Citations for
1KNSTRN, NDC80, SPAG5
Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80.
Kern DM, Monda JK, Su KC, Wilson-Kubalek EM, Cheeseman IM.
Elife 6. pii: e26866. doi: 10.7554/eLife.26866. 2017
2CASC5, MIS12, NDC80
A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC.
Vallardi G, Cordeiro MH, Saurin AT.
Prog Mol Subcell Biol 56:457-484. doi: 10.1007/978-3-319-58592-5_19. 2017
3NDC80
Elevated NDC80 expression is associated with poor prognosis in osteosarcoma patients.
Xu B, Wu DP, Xie RT, Liu LG, Yan XB.
Eur Rev Med Pharmacol Sci 21(9):2045-2053. 2017
4KIF4A, NDC80
Kif4 Is Essential for Mouse Oocyte Meiosis.
Camlin NJ, McLaughlin EA, Holt JE.
PLoS One 12(1):e0170650. doi: 10.1371/journal.pone.0170650. eCollection 2017. 2017
5CENC1, CENPT, MIS12, NDC80
Molecular basis of outer kinetochore assembly on CENP-T.
Huis In 't Veld PJ, Jeganathan S, Petrovic A, Singh P, John J, Krenn V, Weissmann F, Bange T, Musacchio A.
Elife 5. pii: e21007. doi: 10.7554/eLife.21007. 2016
6MIS12, NDC80
Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex.
Kudalkar EM, Scarborough EA, Umbreit NT, Zelter A, Gestaut DR, Riffle M, Johnson RS, MacCoss MJ, Asbury CL, Davis TN.
Proc Natl Acad Sci U S A 112(41):E5583-9. doi: 10.1073/pnas.1513882112. Epub 2015 Oct 1. 2015
7CENPC1, CENPT, NDC80
A quantitative description of Ndc80 complex linkage to human kinetochores.
Suzuki A, Badger BL, Salmon ED.
Nat Commun 6:8161. doi: 10.1038/ncomms9161. 2015
8NDC80, TTK
CELL DIVISION CYCLE. Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C.
Ji Z, Gao H, Yu H.
Science 348(6240):1260-4. doi: 10.1126/science.aaa4029. 2015
9NDC80, TTK
CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.
Hiruma Y, Sacristan C, Pachis ST, Adamopoulos A, Kuijt T, Ubbink M, von Castelmur E, Perrakis A, Kops GJ.
Science 348(6240):1264-7. doi: 10.1126/science.aaa4055. Epub 2015 Jun 11. 2015
10NDC80
N-terminus-modified Hec1 suppresses tumour growth by interfering with kinetochore-microtubule dynamics.
Orticello M, Fiore M, Totta P, Desideri M, Barisic M, Passeri D, Lenzi J, Rosa A, Orlandi A, Maiato H, Del Bufalo D, Degrassi F.
Oncogene 34(25):3325-35. doi: 10.1038/onc.2014.265. Epub 2014 Aug 18. 2015
11NDC80, SKA1
Structural basis for microtubule recognition by the human kinetochore Ska complex.
Abad MA, Medina B, Santamaria A, Zou J, Plasberg-Hill C, Madhumalar A, Jayachandran U, Redli PM, Rappsilber J, Nigg EA, Jeyaprakash AA.
Nat Commun 5:2964. doi: 10.1038/ncomms3964. 2014
12NDC80
Hec1/Ndc80 is overexpressed in human gastric cancer and regulates cell growth.
Qu Y, Li J, Cai Q, Liu B.
J Gastroenterol 49(3):408-18. doi: 10.1007/s00535-013-0809-y. Epub 2013 Apr 17. 2014
13AURKB, NDC80, TTK
Phosphorylation of microtubule-binding protein Hec1 by mitotic kinase Aurora B specifies spindle checkpoint kinase Mps1 signaling at the kinetochore.
Zhu T, Dou Z, Qin B, Jin C, Wang X, Xu L, Wang Z, Zhu L, Liu F, Gao X, Ke Y, Wang Z, Aikhionbare F, Fu C, Ding X, Yao X.
J Biol Chem 288(50):36149-59. doi: 10.1074/jbc.M113.507970. Epub 2013 Nov 1. 2013
14NDC80
Hec1-dependent cyclin B2 stabilization regulates the G2-M transition and early prometaphase in mouse oocytes.
Gui L, Homer H.
