| 1 | NDFIP1, NTRK02, RAB7A
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| Ubiquitin Regulation of Trk Receptor Trafficking and Degradation.
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| Murray SS, Wong AW, Yang J, Li Y, Putz U, Tan SS, Howitt J.
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| Mol Neurobiol ol Neurobiol. 2018 Jun 18. doi: 10.1007/s12035-018-1179-5. [Epub ahead of print]
2018
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| 2 | NDFIP1, NDFIP2
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| NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation.
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| Trimpert C, Wesche D, de Groot T, Pimentel Rodriguez MM, Wong V, van den Berg DTM, Cheval L, Ariza CA, Doucet A, Stagljar I, Deen PMT.
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| PLoS One 12(9):e0183774. doi: 10.1371/journal.pone.0183774. eCollection 2017.
2017
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| 3 | NDFIP1
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| Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production.
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| Layman AAK, Sprout SL, Phillips D, Oliver PM.
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| Sci Rep 7:39649. doi: 10.1038/srep39649.
2017
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| 4 | NDFIP1, NEDD4L
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| The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation.
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| Yip KH, Kolesnikoff N, Hauschild N, Biggs L, Lopez AF, Galli SJ, Kumar S, Grimbaldeston MA.
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| Nat Commun 7:13198. doi: 10.1038/ncomms13198. 2016
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| 5 | NDFIP1, NDFIP2
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| Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.
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| O'Leary CE, Riling CR, Spruce LA, Ding H, Kumar S, Deng G, Liu Y, Seeholzer SH, Oliver PM.
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| Nat Commun 7:11226. doi: 10.1038/ncomms11226.
2016
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| 6 | NDFIP1, NDFIP2, SLC11A2
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| Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver.
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| Foot NJ, Gembus KM, Mackenzie K, Kumar S.
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| Sci Rep 6:24045. doi: 10.1038/srep24045.
2016
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| 7 | KCNH2, NDFIP1, NEDD4L
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| Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).
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| Kang Y, Guo J, Yang T, Li W, Zhang S.
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| Biochem J 472(1):71-82. doi: 10.1042/BJ20141282. Epub 2015 Sep 11.
2015
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| 8 | NDFIP1
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| Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells.
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| Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y.
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| Biochem Biophys Res Commun 465(4):851-6. doi: 10.1016/j.bbrc.2015.08.099. Epub 2015 Aug 28.
2015
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| 9 | ITCH, NDFIP1, UBE2L3
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| Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
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| Kathania M, Zeng M, Yadav VN, Moghaddam SJ, Yang B, Venuprasad K.
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| J Immunol 194(5):2160-7. doi: 10.4049/jimmunol.1402742. Epub 2015 Jan 28.
2015
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| 10 | ATM, BRAT1, NDFIP1
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| Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response
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| Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS.
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| J Biol Chem. Mar 13;290(11):7141-50. doi: 10.1074/jbc.M114.613687. Epub 2015 Jan 28. 2015
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| 11 | NDFIP1, PTEN, RAB5A
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| Rab5 and Ndfip1 are involved in Pten ubiquitination and nuclear trafficking.
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| Li Y, Low LH, Putz U, Goh CP, Tan SS, Howitt J.
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| Traffic 15(7):749-61. doi: 10.1111/tra.12175. Epub 2014 Jun 3.
2014
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| 12 | NDFIP1
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| Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels.
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| Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS.
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| PLoS One 9(1):e87119. doi: 10.1371/journal.pone.0087119. eCollection 2014.
2014
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| 13 | NDFIP1, SLC11A2
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| Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels.
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| Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS.
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| PLoS One 9(1):e87119. doi: 10.1371/journal.pone.0087119. eCollection 2014.
2014
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| 14 | NDFIP1
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| Ndfip1 expression in developing neurons indicates a role for protein ubiquitination by Nedd4 E3 ligases during cortical development.
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| Goh CP, Low LH, Putz U, Gunnersen J, Hammond V, Howitt J, Tan SS.
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| Neurosci Lett 555:225-30. doi: 10.1016/j.neulet.2013.09.017. Epub 2013 Sep 13.
2013
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| 15 | CD28, NDFIP1
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| Ndfip1 enforces a requirement for CD28 costimulation by limiting IL-2 production.
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| Ramos-Hernández N, Ramon HE, Beal AM, Laroche A, Dekleva EA, Oliver PM.
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| J Immunol 191(4):1536-46. doi: 10.4049/jimmunol.1203571. Epub 2013 Jul 12.
2013
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| 16 | NDFIP1, PTEN
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| The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells.
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| Putz U, Howitt J, Doan A, Goh CP, Low LH, Silke J, Tan SS.
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| Sci Signal 5(243):ra70.
2012
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| 17 | NDFIP1
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| The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines.
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| Ramon HE, Beal AM, Liu Y, Worthen GS, Oliver PM.
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| J Immunol 188(8):4023-31. doi: 10.4049/jimmunol.1102779. Epub 2012 Mar 7.
2012
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| 18 | NDFIP1, SLC11A2
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| Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis.
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| Foot NJ, Leong YA, Dorstyn LE, Dalton HE, Ho K, Zhao L, Garrick MD, Yang B, Hiwase D, Kumar S.
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| Blood 117(2):638-46. doi: 10.1182/blood-2010-07-295287. Epub 2010 Oct 19.
2011
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| 19 | NDFIP1, NDFIP2
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| Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.
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| Mund T, Pelham HR.
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| Proc Natl Acad Sci U S A 107(25):11429-34. Epub 2010 Jun 7.PMID: 20534535 2010
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| 20 | NDFIP1, SLC11A2
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| Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.
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| Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS.
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| Proc Natl Acad Sci U S A 106(36):15489-94. Epub 2009 Aug 25.PMID: 19706893 2009
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| 21 | NDFIP1, NDFIP2
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| Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.
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| Mund T, Pelham HR.
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| EMBO Rep 10(5):501-7. Epub 2009 Apr 3.PMID: 19343052 2009
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| 22 | NDFIP1, NEDD4, NEDD4L
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| Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins.
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| Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, Tan SS.
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| J Biol Chem 283(47):32621-7. Epub 2008 Sep 25.
2008
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| 23 | NDFIP1, NDFIP2, SLC11A2, WWP2
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| Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.
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| Foot NJ, Dalton HE, Shearwin-Whyatt LM, Dorstyn L, Tan SS, Yang B, Kumar S.
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| Blood 112(10):4268-75. Epub 2008 Sep 5.PMID: 18776082 2008
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| 24 | C18orf32, EEF1D, GPR89A, MAVS, NDFIP1, PLEKHG5, SHISA5, SLC35B2, TIFA, TMED4, TRA2A, TRIM38, USE1, WLS
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| Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
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| Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T,Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S.
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| Oncogene 22(21):3307-18. 2003
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| 25 | NDFIP1
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| N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.
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| Harvey KF, Shearwin-Whyatt LM, Fotia A, Parton RG, Kumar S.
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| J Biol Chem 277(11):9307-17. Epub 2001 Dec 17. 2002
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| 26 | BEAN1, DEAN, NDFIP1, NEDD4, WBP2
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| Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4.
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| Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S.
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| Biochem J 351 Pt 3:557-65. 2000
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