Citations for
1MYOC, SNTA1
Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex.
Joe MK, Kee C, Tomarev SI.
J Biol Chem 287(16):13216-27. doi: 10.1074/jbc.M111.224063. Epub 2012 Feb 25. 2012
2MYOC
Molecular chaperone function for myocilin.
Anderssohn AM, Cox K, O'Malley K, Dees S, Hosseini M, Boren L, Wagner A, Bradley JM, Kelley MJ, Acott TS.
Invest Ophthalmol Vis Sci. 52(10):7548-55 2011
3GLC1A, GLC1E, MYOC, OPTN
Myocilin and optineurin coding variants in Hispanics of Mexican descent with POAG.
McDonald KK, Abramson K, Beltran MA, Ramirez MG, Alvarez M, Ventura A, Santiago-Turla C, Schmidt S, Hauser MA, Allingham RR.
J Hum Genet 55(10):697-700. Epub 2010 Jul 29. 2010
4CYP1B1, GLC1A, GLC3A, MYOC
Sequence analysis of MYOC and CYP1B1 in a Chinese pedigree of juvenile glaucoma with goniodysgenesis.
Chen X, Yan N, Yun H, Sun J, Yu M, Zhou J, Cao G, Yin H, Li M, Liu X.
Mol Vis 15:1530-6. 2009
5MYOC, GLC1A
Myocilin allele-specific glaucoma phenotype database.
Hewitt AW, Mackey DA, Craig JE.
Hum Mutat 29(2):207-11. 2008
6PEX5, MYOC, GLC1A
Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure.
Shepard AR, Jacobson N, Millar JC, Pang IH, Steely HT, Searby CC, Sheffield VC, Stone EM, Clark AF.
Hum Mol Genet 16(6):609-17. Epub 2007 Feb 22. 2007
7CYP1B1, GLC1A, GLC1E, GLC3A, MYOC, OPTN
Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients.
Kumar A, Basavaraj MG, Gupta SK, Qamar I, Ali AM, Bajaj V, Ramesh TK, Prakash DR, Shetty JS, Dorairaj SK.
Mol Vis 13:667-76. 2007
8IGLL1, MYOC
The identification of myocilin-associated proteins in the human trabecular meshwork.
Fautsch MP, Vrabel AM, Johnson DH.
Exp Eye Res 82(6):1046-52. Epub 2005 Nov 11. 2006
9MYOC
A Genome-wide Scan Maps a Novel Juvenile-Onset Primary Open-Angle Glaucoma Locus to 15q.
Wang DY, Fan BJ, Chua JK, Tam PO, Leung CK, Lam DS, Pang CP.
Invest Ophthalmol Vis Sci 47(12):5315-21. 2006
10GLC1C, MYOC
A large GLC1C Greek family with a myocilin T377M mutation: inheritance and phenotypic variability.
Petersen MB, Kitsos G, Samples JR, Gaudette ND, Economou-Petersen E, Sykes R, Rust K, Grigoriadou M, Aperis G, Choi D, Psilas K, Craig JE, Kramer PL, Mackey DA, Wirtz MK.
Invest Ophthalmol Vis Sci 47(2):620-5. 2006
11MYOC, OPTN, WDR36, GLC1A, GLC1E, GLC1G
Gene mapping for primary open angle glaucoma.
Fan BJ, Wang DY, Lam DS, Pang CP.
Clin Biochem 39(3):249-58. Epub 2005 Dec 5. Review. 2006
12GLC1A, MYOC, CYP1B1
Myocilin gene implicated in primary congenital glaucoma.
Kaur K, Reddy AB, Mukhopadhyay A, Mandal AK, Hasnain SE, Ray K, Thomas R, Balasubramanian D, Chakrabarti S.
Clin Genet 67(4):335-40. 2005
13FLOT1,GLC1A,MYOC
Identification of flotillin-1 as a protein interacting with myocilin: implications for the pathogenesis of primary open-angle glaucoma.
Joe MK, Sohn S, Choi YR, Park H, Kee C.
Biochem Biophys Res Commun 336(4):1201-6. 2005
14MYOC
Overexpression and properties of wild-type and Tyr437His mutated myocilin in the eyes of transgenic mice.
