| 1 | MYOC, SNTA1
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| Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex.
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| Joe MK, Kee C, Tomarev SI.
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| J Biol Chem 287(16):13216-27. doi: 10.1074/jbc.M111.224063. Epub 2012 Feb 25.
2012
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| 2 | MYOC
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| Molecular chaperone function for myocilin.
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| Anderssohn AM, Cox K, O'Malley K, Dees S, Hosseini M, Boren L, Wagner A, Bradley JM, Kelley MJ, Acott TS.
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| Invest Ophthalmol Vis Sci. 52(10):7548-55 2011
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| 3 | GLC1A, GLC1E, MYOC, OPTN
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| Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG.
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| McDonald KK, Abramson K, Beltran MA, Ramirez MG, Alvarez M, Ventura A, Santiago-Turla C, Schmidt S, Hauser MA, Allingham RR.
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| J Hum Genet 55(10):697-700. Epub 2010 Jul 29.
2010
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| 4 | CYP1B1, GLC1A, GLC3A, MYOC
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| Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of juvenile glaucoma with goniodysgenesis.
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| Chen X, Yan N, Yun H, Sun J, Yu M, Zhou J, Cao G, Yin H, Li M, Liu X.
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| Mol Vis 15:1530-6.
2009
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| 5 | MYOC, GLC1A
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| Myocilin allele-specific glaucoma phenotype database.
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| Hewitt AW, Mackey DA, Craig JE.
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| Hum Mutat 29(2):207-11. 2008
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| 6 | PEX5, MYOC, GLC1A
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| Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure.
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| Shepard AR, Jacobson N, Millar JC, Pang IH, Steely HT, Searby CC, Sheffield VC, Stone EM, Clark AF.
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| Hum Mol Genet 16(6):609-17. Epub 2007 Feb 22. 2007
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| 7 | CYP1B1, GLC1A, GLC1E, GLC3A, MYOC, OPTN
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| Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients.
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| Kumar A, Basavaraj MG, Gupta SK, Qamar I, Ali AM, Bajaj V, Ramesh TK, Prakash DR, Shetty JS, Dorairaj SK.
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| Mol Vis 13:667-76.
2007
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| 8 | IGLL1, MYOC
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| The identification of myocilin-associated proteins in the human trabecular meshwork.
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| Fautsch MP, Vrabel AM, Johnson DH.
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| Exp Eye Res 82(6):1046-52. Epub 2005 Nov 11. 2006
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| 9 | MYOC
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| A Genome-wide Scan Maps a Novel Juvenile-Onset Primary Open-Angle Glaucoma Locus to 15q.
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| Wang DY, Fan BJ, Chua JK, Tam PO, Leung CK, Lam DS, Pang CP.
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| Invest Ophthalmol Vis Sci 47(12):5315-21. 2006
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| 10 | GLC1C, MYOC
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| A large GLC1C Greek family with a myocilin T377M mutation: inheritance and phenotypic variability.
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| Petersen MB, Kitsos G, Samples JR, Gaudette ND, Economou-Petersen E, Sykes R, Rust K, Grigoriadou M, Aperis G, Choi D, Psilas K, Craig JE, Kramer PL, Mackey DA, Wirtz MK.
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| Invest Ophthalmol Vis Sci 47(2):620-5. 2006
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| 11 | MYOC, OPTN, WDR36, GLC1A, GLC1E, GLC1G
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| Gene mapping for primary open angle glaucoma.
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| Fan BJ, Wang DY, Lam DS, Pang CP.
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| Clin Biochem 39(3):249-58. Epub 2005 Dec 5. Review. 2006
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| 12 | GLC1A, MYOC, CYP1B1
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| Myocilin gene implicated in primary congenital glaucoma.
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| Kaur K, Reddy AB, Mukhopadhyay A, Mandal AK, Hasnain SE, Ray K, Thomas R, Balasubramanian D, Chakrabarti S.
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| Clin Genet 67(4):335-40. 2005
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| 13 | FLOT1,GLC1A,MYOC
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| Identification of flotillin-1 as a protein interacting with myocilin: implications for the pathogenesis of primary open-angle glaucoma.
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| Joe MK, Sohn S, Choi YR, Park H, Kee C.
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| Biochem Biophys Res Commun 336(4):1201-6. 2005
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| 14 | MYOC
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| Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice.
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| Zillig M, Wurm A, Grehn FJ, Russell P, Tamm ER.
