Citations for
1NDFIP1, NTRK02, RAB7A
Ubiquitin Regulation of Trk Receptor Trafficking and Degradation.
Murray SS, Wong AW, Yang J, Li Y, Putz U, Tan SS, Howitt J.
Mol Neurobiol ol Neurobiol. 2018 Jun 18. doi: 10.1007/s12035-018-1179-5. [Epub ahead of print] 2018
2NDFIP1, NDFIP2
NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation.
Trimpert C, Wesche D, de Groot T, Pimentel Rodriguez MM, Wong V, van den Berg DTM, Cheval L, Ariza CA, Doucet A, Stagljar I, Deen PMT.
PLoS One 12(9):e0183774. doi: 10.1371/journal.pone.0183774. eCollection 2017. 2017
3NDFIP1
Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production.
Layman AAK, Sprout SL, Phillips D, Oliver PM.
Sci Rep 7:39649. doi: 10.1038/srep39649. 2017
4NDFIP1, NEDD4L
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation.
Yip KH, Kolesnikoff N, Hauschild N, Biggs L, Lopez AF, Galli SJ, Kumar S, Grimbaldeston MA.
Nat Commun 7:13198. doi: 10.1038/ncomms13198. 2016
5NDFIP1, NDFIP2
Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.
O'Leary CE, Riling CR, Spruce LA, Ding H, Kumar S, Deng G, Liu Y, Seeholzer SH, Oliver PM.
Nat Commun 7:11226. doi: 10.1038/ncomms11226. 2016
6NDFIP1, NDFIP2, SLC11A2
Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver.
Foot NJ, Gembus KM, Mackenzie K, Kumar S.
Sci Rep 6:24045. doi: 10.1038/srep24045. 2016
7KCNH2, NDFIP1, NEDD4L
Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).
Kang Y, Guo J, Yang T, Li W, Zhang S.
Biochem J 472(1):71-82. doi: 10.1042/BJ20141282. Epub 2015 Sep 11. 2015
8NDFIP1
Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells.
Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y.
Biochem Biophys Res Commun 465(4):851-6. doi: 10.1016/j.bbrc.2015.08.099. Epub 2015 Aug 28. 2015
9ITCH, NDFIP1, UBE2L3
Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
Kathania M, Zeng M, Yadav VN, Moghaddam SJ, Yang B, Venuprasad K.
J Immunol 194(5):2160-7. doi: 10.4049/jimmunol.1402742. Epub 2015 Jan 28. 2015
10NDFIP1, PTEN, RAB5A
Rab5 and Ndfip1 are involved in Pten ubiquitination and nuclear trafficking.
Li Y, Low LH, Putz U, Goh CP, Tan SS, Howitt J.
Traffic 15(7):749-61. doi: 10.1111/tra.12175. Epub 2014 Jun 3. 2014
11NDFIP1
Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels.
Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS.
PLoS One 9(1):e87119. doi: 10.1371/journal.pone.0087119. eCollection 2014. 2014
12NDFIP1, SLC11A2
Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels.
Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS.
PLoS One 9(1):e87119. doi: 10.1371/journal.pone.0087119. eCollection 2014. 2014
13NDFIP1
Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development.
Goh CP, Low LH, Putz U, Gunnersen J, Hammond V, Howitt J, Tan SS.
Neurosci Lett 555:225-30. doi: 10.1016/j.neulet.2013.09.017. Epub 2013 Sep 13. 2013
14CD28, NDFIP1
Ndfip1 enforces a requirement for CD28 costimulation by limiting IL-2 production.
Ramos-Hernández N, Ramon HE, Beal AM, Laroche A, Dekleva EA, Oliver PM.
J Immunol 191(4):1536-46. doi: 10.4049/jimmunol.1203571. Epub 2013 Jul 12. 2013
15NDFIP1, PTEN
The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells.
Putz U, Howitt J, Doan A, Goh CP, Low LH, Silke J, Tan SS.
Sci Signal 5(243):ra70. 2012
16NDFIP1
The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines.
Ramon HE, Beal AM, Liu Y, Worthen GS, Oliver PM.
J Immunol 188(8):4023-31. doi: 10.4049/jimmunol.1102779. Epub 2012 Mar 7. 2012
17NDFIP1, SLC11A2
Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis.
Foot NJ, Leong YA, Dorstyn LE, Dalton HE, Ho K, Zhao L, Garrick MD, Yang B, Hiwase D, Kumar S.
Blood 117(2):638-46. doi: 10.1182/blood-2010-07-295287. Epub 2010 Oct 19. 2011
18NDFIP1, NDFIP2
Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.
Mund T, Pelham HR.
Proc Natl Acad Sci U S A 107(25):11429-34. Epub 2010 Jun 7.PMID: 20534535 2010
19NDFIP1, SLC11A2
Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.
Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS.
Proc Natl Acad Sci U S A 106(36):15489-94. Epub 2009 Aug 25.PMID: 19706893 2009
20NDFIP1, NDFIP2
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.
Mund T, Pelham HR.
EMBO Rep 10(5):501-7. Epub 2009 Apr 3.PMID: 19343052 2009
21NDFIP1, NEDD4, NEDD4L
Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins.
Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, Tan SS.
J Biol Chem 283(47):32621-7. Epub 2008 Sep 25. 2008
22NDFIP1, NDFIP2, SLC11A2, WWP2
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.
Foot NJ, Dalton HE, Shearwin-Whyatt LM, Dorstyn L, Tan SS, Yang B, Kumar S.
Blood 112(10):4268-75. Epub 2008 Sep 5.PMID: 18776082 2008
23C18orf32, EEF1D, GPR89A, MAVS, NDFIP1, PLEKHG5, SHISA5, SLC35B2, TIFA, TMED4, TRA2A, TRIM38, USE1, WLS
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T,Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S.
Oncogene 22(21):3307-18. 2003
24NDFIP1
N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.
Harvey KF, Shearwin-Whyatt LM, Fotia A, Parton RG, Kumar S.
J Biol Chem 277(11):9307-17. Epub 2001 Dec 17. 2002
25BEAN1, DEAN, NDFIP1, NEDD4, WBP2
Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4.
Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S.
Biochem J 351 Pt 3:557-65. 2000