Zillig M, Wurm A, Grehn FJ, Russell P, Tamm ER.
Invest Ophthalmol Vis Sci. 46(1):223-34. 2005
15MYOC, GLC1A
Low prevalence of MYOC mutations in UK primary open-angle glaucoma patients limits the utility of genetic testing.
Aldred MA, Baumber L, Hill A, Schwalbe EC, Goh K, Karwatowski W, Trembath RC.
Hum Genet 115(5):428-31. Epub 2004 Aug 25. 2004
16CYP1B1, MYOC, PITX2
Digenic inheritance of early-onset glaucoma: CYP1B1, a potential modifier gene.
Vincent AL, Billingsley G, Buys Y, Levin AV, Priston M, Trope G, Williams-Lyn D, Heon E.
Am J Hum Genet 70(2):448-60. 2002
17MYOC, OLFM1, OLFM2, OLFM3
Optimedin: a novel olfactomedin-related protein that interacts with myocilin.
Torrado M, Trivedi R, Zinovieva R, Karavanova I, Tomarev SI.
Hum Mol Genet 11(11):1291-301. 2002
18APOE, MYOC
Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene.
Copin B, Brezin AP, Valtot F, Dascotte JC, Bechetoille A, Garchon HJ.
Am J Hum Genet 70(6):1575-81. 2002
19MYOC
Distribution of myocilin and extracellular matrix components in the juxtacanalicular tissue of human eyes.
Ueda J, Wentz-Hunter K, Yue BY.
Invest Ophthalmol Vis Sci. 43(4):1068-76. 2002
20MYOC
In vitro localization of TIGR/MYOC in trabecular meshwork extracellular matrix and binding to fibronectin.
Filla MS, Liu X, Nguyen TD, Polansky JR, Brandt CR, Kaufman PL, Peters DM.
Invest Ophthalmol Vis Sci. 43(1):151-61. 2002
21MYOC
Protein interactions with myocilin.
Wentz-Hunter K, Ueda J, Yue BY.
Invest Ophthalmol Vis Sci. 43(1):176-82. 2002
22GLC1A, MYOC
Analysis of myocilin gene mutations in Japanese patients with normal tension glaucoma and primary open-angle glaucoma.
Mabuchi F, Yamagata Z, Kashiwagi K, Tang S, Iijima H, Tsukahara S.
Clin Genet 59(4):263-8. 2001
23GLC1A, MYOC
Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor.
Jacobson N, Andrews M, Shepard AR, Nishimura D, Searby C, Fingert JH, Hageman G, Mullins R, Davidson BL, Kwon YH, Alward WL, Stone EM, Clark AF, Sheffield VC.
Hum Mol Genet 10(2):117-25. 2001
24GLC1A, MYOC
MYOC mutation frequency in primary open-angle glaucoma patients from Western Switzerland.
Mataftsi A, Achache F, Heon E, Mermoud A, Cousin P, Metthez G, Schorderet DF, Munier FL.
Ophthalmic Genet 22(4):225-31. 2001
25MYOC
Characterization of myocilin-myocilin interactions.
Fautsch MP, Johnson DH.
Invest Ophthalmol Vis Sci. 42(10):2324-31. 2001
26MYOC
Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function.
Kim BS, Savinova OV, Reedy MV, Martin J, Lun Y, Gan L, Smith RS, Tomarev SI, John SW, Johnson RL.
Mol Cell Biol. 21(22):7707-13. 2001
27MYOC
Post-transcriptional modification of the gene genetically linked to juvenile open-angle glaucoma; novel transcripts in human ocular tissues.
Kong TH.
Gene. 280(1-2):115-22. 2001
28GLC1A, MYOC
Novel mutation in the MYOC gene in primary open glaucoma patients.
Vasconcellos JP, Melo MB, Tsukumo DM, Basseres DS, Bordin S, Saad ST, Costa FF.
J Med Genet 37(4):301-3. No abstract available. 2000
29MYOC
The myocilin (MYOC) gene expression in the human trabecular meshwork.