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| Invest Ophthalmol Vis Sci. 46(1):223-34. 2005
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| 15 | MYOC, GLC1A
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| Low prevalence of MYOC mutations in UK primary open-angle glaucoma patients limits the utility of genetic testing.
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| Aldred MA, Baumber L, Hill A, Schwalbe EC, Goh K, Karwatowski W, Trembath RC.
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| Hum Genet 115(5):428-31. Epub 2004 Aug 25. 2004
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| 16 | CYP1B1, MYOC, PITX2
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| Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene.
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| Vincent AL, Billingsley G, Buys Y, Levin AV, Priston M, Trope G, Williams-Lyn D, Heon E.
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| Am J Hum Genet 70(2):448-60. 2002
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| 17 | MYOC, OLFM1, OLFM2, OLFM3
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| Optimedin: a novel olfactomedin-related protein that interacts with myocilin.
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| Torrado M, Trivedi R, Zinovieva R, Karavanova I, Tomarev SI.
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| Hum Mol Genet 11(11):1291-301. 2002
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| 18 | APOE, MYOC
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| Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene.
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| Copin B, Brezin AP, Valtot F, Dascotte JC, Bechetoille A, Garchon HJ.
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| Am J Hum Genet 70(6):1575-81. 2002
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| 19 | MYOC
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| Distribution of myocilin and extracellular matrix components in the juxtacanalicular tissue of human eyes.
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| Ueda J, Wentz-Hunter K, Yue BY.
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| Invest Ophthalmol Vis Sci. 43(4):1068-76. 2002
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| 20 | MYOC
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| In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin.
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| Filla MS, Liu X, Nguyen TD, Polansky JR, Brandt CR, Kaufman PL, Peters DM.
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| Invest Ophthalmol Vis Sci. 43(1):151-61. 2002
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| 21 | MYOC
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| Protein interactions with myocilin.
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| Wentz-Hunter K, Ueda J, Yue BY.
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| Invest Ophthalmol Vis Sci. 43(1):176-82. 2002
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| 22 | GLC1A, MYOC
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| Analysis of myocilin gene mutations in Japanese patients with normal tension glaucoma and primary open-angle glaucoma.
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| Mabuchi F, Yamagata Z, Kashiwagi K, Tang S, Iijima H, Tsukahara S.
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| Clin Genet 59(4):263-8. 2001
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| 23 | GLC1A, MYOC
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| Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor.
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| Jacobson N, Andrews M, Shepard AR, Nishimura D, Searby C, Fingert JH, Hageman G, Mullins R, Davidson BL, Kwon YH, Alward WL, Stone EM, Clark AF, Sheffield VC.
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| Hum Mol Genet 10(2):117-25. 2001
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| 24 | GLC1A, MYOC
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| MYOC mutation frequency in primary open-angle glaucoma patients from Western Switzerland.
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| Mataftsi A, Achache F, Heon E, Mermoud A, Cousin P, Metthez G, Schorderet DF, Munier FL.
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| Ophthalmic Genet 22(4):225-31. 2001
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| 25 | MYOC
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| Characterization of myocilin-myocilin interactions.
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| Fautsch MP, Johnson DH.
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| Invest Ophthalmol Vis Sci. 42(10):2324-31. 2001
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| 26 | MYOC
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| Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function.
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| Kim BS, Savinova OV, Reedy MV, Martin J, Lun Y, Gan L, Smith RS, Tomarev SI, John SW, Johnson RL.
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| Mol Cell Biol. 21(22):7707-13. 2001
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| 27 | MYOC
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| Post-transcriptional modification of the gene genetically linked to juvenile open-angle glaucoma; novel transcripts in human ocular tissues.
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| Kong TH.
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| Gene. 280(1-2):115-22. 2001
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| 28 | GLC1A, MYOC
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| Novel mutation in the MYOC gene in primary open glaucoma patients.
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| Vasconcellos JP, Melo MB, Tsukumo DM, Basseres DS, Bordin S, Saad ST, Costa FF.
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| J Med Genet 37(4):301-3. No abstract available. 2000
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| 29 | MYOC
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| The myocilin (MYOC) gene expression in the human trabecular meshwork.
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| Takahashi H, Noda S, Mashima Y, Kubota R, Ohtake Y, Tanino T, Kudoh J, Minoshima S, Oguchi Y, Shimizu N.
