Citations for
1GRIP1, MYO6, TRIP6
Trip6 promotes dendritic morphogenesis through dephosphorylated GRIP1-dependent myosin VI and F-actin organization.
Lv K, Chen L, Li Y, Li Z, Zheng P, Liu Y, Chen J, Teng J.
J Neurosci 35(6):2559-71. doi: 10.1523/JNEUROSCI.2125-14.2015. 2015
2MYO6, SLC9A3
Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells.
Chen T, Hubbard A, Murtazina R, Price J, Yang J, Cha B, Sarker R, Donowitz M.
J Cell Sci 127(Pt 16):3535-45. doi: 10.1242/jcs.149930. Epub 2014 Jun 13. 2014
3DFNA22, MYO6
Progressive hereditary hearing impairment caused by a MYO6 mutation resembles presbyacusis.
Oonk AM, Leijendeckers JM, Lammers EM, Weegerink NJ, Oostrik J, Beynon AJ, Huygen PL, Kunst HP, Kremer H, Snik AF, Pennings RJ.
Hear Res 299:88-98. doi: 10.1016/j.heares.2012.12.015. Epub 2013 Jan 20. 2013
4DAB2, GIPC1, MYO6, TFAP2A
Myosin VI and Associated Proteins Are Expressed in Human Macrophages but Do Not Play a Role in Foam Cell Formation in THP-1 Cells.
Dawson HJ, Hibbert AP, Chantler PD, Botham KM.
Int J Vasc Med 2013:516015. doi: 10.1155/2013/516015. Epub 2013 Jun 9. 2013
5DOCK7, MYO6
Dock7: a GEF for Rho-family GTPases and a novel myosin VI-binding partner in neuronal PC12 cells.
Majewski Ł, Sobczak M, Havrylov S, Jˇźwiak J, Rędowicz MJ.
Biochem Cell Biol 90(4):565-74. doi: 10.1139/o2012-009. Epub 2012 Apr 4. 2012
6MYO6
Myosin VI is required for maintenance of brush border structure, composition, and membrane trafficking functions in the intestinal epithelial cell.
Hegan PS, Giral H, Levi M, Mooseker MS.
Cytoskeleton (Hoboken) 69(4):235-51. doi: 10.1002/cm.21018. Epub 2012 Mar 2. 2012
7GIPC1, MYO6, VANGL2
Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear.
Giese AP, Ezan J, Wang L, Lasvaux L, Lembo F, Mazzocco C, Richard E, Reboul J, Borg JP, Kelley MW, Sans N, Brigande J, Montcouquiol M.
Development 139(20):3775-85. 2012
8MYO6, OPTN
Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane.
Bond LM, Peden AA, Kendrick-Jones J, Sellers JR, Buss F.
Mol Biol Cell 22(1):54-65. Epub 2010 Dec 9. 2011
9MYO6
Altered renal proximal tubular endocytosis and histology in mice lacking myosin-VI.
Gotoh N, Yan Q, Du Z, Biemesderfer D, Kashgarian M, Mooseker MS, Wang T.
Cytoskeleton (Hoboken) 67(3):178-92. doi: 10.1002/cm.20435. 2010
10DFNA22, MYO6
Genotype-phenotype correlation for DFNA22: characterization of non-syndromic, autosomal dominant, progressive sensorineural hearing loss due to MYO6 mutations.
Topsakal V, Hilgert N, van Dinther J, Tranebjaerg L, Rendtorff ND, Zarowski A, Offeciers E, Van Camp G, van de Heyning P.
Audiol Neurootol 15(4):211-20. doi: 10.1159/000255339. Epub 2009 Nov 5. 2010
11MYO6, OTOF
Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell.
Heidrych P, Zimmermann U, Kuhn S, Franz C, Engel J, Duncker SV, Hirt B, Pusch CM, Ruth P, Pfister M, Marcotti W, Blin N, Knipper M.
Hum Mol Genet 18(15):2779-90. Epub 2009 May 5. 2009
12MYO6
Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses.
Roux I, Hosie S, Johnson SL, Bahloul A, Cayet N, Nouaille S, Kros CJ, Petit C, Safieddine S.
Hum Mol Genet 18(23):4615-28. doi: 10.1093/hmg/ddp429. Epub 2009 Sep 10. 2009
13MYO6, DFNA22
A novel nonsense mutation in MYO6 is associated with progressive nonsyndromic hearing loss in a Danish DFNA22 family.
Sanggaard KM, Kjaer KW, Eiberg H, Nčrnberg G, Nčrnberg P, Hoffman K, Jensen H, S┐rum C, Rendtorff ND, Tranebjaerg L.
Am J Med Genet A 146A(8):1017-25. 2008
14MYO6, DFNA22
A splice-site mutation and overexpression of MYO6 cause a similar phenotype in two families with autosomal dominant hearing loss.
Hilgert N, Topsakal V, van Dinther J, Offeciers E, Van de Heyning P, Van Camp G.
Eur J Hum Genet 16(5):593-602. Epub 2008 Jan 23. 2008
15MYO6, PTPRQ
Dynamic compartmentalization of protein tyrosine phosphatase receptor Q at the proximal end of stereocilia: implication of myosin VI-based transport.
Sakaguchi H, Tokita J, Naoz M, Bowen-Pope D, Gov NS, Kachar B.
Cell Motil Cytoskeleton 65(7):528-38.PMID: 18412156 2008
16LMTK2, MYO6
BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking.
Inoue T, Kon T, Ohkura R, Yamakawa H, Ohara O, Yokota J, Sutoh K.
