miller NL, Wevrick R, Mellon PL.
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| Hum Mol Genet 18(2):248-60. Epub 2008 Oct 17.
2009
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| 23 | MAGEL2, MKRN3, NDN, PWS
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| A paternal deletion of MKRN3, MAGEL2 and NDN does not result in Prader-Willi syndrome.
|
| Kanber D, Giltay J, Wieczorek D, Zogel C, Hochstenbach R, Caliebe A, Kuechler A, Horsthemke B, Buiting K.
|
| Eur J Hum Genet 17(5):582-90. Epub 2008 Dec 10.
2009
|
| 24 | NDN
|
| Necdin: a multi functional protein with potential tumor suppressor role?
|
| Chapman EJ, Knowles MA.
|
| Mol Carcinog 48(11):975-81.PMID: 19626646 2009
|
| 25 | NDN, PWS
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| Necdin plays a role in the serotonergic modulation of the mouse respiratory network: implication for Prader-Willi syndrome.
|
| Zanella S, Watrin F, Mebarek S, Marly F, Roussel M, Gire C, Diene G, Tauber M, Muscatelli F, Hilaire G.
|
| J Neurosci 28(7):1745-55.
2008
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| 26 | EID1, NDN
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| The Prader-Willi syndrome protein necdin interacts with the E1A-like inhibitor of differentiation EID-1 and promotes myoblast differentiation.
|
| Bush JR, Wevrick R.
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| Differentiation 76(9):994-1005. Epub 2008 Jun 13.PMID: 18557765 2008
|
| 27 | ACOT2, AFAP1L1, ALG11, ANKS1A, ARMC6, ARPC1A, ARPC3, ARPC5L, ATG10, ATP5L, BAZ1A, BCAS2, C2orf44, CAPZA1, CAPZA2, CCDC47, CERS2, CMBL, CPSF2, CSTF3, CXorf56, EXT2, FAF2, FBXO4, FIBP, GLRX3, GPS1, GSKIP, INPP5K, KPNA4, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT36, LUC7L2, MAGED1, MED7, MMS22L, MPRIP, MPRIP, MRCL3, NAA25, NDN, NPEPPS, NRDE2, OLA1, ORCTL3, OSTF1, PH4B, PIP5K1B, PKIG, PMVK, PSMC1, PSMC2, PSPH, RAB11FIP1, RBX1, RNF219, RO60, RPS14, SF3B14, SF3B2, SFRS12, STK25, TLK2, TONSL, TPM3, TRMT112, TSPAN17, TWF2, UBE2M, UNC45A, UQCRC1, WRAP73, XPO7, ZRANB2
|
| Large-scale mapping of human protein-protein interactions by mass spectrometry.
|
| Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D.
|
| Mol Syst Biol 3:89. Epub 2007 Mar 13. 2007
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| 28 | NDN
|
| Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation.
|
| Deponti D, François S, Baesso S, Sciorati C, Innocenzi A, Broccoli V, Muscatelli F, Meneveri R, Clementi E, Cossu G, Brunelli S.
|
| J Cell Biol 179(2):305-19.PMID: 17954612 2007
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| 29 | NDN, PWS
|
| Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death.
|
| Andrieu D, Meziane H, Marly F, Angelats C, Fernandez PA, Muscatelli F.
|
| BMC Dev Biol 6:56.
2006
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| 30 | BBS4, MAGEL2, NDN, PWS
|
| Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth.
|
| Lee S, Walker CL, Karten B, Kuny SL, Tennese AA, O'Neill MA, Wevrick R.
|
| Hum Mol Genet 14(5):627-37. Epub 2005 Jan 13. 2005
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| 31 | NDN, HIF1A
|
| Negative regulation of hypoxia inducible factor-1alpha by necdin.
|
| Moon HE, Ahn MY, Park JA, Min KJ, Kwon YW, Kim KW.
|
| FEBS Lett 579(17):3797-801. 2005
|
| 32 | MAGEH1, NDN, NGFR
|
| The p75 neurotrophin receptor interacts with multiple MAGE proteins.
|
| Tcherpakov M, Bronfman FC, Conticello SG, Vaskovsky A, Levy Z, Niinobe M, Yoshikawa K, Arenas E, Fainzilber M.
|
| J Biol Chem. Dec 20;277(51):49101-4. doi: 10.1074/jbc.C200533200. Epub 2002 Oct 31 2002
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| 33 | NDN
|
| Necdin acts as a transcriptional repressor that interacts with multiple guanosine clusters.
|
| Matsumoto K, Taniura H, Uetsuki T, Yoshikawa K.
|
| Gene 272(1-2):173-9. 2001
|
| 34 | NUCB2, NDN
|
| The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm.
|
| Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K.
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| J Biol Chem 275(41):31674-81. 2000
|
| 35 | NDN
|
| Necdin-deficient mice do not show lethality or the obesity and infertility of Prader-Willi syndrome.
|
| Tsai TF, et al.
|
| Nat Genet 22(1):15-6. No abstract available 1999
|
| 36 | NDN
|
| Disruption of the mouse necdin gene results in early post-natal lethality.
|
| Gerard M, et al.
|
| Nat Genet 23(2):199-202 1999
|
| 37 | E2F1, NDN, TP53
|
| Physical and functional interactions of neuronal growth suppressor necdin with p53.
|
| Taniura H, Matsumoto K, Yoshikawa K.
|
| J Biol Chem 274(23):16242-8 1999
|
| 38 | E2F1, NDN
|
| Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1.
|
| Taniura H, Taniguchi N, Hara M, Yoshikawa K.
|
| J Biol Chem 273(2):720-8 1998
|
| 39 | NDN
|
| The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region.
|
| Nakada Y, Taniura H, Uetsuki T, Inazawa J, Yoshikawa K.
|
| Gene 213(1-2):65-72 1998
|
| 40 | NDN
|
| The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse.
|
| MacDonald HR, Wevrick R.
|
| Hum Mol Genet 6(11):1873-8. 1997
|
| 41 | NDN
|
| The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region.
|
| Jay P, Rougeulle C, Massacrier A, Moncla A, Mattei MG, Malzac P, Roeckel N, Taviaux S, Lefranc JL, Cau P, Berta P, Lalande M, Muscatelli F.
|
| Nat Genet 17(3):357-61. 1997
|
| 42 | NDN
|
| The mouse necdin gene is expressed from the paternal allele only and lies in the 7C region of the mouse chromosome 7, a region of conserved synteny to the human Prader-Willi syndrome region.
|
| Watrin F, Roeckel N, Lacroix L, Mignon C, Mattei MG, Disteche C, Muscatelli F.
|
| Eur J Hum Genet 5(5):324-32. 1997
|