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| Curr Eye Res 20(2):81-4. 2000
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| 30 | GLC1A, MYOC
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| Juvenile open angle glaucoma : fine mapping of the TIGR gene to 1q24.3-q25.2 and mutation analysis.
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| Michels-Rautenstrauss KG, Mardin CY, Budde WM, Liehr T, Polansky J, Nguyen T, Timmerman V, Van Broeckhoven C, Naumann GO, Pfeiffer RA, Rautenstrauss BW.
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| Hum Genet 102(1):103-6. 1998
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| 31 | GLC1A, MYOC
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| Novel mutations in the TIGR gene in early and late onset open angle glaucoma.
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| Mansergh FC, Kenna PF, Ayuso C, Kiang AS, Humphries P, Farrar GJ.
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| Hum Mutat 11(3):244-51. 1998
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| 32 | GLC1A, MYOC
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| Genomic organization of the human myocilin gene (MYOC) responsible for primary open angle glaucoma (GLC1A).
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| Kubota R, Kudoh J, Mashima Y, Asakawa S, Minoshima S, Hejtmancik JF, Oguchi Y, Shimizu N.
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| Biochem Biophys Res Commun 242(2):396-400. 1998
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| 33 | GLC1A, MYOC
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| Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A).
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| Alward WLM, et al.
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| N Engl J Med 338 : 1022-1027. 1998
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| 34 | MYOC
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| Gene structure and properties of TIGR, and olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells.
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| Nguyen TD, Chen P, Huang WD, Chen H, Johnson D, Polansky JR.
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| J Biol Chem 273(11):6341-50. 1998
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| 35 | GLC1A, MYOC
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| Homozygotes carrying an autosomal dominant TIGR mutation do not manifest glaucoma.
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| Morissette J, Clepet C, Moisan S, Dubois S, Winstall E, Vermeeren D, Nguyen TD, Polansky JR, Cote G, Anctil JL, Amyot M, Plante M, Falardeau P, Raymond V.
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| Nat Genet 19 : 319-321. 1998
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| 36 | GLC1A, MYOC
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| Novel TIGR/MYOC mutations in families with juvenile onset primary open angle glaucoma.
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| Stoilova D, et al.
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| J Med Genet 35 : 989-992. 1998
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| 37 | GLC1A, MYOC
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| Prevalence of mutations in TIGR/Myocilin in patients with adult and juvenile primary open-angle glaucoma.
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| Wiggs JL, et al.
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| Am J Hum Genet 63 : 1549-1552. 1998
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| 38 | MYOC
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| Characterization and comparison of the human and mouse GLC1A glaucoma genes.
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| Fingert JH, Ying L, Swiderski RE, Nystuen AM, Arbour NC, Alward WL, Sheffield VC, Stone EM.
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| Genome Res. 8(4):377-84. 1998
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| 39 | GLC1A,MYOC,TNFSF4
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| Identification of a gene that causes primary open angle glaucoma.
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| Stone EM, et al.
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| Science 275 : 668-670. 1997
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| 40 | MYOC
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| A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping.
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| Kubota R, Noda S, Wang Y, Minoshima S, Asakawa S, Kudoh J, Mashima Y, Oguchi Y, Shimizu N.
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| Genomics 41(3):360-9. 1997
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| 41 | MYOC
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| Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin.
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| Ortego J, Escribano J, Coca-Prados M.
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| FEBS Lett 413(2):349-53. 1997
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| 42 | GLC1A, MYOC
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| Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma.
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| Adam MF, Belmouden A, Binisti P, Brezin AP, Valtot F, Bechetoille A, Dascotte JC, Copin B, Gomez L, Chaventre A, Bach JF, Garchon HJ.
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| Hum Mol Genet 6(12):2091-7. 1997
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| 43 | GLC1A, MYOC
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| Identification of a new 'TIGR' mutation in a family with juvenile-onset primary open angle glaucoma.
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| Stoilova D, Child A, Brice G, Crick RP, Fleck BW, Sarfarazi M.
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| Ophthalmic Genet 18(3):109-18. 1997
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| 44 | GLC1A, MYOC
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| Mutations in the TIGR gene in familial primary open-angle glaucoma in Japan.
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| Suzuki Y, Shirato S, Taniguchi F, Ohara K, Nishimaki K, Ohta S.
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| Am J Hum Genet 61(5):1202-4. No abstract available. 1997
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