Dev Cell 25(1):43-54. doi: 10.1016/j.devcel.2013.02.008. Epub 2013 Mar 28. 2013
15NDC80, SKA1
The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.
Schmidt JC, Arthanari H, Boeszoermenyi A, Dashkevich NM, Wilson-Kubalek EM, Monnier N, Markus M, Oberer M, Milligan RA, Bathe M, Wagner G, Grishchuk EL, Cheeseman IM.
Dev Cell 23(5):968-80. doi: 10.1016/j.devcel.2012.09.012. Epub 2012 Oct 18. Erratum in: Dev Cell. 2012 Nov 13;23(5):1081. 2012
16AURKB, NDC80, SKA1
Aurora B controls kinetochore-microtubule attachments by inhibiting Ska complex-KMN network interaction.
Chan YW, Jeyaprakash AA, Nigg EA, Santamaria A.
J Cell Biol 196(5):563-71. doi: 10.1083/jcb.201109001. Epub 2012 Feb 27. 2012
17NDC80
Multimodal microtubule binding by the Ndc80 kinetochore complex.
Alushin GM, Musinipally V, Matson D, Tooley J, Stukenberg PT, Nogales E.
Nat Struct Mol Biol 19(11):1161-7. doi: 10.1038/nsmb.2411. Epub 2012 Oct 21. 2012
18NDC80
The Ndc80 kinetochore complex directly modulates microtubule dynamics.
Umbreit NT, Gestaut DR, Tien JF, Vollmar BS, Gonen T, Asbury CL, Davis TN.
Proc Natl Acad Sci U S A 109(40):16113-8. doi: 10.1073/pnas.1209615109. Epub 2012 Aug 20. 2012
19CENPT, NDC80
CENP-T proteins are conserved centromere receptors of the Ndc80 complex.
Schleiffer A, Maier M, Litos G, Lampert F, Hornung P, Mechtler K, Westermann S.
Nat Cell Biol 14(6):604-13. doi: 10.1038/ncb2493. 2012
20NDC80
The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement.
Tooley JG, Miller SA, Stukenberg PT.
Mol Biol Cell. 22(8):1217-26. 2011
21AURKB, MLF1IP, NDC80
CENP-U cooperates with Hec1 to orchestrate kinetochore-microtubule attachment.
Hua S, Wang Z, Jiang K, Huang Y, Ward T, Zhao L, Dou Z, Yao X.
J Biol Chem 286(2):1627-38. Epub 2010 Nov 5. 2011
22NDC80
The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore-microtubule attachment in mitosis.
Sundin LJ, Guimaraes GJ, Deluca JG.
Mol Biol Cell 22(6):759-68. Epub 2011 Jan 26. 2011
23NDC80, NEK2
Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.
Wei R, Ngo B, Wu G, Lee WH.
Mol Biol Cell 22(19):3584-94. doi: 10.1091/mbc.E11-01-0012. Epub 2011 Aug 10. 2011
24NDC80
The Ndc80 kinetochore complex forms oligomeric arrays along microtubules.
Alushin GM, Ramey VH, Pasqualato S, Ball DA, Grigorieff N, Musacchio A, Nogales E.
Nature 467(7317):805-10. 2010
25CASC5, MIS12, NDC80, NSL1
The MIS12 complex is a protein interaction hub for outer kinetochore assembly.
Petrovic A, Pasqualato S, Dube P, Krenn V, Santaguida S, Cittaro D, Monzani S, Massimiliano L, Keller J, Tarricone A, Maiolica A, Stark H, Musacchio A.
J Cell Biol 190(5):835-52. 2010
26HAUS8, NDC80
Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1.
Wu G, Wei R, Cheng E, Ngo B, Lee WH.
Mol Biol Cell 20(22):4686-95. Epub 2009 Sep 23. 2009
27NDC80, NUF2, SPC24, SPC25
Ectopic expression of plasma membrane targeted subunits of the Ndc80-complex as a tool to study kinetochore biochemistry.
Holmström TH, Rehnberg J, Ahonen LJ, Kallio MJ.
Mol Oncol ol Oncol. 2009 Feb 21. [Epub ahead of print]PMID: 19393581 2009
28NDC80, NUF2, SPC24, SPC25
siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis.
Kaneko N, Miura K, Gu Z, Karasawa H, Ohnuma S, Sasaki H, Tsukamoto N, Yokoyama S, Yamamura A, Nagase H, Shibata C, Sasaki I, Horii A.
