| 1 | NCK1, NPHS1, WTIP
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| Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP.
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| Keyvani Chahi A, Martin CE, Jones N.
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| J Biol Chem 291(24):12799-808. doi: 10.1074/jbc.M116.724245. Epub 2016 Mar 31.
2016
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| 2 | EIF2AK3, NCK1
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| Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling.
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| Yamani L, Li B, Larose L.
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| Cell Signal 27(12):2555-67. doi: 10.1016/j.cellsig.2015.09.016. Epub 2015 Oct 3.
2015
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| 3 | NCK1
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| Nck influences preosteoblastic/osteoblastic migration and bone mass.
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| Aryal A C S, Miyai K, Izu Y, Hayata T, Notomi T, Noda M, Ezura Y.
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| Proc Natl Acad Sci U S A 112(50):15432-7. doi: 10.1073/pnas.1518253112. Epub 2015 Nov 30.
2015
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| 4 | NCK1
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| Requisite role for Nck adaptors in cardiovascular development, endothelial-to-mesenchymal transition, and directed cell migration.
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| Clouthier DL, Harris CN, Harris RA, Martin CE, Puri MC, Jones N.
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| Mol Cell Biol 35(9):1573-87. doi: 10.1128/MCB.00072-15. Epub 2015 Feb 17.
2015
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| 5 | NCK1, WASL
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| Allosteric N-WASP activation by an inter-SH3 domain linker in Nck.
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| Okrut J, Prakash S, Wu Q, Kelly MJ, Taunton J.
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| Proc Natl Acad Sci U S A 112(47):E6436-45. doi: 10.1073/pnas.1510876112. Epub 2015 Nov 9.
2015
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| 6 | ELMO1, NCK1, RAC1
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| A novel interaction between SH2 domain of signaling adaptor protein Nck-1 and the upstream regulator of the Rho family GTPase Rac1-engulfment and cell motility 1 (ELMO1) promotes Rac1 activation and cell motility.
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| Zhang G, Chen X, Qiu F, Zhu F, Lei W, Nie J.
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| J Biol Chem Biol Chem. 2014 Jun 13. pii: jbc.M114.549550. [Epub ahead of print]
2014
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| 7 | NCK1, PTPN1
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| Nck1 depletion induces activation of the PI3K/Akt pathway by attenuating PTP1B protein expression.
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| Li H, Dusseault J, Larose L.
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| Cell Commun Signal 12:71. doi: 10.1186/s12964-014-0071-9.
2014
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| 8 | NCK1
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| The cytoplasmic capping complex assembles on adapter protein nck1 bound to the proline-rich C-terminus of Mammalian capping enzyme.
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| Mukherjee C, Bakthavachalu B, Schoenberg DR.
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| PLoS Biol 12(8):e1001933. doi: 10.1371/journal.pbio.1001933. eCollection 2014 Aug.
2014
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| 9 | FYB1, NCK1
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| The adapter proteins ADAP and Nck cooperate in T cell adhesion.
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| Lettau M, Kliche S, Kabelitz D, Janssen O.
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| Mol Immunol 60(1):72-9. doi: 10.1016/j.molimm.2014.03.017. Epub 2014 Apr 24. 2014
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| 10 | NCK1, NCK2
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| Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation.
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| Ngoenkam J, Paensuwan P, Preechanukul K, Khamsri B, Yiemwattana I, Beck-García E, Minguet S, Schamel WW, Pongcharoen S.
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| Cell Commun Signal 12:21. doi: 10.1186/1478-811X-12-21.
2014
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| 11 | CD3E, NCK1
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| Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo.
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| Borroto A, Arellano I, Blanco R, Fuentes M, Orfao A, Dopfer EP, Prouza M, Suchànek M, Schamel WW, Alarcón B.
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| J Immunol 192(5):2042-53. doi: 10.4049/jimmunol.1203414. Epub 2014 Jan 27.
2014
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| 12 | CDC42, ITSN1, NCK1, WASL
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| Cdc42 and the Rho GEF intersectin-1 collaborate with Nck to promote N-WASP-dependent actin polymerisation.
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| Humphries AC, Donnelly SK, Way M.
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| J Cell Sci 127(Pt 3):673-85. doi: 10.1242/jcs.141366. Epub 2013 Nov 27.
2014
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| 13 | FYN, NCK1, NPHS1
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| Direct regulation of nephrin tyrosine phosphorylation by Nck adaptor proteins.
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| New LA, Keyvani Chahi A, Jones N.
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| J Biol Chem 288(3):1500-10. doi: 10.1074/jbc.M112.439463. Epub 2012 Nov 27. 2013
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| 14 | NCK1, WASL, WIPF1
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| WIP provides an essential link between Nck and N-WASP during Arp2/3-dependent actin polymerization.
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| Donnelly SK, Weisswange I, Zettl M, Way M.
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| Curr Biol 23(11):999-1006. doi: 10.1016/j.cub.2013.04.051. Epub 2013 May 23.
2013
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| 15 | NCK1, ZAP70
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| Nck recruitment to the TCR required for ZAP70 activation during thymic development.
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| Borroto A, Arellano I, Dopfer EP, Prouza M, Suchànek M, Fuentes M, Orfao A, Schamel WW, Alarcón B.
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| J Immunol 190(3):1103-12. doi: 10.4049/jimmunol.1202055. Epub 2012 Dec 24.
2013
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| 16 | NCK1
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| Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.
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| Buvall L, Rashmi P, Lopez-Rivera E, Andreeva S, Weins A, Wallentin H, Greka A, Mundel P.
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| Nat Commun 4:2863. doi: 10.1038/ncomms3863.
2013
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| 17 | NCK1, PIK3AP1
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| Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.