Genes Cells 13(5):483-95.PMID: 18429820 2008
17MYO6
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells.
Hertzano R, Shalit E, Rzadzinska AK, Dror AA, Song L, Ron U, Tan JT, Shitrit AS, Fuchs H, Hasson T, Ben-Tal N, Sweeney HL, de Angelis MH, Steel KP, Avraham KB.
PLoS Genet 4(10):e1000207. doi: 10.1371/journal.pgen.1000207. 2008
18CALCOCO2, MYO6, TAX1BP1
T6BP and NDP52 are myosin VI binding partners with potential roles in cytokine signalling and cell adhesion.
Morriswood B, Ryzhakov G, Puri C, Arden SD, Roberts R, Dendrou C, Kendrick-Jones J, Buss F.
J Cell Sci 120(Pt 15):2574-85. Epub 2007 Jul 17. 2007
19MYO6
Myosin VI is required for targeted membrane transport during cytokinesis.
Arden SD, Puri C, Au JS, Kendrick-Jones J, Buss F.
Mol Biol Cell 18(12):4750-61. Epub 2007 Sep 19.PMID: 17881731 2007
20LRP2, GIPC1, MYO6
Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles.
Naccache SN, Hasson T, Horowitz A.
Proc Natl Acad Sci U S A 103(34):12735-40. Epub 2006 Aug 14. 2006
21FHCD, MYO6
Novel association of hypertrophic cardiomyopathy, sensorineural deafness, and a mutation in unconventional myosin VI (MYO6).
Mohiddin SA, Ahmed ZM, Griffith AJ, Tripodi D, Friedman TB, Fananapazir L, Morell RJ.
J Med Genet 41(4):309-14. No abstract available. 2004
22MYO6, DFNA22
Human deafness mutation of myosin VI (C442Y) accelerates the ADP dissociation rate.
Sato O, White HD, Inoue A, Belknap B, Ikebe R, Ikebe M.
J Biol Chem 279(28):28844-54. Epub 2004 Apr 29. 2004
23DFNB37, MYO6
Mutations of MYO6 are associated with recessive deafness, DFNB37.
Ahmed ZM, Morell RJ, Riazuddin S, Gropman A, Shaukat S, Ahmad MM, Mohiddin SA, Fananapazir L, Caruso RC, Husnain T, Khan SN, Riazuddin S, Griffith AJ, Friedman TB, Wilcox ER.
Am J Hum Genet 72(5):1315-22. Epub 2003 Apr 08. 2003
24MYO6
Myo6 facilitates the translocation of endocytic vesicles from cell peripheries.
Aschenbrenner L, Lee T, Hasson T.
Mol Biol Cell 14(7):2728-43. Epub 2003 Mar 20. 2003
25DFNA22, MYO6
MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss.
Melchionda S, Ahituv N, Bisceglia L, Sobe T, Glaser F, Rabionet R, Arbones ML, Notarangelo A, Di Iorio E, Carella M, Zelante L, Estivill X, Avraham KB, Gasparini P.
Am J Hum Genet 69(3):635-40. 2001
26MYO6
Novel myosin VI isoform is abundantly expressed in retina.
Breckler J, Au K, Cheng J, Hasson T, Burnside B.
Exp Eye Res 70(1):121-34. 2000
27MYO6
Genomic structure of the human unconventional myosin VI gene.
Ahituv N, Sobe T, Robertson NG, Morton CC, Taggart RT, Avraham KB.
Gene 261(2):269-75. 2000
28GLC1A, MYO6
Analysis of myocilin mutations in 1703 glaucoma patients from five different populations.
Fingert JH, et al.
Hum Mol Genet 8(5):899-905. 1999
29MYO6
Myosin VI is an actin-based motor that moves backwards.
Wells AL, et al.
Nature 401(6752):505-8 1999
30MYO6
Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice.
Avraham KB, Hasson T, Sobe T, Balsara B, Testa JR, Skvorak AB, Morton CC, Copeland NG, Jenkins NA.
Hum Mol Genet 6(8):1225-31. 1997
31ADAMTS3, AKAP6, ALMS1, ANKRD28, AREL1, ARHGEF10, ARHGEF11, ARHGEF17, ARNT2, BAZ2A, CABIN1, CAST, CHD9, CIC, CLEC16A, CLOCK, CTNND1, DCLK1, DDX46, DIDO1, DNAH9, DNM3, DOCK3, DYNC1H1, ECM29, ENTPD4, EPB41L1, EZH1, FAM65B, FRMPD4, GCC2, HECW1, HERC2, HISPPD1, HUWE1, IGSF1, KAT6B, KIAA0319, KIAA0323, KIAA0355, KIAA0379, KIF3B, KMT2B, LBA1, MADD, MAST4, MCF2L, MDN1, MTMR3, MYO6, N4BP3, NACAD, NRCAM, PCDH9, PCDHGA8, PCDHGC3, PDZD2, PER2, PFAS, PLEKHM1, PLXNB2, PRORP, PRUNE2, PTPRN2, RAPGEF2, RIMBP2, RIMS1, RUSC2, SALL2, SEC16A, SEMA3C, SEMA3E, SETD1A, SFRS14, SNPH, SPECC1L, SPTBN2, SR140, SRCAP, SRRM2, SYNJ2, TECPR2, TLN2, TRIM66, TTC37, UBR2, WNK1, XPO6, ZBTB39, ZBTB5, ZFYVE16, ZFYVE26, ZMYM3, ZNF518A, ZNF609, ZNF629, ZNF646
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A,Kotani H, Nomura N, Ohara O.
DNA Res 4(2):141-50. 1997