Biochem Biophys Res Commun 390(4):1235-40. Epub 2009 Oct 28.PMID: 19878654 2009
29NDC80
Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.
Ciferri C, Pasqualato S, Screpanti E, Varetti G, Santaguida S, Dos Reis G, Maiolica A, Polka J, De Luca JG, De Wulf P, Salek M, Rappsilber J, Moores CA, Salmon ED, Musacchio A.
Cell 133(3):427-39. 2008
30NDC80, NUF2, SPC24, SPC25
Orientation and structure of the Ndc80 complex on the microtubule lattice.
Wilson-Kubalek EM, Cheeseman IM, Yoshioka C, Desai A, Milligan RA.
J Cell Biol 182(6):1055-61. Epub 2008 Sep 15.PMID: 18794333 2008
31CASC5, CENPK, NDC80
KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.
Cheeseman IM, Hori T, Fukagawa T, Desai A.
Mol Biol Cell 19(2):587-94. Epub 2007 Nov 28. 2008
32NDC80
The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment.
Wei RR, Al-Bassam J, Harrison SC.
Nat Struct Mol Biol 14(1):54-9. Epub 2006 Dec 31. 2007
33ATF4, CREB1, NDC80
Functional characterization of the promoter of human kinetochore protein HEC1: novel link between regulation of the cell cycle protein and CREB family transcription factors.
Cheng L, Li L, Qiao X, Liu J, Yao X.
Biochim Biophys Acta 1769(9-10):593-602. Epub 2007 Aug 9.PMID: 17822787 2007
34NDC80
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1.
DeLuca JG, Gall WE, Ciferri C, Cimini D, Musacchio A, Salmon ED.
Cell 127(5):969-82. 2006
35NDC80, NUF2
Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis.
Hayama S, Daigo Y, Kato T, Ishikawa N, Yamabuki T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y.
Cancer Res 66(21):10339-48. 2006
36NDC80, ZW10, ZWINT
Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control.
Lin YT, Chen Y, Wu G, Lee WH.
Oncogene 25(52):6901-14. Epub 2006 May 29.PMID: 16732327 2006
37NDC80, NUF2, SPC24, SPC25
Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain.
Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC.
Structure 14(6):1003-9.PMID: 16765893 2006
38NDC80
Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control.
Lin YT, Chen Y, Wu G, Lee WH.
Oncogene. 25(52):6901-14. 2006
39NDC80, NUF2, SPC24, SPC25
Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.
Ciferri C, De Luca J, Monzani S, Ferrari KJ, Ristic D, Wyman C, Stark H, Kilmartin J, Salmon ED, Musacchio A.
J Biol Chem 280(32):29088-95. Epub 2005 Jun 16.PMID: 15961401 2005
40SPC24, SPC25, NDC80
Identification of two novel components of the human NDC80 kinetochore complex.
Bharadwaj R, Qi W, Yu H.
J Biol Chem 279(13):13076-85. Epub 2003 Dec 29. 2004
41NDC80, NUF2, SPC24, SPC25
The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment.
McCleland ML, Kallio MJ, Barrett-Wilt GA, Kestner CA, Shabanowitz J, Hunt DF, Gorbsky GJ, Stukenberg PT.
Curr Biol 14(2):131-7.PMID: 14738735 2004
42NDC80
Role of hec1 in spindle checkpoint signaling and kinetochore recruitment of mad1/mad2.
Martin-Lluesma S, Stucke VM, Nigg EA.
Science 297(5590):2267-70. 2002
43NDC80, NEK1
Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.
Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH.
J Biol Chem 277(51):49408-16. Epub 2002 Oct 16. 2002
44NDC80, TGIF1, TYMS, YES1
Novel targets for the 18p11.3 amplification frequently observed in esophageal squamous cell carcinomas.
Nakakuki K, Imoto I, Pimkhaokham A, Fukuda Y, Shimada Y, Imamura M, Amagasa T, Inazawa J.
Carcinogenesis 23(1):19-24. 2002
45NDC80
HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis.
Chen Y, Riley DJ, Chen PL, Lee WH.
Mol Cell Biol 17(10):6049-56. 1997
46NDC80
HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins.
Chen Y, Sharp ZD, Lee WH.
J Biol Chem. 272(38):24081-7. 1997