Takahashi H, Noda S, Mashima Y, Kubota R, Ohtake Y, Tanino T, Kudoh J, Minoshima S, Oguchi Y, Shimizu N.
Curr Eye Res 20(2):81-4. 2000
30GLC1A, MYOC
Juvenile open angle glaucoma : fine mapping of the TIGR gene to 1q24.3-q25.2 and mutation analysis.
Michels-Rautenstrauss KG, Mardin CY, Budde WM, Liehr T, Polansky J, Nguyen T, Timmerman V, Van Broeckhoven C, Naumann GO, Pfeiffer RA, Rautenstrauss BW.
Hum Genet 102(1):103-6. 1998
31GLC1A, MYOC
Novel mutations in the TIGR gene in early and late onset open angle glaucoma.
Mansergh FC, Kenna PF, Ayuso C, Kiang AS, Humphries P, Farrar GJ.
Hum Mutat 11(3):244-51. 1998
32GLC1A, MYOC
Genomic organization of the human myocilin gene (MYOC) responsible for primary open angle glaucoma (GLC1A).
Kubota R, Kudoh J, Mashima Y, Asakawa S, Minoshima S, Hejtmancik JF, Oguchi Y, Shimizu N.
Biochem Biophys Res Commun 242(2):396-400. 1998
33GLC1A, MYOC
Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A).
Alward WLM, et al.
N Engl J Med 338 : 1022-1027. 1998
34MYOC
Gene structure and properties of TIGR, and olfactomedin-related glycoprotein cloned from glucocorticoid-induced trabecular meshwork cells.
Nguyen TD, Chen P, Huang WD, Chen H, Johnson D, Polansky JR.
J Biol Chem 273(11):6341-50. 1998
35GLC1A, MYOC
Homozygotes carrying an autosomal dominant TIGR mutation do not manifest glaucoma.
Morissette J, Clepet C, Moisan S, Dubois S, Winstall E, Vermeeren D, Nguyen TD, Polansky JR, Cote G, Anctil JL, Amyot M, Plante M, Falardeau P, Raymond V.
Nat Genet 19 : 319-321. 1998
36GLC1A, MYOC
Novel TIGR/MYOC mutations in families with juvenile onset primary open angle glaucoma.
Stoilova D, et al.
J Med Genet 35 : 989-992. 1998
37GLC1A, MYOC
Prevalence of mutations in TIGR/Myocilin in patients with adult and juvenile primary open-angle glaucoma.
Wiggs JL, et al.
Am J Hum Genet 63 : 1549-1552. 1998
38MYOC
Characterization and comparison of the human and mouse GLC1A glaucoma genes.
Fingert JH, Ying L, Swiderski RE, Nystuen AM, Arbour NC, Alward WL, Sheffield VC, Stone EM.
Genome Res. 8(4):377-84. 1998
39GLC1A,MYOC,TNFSF4
Identification of a gene that causes primary open angle glaucoma.
Stone EM, et al.
Science 275 : 668-670. 1997
40MYOC
A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping.
Kubota R, Noda S, Wang Y, Minoshima S, Asakawa S, Kudoh J, Mashima Y, Oguchi Y, Shimizu N.
Genomics 41(3):360-9. 1997
41MYOC
Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin.
Ortego J, Escribano J, Coca-Prados M.
FEBS Lett 413(2):349-53. 1997
42GLC1A, MYOC
Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma.
Adam MF, Belmouden A, Binisti P, Brezin AP, Valtot F, Bechetoille A, Dascotte JC, Copin B, Gomez L, Chaventre A, Bach JF, Garchon HJ.
Hum Mol Genet 6(12):2091-7. 1997
43GLC1A, MYOC
Identification of a new 'TIGR' mutation in a family with juvenile-onset primary open angle glaucoma.
Stoilova D, Child A, Brice G, Crick RP, Fleck BW, Sarfarazi M.
Ophthalmic Genet 18(3):109-18. 1997
44GLC1A, MYOC
Mutations in the TIGR gene in familial primary open-angle glaucoma in Japan.
Suzuki Y, Shirato S, Taniguchi F, Ohara K, Nishimaki K, Ohta S.
Am J Hum Genet 61(5):1202-4. No abstract available. 1997