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| Castello A, Gaya M, Tucholski J, Oellerich T, Lu KH, Tafuri A, Pawson T, Wienands J, Engelke M, Batista FD.
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| Nat Immunol 14(9):966-75. doi: 10.1038/ni.2685. Epub 2013 Aug 4.
2013
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| 18 | LRFN4, NCK1, SFN
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| A neuronal transmembrane protein LRFN4 complexes with 14-3-3s and NCK1 to induce morphological change in monocytic cells via Rac1-mediated actin cytoskeleton reorganization.
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| Konakahara S, Suzuki Y, Kawakami T, Saitou M, Kajikawa M, Masuho Y, Kohroki J.
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| FEBS Lett EBS Lett. 2012 Jun 4. [Epub ahead of print]
2012
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| 19 | FYB1, NCK1
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| Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization.
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| Pauker MH, Reicher B, Fried S, Perl O, Barda-Saad M.
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| Mol Cell Biol 31(13):2653-66. Epub 2011 May 2. 2011
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| 20 | NCK1, PTPN1
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| Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.
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| Wu CL, Buszard B, Teng CH, Chen WL, Warr CG, Tiganis T, Meng TC.
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| Biochem J 439(1):151-9. doi: 10.1042/BJ20110799.
2011
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| 21 | NCK1, RASA1
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| Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity.
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| Ger M, Zitkus Z, Valius M.
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| Cell Signal 23(10):1651-8. doi: 10.1016/j.cellsig.2011.05.019. Epub 2011 Jun 2.
2011
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| 22 | GRAP2, LCP2, NCK1
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| The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway.
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| Preisinger C, Kolch W.
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| Cell Signal 22(5):848-56. Epub 2010 Jan 14.PMID: 20079431 2010
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| 23 | NCK1, NCK2, SORBS1
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| Ponsin interacts with Nck adapter proteins: implications for a role in cytoskeletal remodelling during differentiation of skeletal muscle cells.
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| Gehmlich K, Hayess K, Legler C, Haebel S, Van der Ven PF, Ehler E, Fürst DO.
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| Eur J Cell Biol 89(5):351-64. Epub 2010 Feb 2.PMID: 20129698 2010
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| 24 | NCK1, TMEM22
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| Association of genetic variants at 3q22 with nephropathy in patients with type 1 diabetes mellitus.
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| He B, Osterholm AM, Hoverfält A, Forsblom C, Hjörleifsdóttir EE, Nilsson AS, Parkkonen M, Pitkäniemi J, Hreidarsson A, Sarti C, McKnight AJ, Maxwell AP, Tuomilehto J, Groop PH, Tryggvason K.
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| Am J Hum Genet 84(1):5-13. Epub 2008 Dec 11.
2009
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| 25 | NCK1, NCK2
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| Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration.
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| Guan S, Fan J, Han A, Chen M, Woodley DT, Li W.
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| J Invest Dermatol 129(8):1909-20. Epub 2009 Feb 26.PMID: 19242519 2009
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| 26 | EIF2AK2, NCK1
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| Nck-1 interacts with PKR and modulates its activation by dsRNA.
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| Cardin E, Larose L.
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| Biochem Biophys Res Commun 377(1):231-5. Epub 2008 Oct 1.PMID: 18835251 2008
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| 27 | NCK1, NCK2, SOCS7
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| Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.
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| Kremer BE, Adang LA, Macara IG.
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| Cell 130(5):837-50.PMID: 17803907 2007
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| 28 | CD3E, EPS8L1, NCK1
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| Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon.
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| Kesti T, Ruppelt A, Wang JH, Liss M, Wagner R, Taskén K, Saksela K.
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| J Immunol 179(2):878-85.
2007
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| 29 | NCK1, NCK2
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| The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.
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| Frese S, Schubert WD, Findeis AC, Marquardt T, Roske YS, Stradal TE, Heinz DW.
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| J Biol Chem 281(26):18236-45. Epub 2006 Apr 24. 2006
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| 30 | MINK1, NCK1
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| Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta.
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| Hu Y, Leo C, Yu S, Huang BC, Wang H, Shen M, Luo Y, Daniel-Issakani S, Payan DG, Xu X.
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| J Biol Chem 279(52):54387-97. Epub 2004 Oct 6. Erratum in: J Biol Chem. 2005 Feb 11;280(6):5128. 2004
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| 31 | EPHB1, NCK1
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| EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118.
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| Vindis C, Teli T, Cerretti DP, Turner CE, Huynh-Do U.
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| J Biol Chem 279(27):27965-70. Epub 2004 Apr 23. 2004
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| 32 | NCK1, NCK2
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| Identification of Nck family genes, chromosomal localization, expression, and signaling specificity.
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| Chen M, et al.
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| J Biol Chem 273 : 25171-25178. 1998
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| 33 | NCK1, NCK2
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| A casein kinase I activity is constitutively associated with Nck.
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| Lussier G, et al.
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| J Biol Chem 272 : 2688-2694. 1997
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| 34 | ARF4, D3S1636, D3S1638, D3S1640, D3S1643, D3S1644, D3S1646, D3S1656, D3S1658, D3S1710, D3S1726, ELNL1, NCK1
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| Localization of human ARF2 and NCK genes and 13 other NotI-linking clones to chromosome 3 by fluorescence in situ hybridization.
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| Vorobieva N, et al.
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| Cytogenet Cell Genet 68 : 91-94. 1995
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| 35 | GRB2, NCK1, SHC1
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| Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).
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| Huebner K, et al.
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| Genomics 22 : 281-287. 1994
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| 36 | NCK1
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| Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3.
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| Lehmann JM, et al.
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| Nucleic Acids Res 18 : 1048. 1990
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